Inflammation in atrial fibrillation


Förderkennzeichen

81Z2710104

Projektnummer

481

Institution
Universitätsklinikum Hamburg-Eppendorf
Projektleiter
Stephan Willems
Standort
Hamburg/Kiel/Lübeck
Kurzbeschreibung

The development of cardiac fibrosis and a higher susceptibility of atrial fibrillation (AF) have been shown in an animal model of long-term hypertension. However, the causal relationship … 

The development of cardiac fibrosis and a higher susceptibility of atrial fibrillation (AF) have been shown in an animal model of long-term hypertension. However, the causal relationship between hypertension, fibrosis and AF remains unclear. Using Angiotensin II, we have established a long-term hypertension model in sheep in order to elucidate structural and electrophysiological changes as a prerequisite for AF. Since the intrinsic cardiac nervous system (ICANS) is known affect AF and other arrhythmias and might present a potential target for catheter-based interventions, we additionally characterise the role of the ICANS in arrhythmias using our sheep model.

Projektart
Standortprojekt
Stichwörter
arrythmias, atrial fibrillation, Hypertension, Left ventricular hypertrophy, cardiac nervous system
Topic
other arrhythmias
Fördersumme
€ 386.990,40
Beginn
29.10.2014
Ende
31.12.2018