Cell Adhesion in CHD


Förderkennzeichen

81Z1600313

Projektnummer

437

Institution
Max-Planck-Institut für Biochemie
Projektleiter
Reinhard Fässler
Standort
München
Kurzbeschreibung

The project „cell adhesion in coronary heart diseases“ makes use of genetically modified mouse lines to analyze the role of integrin-mediated adhesion of vascular smooth muscle cell and … 

The project „cell adhesion in coronary heart diseases“ makes use of genetically modified mouse lines to analyze the role of integrin-mediated adhesion of vascular smooth muscle cell and cardiomyocyte to the extracellular matrix (cell-matrix adhesion) and neighboring cells (cell-cell adhesion) in vivo. We aim to characterize ?-Parvin and ?-Parvin-regulated signal pathways that control vascular and cardiomyocyte function and the progression of CHDs (such as aneurysms, hypertonia or hypertrophy) by a combination of genetic experiments in mice, cell biology and proteomic analysis. A second aim is the development of therapeutic strategies for the treatment of CHDs using synthetic peptides that bind to and inactivate cell adhesion proteins.

Projektart
Standortprojekt
Stichwörter
cell adhesion signaling, knock-out mice, parvin, integrin, cardiomyocytes, vascular smooth muscle cells, hypertrophy, proteomics
Topic
endothelial cells/vascular function
Fördersumme
€ 775.111,00
Beginn
15.10.2011
Ende
31.12.2018