Immunotherapy of Vascular Disease


Förderkennzeichen

81Z1600212

Projektnummer

433

Institution
Klinikum der Universität München
Projektleiter
Christian Weber
Standort
München
Kurzbeschreibung

The newly established research group headed by the DZHK-Professor Oliver Soehnlein shall develop and pursue novel concepts for target identification and therapeutic exploitation in the … 

The newly established research group headed by the DZHK-Professor Oliver Soehnlein shall develop and pursue novel concepts for target identification and therapeutic exploitation in the context of the chemokine-interactome, leukocytic granule proteins, and costimulatory molecules for the treatment of inflammatory aspects of cardiovascular diseases. These are based on detailed structure-function analyses, modelling of molecular interactions, and synthetic peptide chemistry for generation of interceptors, which shall be validated and optimized for safety and efficacy during atherogenic immune cell recruitment. It is the aim to generate peptides for use in clinical studies which shall be realized in subsequent funding periods.

Projektart
Standortprojekt
Stichwörter
chemokine, heteromer, neutrophil, platelet, inflammation, recruitment
Topic
inflammation/vascular inflammation
Fördersumme
€ 1.849.181,03
Beginn
15.10.2011
Ende
31.12.2018