Publikationen 2014

Dezember

No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects. Baumert, J., Huang, J., McKnight, B., Sabater-Lleal, M., Steri, M., Chu, A. Y., Trompet, S., Lopez, L. M., Fornage, M., Teumer, A., Tang, W., Rudnicka, A. R., Malarstig, A., Hottenga, J., Kavousi, M., Lahti, J., Tanaka, T., Hayward, C., Huffman, J. E., Morange, P. et al. PloS one 9, e111156, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25551457

Critical Role of Platelet Glycoprotein Ibalpha in Arterial Remodeling. Chandraratne, S., von Bruehl, M., Pagel, J., Stark, K., Kleinert, E., Konrad, I., Farschtschi, S., Coletti, R., Gartner, F., Chillo, O., Legate, K. R., Lorenz, M., Rutkowski, S., Caballero-Martinez, A., Starke, R., Tirniceriu, A., Pauleikhoff, L., Fischer, S., Assmann, G., Mueller-Hoecker, J. et al. Arteriosclerosis, thrombosis, and vascular biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25550202

Dimerization of Camp Phosphodiesterase-4 (Pde4) in Living Cells Requires Interfaces Located in Both the Ucr1 and Catalytic Unit Domains. Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S., Adams, D. R. & Houslay, M. D. Cellular signalling, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25546709

Da Silva's Cone Repair for Ebstein's Anomaly: Effect on Right Ventricular Size and Functiondagger. Lange, R., Burri, M., Eschenbach, L. K., Badiu, C. C., da Silva, J. P., Nagdyman, N., Fratz, S., Horer, J., Kuhn, A., Schreiber, C. & Vogt, M. O. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25535206

Plasma Fibroblast Growth Factor 23 and Risk of Cardiovascular Disease: Results from the Epic-Germany Case-Cohort Study. di Giuseppe, R., Kuhn, T., Hirche, F., Buijsse, B., Dierkes, J., Fritsche, A., Kaaks, R., Boeing, H., Stangl, G. I. & Weikert, C. European journal of epidemiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25527370

DNA Methylation and Epigenetics: Exploring the Terra Incognita of the Atherosclerotic Landscape. Santovito, D., Egea, V. & Weber, C. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25527822

Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity. Dorn, T., Goedel, A., Lam, J. T., Haas, J., Tian, Q., Herrmann, F., Bundschu, K., Dobreva, G., Schiemann, M., Dirschinger, R., Guo, Y., Kuhl, S. J., Sinnecker, D., Lipp, P., Laugwitz, K., Kuhl, M. & Moretti, A. Stem cells, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25524439

Recurrent Spontaneous Coronary Dissections in a Patient with a De Novo Fibrillin-1 Mutation without Marfan Syndrome. Von Hundelshausen, P., Oexle, K., Bidzhekov, K., Schmitt, M. M., Hristov, M., Blanchet, X., Kaemmerer, H., Matyas, G., Meitinger, T. & Weber, C. Thrombosis and haemostasis, (2014). http://th.schattauer.de/en/contents/ahead-of-print/december-18-2014/issue/special/manuscript/23870/show.html

Creating an Arc-Shaped Aorta: Use of the Subclavian Artery for Interrupted Aortic Arch Repair. Burri, M., Kasnar-Samprec, J., Cleuziou, J., Nobauer, C., Vogt, M. O., Lange, R., Schreiber, C. & Horer, J. The Annals of thoracic surgery, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25528725

Potential Reduction of Interstitial Myocardial Fibrosis with Renal Denervation. Doltra, A., Messroghli, D., Stawowy, P., Hassel, J. H., Gebker, R., Leppanen, O., Grafe, M., Schneeweis, C., Schnackenburg, B., Fleck, E. & Kelle, S. Journal of the American Heart Association 3, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25516438

Clinical and Radiological Spectrum of Posterior Reversible Encephalopathy Syndrome: Does Age Make a Difference? - a Retrospective Comparison between Adult and Pediatric Patients. Siebert, E., Bohner, G., Endres, M. & Liman, T. G. PloS one 9, e115073, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25514795

Is It All Determined at Menarche? Schnabel, R. B. Circulation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25512443

Mto1-Deficient Mouse Model Mirrors the Human Phenotype Showing Complex I Defect and Cardiomyopathy Becker, L., Kling, E., Schiller, E., Zeh, R., Schrewe, A., Holter, S. M., Mossbrugger, I., Calzada-Wack, J., Strecker, V., Wittig, I., Dumitru, I., Wenz, T., Bender, A., Aichler, M., Janik, D., Neff, F., Walch, A., Quintanilla-Fend, L., Floss, T., Bekeredjian, R. et al. PloS one, (2014). http://www.plosone.org/article/authors/info%3Adoi%2F10.1371%2Fjournal.pone.0114918

Immunoadsorption Therapy in Dilated Cardiomyopathy. Felix, S. B., Beug, D. & Dorr, M. Expert review of cardiovascular therapy, 1-8, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25494978

Vascular Change and Opposing Effects of the Angiotensin Type 2 Receptor in a Mouse Model of Vascular Cognitive Impairment. Fuchtemeier, M., Brinckmann, M. P., Foddis, M., Kunz, A., Po, C., Curato, C., Dirnagl, U. & Farr, T. D. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25492118

Exome Sequencing Identifies Rare Ldlr and Apoa5 Alleles Conferring Risk for Myocardial Infarction. authors, A. l. o., their affiliations appears at the end of the, p., Project, N. E. S. & Project, N. E. S. Nature, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25487149

Expert Position Paper on Air Pollution and Cardiovascular Disease. Newby, D. E., Mannucci, P. M., Tell, G. S., Baccarelli, A. A., Brook, R. D., Donaldson, K., Forastiere, F., Franchini, M., Franco, O. H., Graham, I., Hoek, G., Hoffmann, B., Hoylaerts, M. F., Kunzli, N., Mills, N., Pekkanen, J., Peters, A., Piepoli, M. F., Rajagopalan, S., Storey, R. F. et al. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25492627

Mir-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction. Izarra, A., Moscoso, I., Levent, E., Canon, S., Cerrada, I., Diez-Juan, A., Blanca, V., Nunez-Gil, I.-J., Valiente, I., Ruiz-Sauri, A., Sepulveda, P., Tiburcy, M., Zimmermann, W.-H. & Bernad, S. Stem Cell Reports 3, 1-14, (2014). http://www.cell.com/stem-cell-reports/pdf/S2213-6711%2814%2900332-4.pdf

Calcium/Calmodulin-Dependent Protein Kinase Ii Couples Wnt Signaling with Histone Deacetylase 4 and Mediates Dishevelled-Induced Cardiomyopathy. Zhang, M., Hagenmueller, M., Riffel, J. H., Kreusser, M. M., Bernhold, E., Fan, J., Katus, H. A., Backs, J. & Hardt, S. E. Hypertension, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25489064

Mutations in the Deubiquitinase Gene Usp8 Cause Cushing's Disease. Reincke, M., Sbiera, S., Hayakawa, A., Theodoropoulou, M., Osswald, A., Beuschlein, F., Meitinger, T., Mizuno-Yamasaki, E., Kawaguchi, K., Saeki, Y., Tanaka, K., Wieland, T., Graf, E., Saeger, W., Ronchi, C. L., Allolio, B., Buchfelder, M., Strom, T. M., Fassnacht, M. & Komada, M. Nature genetics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25485838

The Src Homology and Collagen a (Shca) Adaptor Protein Is Required for the Spatial Organization of the Costamere/Z-Disk Network During Heart Development. Mlih, M., Host, L., Martin, S., Niederhoffer, N., Monassier, L., Terrand, J., Messaddeq, N., Radke, M., Gotthardt, M., Bruban, V., Kober, F., Bernard, M., Canet-Soulas, E., Abt-Jijon, F., Boucher, P. & Matz, R. L. The Journal of biological chemistry, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25488665

The Continuum of Personalized Cardiovascular Medicine: A Position Paper of the European Society of Cardiology. Kirchhof, P., Sipido, K. R., Cowie, M. R., Eschenhagen, T., Fox, K. A., Katus, H., Schroeder, S., Schunkert, H., Priori, S., Esc Crt, R. & European Affairs Work Shop on Personalized, M. Eur Heart J 35, 3250-3257, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25148837

Homozygous and Compound-Heterozygous Mutations in Tgds Cause Catel-Manzke Syndrome. Ehmke, N., Caliebe, A., Koenig, R., Kant, S. G., Stark, Z., Cormier-Daire, V., Wieczorek, D., Gillessen-Kaesbach, G., Hoff, K., Kawalia, A., Thiele, H., Altmuller, J., Fischer-Zirnsak, B., Knaus, A., Zhu, N., Heinrich, V., Huber, C., Harabula, I., Spielmann, M., Horn, D. et al. AJHG 95, (2014). http://www.sciencedirect.com/science/article/pii/S0002929714004704

Mirnas Can Be Generally Associated with Human Pathologies as Exemplified for Mir-144*. Keller, A., Leidinger, P., Vogel, B., Backes, C., ElSharawy, A., Galata, V., Muller, S. C., Marquart, S., Schrauder, M. G., Strick, R., Bauer, A., Wischhusen, J., Beier, M., Kohlhaas, J., Katus, H. A., Hoheisel, J., Franke, A., Meder, B. & Meese, E. BMC medicine 12, 224, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25465851

Hyperreactivity of Junctional Adhesion Molecule a-Deficient Platelets Accelerates Atherosclerosis in Hyperlipidemic Mice. Karshovska, E., Zhao, Z., Blanchet, X., Schmitt, M. M., Bidzhekov, K., Soehnlein, O., von Hundelshausen, P., Mattheij, N. J., Cosemans, J. M., Megens, R. T., Koeppel, T., Schober, A., Hackeng, T. M., Weber, C. & Koenen, R. R. Circulation research, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25472975

Mybpc3 Gene Therapy for Neonatal Cardiomyopathy Enables Long-Term Disease Prevention in Mice. Mearini, G., Stimpel, D., Geertz, B., Weinberger, F., Kramer, E., Schlossarek, S., Mourot-Filiatre, J., Stoehr, A., Dutsch, A., Wijnker, P. J., Braren, I., Katus, H. A., Muller, O. J., Voit, T., Eschenhagen, T. & Carrier, L. Nature communications 5, 5515, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25463264

Cardiovascular Magnetic Resonance-Based Evaluation of Myocardial Rotational Mechanics. Kowallick, J. T. & Schuster, A. American journal of physiology. Heart and circulatory physiology 307, H1685, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25445802

Changes in the Cardiac Metabolome Caused by Perhexiline Treatment in a Mouse Model of Hypertrophic Cardiomyopathy. Gehmlich, K., Dodd, M. S., William Allwood, J., Kelly, M., Bellahcene, M., Lad, H. V., Stockenhuber, A., Hooper, C., Ashrafian, H., Redwood, C. S., Carrier, L. & Dunn, W. B. Molecular bioSystems, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25437646

Myeloid Zinc Finger 1 (Mzf1) Differentially Modulates Murine Cardiogenesis by Interacting with an Nkx2.5 Cardiac Enhancer. Doppler, S. A., Werner, A., Barz, M., Lahm, H., Deutsch, M. A., Dressen, M., Schiemann, M., Voss, B., Gregoire, S., Kuppusamy, R., Wu, S. M., Lange, R. & Krane, M. PloS one 9, e113775, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25436607

Interhelical Interaction and Receptor Phosphorylation Regulate Activation Kinetics of Different Human Beta1-Adrenoceptor Variants. Ahles, A., Rodewald, F., Rochais, F., Buenemann, M. & Engelhardt, S. The Journal of biological chemistry, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25451930

[Sex and Gender Differences in Cardiovascular Prevention]. Tschaftary, A. & Oertelt-Prigione, S. Deutsche medizinische Wochenschrift 139, 2541-2545, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25423468

Exercise Training in Secondary Prevention of Cardiovascular Disease: Are the Guidelines Still up to Date? Suchy, C., Pressler, A. & Halle, M. Aktuel Kardiol 3, 365-369, (2014). https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1383309

[German Centres for Health Science - Faster from the Idea to the Patient]. Hasenfuss, G. Deutsche medizinische Wochenschrift 139, 2487-2488, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25423453

November

Paper of the month

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation, doi: 10.1172/JCI74349, (DZHK-Autoren: Ahles, Dendorfer, Engelhardt)

dzhk.de/dzhk-paper-of-the-month/paper-of-the-month/article/november-2014/

Relation of Body Mass Index to Bleeding During Percutaneous Coronary Interventions. Ndrepepa, G., Fusaro, M., Cassese, S., Guerra, E., Schunkert, H. & Kastrati, A. The American Journal of Cardiology, (2014). http://www.ajconline.org/article/S0002-9149%2814%2902163-8/abstract

Endomyocardial Biopsy and Ultrastructural Changes in Dilated Cardiomyopathy: Taking a 'Deeper' Look into Patients' Prognosis. Savvatis, K., Schultheiss, H. P. & Tschope, C. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25433023

Three-Dimensional Balanced Steady State Free Precession Myocardial Perfusion Cardiovascular Magnetic Resonance at 3t Using Dual-Source Parallel Rf Transmission: Initial Experience. Jogiya, R., Schuster, A., Zaman, A., Motwani, M., Kouwenhoven, M., Nagel, E., Kozerke, S. & Plein, S. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16, 90, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25429993

The German Cpu Registry: Dyspnea Independently Predicts Negative Short-Term Outcome in Patients Admitted to German Chest Pain Units. Hellenkamp, K., Darius, H., Giannitsis, E., Erbel, R., Haude, M., Hamm, C., Hasenfuss, G., Heusch, G., Mudra, H., Munzel, T., Schmitt, C., Schumacher, B., Senges, J., Voigtlander, T. & Maier, L. S. International journal of cardiology, (2014). http://www.internationaljournalofcardiology.com/article/S0167-5273%2814%2902380-8/abstract?cc=y

Ccl19 and Ccl21 Modulate the Inflammatory Milieu in Atherosclerotic Lesions. Akhavanpoor, M., Gleissner, C. A., Gorbatsch, S., Doesch, A. O., Akhavanpoor, H., Wangler, S., Jahn, F., Lasitschka, F., Katus, H. A. & Erbel, C. Drug design, development and therapy 8, 2359-2371, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25473269

Diagnosis and Management of Ischemic Cardiomyopathy: Role of Cardiovascular Magnetic Resonance Imaging. Doesch, C. & Papavassiliu, T. World journal of cardiology 6, 1166-1174, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25429329

Proteasome Inhibition Slightly Improves Cardiac Function in Mice with Hypertrophic Cardiomyopathy. Schlossarek, S., Singh, S., Geertz, B., Schulz, H., Reischmann, S., Hubner, N. & Carrier, L. Front. Physiol. 5, (2014).

Pet/Ct and Mr Imaging Biomarker of Lipid-Rich Plaques Using [Cu]-Labeled Scavenger Receptor (Cd68-Fc). Bigalke, B., Phinikaridou, A., Andia, M. E., Cooper, M. S., Schuster, A., Wurster, T., Onthank, D., Munch, G., Blower, P., Gawaz, M., Nagel, E. & Botnar, R. M. International journal of cardiology 177, 287-291, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25499394

Mutations in Gtpbp3 Cause a Mitochondrial Translation Defect Associated with Hypertrophic Cardiomyopathy, Lactic Acidosis, and Encephalopathy. Kopajtich, R., Nicholls, T. J., Rorbach, J., Metodiev, M. D., Freisinger, P., Mandel, H., Vanlander, A., Ghezzi, D., Carrozzo, R., Taylor, R. W., Marquard, K., Murayama, K., Wieland, T., Schwarzmayr, T., Mayr, J. A., Pearce, S. F., Powell, C. A., Saada, A., Ohtake, A., Invernizzi, F. et al. American journal of human genetics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25434004

Scnt-Derived Escs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts. Deuse, T., Wang, D., Stubbendorff, M., Itagaki, R., Grabosch, A., Greaves, L. C., Alawi, M., Grunewald, A., Hu, X., Hua, X., Velden, J., Reichenspurner, H., Robbins, R. C., Jaenisch, R., Weissmann, I. L. & Schrepfer, S. Cell Stem Cell, (2014). http://www.cell.com/cell-stem-cell/fulltext/S1934-5909%2814%2900515-3
Zur Pressemitteilung dzhk.de/aktuelles/news/news-detail/article/uke-forscher-entdecken-moegliches-risiko-bei-stammzelltherapien/

Galectin-3 in Patients with Heart Failure with Preserved Ejection Fraction: Results from the Aldo-Dhf Trial. Edelmann, F., Holzendorf, V., Wachter, R., Nolte, K., Schmidt, A. G., Kraigher-Krainer, E., Duvinage, A., Unkelbach, I., Dungen, H. D., Tschope, C., Herrmann-Lingen, C., Halle, M., Hasenfuss, G., Gelbrich, G., Stough, W. G. & Pieske, B. M. European journal of heart failure, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25418979

Development of Phosphatase Inhibitor-1 Peptides Acting as Indirect Activators of Phosphatase 1. Sotoud, H., Borgmeyer, U., Schulze, C., El-Armouche, A. & Eschenhagen, T. Naunyn Schmiedebergs Arch Pharmacol, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25416155

Inflammatory Markers and Extent and Progression of Early Atherosclerosis: Meta-Analysis of Individual-Participant-Data from 20 Prospective Studies of the Prog-Imt Collaboration. Willeit, P., Thompson, S. G., Agewall, S., Bergstrom, G., Bickel, H., Catapano, A. L., Chien, K. L., de Groot, E., Empana, J. P., Etgen, T., Franco, O. H., Iglseder, B., Johnsen, S. H., Kavousi, M., Lind, L., Liu, J., Mathiesen, E. B., Norata, G. D., Olsen, M. H., Papagianni, A. et al. European journal of preventive cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25416041

Comparison of Vascular Closure Devices Vs Manual Compression after Femoral Artery Puncture: The Isar-Closure Randomized Clinical Trial. Schulz-Schupke, S., Helde, S., Gewalt, S., Ibrahim, T., Linhardt, M., Haas, K., Hoppe, K., Bottiger, C., Groha, P., Bradaric, C., Schmidt, R., Bott-Flugel, L., Ott, I., Goedel, J., Byrne, R. A., Schneider, S., Burgdorf, C., Morath, T., Kufner, S., Joner, M. et al. JAMA : the journal of the American Medical Association 312, 1981-1987, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25399273

Comparative Proteomic Analysis Reveals Sex and Estrogen Receptor Beta Effects in the Pressure Overloaded Heart. Kararigas, G., Fliegner, D., Forler, S., Klein, O., Schubert, C., Gustafsson, J. A., Klose, J. & Regitz-Zagrosek, V. Journal of proteome research, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25406860

Regional Differences of Undiagnosed Type 2 Diabetes and Prediabetes Prevalence Are Not Explained by Known Risk Factors. Tamayo, T., Schipf, S., Meisinger, C., Schunk, M., Maier, W., Herder, C., Roden, M., Nauck, M., Peters, A., Volzke, H. & Rathmann, W. PloS one 9, e113154, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25402347

Cardiac Myocyte-Secreted Camp Exerts Paracrine Action Via Adenosine Receptor Activation. Sassi, Y., Ahles, A., Truong, D. J., Baqi, Y., Lee, S. Y., Husse, B., Hulot, J. S., Foinquinos, A., Thum, T., Muller, C. E., Dendorfer, A., Laggerbauer, B. & Engelhardt, S. The Journal of clinical investigation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25401477

Assessment of DNA Synthesis in Islet-1+ Cells in the Adult Murine Heart. Weinberger, F., Mehrkens, D., Starbatty, J., Nicol, P. & Eschenhagen, T. Biochemical and biophysical research communications, (2014). http://www.sciencedirect.com/science/article/pii/S0006291X14021056

Nt-Probnp and the Risk of Dementia: A Prospective Cohort Study with 14 Years of Follow-Up. Tynkkynen, J., Laatikainen, T., Salomaa, V., Havulinna, A. S., Blankenberg, S., Zeller, T. & Hernesniemi, J. A. Journal of Alzheimer's disease : JAD, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25408211

Activation of the Chemosensing Transient Receptor Potential Channel A1 (Trpa1) by Alkylating Agents. Stenger, B., Zehfuss, F., Muckter, H., Schmidt, A., Balszuweit, F., Schafer, E., Buch, T., Gudermann, T., Thiermann, H. & Steinritz, D. Archives of toxicology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25395009

The Toxic Effect of R350p Mutant Desmin in Striated Muscle of Man and Mouse. Clemen, C. S., Stockigt, F., Strucksberg, K.-H., Chevessier, F., Winter, L., Schutz, J., Bauer, R., Thorweihe, J.-M., Wenzel, D., Schlotzer-Schrehardt, U., Rasche, V., Krsmanovic, P., Katus, H., Rottbauer, W., Just, S., Muller, O. J., Friedrich, O., Meyer, R., Herrmann, H., Schrickel, J. W. et al. Acta Neuropathologica (2014). http://link.springer.com/article/10.1007/s00401-014-1363-2

Inactivating Mutations in Npc1l1 and Protection from Coronary Heart Disease. The Myocardial Infarction Genetics Consortium, I. The New England journal of medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25390462

Endothelin-1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tanaka, A., Yuasa, S., Mearini, G., Egashira, T., Seki, T., Kodaira, M., Kusumoto, D., Kuroda, Y., Okata, S., Suzuki, T., Inohara, T., Arimura, T., Makino, S., Kimura, K., Kimura, A., Furukawa, T., Carrier, L., Node, K. & Fukuda, K. Journal of the American Heart Association 3, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25389285

Neutrophils in Atherosclerosis. A Brief Overview. Hartwig, H., Silvestre Roig, C., Daemen, M., Lutgens, E. & Soehnlein, O. Hamostaseologie 35, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25385255

Induction of Tet3-Dependent Epigenetic Remodeling by Low-Dose Hydralazine Attenuates Progression of Chronic Kidney Disease. Tampe, B., Tampe, D., Zeisberg, E., Muller, G., Bechtel-Walz, W., Koziolek, M., Kalluri, R. & Zeisberg, M. EBioMedicine, (2014). http://www.sciencedirect.com/science/article/pii/S2352396414000292

MicroRNA-Specific Regulatory Mechanisms in Atherosclerosis. Nazari-Jahantigh, M., Egea, V., Schober, A. & Weber, C. J Mol Cell Cardiol, (2014). http://www.jmmc-online.com/article/S0022-2828%2814%2900342-3/abstract

Ecg-Synchronized Ct Angiography in 324 Consecutive Pediatric Patients: Spectrum of Indications and Trends in Radiation Dose. Meinel, F. G., Henzler, T., Schoepf, U. J., Park, P. W., Huda, W., Spearman, J. V., Dyer, K. T., Rao, A. G. & Hlavacek, A. M. Pediatric cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25380963

Inhibition of Cardiac Kv1.5 Potassium Current by the Anesthetic Midazolam: Mode of Action. Vonderlin, N., Fischer, F., Zitron, E., Seyler, C., Scherer, D., Thomas, D., Katus, H. A. & Scholz, E. P. Drug design, development and therapy 8, 2263-2271, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25422586

Genome-Wide Association Study for Refractive Astigmatism Reveals Genetic Co-Determination with Spherical Equivalent Refractive Error: The Cream Consortium. Li, Q., Wojciechowski, R., Simpson, C. L., Hysi, P. G., Verhoeven, V. J., Ikram, M. K., Hohn, R., Vitart, V., Hewitt, A. W., Oexle, K., Makela, K. M., MacGregor, S., Pirastu, M., Fan, Q., Cheng, C. Y., St Pourcain, B., McMahon, G., Kemp, J. P., Northstone, K., Rahi, J. S. et al. Human genetics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25367360

Real-Time Magnetic Resonance Imaging of Cardiac Function and Flow - Recent Progress. Zhang, S., Joseph, A., Voit, D., Schaetz, S., Merboldt, K. D., Unterberg-Buchwald, C., Hennemuth, A., Lotz, J. & Frahm, J. QIMS 4, (2014). http://www.amepc.org/qims/article/view/4050/5794

Drug-Eluting Stents for Drug-Eluting Stent Restenosis: Stick with the Old or Switch to a New One? Kufner, S. & Kastrati, A. Coronary artery disease 25, 633-635, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25365642

Fhl2 Expression and Variants in Hypertrophic Cardiomyopathy. Friedrich, F. W., Reischmann, S., Schwalm, A., Unger, A., Ramanujam, D., Munch, J., Muller, O. J., Hengstenberg, C., Galve, E., Charron, P., Linke, W. A., Engelhardt, S., Patten, M., Richard, P., van der Velden, J., Eschenhagen, T., Isnard, R. & Carrier, L. Basic research in cardiology 109, 451, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25358972

Tlr4 Signaling Mediates Sbp Increase with Age–a Translational Investigation. Baumann, M., Schneider, S., Kemmer, S., Chmielewski, S., Aoqui, C., Hoppmann, P., Stock, K., Laugwitz, K. L., Heemann, U. & Kastrati, A. Artery Research 8, (2014). http://www.arteryresearch.com/article/S1872-9312%2814%2900118-5/abstract

Optimising Exercise Training in Prevention and Treatment of Diastolic Heart Failure (Optimex-Clin): Rationale and Design of a Prospective, Randomised, Controlled Trial. Suchy, C., Massen, L., Rognmo, O., Van Craenenbroeck, E. M., Beckers, P., Kraigher-Krainer, E., Linke, A., Adams, V., Wisloff, U., Pieske, B. & Halle, M. European journal of preventive cardiology 21, 18-25, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25354950

[Prevalence of the Metabolic Syndrome and Its Risk Factors]. Schaller, N., Blume, K., Hanssen, H., Schuster, T., Schmidt-Trucksass, A., Bischof, J. & Halle, M. Deutsche medizinische Wochenschrift 139, 2279-2284, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25350240

Interleukin-6 Receptor Inhibition Modulates the Immune Reaction and Restores Titin Phosphorylation in Experimental Myocarditis. Savvatis, K., Muller, I., Frohlich, M., Pappritz, K., Zietsch, C., Hamdani, N., Grote, K., Schieffer, B., Klingel, K., Van Linthout, S., Linke, W. A., Schultheiss, H. P. & Tschope, C. Basic research in cardiology 109, 449, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25344085

In-Silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology. Loewe, A., Lutz, Y., Wilhelms, M., Sinnecker, D., Barthel, P., Scholz, E. P., Dossel, O., Schmidt, G. & Seemann, G. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, iv30-iv38, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25362168

Oktober

Paper of the month

Aspirin treatment and outcomes after percutaneous coronary intervention: results of the ISAR-ASPI registry, doi: 10.1016/j.jacc.2014.05.049, (DZHK-Autoren: Bernlochner, Schulz, Morath, Schunkert, Laugwitz, Kastrati, Sibbing)

dzhk.de/dzhk-paper-of-the-month/paper-of-the-month/article/oktober-2014/

Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism Is Associated with Progressive Atherosclerosis and Incident Cardiovascular Disease. Pechlaner, R., Willeit, P., Summerer, M., Santer, P., Egger, G., Kronenberg, F., Demetz, E., Weiss, G., Tsimikas, S., Witztum, J. L., Willeit, K., Iglseder, B., Paulweber, B., Kedenko, L., Haun, M., Meisinger, C., Gieger, C., Muller-Nurasyid, M., Peters, A., Willeit, J. et al. Arteriosclerosis, thrombosis, and vascular biology, (2014). www.ncbi.nlm.nih.gov/pubmed/25359861

Laminar Shear Stress Inhibits Endothelial Cell Metabolism Via Kruppel-Like Factor 2-Mediated Repression of 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-3. Doddaballapur, A., Michalik, K. M., Manavski, Y., Lucas, T., Houtkooper, R. H., You, X., Chen, W., Zeiher, A. M., Potente, M., Dimmeler, S. & Boon, R. A. Arteriosclerosis, thrombosis, and vascular biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25359860

In Vivo Quantification of the Apical Fixation Forces of Different Mitral Valved Stent Designs in the Beating Heart. Pokorny, S., Huenges, K., Engel, A., Gross, J., Frank, D., Morlock, M. M., Cremer, J. & Lutter, G. Annals of biomedical engineering, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25352439

Long-Term Changes in Body Weight Are Associated with Changes in Blood Pressure Levels. Markus, M. R., Ittermann, T., Baumeister, S. E., Troitzsch, P., Schipf, S., Lorbeer, R., Aumann, N., Wallaschofski, H., Dorr, M., Rettig, R. & Volzke, H. Nutrition, Metabolism and Cardiovascular Diseases, (2014).  http://www.sciencedirect.com/science/article/pii/S0939475314003196

Catabolic Signaling and Muscle Wasting after Acute Ischemic Stroke in Mice: Indication for a Stroke-Specific Sarcopenia. Springer, J., Schust, S., Peske, K., Tschirner, A., Rex, A., Engel, O., Scherbakov, N., Meisel, A., von Haehling, S., Boschmann, M., Anker, S. D., Dirnagl, U. & Doehner, W. Stroke; a journal of cerebral circulation, (2014). www.ncbi.nlm.nih.gov/pubmed/25352483

Adeno-Associated Viral Vector 2.9 Thymosin beta-4 Application Attenuates Rejection after Heart Transplantation: Results of a Preclinical Study in the Pig. Postrach, J., Schmidt, M., Thormann, M., Thein, E., Burdorf, L., Reichart, B., Sotlar, K., Walz, C., Faber, C., Bauer, A., Schmoeckel, M., Kupatt, C. & Hinkel, R. Transplantation 98, 835-843, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25321165

Occurrence of the Jak2 V617f Mutation in Patients with Peripheral Arterial Disease. Muendlein, A., Kinz, E., Gasser, K., Leiherer, A., Rein, P., Saely, C. H., Grallert, H., Peters, A., Fraunberger, P., Drexel, H. & Lang, A. H. American journal of hematology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25345590

Prognostic Relevance of Cardiac Troponin T Levels and Their Dynamic Changes Measured with a High-Sensitivity Assay in Acute Ischaemic Stroke: Analyses from the Trelas Cohort. Scheitz, J. F., Mochmann, H.-C., Erdur, H., Tutuncu, S., Haeusler, K. G., Grittner, U., Laufs, U., Endres, M. & Nolte, C. H. International journal of cardiology, (2014). http://www.internationaljournalofcardiology.com/article/S0167-5273%2814%2901973-1/abstract

Tachycardia-Induced Silencing of Subcellular Ca2+ Signaling in Atrial Myocytes. Greiser, M., Kerfant, B. G., Williams, G. S., Voigt, N., Harks, E., Dibb, K. M., Giese, A., Meszaros, J., Verheule, S., Ravens, U., Allessie, M. A., Gammie, J. S., van der Velden, J., Lederer, W. J., Dobrev, D. & Schotten, U. The Journal of clinical investigation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25329692

Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles. Wagner, E., Brandenburg, S., Kohl, T. & Lehnart, S. E. Journal of visualized experiments : JoVE, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25350293

Situs Inversus Totalis with Congenitally Corrected Transposition of the Great Arteries: Insights from Cardiac Mri. Sohns, J. M., Steinmetz, M., Schneider, H., Fasshauer, M., Staab, W., Kowallick, J. T., Schuster, A., Ritter, C., Lotz, J. & Unterberg-Buchwald, C. Springerplus 3, 601, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25392774

Late Enhanced Computed Tomography in Hypertrophic Cardiomyopathy Enables Accurate Left-Ventricular Volumetry. Langer, C., Both, M., Harders, H., Lutz, M., Eden, M., Kuhl, C., Sattler, B., Jansen, O., Schaefer, P. & Frey, N. European radiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25316053

Quantitative Assessment of Magnetic Resonance Derived Myocardial Perfusion Measurements Using Advanced Techniques: Microsphere Validation in an Explanted Pig Heart System. Schuster, A., Zarinabad, N., Ishida, M., Sinclair, M., van den Wijngaard, J., Morton, G., Hautvast, G., Bigalke, B., van Horssen, P., Smith, N., Spaan, J., Siebes, M., Chiribiri, A. & Nagel, E. Journal of Cardiovascular Magnetic Resonance 16, (2014). http://www.jcmr-online.com/content/16/1/82/abstract#

Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication. Lindner, D., Li, J., Savvatis, K., Klingel, K., Blankenberg, S., Tschope, C. & Westermann, D. Mediators of Inflammation 2014, (2014). http://www.hindawi.com/journals/mi/2014/519528/abs/

Pharmacological Inhibition of Coronary Restenosis: Systemic and Local Approaches. Guerra, E., Byrne, R. A. & Kastrati, A. Expert opinion on pharmacotherapy 15, 2155-2171, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25145263

Muscular Ventricular Septal Defect in a Newborn with Truncus Arteriosus Communis: Perventricular Transcatheter Closure under Echocardiographic Guidance Only, a Case Report. Elhmidi, Y., Hoerer, J., Lange, R. & Schreiber, C. World journal for pediatric & congenital heart surgery 5, 589-591, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25324260

Spatiotemporal Phase Unwrapping for Real-Time Phase-Contrast Flow Mri. Untenberger, M., Hullebrand, M., Tautz, L., Joseph, A. A., Voit, D., Merboldt, K. D. & Frahm, J. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25302683

Large-Scale Experience with an Anchorless Vascular Closure Device in a Real-Life Clinical Setting. Schelp, V., Freitag-Wolf, S., Hinzmann, D., Bramlage, P., Frey, N. & Frank, D. Clinical research in cardiology : official journal of the German Cardiac Society, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25293675

Prognostic Role of Restenosis in 10 004 Patients Undergoing Routine Control Angiography after Coronary Stenting. Cassese, S., Byrne, R. A., Schulz, S., Hoppman, P., Kreutzer, J., Feuchtenberger, A., Ibrahim, T., Ott, I., Fusaro, M., Schunkert, H., Laugwitz, K. L. & Kastrati, A. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25298237

Maladaptive Remodeling Is Associated with Impaired Survival in Women but Not in Men after Aortic Valve Replacement. Petrov, G., Dworatzek, E., Schulze, T. M., Dandel, M., Kararigas, G., Mahmoodzadeh, S., Knosalla, C., Hetzer, R. & Regitz-Zagrosek, V. J Am Coll Cardiol Img, (2014). http://imaging.onlinejacc.org/article.aspx?articleid=1915283

Cmr-Derived Tapse Measurement: A Semi-Quantitative Method of Right Ventricular Function Assessment in Patients with Hypertrophic Cardiomyopathy. Doesch, C., Zompolou, C., Streitner, F., Haghi, D., Schimpf, R., Rudic, B., Kuschyk, J., Schoenberg, S. O., Borggrefe, M. & Papavassiliu, T. Neth Heart J, (2014). http://link.springer.com/article/10.1007/s12471-014-0601-5

Relevance of Depression for Anticoagulation Management in a Routine Medical Care Setting: Results from the Thrombeval Study Program. Michal, M., Prochaska, J. H., Ullmann, A., Keller, K., Gobel, S., Coldewey, M., Munzel, T., Wiltink, J., Beutel, M. E. & Wild, P. Journal of Thrombosis and Haemostasis, (2014). http://onlinelibrary.wiley.com/doi/10.1111/jth.12743/abstract

Cardiac Cam Kinase Ii Genes Delta and Gamma Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy. Kreusser, M. M., Lehmann, L. H., Keranov, S., Hoting, M. O., Oehl, U., Kohlhaas, M., Reil, J. C., Neumann, K., Schneider, M. D., Hill, J. A., Dobrev, D., Maack, C., Maier, L. S., Grone, H. J., Katus, H. A., Olson, E. N. & Backs, J. Circulation 130, 1262-1273, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25124496

Sex-Dependent Regulation of Fibrosis and Inflammation in Human Left Ventricular Remodelling under Pressure Overload. Kararigas, G., Dworatzek, E., Petrov, G., Summer, H., Schulze, T. M., Baczko, I., Knosalla, C., Golz, S., Hetzer, R. & Regitz-Zagrosek, V. European journal of heart failure, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25287281

High-Sensitivity Cardiac Troponin I in the General Population - Defining Reference Populations for the Determination of the 99th Percentile in the Gutenberg Health Study. Zeller, T., Ojeda, F., Brunner, F. J., Peitsmeyer, P., Munzel, T., Binder, H., Pfeiffer, N., Michal, M., Wild, P. S., Blankenberg, S. & Lackner, K. J. Clinical chemistry and laboratory medicine : CCLM / FESCC, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25283141

Angiopoietin-2, Its Soluble Receptor Tie-2 and Subclinical Cardiovascular Disease in a Population-Based Sample. Lorbeer, R., Baumeister, S. E., Dorr, M., Felix, S. B., Nauck, M., Grotevendt, A., Markus, M. R., von Sarnowski, B., Volzke, H., Vasan, R. S., Wallaschofski, H. & Lieb, W. Heart, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25286927

Quantification of Left Ventricular Torsion and Diastolic Recoil Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking. Kowallick, J. T., Lamata, P., Hussain, S. T., Kutty, S., Steinmetz, M., Sohns, J. M., Fasshauer, M., Staab, W., Unterberg-Buchwald, C., Bigalke, B., Lotz, J., Hasenfuss, G. & Schuster, A. PloS one 9, e109164, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25285656

Defining the Role of Common Variation in the Genomic and Biological Architecture of Adult Human Height. Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., Chu, A. Y., Estrada, K., Luan, J., Kutalik, Z., Amin, N., Buchkovich, M. L., Croteau-Chonka, D. C., Day, F. R., Duan, Y., Fall, T., Fehrmann, R., Ferreira, T., Jackson, A. U., Karjalainen, J. et al. Nature genetics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25282103

Parent-of-Origin-Specific Allelic Associations among 106 Genomic Loci for Age at Menarche. Perry, J. R., Day, F., Elks, C. E., Sulem, P., Thompson, D. J., Ferreira, T., He, C., Chasman, D. I., Esko, T., Thorleifsson, G., Albrecht, E., Ang, W. Q., Corre, T., Cousminer, D. L., Feenstra, B., Franceschini, N., Ganna, A., Johnson, A. D., Kjellqvist, S., Lunetta, K. L. et al. Nature 514, 92-97, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25231870

Hypertension Prevalence, Awareness, Treatment and Control in Germany 1998 and 2008-11. Neuhauser, H. K., Adler, C., Rosario, A. S., Diederichs, C. & Ellert, U. Journal of human hypertension, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25273858
Zur Pressemitteilung dzhk.de/aktuelles/news/news-detail/article/blutdruck-der-deutschen-ist-gesunken-junge-maenner-profitieren-nicht-von-diesem-trend/

Aspirin Treatment and Outcomes after Percutaneous Coronary Intervention: Results of the Isar-Aspi Registry. Mayer, K., Bernlochner, I., Braun, S., Schulz, S., Orban, M., Morath, T., Cala, L., Hoppmann, P., Schunkert, H., Laugwitz, K. L., Kastrati, A. & Sibbing, D. Journal of the American College of Cardiology 64, 863-871, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25169169

September

Paper of the month

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling, PNAS, doi: 10.1073/pnas.1409026111, (DZHK-Autoren: Lehmann, Spiger, Wieland, Katus, Backs)

http://dzhk.de/dzhk-paper-of-the-month/paper-of-the-month/article/september-2014/

Effects of Long-Term Endurance and Resistance Training on Diastolic Function, Exercise Capacity, and Quality of Life in Asymptomatic Diastolic Dysfunction Vs. Heart Failure with Preserved Ejection Fraction. Nolte, K., Schwarz, S., Gelbrich, G., Mensching, S., Siegmund, F., Wachter, R., Hasenfuss, G., Dungen, H. D., Herrmann-Lingen, C., Halle, M., Pieske, B. & Edelmann, F. ESC Heart Failure, (2014). http://onlinelibrary.wiley.com/doi/10.1002/2055-5822.12007/full

Sex-Related Differences in 2197 Patients Undergoing Isolated Surgical Aortic Valve Replacement. Elhmidi, Y., Piazza, N., Mazzitelli, D., Wottke, M., Lange, R. & Bleiziffer, S. Journal of cardiac surgery, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25264220

Pulmonary Venous Hypertension Vs. Pulmonary Arterial Hypertension: Usefulness of Echocardiography in the Case of Misleading Heart Catheterization Data. Dandel, M., Knosalla, C. & Hetzer, R. International journal of cardiology, (2014). http://www.sciencedirect.com/science/article/pii/S0167527314018075

Preventing Leptin Resistance by Blocking Angiotensin Ii at Receptors in Diet-Induced Obese Rats. Muller-Fielitz, H., Lau, M., Geissler, C., Werner, L., Piehl, M. & Raasch, W. British journal of pharmacology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25258168

A Genetic Variant in the Seed Region of Mir-4513 Shows Pleiotropic Effects on Lipid and Glucose Homeostasis, Blood Pressure and Coronary Artery Disease. Ghanbari, M., de Vries, P. S., de Looper, H., Peters, M. J., Schurmann, C., Yaghootkar, H., Dorr, M., Frayling, T. M., Uitterlinden, A. G., Hofman, A., van Meurs, J. B., Erkeland, S. J., Franco, O. H. & Dehghan, A. Human mutation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25256095

Right Ventricular Dysfunction, Late Gadolinium Enhancement, and Female Gender Predict Poor Outcome in Patients with Dilated Cardiomyopathy. Doesch, C., Dierks, D.-M., Haghi, D., Schimpf, R., Kuschyk, J., Suselbeck, T., Schoenberg, S. O., Borggrefe, M. & Papavassiliu, T. International journal of cardiology, (2014). http://www.internationaljournalofcardiology.com/article/S0167-5273%2814%2901706-9/abstract

Resolvin D1 Limits 5-Lipoxygenase Nuclear Localization and Leukotriene B4 Synthesis by Inhibiting a Calcium-Activated Kinase Pathway. Fredman, G., Ozcan, L., Spolitu, S., Hellmann, J., Spite, M., Backs, J. & Tabas, I. Proceedings of the National Academy of Sciences of the United States of America, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25246560

Pet/Ct and Mr Imaging Biomarker of Lipid-Rich Plaques Using [64cu]-Labeled Scavenger Receptor (Cd68-Fc). Bigalke, B., Phinikaridou, A., Andia, M. E., Cooper, M., Schuster, A., Wurster, T., Onthank, D., Munch, G., Blower, P., Gawaz, M., Nagel, E. & Botnar, R. M. International journal of cardiology, (2014). http://www.sciencedirect.com/science/article/pii/S0167527314017197

Biomarcare: Rationale and Design of the European Biomarcare Project Including 300,000 Participants from 13 European Countries. Zeller, T., Hughes, M., Tuovinen, T., Schillert, A., Conrads-Frank, A., Ruijter, H. D., Schnabel, R. B., Kee, F., Salomaa, V., Siebert, U., Thorand, B., Ziegler, A., Breek, H., Pasterkamp, G., Kuulasmaa, K., Koenig, W. & Blankenberg, S. European journal of epidemiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25238720

Automatic Camera-Based Identification and 3-D Reconstruction of Electrode Positions in Electrocardiographic Imaging. Schulze, W. H., Mackens, P., Potyagaylo, D., Rhode, K., Tulumen, E., Schimpf, R., Papavassiliu, T., Borggrefe, M. & Dossel, O. Biomedizinische Technik. Biomedical engineering, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25229412

Proteasome Isoforms Exhibit Only Quantitative Differences in Cleavage and Epitope Generation. Mishto, M., Liepe, J., Textoris-Taube, K., Keller, C., Henklein, P., Weberruss, M., Dahlmann, B., Enenkel, C., Voigt, A., Kuckelkorn, U., Stumpf, M. P. & Kloetzel, P. M. European journal of immunology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25231383

Impact of in-Hospital Stent Thrombosis and Cerebrovascular Accidents on Long-Term Prognosis after Percutaneous Coronary Intervention. Guerra, E., Ndrepepa, G., Schulz, S., Byrne, R. A., Hoppmann, P., Kufner, S., Ibrahim, T., Tada, T., Schunkert, H., Laugwitz, K.-L. & Kastrati, A. American Heart Journal, (2014). http://www.ahjonline.com/article/S0002-8703%2814%2900558-4/abstract

B-Lymphoblastic Lymphoma: A Heartening Diagnosis. Goedel, A., Hoellein, A., Rischpler, C. & Gotze, K. European heart journal cardiovascular Imaging, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25227266

Rat Engineered Heart Tissue: A Novel Tool in the Safety Pharmacology Toolkit? Heijman, J. & Dobrev, D. Basic research in cardiology 109, 437, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25209141

Effects of Proarrhythmic Drugs on Relaxation Time and Beating Pattern in Rat Engineered Heart Tissue. Eder, A., Hansen, A., Uebeler, J., Schulze, T., Neuber, C., Schaaf, S., Yuan, L., Christ, T., Vos, M. A. & Eschenhagen, T. Basic research in cardiology 109, 436, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25209140

Flotillin-1 Facilitates Toll-Like Receptor 3 Signaling in Human Endothelial Cells. Fork, C., Hitzel, J., Nichols, B. J., Tikkanen, R. & Brandes, R. P. Basic research in cardiology 109, 439, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25204797

Functional Microrna Library Screening Identifies the Hypoxamir Mir-24 as a Potent Regulator of Smooth Muscle Cell Proliferation and Vascularization. Fiedler, J., Stohr, A., Gupta, S. K., Hartmann, D., Holzmann, A., Just, A., Hansen, A., Hilfiker-Kleiner, D., Eschenhagen, T. & Thum, T. Antioxidants & redox signaling 21, 1167-1176, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24063572

Detection of Acute Inflammatory Myocarditis in Epstein Barr Virus Infection Using Hybrid 18f-Fluoro-Deoxyglucose-Positron Emission Tomography/Magnetic Resonance Imaging. von Olshausen, G., Hyafil, F., Langwieser, N., Laugwitz, K. L., Schwaiger, M. & Ibrahim, T. Circulation 130, 925-926, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25199667

Ca2+ /Calmodulin-Dependent Protein Kinase Ii Equally Induces Sarcoplasmic Reticulum Ca2+ Leak in Human Ischaemic and Dilated Cardiomyopathy. Fischer, T. H., Eiringhaus, J., Dybkova, N., Forster, A., Herting, J., Kleinwachter, A., Ljubojevic, S., Schmitto, J. D., Streckfuss-Bomeke, K., Renner, A., Gummert, J., Hasenfuss, G., Maier, L. S. & Sossalla, S. European journal of heart failure, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25201344

Cam Kinase Ii Mediates Maladaptive Post-Infarct Remodeling and Pro-Inflammatory Chemoattractant Signaling but Not Acute Myocardial Ischemia/Reperfusion Injury. Weinreuter, M., Kreusser, M. M., Beckendorf, J., Schreiter, F. C., Leuschner, F., Lehmann, L. H., Hofmann, K. P., Rostosky, J. S., Diemert, N., Xu, C., Volz, H. C., Jungmann, A., Nickel, A., Sticht, C., Gretz, N., Maack, C., Schneider, M. D., Grone, H. J., Muller, O. J., Katus, H. A. et al. EMBO molecular medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25193973

New Insights in (Inter)Cellular Mechanisms by Heart Failure with Preserved Ejection Fraction. Tschope, C. & Van Linthout, S. Current heart failure reports, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25189801

Class Iii Antiarrhythmic Drug Dronedarone Inhibits Cardiac Inwardly Rectifying Kir2.1 Channels through Binding at Residue E224. Xynogalos, P., Seyler, C., Scherer, D., Koepple, C., Scholz, E. P., Thomas, D., Katus, H. A. & Zitron, E. Naunyn Schmiedebergs Arch Pharmacol, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25182566

Homoarginine and Cardiovascular Outcome in the Population-Based Dallas Heart Study. Atzler, D., Gore, M. O., Ayers, C. R., Choe, C. U., Boger, R. H., de Lemos, J. A., McGuire, D. K. & Schwedhelm, E. Arteriosclerosis, thrombosis, and vascular biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25189571

Proteome Analysis of Heart Biopsies Using a Trizol-Based Protein Extraction. Pop, C., Ameling, S., Empen, K., Rudebusch, J., Vishnu, D., Felix, S. B., Loghin, F., Volker, U. & Hammer, E. Clinica chimica acta; international journal of clinical chemistry, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25195007

Bcl10 Mediates Angiotensin Ii-Induced Cardiac Damage and Electrical Remodeling. Marko, L., Henke, N., Park, J. K., Spallek, B., Qadri, F., Balogh, A., Apel, I. J., Oravecz-Wilson, K. I., Choi, M., Przybyl, L., Binger, K. J., Haase, N., Wilck, N., Heuser, A., Fokuhl, V., Ruland, J., Lucas, P. C., McAllister-Lucas, L. M., Luft, F. C., Dechend, R. et al. Hypertension, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25185127

Essential Role of Sympathetic Endothelin a Receptors for Adverse Cardiac Remodeling. Lehmann, L., Rostosky, J. S., Buss, S. J., Kreusser, M. M., Krebs, J., Mier, W., Enseleit, F., Spiger, K., Hardt, S. E., Wieland, T., Haass, M., Luscher, T. F., Schneider, M. D., Parlato, R., Grone, H. J., Haberkorn, U., Yanagisawa, M., Katus, H. A. & Backs, J. PNAS, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25197047
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Serum Thyroid-Stimulating Hormone Levels Are Not Associated with Exercise Capacity and Lung Function Parameters in Two Population-Based Studies. Ittermann, T., Glaser, S., Ewert, R., Felix, S. B., Volzke, H. & Dorr, M. BMC Pulmonary Medicine 14, (2014). http://www.biomedcentral.com/1471-2466/14/145/abstract#

Characteristics Associated with Non-Participation in a 7 Day Accelerometer Study. Weymar, F., Braatz, J., Guertler, D., van den Berg, N., Meyer, C., John, U., Felix, S. B., Dorr, M. & Ulbricht, S. Gesundheitswesen 2014 76, (2014). https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1387066

Characteristics Associated with Non-Participation in a 7 Day Accelerometer Study. Weymar, F., Braatz, J., Guertler, D., van den Berg, N., Meyer, C., John, U., Felix, S. B., Dorr, M. & Ulbricht, S. Gesundheitswesen 2014, (2014). https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1387066

Cardiac Fibroblasts Support Cardiac Inflammation in Heart Failure. Lindner, D., Zietsch, C., Tank, J., Sossalla, S., Fluschnik, N., Hinrichs, S., Maier, L., Poller, W., Blankenberg, S., Schultheiss, H. P., Tschope, C. & Westermann, D. Basic research in cardiology 109, 428, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25086637

Toward Panoramic in Situ Mapping of Action Potential Propagation in Transgenic Hearts to Investigate Initiation and Therapeutic Control of Arrhythmias. Dura, M., Schroder-Schetelig, J., Luther, S. & Lehnart, S. E. Frontiers in physiology 5, 337, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25197047

August

Paper of the month

The Cardiac CaMKII Genes Delta and Gamma Contribute Redundantly to Adverse Remodeling but Inhibit Calcineurin-Induced Myocardial Hypertrophy, Circulation, doi:10.1161/CIRCULATIONAHA.114.006185 (DZHK-Autoren: Lehmann, Hoting, Maier, Katus, Backs)

dzhk.de/dzhk-paper-of-the-month/paper-of-the-month/article/august-2014/

Lack in Treatment Options for Virus-Induced Inflammatory Cardiomyopathy: Can Ips-Derived Cardiomyocytes Close the Gap? Van Linthout, S., Tschope, C. & Schultheiss, H. P. Circulation research 115, 540-541, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25170089

Extending Human Induced Pluripotent Stem Cell Technology to Infectious Diseases: New Model for Viral Myocarditis. Sinnecker, D., Laugwitz, K. L. & Moretti, A. Circulation research 115, 537-539, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25170088

Revisiting the Bioscience of Drug-Eluting Stent Technology. Mehilli, J. & Massberg, S. Lancet, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25189360

Prasugrel Vs. Clopidogrel in Cardiogenic Shock Patients Undergoing Primary Pci for Acute Myocardial Infarction. Results of the Isar-Shock Registry. Orban, M., Mayer, K., Morath, T., Bernlochner, I., Hadamitzky, M., Braun, S., Schulz, S., Hoppmann, P., Hausleiter, J., Tiroch, K., Mehilli, J., Schunkert, H., Massberg, S., Laugwitz, K. L., Sibbing, D. & Kastrati, A. Thrombosis and haemostasis 112, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25183544

Modulation of K 2.1 and K 10.1 K Channel Sensitivity to Carvedilol by Alternative Mrna Translation Initiation. Kisselbach, J., Seyler, C., Schweizer, P. A., Gerstberger, R., Becker, R., Katus, H. A. & Thomas, D. British journal of pharmacology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25168769

Ubiquitin-Like Protein Isg15 in Host Defense against Heart Failure in a Mouse Model of Virus-Induced Cardiomyopathy. Rahnefeld, A., Klingel, K., Schuermann, A., Diny, N. L., Althof, N., Lindner, A., Bleienheuft, P., Savvatis, K., Respondek, D., Opitz, E., Ketscher, L., Sauter, M., Seifert, U., Tschope, C., Poller, W., Knobeloch, K. P. & Voigt, A. Circulation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25165091

Atlas of the Clinical Genetics of Human Dilated Cardiomyopathy. Haas, J., Frese, K. S., Peil, B., Kloos, W., Keller, A., Nietsch, R., Feng, Z., Muller, S., Kayvanpour, E., Vogel, B., Sedaghat-Hamedani, F., Lim, W. K., Zhao, X., Fradkin, D., Kohler, D., Fischer, S., Franke, J., Marquart, S., Barb, I., Li, D. T. et al. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25163546

Innate Immune Receptors in Heart Failure: Side Effect or Potential Therapeutic Target? Wagner, K. B., Felix, S. B. & Riad, A. World journal of cardiology 6, 791-801, (2014).

The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated with Mutations in the Hcn4 Channel. Schweizer, P. A., Schroter, J., Greiner, S., Haas, J., Yampolsky, P., Mereles, D., Buss, S. J., Seyler, C., Bruehl, C., Draguhn, A., Koenen, M., Meder, B., Katus, H. A. & Thomas, D. Journal of the American College of Cardiology 64, 757-767, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25145518

High Serum Tsh Levels Are Associated with Retinal Arteriolar Narrowing in the General Population. Ittermann, T., Dorr, M., Volzke, H., Tost, F. & Jurgens, C. Thyroid : official journal of the American Thyroid Association, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25156414

Whole-Exome Sequencing in an Extended Family with Myocardial Infarction Unmasks Familial Hypercholesterolemia. Braenne, I., Reiz, B., Medack, A., Kleinecke, M., Fischer, M., Tuna, S., Hengstenberg, C., Deloukas, P., Erdmann, J. & Schunkert, H. BMC cardiovascular disorders 14, 108, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25154303

Influence of Sex on Outcome Following Transcatheter Aortic Valve Implantation (Tavi): Systematic Review and Meta-Analysis. Stangl, V., Baldenhofer, G., Laule, M., Baumann, G. & Stangl, K. Journal of interventional cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25156031

Nighttime Aircraft Noise Impairs Endothelial Function and Increases Blood Pressure in Patients with or at High Risk for Coronary Artery Disease. Schmidt, F., Kolle, K., Kreuder, K., Schnorbus, B., Wild, P., Hechtner, M., Binder, H., Gori, T. & Munzel, T. Clinical research in cardiology : official journal of the German Cardiac Society, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25145323

The Continuum of Personalized Cardiovascular Medicine: A Position Paper of the European Society of Cardiology. Kirchhof, P., Sipido, K. R., Cowie, M. R., Eschenhagen, T., Fox, K. A. A., Katus, H., Schroeder, S., Schunkert, H. & Priori, S. Eur Heart J, (2014). http://eurheartj.oxfordjournals.org/content/early/2014/08/22/eurheartj.ehu312.full

Pharmacological Inhibition of Coronary Restenosis: Systemic and Local Approaches. Guerra, E., Byrne, R. A. & Kastrati, A. Expert opinion on pharmacotherapy, 1-17, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25145263

Cardiac Arrhythmia Induced by Genetic Silencing of 'Funny' (F) Channels Is Rescued by Girk4 Inactivation. Mesirca, P., Alig, J., Torrente, A. G., Muller, J. C., Marger, L., Rollin, A., Marquilly, C., Vincent, A., Dubel, S., Bidaud, I., Fernandez, A., Seniuk, A., Engeland, B., Singh, J., Miquerol, L., Ehmke, H., Eschenhagen, T., Nargeot, J., Wickman, K., Isbrandt, D. et al. Nature communications 5, 4664, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25144323

Neutrophils in Atherosclerosis: From Mice to Man. Doring, Y., Drechsler, M., Soehnlein, O. & Weber, C. Arteriosclerosis, thrombosis, and vascular biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25147339

Acceleration and Deceleration Capacity of Fetal Heart Rate in an in-Vivo Sheep Model. Rivolta, M. W., Stampalija, T., Casati, D., Richardson, B. S., Ross, M. G., Frasch, M. G., Bauer, A., Ferrazzi, E. & Sassi, R. PloS one 9, e104193, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25141131

Targeting the Ubiquitin-Proteasome System in Heart Disease: The Basis for New Therapeutic Strategies. Drews, O. & Taegtmeyer, H. Antioxidants & redox signaling, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25133688

Associations between Depression and Diabetes in the Community: Do Symptom Dimensions Matter? Results from the Gutenberg Health Study. Wiltink, J., Michal, M., Wild, P. S., Schneider, A., Konig, J., Blettner, M., Munzel, T., Schulz, A., Weber, M., Fottner, C., Pfeiffer, N., Lackner, K. & Beutel, M. E. PloS one 9, e105499, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25127227

Persistent Left Superior Vena Cava Detected after Central Venous Catheter Insertion. Sohns, J. M., Fasshauer, M., Staab, W., Steinmetz, M., Unterberg-Buchwald, C., Menke, J. & Lotz, J. SpringerPlus 3, (2014). http://www.springerplus.com/content/3/1/437/abstract#

Integrating Genetic, Transcriptional, and Functional Analyses to Identify Five Novel Genes for Atrial Fibrillation. Sinner, M. F., Tucker, N. R., Lunetta, K. L., Ozaki, K., Smith, J. G., Trompet, S., Bis, J. C., Lin, H., Chung, M. K., Nielsen, J. B., Lubitz, S. A., Krijthe, B. P., Magnani, J. W., Ye, J., Gollob, M. H., Tsunoda, T., Muller-Nurasyid, M., Lichtner, P., Peters, A., Dolmatova, E. et al. Circulation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25124494

Long Term Impact of Cardiac Contractility Modulation on Qrs Duration. Roger, S., Michels, J., Heggemann, F., Stach, K., Rousso, B., Borggrefe, M. & Kuschyk, J. J Electrocardiol, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25201417

The Cardiac Camkii Genes Delta and Gamma Contribute Redundantly to Adverse Remodeling but Inhibit Calcineurin-Induced Myocardial Hypertrophy. Kreusser, M. M., Lehmann, L. H., Keranov, S., Hoting, M. O., Kohlhaas, M., Reil, J. C., Neumann, K., Schneider, M. D., Hill, J. A., Dobrev, D., Maack, C., Maier, L. S., Grone, H. J., Katus, H. A., Olson, E. N. & Backs, J. Circulation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25124496

Deficiency of Mapk-Activated Protein Kinase 2 (Mk2) Prevents Adverse Remodelling and Promotes Endothelial Healing after Arterial Injury. Kapopara, P. R., von Felden, J., Soehnlein, O., Wang, Y., Napp, L. C., Sonnenschein, K., Wollert, K. C., Schieffer, B., Gaestel, M., Bauersachs, J. & Bavendiek, U. Thrombosis and haemostasis 112, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25120198

Sex Differences in the Non-Invasive Risk Stratification and Prognosis after Myocardial Infarction. Sinnecker, D., Huster, K. M., Muller, A., Dommasch, M., Hapfelmeier, A., Gebhardt, J., Hnatkova, K., Laugwitz, K. L., Malik, M., Barthel, P. & Schmidt, G. Journal of Electrocardiology, (2014). http://www.sciencedirect.com/science/article/pii/S0022073614003161

Quantification of Left Atrial Strain and Strain Rate Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking: A Feasibility Study. Kowallick, J. T., Kutty, S., Edelmann, F., Chiribiri, A., Villa, A., Steinmetz, M., Sohns, J. M., Staab, W., Bettencourt, N., Unterberg-Buchwald, C., Hasenfuss, G., Lotz, J. & Schuster, A. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16, 60, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25196447

Thrombospondin-1 Deficiency Causes a Shift from Fibroproliferative to Inflammatory Kidney Disease and Delays Onset of Renal Failure. Zeisberg, M., Tampe, B., LeBleu, V., Tampe, D., Zeisberg, E. & Kalluri, R. The American journal of pathology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25111226

Platelets and Their Chemokines in Atherosclerosis-Clinical Applications. von Hundelshausen, P. & Schmitt, M. M. Frontiers in physiology 5, 294, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25152735

Low Levels of Natural Igm Antibodies against Phosphorylcholine Are Independently Associated with Vascular Remodeling in Patients with Coronary Artery Disease. Gleissner, C. A., Erbel, C., Haeussler, J., Akhavanpoor, M., Domschke, G., Linden, F., Doesch, A. O., Conradson, G., Buss, S. J., Hofmann, N. P., Gitsioudis, G., Katus, H. A. & Korosoglou, G. Clinical research in cardiology : official journal of the German Cardiac Society, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25103819

Adventitial Inflammation and Its Interaction with Intimal Atherosclerotic Lesions. Akhavanpoor, M., Wangler, S., Gleissner, C. A., Korosoglou, G., Katus, H. A. & Erbel, C. Frontiers in physiology 5, 296, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25152736

Vernakalant Activates Human Cardiac K17.1 Background K Channels. Seyler, C., Schweizer, P. A., Zitron, E., Katus, H. A. & Thomas, D. Biochemical and biophysical research communications, (2014). http://www.ncbi.nlm.nih.gov/pubmed/2510815

Complaints of Sleep Disturbances Are Associated with Cardiovascular Disease: Results from the Gutenberg Health Study. Michal, M., Wiltink, J., Kirschner, Y., Schneider, A., Wild, P. S., Munzel, T., Blettner, M., Schulz, A., Lackner, K., Pfeiffer, N., Blankenberg, S., Tschan, R., Tuin, I. & Beutel, M. E. PloS one 9, e104324, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25093413

Severe Autonomic Failure as a Predictor of Mortality in Aortic Valve Stenosis. Zuern, C. S., Rizas, K., Eick, C., Vogtt, M., Bigalke, B., Gawaz, M. & Bauer, A. International journal of cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25131928

Ct-Angiography-Based Evaluation of the Aortic Annulus for Prosthesis Sizing in Transcatheter Aortic Valve Implantation (Tavi)-Predictive Value and Optimal Thresholds for Major Anatomic Parameters. Schwarz, F., Lange, P., Zinsser, D., Greif, M., Boekstegers, P., Schmitz, C., Reiser, M. F., Kupatt, C. & Becker, H. C. PloS one 9, e103481, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25084451

The Effect of Black Tea on Blood Pressure: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. Greyling, A., Ras, R. T., Zock, P. L., Lorenz, M., Hopman, M. T., Thijssen, D. H. & Draijer, R. PloS one 9, e103247, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25079225

Giant Bypass Aneurysm, a Cause of Suspected Cardiac Mass. Sohns, J. M., Fasshauer, M., Staab, W., Steinmetz, M., Lotz, J. & Unterberg-Buchwald, C. Springerplus 3, 433, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25184106

Biomarkers of Coronary Artery Disease: The Promise of the Transcriptome. Siemelink, M. A. & Zeller, T. Current cardiology reports 16, 513, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24950674

Janus-Faced Role of Kruppel-Like Factor 2-Dependent Regulation of Micrornas in Endothelial Proliferation. Natarelli, L. & Schober, A. Arteriosclerosis, thrombosis, and vascular biology 34, 1605-1606, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25031325

Juli

Paper of the month

Silencing of CCR2 inmyocarditis, European Heart Journal, doi:10.1093/eurheartj/ehu225 (DZHK-Autoren: Leuschner, Meder, Katus)

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Rapid and Highly Efficient Inducible Cardiac Gene Knockout in Adult Mice Using Aav-Mediated Expression of Cre Recombinase. Werfel, S., Jungmann, A., Lehmann, L., Ksienzyk, J., Bekeredjian, R., Kaya, Z., Leuchs, B., Nordheim, A., Backs, J., Engelhardt, S., Katus, H. A. & Muller, O. J. Cardiovasc Res, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25082846

Accelerometer and Gyroscope Based Gait Analysis Using Spectral Analysis of Patients with Osteoarthritis of the Knee. Staab, W., Hottowitz, R., Sohns, C., Sohns, J. M., Gilbert, F., Menke, J., Niklas, A. & Lotz, J. Journal of Physical Therapy Science 26, 997-1002, (2014). https://www.jstage.jst.go.jp/article/jpts/26/7/26_jpts-2013-562/_article

Real-Time Phase-Contrast Flow Mri of the Ascending Aorta and Superior Vena Cava as a Function of Intrathoracic Pressure (Valsalva Manoeuvre). Kowallick, J. T., Joseph, A. A., Unterberg-Buchwald, C., Fasshauer, M., van Wijk, K., Merboldt, K. D., Voit, D., Frahm, J., Lotz, J. & Sohns, J. M. The British journal of radiology, 20140401, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25074791

St2 May Not Be a Useful Predictor for Incident Cardiovascular Events, Heart Failure and Mortality. Hughes, M. F., Appelbaum, S., Havulinna, A. S., Jagodzinski, A., Zeller, T., Kee, F., Blankenberg, S., Salomaa, V., on behalf of the, F. & BiomarCa, R. E. i. Heart, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25080471

Lights on for Hif-1alpha: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging. Hesse, A. R., Levent, E., Zieseniss, A., Tiburcy, M., Zimmermann, W. H. & Katschinski, D. M. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 34, 455-462, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25095893

Nadph Oxidase 2 Mediates Angiotensin Ii-Dependent Cellular Arrhythmias Via Pka and Camkii. Wagner, S., Dantz, C., Flebbe, H., Azizian, A., Sag, C. M., Engels, S., Mollencamp, J., Dybkova, N., Islam, T., Shah, A. M. & Maier, L. S. J Mol Cell Cardiol, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25073061

Incidence of Sudden Cardiac Death in Germany: Results from an Emergency Medical Service Registry in Lower Saxony. Martens, E., Sinner, M. F., Siebermair, J., Raufhake, C., Beckmann, B. M., Veith, S., Duvel, D., Steinbeck, G. & Kaab, S. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25061228

Modeling Immunity and Inflammation in Stroke: Can Mice Be Trusted? Dirnagl, U. Stroke; a journal of cerebral circulation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25061077

Real-Time Phase-Contrast Flow Mri of Haemodynamic Changes in the Ascending Aorta and Superior Vena Cava During Mueller Manoeuvre. Fasshauer, M., Joseph, A. A., Kowallick, J. T., Unterberg-Buchwald, C., Merboldt, K. D., Voit, D., Steinmetz, M., Staab, W., Schaetz, S., Zhang, S., Frahm, J., Lotz, J. & Sohns, J. M. Clinical radiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25060931

Systematic Permutation Testing in Gwas Pathway Analyses: Identification of Genetic Networks in Dilated Cardiomyopathy and Ulcerative Colitis. Backes, C., Ruhle, F., Stoll, M., Haas, J., Frese, K., Franke, A., Lieb, W., Wichmann, H. E., Weis, T., Kloos, W., Lenhof, H. P., Meese, E., Katus, H., Meder, B. & Keller, A. BMC genomics 15, 622, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25052024

Scn5a Mutations and Polymorphisms in Patients with Ventricular Fibrillation During Acute Myocardial Infarction. Boehringer, T., Bugert, P., Borggrefe, M. & Elmas, E. Molecular medicine reports, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25051102

B-Type Natriuretic Peptide and C-Reactive Protein in the Prediction of Atrial Fibrillation Risk: The Charge-Af Consortium of Community-Based Cohort Studies. Sinner, M. F., Stepas, K. A., Moser, C. B., Krijthe, B. P., Aspelund, T., Sotoodehnia, N., Fontes, J. D., Janssens, A. C., Kronmal, R. A., Magnani, J. W., Witteman, J. C., Chamberlain, A. M., Lubitz, S. A., Schnabel, R. B., Vasan, R. S., Wang, T. J., Agarwal, S. K., McManus, D. D., Franco, O. H., Yin, X. et al. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25037055

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease. Makinen, V. P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segre, A. V., Ghosh, S., Vivar, J., Nikpay, M., Stewart, A. F., Nelson, C. P., Willenborg, C., Erdmann, J., Blakenberg, S., O'Donnell, C. J., Marz, W., Laaksonen, R., Epstein, S. E. et al. PLoS genetics 10, e1004502, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25033284

Health-Related Quality of Life and Physical Activity in Children and Adolescents 2 Years after an Inpatient Weight-Loss Program. Rank, M., Wilks, D. C., Foley, L., Jiang, Y., Langhof, H., Siegrist, M. & Halle, M. The Journal of pediatrics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25039048

Dual Antiplatelet Treatment after Stenting: Is Longer Better? Sibbing, D. & Massberg, S. Lancet, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25037991

Treatment of Acute Left Main Occlusion by Early Revascularization Combined with Extracorporeal Circulation Achieves Substantial Myocardial Salvage as Assessed by Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging. Langwieser, N., Sinnecker, D., Rischpler, C., Batrice, A., van Marwick, S., Schwaiger, M., Laugwitz, K. L., Nekolla, S. G. & Ibrahim, T. Resuscitation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25047572

P425cytoprotection by the No-Donor Snap and Bnp against Ischemia/Reperfusion Injury in Rat Engineered Heart Tissue. Gorbe, A., Eder, A., Varga, Z., Paloczi, J., Hansen, A., Ferdinandy, P. & Eschenhagen, T. Cardiovasc Res 103 Suppl 1, S78, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25020808

Vitamin D Promotes Vascular Regeneration. Wong, M. S., Leisegang, M. S., Kruse, C., Vogel, J., Schurmann, C., Dehne, N., Weigert, A., Herrmann, E., Brune, B., Shah, A. M., Steinhilber, D., Offermanns, S., Carmeliet, G., Badenhoop, K., Schroder, K. & Brandes, R. P. Circulation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25015343

Sexual Dimorphic Response to Exercise in Hypertrophic Cardiomyopathy-Associated Mybpc3-Targeted Knock-in Mice. Najafi, A., Schlossarek, S., van Deel, E. D., van den Heuvel, N., Guclu, A., Goebel, M., Kuster, D. W., Carrier, L. & van der Velden, J. Pflugers Archiv : European journal of physiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25010737

Mutations in Scn10a Are Responsible for a Large Fraction of Cases of Brugada Syndrome. Hu, D., Barajas-Martinez, H., Pfeiffer, R., Dezi, F., Pfeiffer, J., Buch, T., Betzenhauser, M. J., Belardinelli, L., Kahlig, K. M., Rajamani, S., DeAntonio, H. J., Myerburg, R. J., Ito, H., Deshmukh, P., Marieb, M., Nam, G. B., Bhatia, A., Hasdemir, C., Haissaguerre, M., Veltmann, C. et al. Journal of the American College of Cardiology 64, 66-79, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24998131

Increased Concentration of Circulating Angiogenesis and Nitric Oxide Inhibitors Induces Endothelial to Mesenchymal Transition and Myocardial Fibrosis in Patients with Chronic Kidney Disease. Charytan, D. M., Padera, R., Helfand, A. M., Zeisberg, M., Xu, X., Liu, X., Himmelfarb, J., Cinelli, A., Kalluri, R. & Zeisberg, E. M. International journal of cardiology, (2014). http://www.internationaljournalofcardiology.com/article/S0167-5273%2814%2901149-8/abstract

Loss-of-Function Mutations in Apoc3, Triglycerides, and Coronary Disease. Tg, Hdl Working Group of the Exome Sequencing Project, N. H. L., Blood, I., Crosby, J., Peloso, G. M., Auer, P. L., Crosslin, D. R., Stitziel, N. O., Lange, L. A., Lu, Y., Tang, Z. Z., Zhang, H., Hindy, G., Masca, N., Stirrups, K., Kanoni, S., Do, R., Jun, G., Hu, Y., Kang, H. M. et al. The New England journal of medicine 371, 22-31, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24941081

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. Lim, E. T., Wurtz, P., Havulinna, A. S., Palta, P., Tukiainen, T., Rehnstrom, K., Esko, T., Magi, R., Inouye, M., Lappalainen, T., Chan, Y., Salem, R. M., Lek, M., Flannick, J., Sim, X., Manning, A., Ladenvall, C., Bumpstead, S., Hamalainen, E., Aalto, K. et al. PLoS genetics 10, e1004494, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25078778

Real-Time Flow Mri of the Aorta at a Resolution of 40 Msec. Joseph, A., Kowallick, J. T., Merboldt, K. D., Voit, D., Schaetz, S., Zhang, S., Sohns, J. M., Lotz, J. & Frahm, J. Journal of magnetic resonance imaging : JMRI 40, 206-213, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24123295

Harmonization of Study and Reference Data by Phaselift: Saving Time When Imputing Study Data. Gorski, M., Winkler, T. W., Stark, K., Muller-Nurasyid, M., Ried, J. S., Grallert, H., Weber, B. H. & Heid, I. M. Genet Epidemiol 38, 381-388, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24962562

The Left and Right Ventricle in the Grip of Protein Degradation: Similarities and Unique Patterns in Regulation. Drews, O. J Mol Cell Cardiol 72, 52-55, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24625636

Polymorphic Variants of Adrenoceptors: Pharmacology, Physiology, and Role in Disease. Ahles, A. & Engelhardt, S. Pharmacological reviews 66, 598-637, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24928328

Silencing of Ccr2 in Myocarditis. Leuschner, F., Courties, G., Dutta, P., Mortensen, L. J., Gorbatov, R., Sena, B., Novobrantseva, T. I., Borodovsky, A., Fitzgerald, K., Koteliansky, V., Iwamoto, Y., Bohlender, M., Meyer, S., Lasitschka, F., Meder, B., Katus, H. A., Lin, C., Libby, P., Swirski, F. K., Anderson, D. G. et al. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24950695

Juni

Paper of the month

The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages, Nature Communications (2014), doi:10.1038/ncomms4944 (DZHK-Autoren: Müller-Fielitz, Offermanns, Schwaninger)

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Phenotypic Characterization of Mir-92a-/- Mice Reveals an Important Function of Mir-92a in Skeletal Development. Penzkofer, D., Bonauer, A., Fischer, A., Tups, A., Brandes, R. P., Zeiher, A. M. & Dimmeler, S. PloS one 9, e101153, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24979655

Influence of the Confounding Factors Age and Sex on Microrna Profiles from Peripheral Blood. Meder, B., Backes, C., Haas, J., Leidinger, P., Stahler, C., Grossmann, T., Vogel, B., Frese, K., Giannitsis, E., Katus, H. A., Meese, E. & Keller, A. Clinical chemistry, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24987111

Clinical Outcomes of Patients Treated with Nobori Biolimus-Eluting Stent: Meta-Analysis of Randomized Trials. Cassese, S., Fusaro, M., Byrne, R. A., Tada, T., Hoppmann, P., Joner, M., Laugwitz, K. L., Schunkert, H. & Kastrati, A. International journal of cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25012497

Diagnosis of Heart Failure with Preserved Ejection Fraction. Wachter, R. & Edelmann, F. Heart failure clinics 10, 399-406, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24975904

Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association with Glycemic Traits. Herder, C., Nuotio, M. L., Shah, S., Blankenberg, S., Brunner, E. J., Carstensen, M., Gieger, C., Grallert, H., Jula, A., Kahonen, M., Kettunen, J., Kivimaki, M., Koenig, W., Kristiansson, K., Langenberg, C., Lehtimaki, T., Luotola, K., Marzi, C., Muller, C., Peters, A. et al. Diabetes, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24969107

Collagen-Based Engineered Heart Muscle. Tiburcy, M., Meyer, T., Soong, P. L. & Zimmermann, W. H. Methods in molecular biology 1181, 167-176, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25070336

Generation of Strip-Format Fibrin-Based Engineered Heart Tissue (Eht). Schaaf, S., Eder, A., Vollert, I., Stohr, A., Hansen, A. & Eschenhagen, T. Methods in molecular biology 1181, 121-129, (2014). http://www.ncbi.nlm.nih.gov/pubmed/25070332

Rna-Binding Protein Rbm20 Represses Splicing to Orchestrate Cardiac Pre-Mrna Processing. Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M. H., Selbach, M., Barton, P. J., Cook, S. A., Rajewsky, N., Gotthardt, M., Landthaler, M. & Hubner, N. The Journal of clinical investigation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24960161

The Activity of Catechol-O-Methyltransferase (Comt) Is Not Impaired by High Doses of Epigallocatechin-3-Gallate (Egcg) in Vivo. Lorenz, M., Paul, F., Moobed, M., Baumann, G., Zimmemann, B. F., Stangl, K. & Stangl, V. European journal of pharmacology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24972245

Local Observability of State Variables and Parameters in Nonlinear Modeling Quantified by Delay Reconstruction. Parlitz, U., Schumann-Bischoff, J. & Luther, S. Chaos 24, (2014). http://scitation.aip.org/content/aip/journal/chaos/24/2/10.1063/1.4884344

The Case for Sex- and Gender-Specific Medicine. Bairey Merz, C. N. & Regitz-Zagrosek, V. JAMA internal medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24957916

Genetic Association Study of Qt Interval Highlights Role for Calcium Signaling Pathways in Myocardial Repolarization. Arking, D. E., Pulit, S. L., Crotti, L., van der Harst, P., Munroe, P. B., Koopmann, T. T., Sotoodehnia, N., Rossin, E. J., Morley, M., Wang, X., Johnson, A. D., Lundby, A., Gudbjartsson, D. F., Noseworthy, P. A., Eijgelsheim, M., Bradford, Y., Tarasov, K. V., Dorr, M., Muller-Nurasyid, M., Lahtinen, A. M. et al. Nature genetics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24952745

Serum Reference Intervals of Homoarginine, Adma, and Sdma in the Study of Health in Pomerania. Atzler, D., Schwedhelm, E., Nauck, M., Ittermann, T., Boger, R. H. & Friedrich, N. Clinical chemistry and laboratory medicine : CCLM / FESCC, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24945429

Loss-of-Function Mutations in Apoc3, Triglycerides, and Coronary Disease. The, T. G., Hdl Working Group of the Exome Sequencing Project, N. H. L. & Blood, I. The New England journal of medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24941081

Cloning, Functional Characterization and Remodeling of K3.1 (Task-1) Potassium Channels in a Porcine Model of Atrial Fibrillation and Heart Failure. Schmidt, C., Wiedmann, F., Langer, C., Tristram, F., Anand, P., Wenzel, W., Lugenbiel, P., Schweizer, P. A., Katus, H. A. & Thomas, D. Heart rhythm : the official journal of the Heart Rhythm Society, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24952150

Rip3, a Kinase Promoting Necroptotic Cell Death, Mediates Adverse Remodeling after Myocardial Infarction. Luedde, M., Lutz, M., Carter, N., Sosna, J., Jacoby, C., Vucur, M., Gautheron, J., Roderburg, C., Borg, N., Reisinger, F., Hippe, H. J., Linkermann, A., Wolf, M. J., Rose-John, S., Lullmann-Rauch, R., Adam, D., Flogel, U., Heikenwaelder, M., Luedde, T. & Frey, N. Cardiovasc Res, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24920296

The Cxcl12/Cxcr4 Chemokine Ligand/Receptor Axis in Cardiovascular Disease. Doring, Y., Pawig, L., Weber, C. & Noels, H. Frontiers in physiology 5, 212, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24966838

Novel Calmodulin (Calm2) Mutations Associated with Congenital Arrhythmia Susceptibility. Makita, N., Yagihara, N., Crotti, L., Johnson, C. N., Beckmann, B. M., Roh, M. S., Shigemizu, D., Lichtner, P., Ishikawa, T., Aiba, T., Homfray, T., Behr, E. R., Klug, D., Denjoy, I., Mastantuono, E., Theisen, D., Tsunoda, T., Satake, W., Toda, T., Nakagawa, H. et al. Circulation. Cardiovascular genetics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24917665

Mendelian Randomization Studies in Coronary Artery Disease. Jansen, H., Samani, N. J. & Schunkert, H. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24917639

Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis. Collet, T. H., Bauer, D. C., Cappola, A. R., Asvold, B. O., Weiler, S., Vittinghoff, E., Gussekloo, J., Bremner, A., den Elzen, W. P., Maciel, R. M., Vanderpump, M. P., Cornuz, J., Dorr, M., Wallaschofski, H., Newman, A. B., Sgarbi, J. A., Razvi, S., Volzke, H., Walsh, J. P., Aujesky, D. et al. The Journal of clinical endocrinology and metabolism, jc20141250, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24915118

Mrtf-a Controls Vessel Growth and Maturation by Increasing the Expression of Ccn1 and Ccn2. Hinkel, R., Trenkwalder, T., Petersen, B., Husada, W., Gesenhues, F., Lee, S., Hannappel, E., Bock-Marquette, I., Theisen, D., Leitner, L., Boekstegers, P., Cierniewski, C., Muller, O. J., le Noble, F., Adams, R. H., Weinl, C., Nordheim, A., Reichart, B., Weber, C., Olson, E. et al. Nature communications 5, 3970, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24910328

Molecular Mechanism Regulating Myosin and Cardiac Functions by Elc. Lossie, J., Kohncke, C., Mahmoodzadeh, S., Steffen, W., Canepari, M., Maffei, M., Taube, M., Larcheveque, O., Baumert, P., Haase, H., Bottinelli, R., Regitz-Zagrosek, V. & Morano, I. Biochemical and biophysical research communications, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24911555

Microrna-155 and Macrophages: A Fatty Liaison. Hartmann, P., Schober, A. & Weber, C. Cardiovasc Res, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24907979

Stiffness of Left Ventricular Cardiac Fibroblasts Is Associated with Ventricular Dilation in Patients with Recent-Onset Nonischemic and Nonvalvular Cardiomyopathy. Glaubitz, M., Block, S., Witte, J., Empen, K., Gross, S., Schlicht, R., Weitmann, K., Klingel, K., Kandolf, R., Hoffmann, W., Gottschalk, K. E., Busch, M., Dorr, M., Helm, C. A., Felix, S. B. & Riad, A. Circ J 78, 1693-1700, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24899232

The Importance of Patient-Reported Outcomes: A Call for Their Comprehensive Integration in Cardiovascular Clinical Trials. Anker, S. D., Agewall, S., Borggrefe, M., Calvert, M., Jaime Caro, J., Cowie, M. R., Ford, I., Paty, J. A., Riley, J. P., Swedberg, K., Tavazzi, L., Wiklund, I. & Kirchhof, P. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24904027

Atherosclerosis-Multiple Pathways to Lesional Macrophages. Schulz, C. & Massberg, S. Science translational medicine 6, 239ps232, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24898743

Postextrasystolic Blood Pressure Potentiation Predicts Poor Outcome of Cardiac Patients. Sinnecker, D., Dirschinger, R. J., Barthel, P., Muller, A., Morley-Davies, A., Hapfelmeier, A., Dommasch, M., Huster, K. M., Hasenfuss, G., Laugwitz, K. L., Malik, M. & Schmidt, G. Journal of the American Heart Association 3, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24895163

Guanabenz Interferes with Er Stress and Exerts Protective Effects in Cardiac Myocytes. Neuber, C., Uebeler, J., Schulze, T., Sotoud, H., El-Armouche, A. & Eschenhagen, T. PloS one 9, e98893, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24892553

Potential Confounders of Signal-Averaged P-Wave Duration - Strenuous Exercise and Catecholamines. Scherr, J. & Halle, M. Scandinavian journal of medicine & science in sports 24, 602, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24833112

Label-Free Determination of Hemodynamic Parameters in the Microcirculaton with Third Harmonic Generation Microscopy. Dietzel, S., Pircher, J., Nekolla, A. K., Gull, M., Brandli, A. W., Pohl, U. & Rehberg, M. PloS one 9, e99615, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24933027

The Beta-Hydroxybutyrate Receptor Hca2 Activates a Neuroprotective Subset of Macrophages. Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Muller-Fielitz, H., Pokorna, B., Vollbrandt, T., Stolting, I., Nadrowitz, R., Okun, J. G., Offermanns, S. & Schwaninger, M. Nature communications 5, 3944, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24845831

Mai

Paper of the month

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury, Nature (2014), doi:10.1038/nature13232 (DZHK-Autoren: Deuse, Zeller, Eschenhagen, Blankenberg, Reichenspurner, Schrepfer)

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Dapper-1 Is Essential for Wnt5a Induced Cardiomyocyte Hypertrophy by Regulating the Wnt/Pcp Pathway. Hagenmueller, M., Riffel, J. H., Bernhold, E., Fan, J., Katus, H. A. & Hardt, S. E. FEBS letters, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24879894

Proarrhythmic Effect of "Reverse Mode Switch" in a Patient with Long-Qt Syndrome. Rudic, B., Tulumen, E., Borggrefe, M. & Schimpf, R. Journal of cardiovascular electrophysiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24863425

Glycated Hemoglobin as a Marker of Subclinical Atherosclerosis and Cardiac Remodeling among Non-Diabetic Adults from the General Population. Haring, R., Baumeister, S. E., Lieb, W., von Sarnowski, B., Volzke, H., Felix, S. B., Nauck, M. & Wallaschofski, H. Diabetes research and clinical practice, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24972524

Remote Monitoring of Implantable Cardioverter-Defibrillators : Problems and Implications Using a Telemonitoring System. Siebermair, J., Clauss, S., Martens, E., Schuessler, F., Oversohl, N., Haserueck, N., Estner, H. L., Kaab, S. & Wakili, R. Herz, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24848864

Gendermeddb: An Interactive Database of Sex and Gender-Specific Medical Literature. Oertelt-Prigione, S., Gohlke, B. O., Dunkel, M., Preissner, R. & Regitz-Zagrosek, V. Biology of sex differences 5, 7, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24904731

Cohort Profile: Greifswald Approach to Individualized Medicine (Gani_Med). Grabe, H. J., Assel, H., Bahls, T., Dorr, M., Endlich, K., Endlich, N., Erdmann, P., Ewert, R., Felix, S. B., Fiene, B., Fischer, T., Flessa, S., Friedrich, N., Gadebusch-Bondio, M., Salazar, M. G., Hammer, E., Haring, R., Havemann, C., Hecker, M., Hoffmann, W. et al. Journal of translational medicine 12, 144, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24886498

Of Mice and Men - Modeling Post-Stroke Depression Experimentally. Kronenberg, G., Gertz, K., Heinz, A. & Endres, M. British journal of pharmacology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24838087

Functional Improvement and Maturation of Rat and Human Engineered Heart Tissue by Chronic Electrical Stimulation. Hirt, M. N., Boeddinghaus, J., Mitchell, A., Schaaf, S., Bornchen, C., Muller, C., Schulz, H., Hubner, N., Stenzig, J., Stoehr, A., Neuber, C., Eder, A., Luther, P. K., Hansen, A. & Eschenhagen, T. J Mol Cell Cardiol, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24852842

Weight of the Bleeding Impact on Early and Late Mortality after Percutaneous Coronary Intervention. Ndrepepa, G., Guerra, E., Schulz, S., Fusaro, M., Cassese, S. & Kastrati, A. Journal of thrombosis and thrombolysis, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24832461

Regional Variations in Hypertension Prevalence and Management in Germany: Results from the German Health Interview and Examination Survey (Degs1). Diederichs, C. & Neuhauser, H. Journal of hypertension, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24834980

Microrna-126 in Atherosclerosis. Boon, R. A. & Dimmeler, S. Arteriosclerosis, thrombosis, and vascular biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24833799

Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models. Stubbendorff, M., Hua, X., Deuse, T., Ali, Z., Reichenspurner, H., Maegdefessel, L., Robbins, R. C. & Schrepfer, S. Journal of visualized experiments : JoVE, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24893977

S100a1 Is Released from Ischemic Cardiomyocytes and Signals Myocardial Damage Via Toll-Like Receptor 4. Rohde, D., Schon, C., Boerries, M., Didrihsone, I., Ritterhoff, J., Kubatzky, K. F., Volkers, M., Herzog, N., Mahler, M., Tsoporis, J. N., Parker, T. G., Linke, B., Giannitsis, E., Gao, E., Peppel, K., Katus, H. A. & Most, P. EMBO molecular medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24833748

Incidence of All-Cause and Cardiovascular Mortality Predicted by Symmetric Dimethylarginine in the Population-Based Study of Health in Pomerania. Schwedhelm, E., Wallaschofski, H., Atzler, D., Dorr, M., Nauck, M., Volker, U., Kroemer, H. K., Volzke, H., Boger, R. H. & Friedrich, N. PloS one 9, e96875, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24819070

Imaging Diastolic Dysfunction with Cardiovascular Magnetic Resonance. Kowallick, J. T., Edelmann, F., Lotz, J., Lamata, P. & Schuster, A. Journal of Cardiol Ther 1, (2014). http://www.ghrnet.org/index.php/jct/article/view/670/767

[Diastolic Heart Failure.]. Wachter, R. Der Internist, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24806270

Prasugrel Plus Bivalirudin Vs. Clopidogrel Plus Heparin in Patients with St-Segment Elevation Myocardial Infarction. Schulz, S., Richardt, G., Laugwitz, K. L., Morath, T., Neudecker, J., Hoppmann, P., Mehran, R., Gershlick, A. H., Tolg, R., Anette Fiedler, K., Abdel-Wahab, M., Kufner, S., Schneider, S., Schunkert, H., Ibrahim, T., Mehilli, J., Kastrati, A. & and for the Bavarian Reperfusion Alternatives Evaluation, I. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24816809

Genetically Encoded Ca2+ Indicators in Cardiac Myocytes. Kaestner, L., Scholz, A., Tian, Q., Ruppenthal, S., Tabellion, W., Wiesen, K., Katus, H. A., Muller, O. J., Kotlikoff, M. I. & Lipp, P. Circulation research 114, 1623-1639, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24812351

Alignment-Annotator Web Server: Rendering and Annotating Sequence Alignments. Gille, C., Fahling, M., Weyand, B., Wieland, T. & Gille, A. Nucleic acids research, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24813445

Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction. Zafiriou, M. P., Noack, C., Unsold, B., Didie, M., Pavlova, E., Fischer, H. J., Reichardt, H. M., Bergmann, M. W., El-Armouche, A., Hubertus-Zimmermann, W. & Zelarayan, L. C. Stem cells, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24806289

There's Life in the Old Dog Yet: Clopidogrel Competing with Prasugrel and Ticagrelor for Treatment of Acs Patients. Sibbing, D. & Massberg, S. Thrombosis and haemostasis 112, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24816864

Tubulin Polymerization Disrupts Cardiac Beta-Adrenergic Regulation of Late Ina. Dybkova, N., Wagner, S., Backs, J., Hund, T. J., Mohler, P. J., Sowa, T., Nikolaev, V. O. & Maier, L. S. Cardiovasc Res, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24812278

The Total Right/Left-Volume-Index: A New and Simplified Cardiac Magnetic Resonance Measure to Evaluate the Severity of Ebstein's Anomaly of the Tricuspid Valve: A Comparison with Heart Failure Markers from Various Modalities. Hosch, O., Sohns, J. M., Nguyen, T. T., Lauerer, P., Rosenberg, C., Kowallick, J. T., Kutty, S., Unterberg, C., Schuster, A., Fasshauer, M., Staab, W., Paul, T., Lotz, J. & Steinmetz, M. Circulation. Cardiovascular imaging, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24807407

Programming and Isolation of Highly Pure Physiologically and Pharmacologically Functional Sinus-Nodal Bodies from Pluripotent Stem Cells. Jung, J. J., Husse, B., Rimmbach, C., Krebs, S., Stieber, J., Steinhoff, G., Dendorfer, A., Franz, W.-M. & David, R. Stem Cell Reports 2, 1-14, (2014).  

Risk Stratification for Sudden Cardiac Death: Current Status and Challenges for the Future. Wellens, H. J., Schwartz, P. J., Lindemans, F. W., Buxton, A. E., Goldberger, J. J., Hohnloser, S. H., Huikuri, H. V., Kaab, S., La Rovere, M. T., Malik, M., Myerburg, R. J., Simoons, M. L., Swedberg, K., Tijssen, J., Voors, A. A. & Wilde, A. A. Eur Heart J, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24801071

Assessment of Mean Respiratory Rate from Ecg Recordings for Risk Stratification after Myocardial Infarction. Sinnecker, D., Dommasch, M., Barthel, P., Muller, A., Dirschinger, R. J., Hapfelmeier, A., Huster, K. M., Laugwitz, K. L., Malik, M. & Schmidt, G. J Electrocardiol, (2014). http://www.jecgonline.com/article/S0022-0736%2814%2900153-8/abstract

Correlates of Poor Outcome among Patients with Bleeding after Coronary Interventions. Ndrepepa, G., Guerra, E., Schulz, S., Hoppmann, P., Laugwitz, K. L. & Kastrati, A. Coronary artery disease, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24801558

Macrophages in Homeostatic Immune Function. Jantsch, J., Binger, K. J., Müller, D. N. & Titze, J. Front. Physiol., (2014). http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00146/full

Natural Variation of Histone Modification and Its Impact on Gene Expression in the Rat Genome. Rintisch, C., Heinig, M., Bauerfeind, A., Schafer, S., Mieth, C., Patone, G., Hummel, O., Chen, W., Cook, S., Cuppen, E., Colome-Tatche, M., Johannes, F., Jansen, R. C., Neil, H., Werner, M., Pravenec, M., Vingron, M. & Hubner, N. Genome research, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24793478

Data-Driven Treatment Selection for Seamless Phase Ii/Iii Trials Incorporating Early-Outcome Data. Kunz, C. U., Friede, T., Parsons, N., Todd, S. & Stallard, N. Pharmaceutical statistics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24789367

Comparison of End-Diastolic Versus End-Systolic Cardiac-Computed Tomography Reconstruction Interval in Patient's Prior to Pulmonary Vein Isolation. Staab, W., Goth, S., Sohns, C., Sohns, J. M., Steinmetz, M., Unterberg-Buchwald, C., Schuster, A., Kowallick, J. T., Fasshauer, M. & Lotz, J. SpringerPlus 3, (2014). http://www.springerplus.com/content/3/1/218/abstract#

No, Via Its Target Cx37, Modulates Calcium Signal Propagation Selectively at Myoendothelial Gap Junctions. Pogoda, K., Fuller, M., Pohl, U. & Kameritsch, P. Cell communication and signaling : CCS 12, 33, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24885166

Transient Impact of Baseline Depression on Mortality in Patients with Stable Coronary Heart Disease During Long-Term Follow-Up. Meyer, T., Hussein, S., Lange, H. W. & Herrmann-Lingen, C. Clinical research in cardiology : official journal of the German Cardiac Society 103, 389-395, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24464107

Histone Deacetylase Signaling in Cardioprotection. Lehmann, L. H., Worst, B. C., Stanmore, D. A. & Backs, J. Cellular and molecular life sciences : CMLS 71, 1673-1690, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24310814

Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation. Kimmelman, J., Mogil, J. S. & Dirnagl, U. PLoS biology 12, e1001863, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24844265

Dichloroacetate Prevents Restenosis in Preclinical Animal Models of Vessel Injury. Deuse, T., Hua, X., Wang, D., Maegdefessel, L., Heeren, J., Scheja, L., Bolanos, J. P., Rakovic, A., Spin, J. M., Stubbendorff, M., Ikeno, F., Langer, F., Zeller, T., Schulte-Uentrop, L., Stoehr, A., Itagaki, R., Haddad, F., Eschenhagen, T., Blankenberg, S., Kiefmann, R. et al. Nature, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24747400

April

Paper of the month

Assessment of microRNAs in patients with unstable angina pectoris, European Heart Journal, doi: 10.1093/eurheartj/ehu151, (DZHK-authors: Zeller, Keller, Wild, Münzel, Blankenberg)

dzhk.de/dzhk-paper-of-the-month/paper-of-the-month/article/april-2014/

Effects of Ranolazine on Torsades De Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model. Sossalla, S., Wallisch, N., Toischer, K., Sohns, C., Vollmann, D., Seegers, J., Luthje, L., Maier, L. S. & Zabel, M. Cardiovascular therapeutics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24785406

Microvascular Obstruction in Patients with Non-St-Elevation Myocardial Infarction: A Contrast-Enhanced Cardiac Magnetic Resonance Study. Guerra, E., Hadamitzky, M., Ndrepepa, G., Bauer, C., Ibrahim, T., Ott, I., Laugwitz, K. L., Schunkert, H. & Kastrati, A. The international journal of cardiovascular imaging, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24781031

Effect of the Use of Ambulance-Based Thrombolysis on Time to Thrombolysis in Acute Ischemic Stroke: A Randomized Clinical Trial. Ebinger, M., Winter, B., Wendt, M., Weber, J. E., Waldschmidt, C., Rozanski, M., Kunz, A., Koch, P., Kellner, P. A., Gierhake, D., Villringer, K., Fiebach, J. B., Grittner, U., Hartmann, A., Mackert, B. M., Endres, M., Audebert, H. J. & Consortium, S. JAMA : the journal of the American Medical Association 311, 1622-1631, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24756512

Prevalence of Non-Cardiac Findings in Computed Tomography Angiography Prior to Transcatheter Aortic Valve Replacement. Staab, W., Bergau, L., Lotz, J. & Sohns, C. Journal of Cardiovascular Computed Tomography, (2014). http://www.journalofcardiovascularct.com/article/S1934-5925%2814%2900098-7/abstract

Long Noncoding Rna Malat1 Regulates Endothelial Cell Function and Vessel Growth. Michalik, K. M., You, X., Manavski, Y., Doddaballapur, A., Zornig, M., Braun, T., John, D., Ponomareva, Y., Chen, W., Uchida, S., Boon, R. A. & Dimmeler, S. Circulation research 114, 1389-1397, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24602777

Assessment of Coupling between Trans-Abdominally Acquired Fetal Ecg and Uterine Activity by Bivariate Phase-Rectified Signal Averaging Analysis. Casati, D., Stampalija, T., Rizas, K., Ferrazzi, E., Mastroianni, C., Rosti, E., Quadrifoglio, M. & Bauer, A. PloS one 9, e94557, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24759939

Synchronized Integrin Engagement and Chemokine Activation Is Crucial in Neutrophil Extracellular Trap-Mediated Sterile Inflammation. Rossaint, J., Herter, J. M., Van Aken, H., Napirei, M., Doring, Y., Weber, C., Soehnlein, O. & Zarbock, A. Blood 123, 2573-2584, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24335230

Cross-Sectional and Longitudinal Relations of Insulin-Like Growth Factor-I and Igf Binding Protein 3 with Lipid Metabolism. Eggert, M. L., Wallaschofski, H., Grotevendt, A., Nauck, M., Volzke, H., Samietz, S. & Friedrich, N. European journal of endocrinology / European Federation of Endocrine Societies, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24743393

Cardiac Fibroblast-Derived Microrna Passenger Strand-Enriched Exosomes Mediate Cardiomyocyte Hypertrophy. Bang, C., Batkai, S., Dangwal, S., Gupta, S. K., Foinquinos, A., Holzmann, A., Just, A., Remke, J., Zimmer, K., Zeug, A., Ponimaskin, E., Schmiedl, A., Yin, X., Mayr, M., Halder, R., Fischer, A., Engelhardt, S., Wei, Y., Schober, A., Fiedler, J. et al. The Journal of clinical investigation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24743145

Interspecies Differences in Virus Uptake Versus Cardiac Function of the Coxsackievirus and Adenovirus Receptor (Car). Freiberg, F., Sauter, M., Pinkert, S., Govindarajan, T., Kaldrack, J., Thakkar, M., Fechner, H., Klingel, K. & Gotthardt, M. Journal of virology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24741103

Cathelicidin Ll-37 Induces Time-Resolved Release of Ltb4 and Txa2 by Human Macrophages and Triggers Eicosanoid Generation in Vivo. Wan, M., Soehnlein, O., Tang, X., van der Does, A. M., Smedler, E., Uhlen, P., Lindbom, L., Agerberth, B. & Haeggstrom, J. Z. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24736410

Genetic Background Defines the Regulation of Postnatal Cardiac Growth by 17beta-Estradiol through a Beta-Catenin Mechanism. Kararigas, G., Nguyen, B. T., Zelarayan, L. C., Hassenpflug, M., Toischer, K., Sanchez-Ruderisch, H., Hasenfuss, G., Bergmann, M. W., Jarry, H. & Regitz-Zagrosek, V. Endocrinology, en20132180, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24731099

Assessment of Micrornas in Patients with Unstable Angina Pectoris. Zeller, T., Keller, T., Ojeda, F., Reichlin, T., Twerenbold, R., Tzikas, S., Wild, P., Reiter, M., Czyz, E., Lackner, K. J., Munzel, T., Mueller, C. & Blankenberg, S. Eur Heart J 35, (2014). http://eurheartj.oxfordjournals.org/content/early/2014/04/11/eurheartj.ehu151.abstract

Deficiency of Endothelial Cxcr4 Reduces Reendothelialization and Enhances Neointimal Hyperplasia after Vascular Injury in Atherosclerosis-Prone Mice. Noels, H., Zhou, B., Tilstam, P. V., Theelen, W., Li, X., Pawig, L., Schmitz, C., Akhtar, S., Simsekyilmaz, S., Shagdarsuren, E., Schober, A., Adams, R. H., Bernhagen, J., Liehn, E. A., Doring, Y. & Weber, C. Arteriosclerosis, thrombosis, and vascular biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24723559

A Comparative Cohort Study on Personalised Antiplatelet Therapy in Pci-Treated Patients with High on-Clopidogrel Platelet Reactivity. Results of the Isar-Hpr Registry. Mayer, K., Schulz, S., Bernlochner, I., Morath, T., Braun, S., Hausleiter, J., Massberg, S., Schunkert, H., Laugwitz, K. L., Kastrati, A. & Sibbing, D. Thrombosis and haemostasis 112, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24718389

[Heart Failure : Cardiovascular Autonomic Neuropathy in Patients with Diabetes Mellitus.]. Bellmann, B. & Tschope, C. Herz, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24715197

Inhibition of Human Insulin Gene Transcription and Mafa Transcriptional Activity by the Dual Leucine Zipper Kinase. Stahnke, M. J., Dickel, C., Schroder, S., Kaiser, D., Blume, R., Stein, R., Pouponnot, C. & Oetjen, E. Cellular signalling, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24726898

Circulating Endothelial Microparticles in Female Migraineurs with Aura. Liman, T. G., Bachelier-Walenta, K., Neeb, L., Rosinski, J., Reuter, U., Bohm, M. & Endres, M. Cephalalgia : an international journal of headache, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24715500

Rare Variants in Nr2f2 Cause Congenital Heart Defects in Humans. Al Turki, S., Manickaraj, A. K., Mercer, C. L., Gerety, S. S., Hitz, M. P., Lindsay, S., D'Alessandro, L. C., Swaminathan, G. J., Bentham, J., Arndt, A. K., Low, J., Breckpot, J., Gewillig, M., Thienpont, B., Abdul-Khaliq, H., Harnack, C., Hoff, K., Kramer, H. H., Schubert, S., Siebert, R. et al. American journal of human genetics 94, 574-585, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24702954

Fine Tuning Effector and Regulatory T-Cell Dynamics: A Novel Tool for Plaque Regression? Steffens, S. Cardiovasc Res 102, 3-5, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24556952

Safety and Efficacy of a Potential Treatment Algorithm by Using Manual Compression Repair and Ultrasound-Guided Thrombin Injection for the Management of Iatrogenic Femoral Artery Pseudoaneurysm in a Large Patient Cohort. Dzijan-Horn, M., Langwieser, N., Groha, P., Bradaric, C., Linhardt, M., Bottiger, C., Byrne, R. A., Steppich, B., Koppara, T., Godel, J., Hadamitzky, M., Ott, I., von Beckerath, N., Kastrati, A., Laugwitz, K. L. & Ibrahim, T. Circulation. Cardiovascular interventions 7, 207-215, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24692534

Programmed Cell Death-1 Deficiency Exacerbates T Cell Activation and Atherogenesis Despite Expansion of Regulatory T Cells in Atherosclerosis-Prone Mice. Cochain, C., Chaudhari, S. M., Koch, M., Wiendl, H., Eckstein, H. H. & Zernecke, A. PloS one 9, e93280, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24691202

The Abc of Thrombopoiesis. Soehnlein, O. Arteriosclerosis, thrombosis, and vascular biology 34, 700-701, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24665122

Mapping the Genetic Architecture of Gene Regulation in Whole Blood. Schramm, K., Marzi, C., Schurmann, C., Carstensen, M., Reinmaa, E., Biffar, R., Eckstein, G., Gieger, C., Grabe, H. J., Homuth, G., Kastenmuller, G., Magi, R., Metspalu, A., Mihailov, E., Peters, A., Petersmann, A., Roden, M., Strauch, K., Suhre, K., Teumer, A. et al. PloS one 9, e93844, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24740359

Elevated Levels of Hemoglobin A1c Are Associated with Cerebral White Matter Disease in Patients with Stroke. Rozanski, M., Richter, T. B., Grittner, U., Endres, M., Fiebach, J. B. & Jungehulsing, G. J. Stroke; a journal of cerebral circulation 45, 1007-1011, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24569817

Thyroid-Stimulating Hormone, White Matter Hyperintensities, and Functional Outcome in Acute Ischemic Stroke Patients. Leonards, C. O., Schneider, H. J., Liman, T. G., Fiebach, J. B., Endres, M. & Ebinger, M. Cerebrovasc Dis Extra 4, 61-68, (2014). http://www.karger.com/Article/Abstract/360217

How to Measure the Right Ventricular Outflow Tract with Cardiovascular Magnetic Resonance Imaging: A Head-to-Head Comparison of Methods. Doesch, C., Michaely, H., Haghi, D., Schoenberg, S. O., Borggrefe, M. & Papavassiliu, T. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 55, 107-118, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24681788

Monitoring High-Intensity Interval Training in Cvd Patients: Focus on Lactate and Recovery Phases. Christle, J., Pressler, A., Gibala, M. & Halle, M. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, (2014). http://www.fasebj.org/content/28/1_Supplement/705.13.short

Disagreement of the Two Oscillometric Blood Pressure Measurement Devices, Datascope Accutorr Plus and Omron Hem-705cp Ii, and Bidirectional Conversion of Blood Pressure Values. Adler, C., Ellert, U. & Neuhauser, H. K. Blood pressure monitoring 19, 109-117, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24583967

März

Paper of the month

MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1, Nature Medicine 2014, doi:10.1038/nm.3487, (DZHK-Autoren: Schober, Weber)

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Tracer Kinetic Modeling in Myocardial Perfusion Quantification Using Mri. Schwab, F., Ingrisch, M., Marcus, R., Bamberg, F., Hildebrandt, K., Adrion, C., Gliemi, C., Nikolaou, K., Reiser, M. & Theisen, D. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24687430

Evaluation of Oral Anticoagulation Therapy: Rationale and Design of the Thrombeval Study Programme. Prochaska, J. H., Coldewey, M., Gobel, S., Keller, K., Hendelmeier, M., Konstantinides, S., Munzel, T., Wild, P. S. & for the thromb, E. S. G. European journal of preventive cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24685605

Mice with Cardiac-Restricted Overexpression of Myozap Are Sensitized to Biomechanical Stress and Develop a Protein-Aggregate Associated Cardiomyopathy. Frank, D., Rangrez, A. Y., Poyanmehr, R., Seeger, T. S., Kuhn, C., Eden, M., Stiebeling, K., Bernt, A., Grund, C., Franke, W. W. & Frey, N. J Mol Cell Cardiol, (2014). http://www.sciencedirect.com/science/article/pii/S0022282814000935

Atherogenic Mononuclear Cell Recruitment Is Facilitated by Oxidized Lipoprotein-Induced Endothelial Junctional Adhesion Molecule-a Redistribution. Schmitt, M. M., Fraemohs, L., Hackeng, T. M., Weber, C. & Koenen, R. R. Atherosclerosis 234, 254-264, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24704627

Ryanodine Receptor-Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model. Li, N., Chiang, D. Y., Wang, S., Wang, Q., Sun, L., Voigt, N., Respress, J. L., Ather, S., Skapura, D. G., Jordan, V. K., Horrigan, F. T., Schmitz, W., Muller, F. U., Valderrabano, M., Nattel, S., Dobrev, D. & Wehrens, X. H. Circulation 129, 1276-1285, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24398018

The Janus Face of Bnp Therapy in Chronic Heart Failure: Beneficial Effects Unmasked by Beta Blockers? Dewenter, M., Vettel, C. & El-Armouche, A. Heart, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24667282

Cxcl4-Induced Plaque Macrophages Can Be Specifically Identified by Co-Expression of Mmp7+S100a8+ in Vitro and in Vivo. Erbel, C., Tyka, M., Helmes, C. M., Akhavanpoor, M., Rupp, G., Domschke, G., Linden, F., Wolf, A., Doesch, A., Lasitschka, F., Katus, H. A. & Gleissner, C. A. Innate immunity, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24663337

Found in Translation: Preclinical Stroke Research Predicts Human Pathophysiology, Clinical Phenotypes, and Therapeutic Outcomes. Dirnagl, U. & Endres, M. Stroke; a journal of cerebral circulation, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24652307

Current Role of Cardiac and Extra-Cardiac Pathologies in Clinically Indicated Cardiac Computed Tomography with Emphasis on Status before Pulmonary Vein Isolation. Sohns, J. M., Menke, J., Staab, W., Spiro, J., Fasshauer, M., Kowallick, J. T., Bergau, L., Zwaka, P. A., Unterberg-Buchwald, C., Lotz, J. & Schwarz, A. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24648234

Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Development and Toxicity Testing. Sinnecker, D., Laugwitz, K. L. & Moretti, A. Pharmacology & therapeutics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24657289

Sex Differences in Exercise-Induced Physiological Myocardial Hypertrophy Are Modulated by Estrogen Receptor Beta. Dworatzek, E., Mahmoodzadeh, S., Schubert, C., Westphal, C., Leber, J., Kusch, A., Kararigas, G., Fliegner, D., Moulin, M., Ventura-Clapier, Gustafsson, J., Davidson, M., Dragun, D. & Regitz-Zagrosek, V. Cardiovasc Res, (2014). http://cardiovascres.oxfordjournals.org/content/early/2014/03/19/cvr.cvu065.abstract

Lnduced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Development and Toxicity Testing. Sinnecker, D., Laugwitz, K. L. & Moretti, A. Pharmacology & therapeutics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24657289

Comparison of Prasugrel and Bivalirudin Vs Clopidogrel and Heparin in Patients with St-Segment Elevation Myocardial Infarction: Design and Rationale of the Bavarian Reperfusion Alternatives Evaluation (Brave) 4 Trial. Schulz, S., Richardt, G., Laugwitz, K. L., Mehran, R., Gershlick, A. H., Morath, T., Mayer, K., Neudecker, J., Tolg, R., Ibrahim, T., Hauschke, D., Braun, D., Schunkert, H., Kastrati, A., Mehilli, J. & for the Bavarian Reperfusion Alternatives Evaluation, I. Clinical cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24633823

The Role of Endothelin-1 in the Sympathetic Nervous System in the Heart. Lehmann, L. H., Stanmore, D. A. & Backs, J. Life sciences, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24632477

Neutrophils Cast Nets in Atherosclerosis: Employing Peptidylarginine Deiminase as a Therapeutic Target. Doring, Y., Soehnlein, O. & Weber, C. Circulation research 114, 931-934, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24625721

Deficiency of the Sialyltransferase St3gal4 Reduces Ccl5-Mediated Myeloid Cell Recruitment and Arrest: Short Communication. Doring, Y., Noels, H., Mandl, M., Kramp, B., Neideck, C., Lievens, D., Drechsler, M., Megens, R. T., Tilstam, P. V., Langer, M., Hartwig, H., Theelen, W., Marth, J. D., Sperandio, M., Soehnlein, O. & Weber, C. Circulation research 114, 976-981, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24425712

Effects of Exercise Training on Different Quality of Life Dimensions in Heart Failure with Preserved Ejection Fraction: The Ex-Dhf-P Trial. Nolte, K., Herrmann-Lingen, C., Wachter, R., Gelbrich, G., Dungen, H. D., Duvinage, A., Hoischen, N., von Oehsen, K., Schwarz, S., Hasenfuss, G., Halle, M., Pieske, B. & Edelmann, F. European journal of preventive cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24627449

The Beta3-Integrin Binding Protein Beta3-Endonexin Is a Novel Negative Regulator of Hypoxia-Inducible Factor-1. Kracun, D., Riess, F., Kanchev, I., Gawaz, M. & Gorlach, A. Antioxidants & redox signaling, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24386901

Randomised, Double-Blind Trial on the Value of Tapered Discontinuation of Clopidogrel Maintenance Therapy after Drug-Eluting Stent Implantation. Intracoronary Stenting and Antithrombotic Regimen: Caution in Discontinuing Clopidogrel Therapy - Isar-Caution. Fiedler, K. A., Mehilli, J., Kufner, S., Schlichting, A., Ibrahim, T., Sibbing, D., Ott, I., Schunkert, H., Laugwitz, K. L., Kastrati, A. & Schulz, S. Thrombosis and haemostasis 111, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24633406

Constitutive Activation of Pka Catalytic Subunit in Adrenal Cushing's Syndrome. Beuschlein, F., Fassnacht, M., Assie, G., Calebiro, D., Stratakis, C. A., Osswald, A., Ronchi, C. L., Wieland, T., Sbiera, S., Faucz, F. R., Schaak, K., Schmittfull, A., Schwarzmayr, T., Barreau, O., Vezzosi, D., Rizk-Rabin, M., Zabel, U., Szarek, E., Salpea, P., Forlino, A. et al. The New England journal of medicine 370, 1019-1028, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24571724

Integrated Mechanisms of Camkii-Dependent Ventricular Remodeling. Kreusser, M. M. & Backs, J. Front. Pharmacol. 5, (2014). http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00036/abstract

DNA Methylation and Body-Mass Index: A Genome-Wide Analysis. Dick, K. J., Nelson, C. P., Tsaprouni, L., Sandling, J. K., Aissi, D., Wahl, S., Meduri, E., Morange, P. E., Gagnon, F., Grallert, H., Waldenberger, M., Peters, A., Erdmann, J., Hengstenberg, C., Cambien, F., Goodall, A. H., Ouwehand, W. H., Schunkert, H., Thompson, J. R., Spector, T. D. et al. Lancet, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24630777

Targeting the Ubiquitin-Proteasome System in Atherosclerosis: Status Quo, Challenges, and Perspectives. Wilck, N. & Ludwig, A. Antioxidants & redox signaling, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24506455

The Left and Right Ventricle in the Grip of Protein Degradation: Similarities and Unique Patterns in Regulation. Drews, O. J Mol Cell Cardiol 72C, 52-55, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24625636

Comparison of Three Troponins as Predictors of Future Cardiovascular Events - Prospective Results from the Finrisk and Biomacare Studies. Neumann, J. T., Havulinna, A. S., Zeller, T., Appelbaum, S., Kunnas, T., Nikkari, S., Jousilahti, P., Blankenberg, S., Sydow, K. & Salomaa, V. PloS one 9, e90063, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24594734

Comparative Prognostic Value of Low-Density Lipoprotein Cholesterol and C-Reactive Protein in Patients with Stable Coronary Artery Disease Treated with Percutaneous Coronary Intervention and Chronic Statin Therapy. Ndrepepa, G., Braun, S., Tada, T., Guerra, E., Schunkert, H., Laugwitz, K. L. & Kastrati, A. Cardio Revasc Med, (2014). http://www.cardiorevascmed.com/article/S1553-8389%2814%2900049-9/abstract

Microrna-126-5p Promotes Endothelial Proliferation and Limits Atherosclerosis by Suppressing Dlk1. Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T., Heyll, K., Noels, H., Hristov, M., Wang, S., Kiessling, F., Olson, E. N. & Weber, C. Nature medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24584117

Current Treatment of in-Stent Restenosis. Alfonso, F., Byrne, R. A., Rivero, F. & Kastrati, A. Journal of the American College of Cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24632282

Myocardial Tissue Engineering: In Vitro Models. Vunjak Novakovic, G., Eschenhagen, T. & Mummery, C. Cold Spring Harbor perspectives in medicine 4, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24591534

Coronary Heart Disease-Associated Variation in Tcf21 Disrupts a Mir-224 Binding Site and Mirna-Mediated Regulation. Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., Assimes, T. L., Kaiser, F. J., Perisic, L., Hedin, U., Maegdefessel, L., Schunkert, H., Erdmann, J., Quertermous, T. & Sczakiel, G. PLoS genetics 10, e1004263, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24676100

Contribution of Ventricular Assist Devices to the Recovery of Failing Hearts: A Review and the Berlin Heart Center Experience. Dandel, M., Knosalla, C. & Hetzer, R. European journal of heart failure 16, 248-263, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24464654

Februar

Paper of the month

Disruption of Vascular Ca2+-Activated Chloride Currents Lowers Blood Pressure. The Journal of clinical investigation 124, 675-686, (2014) (DZHK-Autoren: Seniuk, Ehmke)

dzhk.de/dzhk-paper-of-the-month/paper-of-the-month/article/februar-2014/

Pq Segment Depression in Short Qt Syndrome Patients: A Novel Marker for Diagnosing Short Qt Syndrome?: Short Qt Syndrome and Pq Segment Depression. Tulumen, E., Giustetto, C., Christian Wolpert, C., Maury, P., Anttonen, O., Probst, V., Blanc, J. J., Sbragia, P., Scrocco, C., Rudic, B., Veltmann, C., Sun, Y., Gaita, F., Antzelevitch, C., Borggrefe, M. & Schimpf, R. Heart rhythm : the official journal of the Heart Rhythm Society, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24589867

Automated Analysis of Contractile Force and Ca2+ Transients in Engineered Heart Tissue. Stoehr, A., Neuber, C., Baldauf, C., Vollert, I., Friedrich, F. W., Flenner, F., Carrier, L., Eder, A., Schaaf, S., Hirt, M. N., Aksehirlioglu, B., Tong, C. W., Moretti, A., Eschenhagen, T. & Hansen, A. American journal of physiology. Heart and circulatory physiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24585781

Long-Term Outcomes of Biodegradable Versus Durable Polymer Drug-Eluting Stents in Patients with Acute St-Segment Elevation Myocardial Infarction: A Pooled Analysis of Individual Patient Data from Three Randomised Trials. de Waha, A., King, L. A., Stefanini, G. G., Byrne, R. A., Serruys, P. W., Meier, B., Juni, P., Kastrati, A. & Windecker, S. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24602961

High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice. Chevre, R., Gonzalez-Granado, J. M., Megens, R. T., Sreeramkumar, V., Silvestre-Roig, C., Molina-Sanchez, P., Weber, C., Soehnlein, O., Hidalgo, A. & Andres, V. Circulation research 114, 770-779, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24366169

Rubbing Salt into Wounded Endothelium: Sodium Potentiates Proatherogenic Effects of Tnf-Alpha under Non-Uniform Shear Stress. Wild, J., Soehnlein, O., Dietel, B., Urschel, K., Garlichs, C. D. & Cicha, I. Thrombosis and haemostasis 112, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24573382

Prevalence and Associations of Diabetic Retinopathy in a Large Cohort of Prediabetic Subjects: The Gutenberg Health Study. Lamparter, J., Raum, P., Pfeiffer, N., Peto, T., Hohn, R., Elflein, H., Wild, P., Schulz, A., Schneider, A. & Mirshahi, A. J Diabet Complications, (2014). http://www.sciencedirect.com/science/article/pii/S1056872714000506

Feasibility of Dynamic Ct-Based Adenosine Stress Myocardial Perfusion Imaging to Detect and Differentiate Ischemic and Infarcted Myocardium in an Large Experimental Porcine Animal Model. Bamberg, F., Hinkel, R., Marcus, R. P., Baloch, E., Hildebrandt, K., Schwarz, F., Hetterich, H., Sandner, T. A., Schlett, C. L., Ebersberger, U., Kupatt, C., Hoffmann, U., Reiser, M. F., Theisen, D. & Nikolaou, K. The international journal of cardiovascular imaging, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24570085

Prevalence of Age-Related Macular Degeneration in a Large European Cohort: Results from the Population-Based Gutenberg Health Study. Korb, C. A., Kottler, U. B., Wolfram, C., Hoehn, R., Schulz, A., Zwiener, I., Wild, P. S., Pfeiffer, N. & Mirshahi, A. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24566902

High-Density Lipoproteins Induce the Migration Capacity of Mesenchymal Stromal Cells. Spillmann, F., Miteva, K., Warstat, K., Perisic, S., Ringe, J., Tschope, C. & van Linthout, S. Stem Cell Res Ther 4, (2014). http://omicsonline.org/open-access/high-density-lipoproteins-induce-migration-capacity-mesenchymal-stromal-cells-2157-7633.1000176.pdf

The Effects of Oral Hydrolytic Enzymes and Flavonoids on Inflammatory Markers and Coagulation after Marathon Running: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial. Grabs, V., Nieman, D. C., Haller, B., Halle, M. & Scherr, J. BMC sports science, medicine and rehabilitation 6, 8, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24559067

Camkii Regulation of Cardiac K Channels. Mustroph, J., Maier, L. S. & Wagner, S. Frontiers in pharmacology 5, 20, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24600393

Nocturnal Respiratory Rate Predicts Non-Sudden Cardiac Death in Survivors of Acute Myocardial Infarction. Dommasch, M., Sinnecker, D., Barthel, P., Muller, A., Dirschinger, R. J., Hapfelmeier, A., Huster, K. M., Laugwitz, K. L., Malik, M. & Schmidt, G. Journal of the American College of Cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24613329

Discriminating Atrial Flutter from Atrial Fibrillation Using a Multilevel Model of Atrioventricular Conduction. Scholz, E. P., Kehrle, F., Vossel, S., Hess, A., Zitron, E., Katus, H. A. & Sager, S. Heart rhythm : the official journal of the Heart Rhythm Society, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24561160

Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia. Marsman, R. F., Bezzina, C. R., Freiberg, F., Verkerk, A. O., Adriaens, M. E., Podliesna, S., Chen, C., Purfurst, B., Spallek, B., Koopmann, T. T., Baczko, I., Dos Remedios, C. G., George, A. L., Jr., Bishopric, N. H., Lodder, E. M., de Bakker, J. M., Fischer, R., Coronel, R., Wilde, A. A., Gotthardt, M. et al. Journal of the American College of Cardiology 63, 549-559, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24291282

Sirolimus-Eluting Versus Paclitaxel-Eluting Stents in Diabetic and Non-Diabetic Patients with in Sirolimus-Eluting Stent Restenosis: Results from the Isar-Desire 2 Trial. Kufner, S., Byrne, R. A., de Waha, A., Schulz, S., Joner, M., Laugwitz, K. L. & Kastrati, A. Cardiovascular Revascularization Medicine, (2014). http://www.cardiorevascmed.com/article/PIIS1553838914000475/abstract

Inhibition of Cullin-Ring E3 Ubiquitin Ligase 7 by Simian Virus 40 Large T Antigen. Hartmann, T., Xu, X., Kronast, M., Muehlich, S., Meyer, K., Zimmermann, W., Hurwitz, J., Pan, Z. Q., Engelhardt, S. & Sarikas, A. Proceedings of the National Academy of Sciences of the United States of America, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24550499

Induction of Atrial Fibrillation by Neutrophils Critically Depends on Cd11b/Cd18 Integrins. Friedrichs, K., Adam, M., Remane, L., Mollenhauer, M., Rudolph, V., Rudolph, T. K., Andrie, R. P., Stockigt, F., Schrickel, J. W., Ravekes, T., Deuschl, F., Nickenig, G., Willems, S., Baldus, S. & Klinke, A. PloS one 9, e89307, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24558493

Blocking Cd40-Traf6 Signaling Is a Therapeutic Target in Obesity-Associated Insulin Resistance. Chatzigeorgiou, A., Seijkens, T., Zarzycka, B., Engel, D., Poggi, M., van den Berg, S., van den Berg, S., Soehnlein, O., Winkels, H., Beckers, L., Lievens, D., Driessen, A., Kusters, P., Biessen, E., Garcia-Martin, R., Klotzsche-von Ameln, A., Gijbels, M., Noelle, R., Boon, L., Hackeng, T. et al. Proceedings of the National Academy of Sciences of the United States of America 111, 2686-2691, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24492375

Crucial Role for Ca2(+)/Calmodulin-Dependent Protein Kinase-Ii in Regulating Diastolic Stress of Normal and Failing Hearts Via Titin Phosphorylation. Hamdani, N., Krysiak, J., Kreusser, M. M., Neef, S., Dos Remedios, C. G., Maier, L. S., Kruger, M., Backs, J. & Linke, W. A. Circulation research 112, 664-674, (2013). http://www.ncbi.nlm.nih.gov/pubmed/23283722

Pde2-Mediated Camp Hydrolysis Accelerates Cardiac Fibroblast to Myofibroblast Conversion and Is Antagonized by Exogenous Activation of Cgmp Signaling Pathways. Vettel, C., Lammle, S., Ewens, S., Cevirgen, C., Emons, J., Ongherth, A., Dewenter, M., Lindner, D., Westermann, D., Nikolaev, V. O., Lutz, S., Zimmermann, W. H. & El-Armouche, A. American journal of physiology. Heart and circulatory physiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24531807

Isoenzyme-Specific Regulation of Cardiac Kv1.5/Kvβ1.2 Ion Channel Complex by Protein Kinase C: Central Role of Pkcβii. Fischer, F., Vonderlin, N., Seyler, C., Zitron, E., Korkmaz, S., Szabo, Z., Thomas, D., Katus, H. A. & Scholz, E. P. Naunyn-Schmiedeberg's Archives of Pharmacology (2014). http://link.springer.com/article/10.1007%2Fs00210-014-0965-5

Vegf-B: A More Balanced Approach toward Cardiac Neovascularization? Kupatt, C. & Hinkel, R. EMBO molecular medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24521742

Heart Failure-Specific Changes in Protein Kinase Signalling. Lorenz, K., Stathopoulou, K., Schmid, E., Eder, P. & Cuello, F. Pflugers Archiv : European journal of physiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24510065

Herg K(+) Channel-Dependent Apoptosis and Cell Cycle Arrest in Human Glioblastoma Cells. Staudacher, I., Jehle, J., Staudacher, K., Pledl, H. W., Lemke, D., Schweizer, P. A., Becker, R., Katus, H. A. & Thomas, D. PloS one 9, e88164, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24516604

Controlled Intramyocardial Release of Engineered Chemokines by Biodegradable Hydrogels as a Treatment Approach of Myocardial Infarction. Projahn, D., Simsekyilmaz, S., Singh, S., Kanzler, I., Kramp, B. K., Langer, M., Burlacu, A., Bernhagen, J., Klee, D., Zernecke, A., Hackeng, T. M., Groll, J., Weber, C., Liehn, E. A. & Koenen, R. R. Journal of cellular and molecular medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24512349

Dynamic Myocardial Ct Perfusion Imaging for Evaluation of Myocardial Ischemia as Determined by Mr Imaging. Bamberg, F., Marcus, R. P., Becker, A., Hildebrandt, K., Bauner, K., Schwarz, F., Greif, M., von Ziegler, F., Bischoff, B., Becker, H. C., Johnson, T. R., Reiser, M. F., Nikolaou, K. & Theisen, D. JACC. Cardiovascular imaging, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24529887

Bone Marrow-Specific Knock-in of a Non-Activatable Ikkalpha Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice. Tilstam, P. V., Gijbels, M. J., Habbeddine, M., Cudejko, C., Asare, Y., Theelen, W., Zhou, B., Doring, Y., Drechsler, M., Pawig, L., Simsekyilmaz, S., Koenen, R. R., de Winther, M. P., Lawrence, T., Bernhagen, J., Zernecke, A., Weber, C. & Noels, H. PloS one 9, e87452, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24498325

Disruption of Vascular Ca2+-Activated Chloride Currents Lowers Blood Pressure. Heinze, C., Seniuk, A., Sokolov, M. V., Huebner, A. K., Klementowicz, A. E., Szijarto, I. A., Schleifenbaum, J., Vitzthum, H., Gollasch, M., Ehmke, H., Schroeder, B. C. & Hubner, C. A. The Journal of clinical investigation 124, 675-686, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24401273

Microvascular Dysfunction in the Course of Metabolic Syndrome Induced by High-Fat Diet. Aoqui, C., Chmielewski, S., Scherer, E., Eissler, R., Sollinger, D., Heid, I., Braren, R., Schmaderer, C., Megens, R. T., Weber, C., Heemann, U., Tschop, M. & Baumann, M. Cardiovascular diabetology 13, 31, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24490784

Therapeutic Safety of High Myocardial Expression Levels of the Molecular Inotrope S100a1 in a Preclinical Heart Failure Model. Weber, C., Neacsu, I., Krautz, B., Schlegel, P., Sauer, S., Raake, P., Ritterhoff, J., Jungmann, A., Remppis, A. B., Stangassinger, M., Koch, W. J., Katus, H. A., Muller, O. J., Most, P. & Pleger, S. T. Gene therapy 21, 131-138, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24305416

Beta-Catenin-Dependent Pathway Activation by Both Promiscuous "Canonical" Wnt3a-, and Specific "Noncanonical" Wnt4- and Wnt5a-Fzd Receptor Combinations with Strong Differences in Lrp5 and Lrp6 Dependency. Ring, L., Neth, P., Weber, C., Steffens, S. & Faussner, A. Cellular signalling 26, 260-267, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24269653

Chronic Blockade of Angiotensin at(1) Receptors Improves Cardinal Symptoms of Metabolic Syndrome in Diet-Induced Obesity in Rats. Muller-Fielitz, H., Hubel, N., Mildner, M., Vogt, F. M., Barkhausen, J. & Raasch, W. British journal of pharmacology 171, 746-760, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24490862

On the Temporal Fidelity of Nonlinear Inverse Reconstructions for Real-Time Mri – the Motion Challenge. Frahm, J., Schatz, S., Untenberger, M., Zhang, S., Voit, D., Merboldt, K.-D., Sohns, J. M., Lotz, J. & Uecker, M. The Open Medical Imaging Journal 8, (2014). http://www.benthamscience.com/open/tomij/articles/V008/1TOMIJ.pdf

[Cardiac Sarcoidosis: Diagnostic and Therapeutic Algorithms]. Costabel, U., Skowasch, D., Pabst, S., Stork, S., Tschope, C., Allewelt, M., Worth, H., Muller-Quernheim, J. & Grohe, C. Pneumologie 68, 124-132, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24497049

Januar

Type D Personality Is Unrelated to Major Adverse Cardiovascular Events in Patients with Coronary Artery Disease Treated by Intracoronary Stenting. Meyer, T., Hussein, S., Lange, H. W. & Herrmann-Lingen, C. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24481867

Release Kinetics of Early Ischaemic Biomarkers in a Clinical Model of Acute Myocardial Infarction. Liebetrau, C., Nef, H. M., Dorr, O., Gaede, L., Hoffmann, J., Hahnel, A., Rolf, A., Troidl, C., Lackner, K. J., Keller, T., Hamm, C. W. & Mollmann, H. Heart, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24488609

Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis. Tampe, B., Tampe, D., Muller, C. A., Sugimoto, H., Lebleu, V., Xu, X., Muller, G. A., Zeisberg, E. M., Kalluri, R. & Zeisberg, M. Journal of the American Society of Nephrology : JASN, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24480825

Induction of Microrna-138 by Pro-Inflammatory Cytokines Causes Endothelial Cell Dysfunction. Sen, A., Most, P. & Peppel, K. FEBS letters, (2014). www.ncbi.nlm.nih.gov/pubmed/24486907

A Meta-Analysis of Genome-Wide Association Studies Identifies Orm1 as a Novel Gene Controlling Thrombin Generation Potential. Rocanin-Arjo, A., Cohen, W., Carcaillon, L., Frere, C., Saut, N., Letenneur, L., Alhenc-Gelas, M., Dupuy, A. M., Bertrand, M., Alessi, M. C., Germain, M., Wild, P. S., Zeller, T., Cambien, F., Goodall, A. H., Amouyel, P., Scarabin, P. Y., Tregouet, D. A., Morange, P. E. & CardioGenics, C. Blood 123, 777-785, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24357727

Cardiomyocyte-Specific Estrogen Receptor Alpha Increases Angiogenesis, Lymphangiogenesis and Reduces Fibrosis in the Female Mouse Heart Post-Myocardial Infarction. Mahmoodzadeh, S., Leber, J., Zhang, X., Jaisser, F., Messaoudi, S., Morano, I., Furth, P. A., Dworatzek, E. & Regitz-Zagrosek, V. J Cell Sci Ther 5, (2014). http://omicsonline.org/open-access/cardiomyocytespecific-estrogen-receptor-alpha-increases-angiogenesis-lymphangiogenesis-and-reduces-fibrosis-in-the-female-mouse-heart-postmyocardial-infarction-2157-7013.1000153.pdf

Nicotinamide Phosphoribosyltransferase Inhibition Reduces Intraplaque Cxcl1 Production and Associated Neutrophil Infiltration in Atherosclerotic Mice. Nencioni, A., da Silva, R. F., Fraga-Silva, R. A., Steffens, S., Fabre, M., Bauer, I., Caffa, I., Magnone, M., Sociali, G., Quercioli, A., Pelli, G., Lenglet, S., Galan, K., Burger, F., Vazquez Calvo, S., Bertolotto, M., Bruzzone, S., Ballestrero, A., Patrone, F., Dallegri, F. et al. Thrombosis and haemostasis 111, 308-322, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24196571

[Genetic Analyses as Basis for a Personalized Medicine in Patients with Coronary Artery Disease.]. Kessler, T., Kaess, B., Bourier, F., Erdmann, J. & Schunkert, H. Herz, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24464254

Strengths and Weaknesses of a New Mouse Model of Thrombosis Induced by Inferior Vena Cava Stenosis. Geddings, J. E., Aleman, M. M., Wolberg, A. S., von Brupsilonhl, M. L., Massberg, S. & Mackman, N. Journal of thrombosis and haemostasis : JTH, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24460606

Nanomedicine-Based Strategies for Treatment of Atherosclerosis. Schiener, M., Hossann, M., Viola, J. R., Ortega-Gomez, A., Weber, C., Lauber, K., Lindner, L. H. & Soehnlein, O. Trends in molecular medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24594264

From Heart to Toe: Heart's Contribution on Peripheral Microrna Levels. Boeckel, J. N., Reis, S. M., Leistner, D., Thome, C. E., Zeiher, A. M., Fichtlscherer, S. & Keller, T. International journal of cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24508494

Randomized Comparison of Biolimus-Eluting Stents with Biodegradable Polymer Versus Everolimus-Eluting Stents with Permanent Polymer Coatings Assessed by Optical Coherence Tomography. Tada, T., Kastrati, A., Byrne, R. A., Schuster, T., Cuni, R., King, L. A., Cassese, S., Joner, M., Pache, J., Massberg, S., Schomig, A. & Mehilli, J. The international journal of cardiovascular imaging, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24452729

Muller Glia Cells Regulate Notch Signaling and Retinal Angiogenesis Via the Generation of 19,20-Dihydroxydocosapentaenoic Acid. Hu, J., Popp, R., Fromel, T., Ehling, M., Awwad, K., Adams, R. H., Hammes, H. P. & Fleming, I. The Journal of experimental medicine, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24446488

Increased Beta-Adrenergic Inotropy in Ventricular Myocardium from Trpm4-/- Mice. Mathar, I., Kecskes, M., Van der Mieren, G., Jacobs, G., Camacho Londono, J. E., Uhl, S., Flockerzi, V., Voets, T., Freichel, M., Nilius, B., Herijgers, P. & Vennekens, R. Circulation research 114, 283-294, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24226423

Novel Genetic Markers Associate with Atrial Fibrillation Risk in Europeans and Japanese. Lubitz, S. A., Lunetta, K. L., Lin, H., Arking, D. E., Trompet, S., Li, G., Krijthe, B. P., Chasman, D. I., Barnard, J., Kleber, M. E., Dorr, M., Ozaki, K., Smith, A. V., Muller-Nurasyid, M., Walter, S., Agarwal, S. K., Bis, J. C., Brody, J. A., Chen, L. Y., Everett, B. M. et al. Journal of the American College of Cardiology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24486271

Cardiac Tissue Engineering: State of the Art. Hirt, M. N., Hansen, A. & Eschenhagen, T. Circulation research 114, 354-367, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24436431

Hcn Channels: New Roles in Sinoatrial Node Function. Wahl-Schott, C., Fenske, S. & Biel, M. Current opinion in pharmacology 15C, 83-90, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24441197

Predictors of Antiplatelet Response to Prasugrel During Maintenance Treatment. Mayer, K., Orban, M., Bernlochner, I., Braun, S., Schulz, S., Gross, L., Hadamitzky, M., Schunkert, H., Laugwitz, K. L., Massberg, S., Kastrati, A. & Sibbing, D., (2014). http://informahealthcare.com/doi/abs/10.3109/09537104.2013.863857

Rationale and Design of the Isar-Triple Study: The Intracoronary Stenting and Antithrombotic Regimen - Testing of a Six-Week Versus a Six-Month Clopidogrel Treatment Regimen in Patients with Concomitant Aspirin and Oral Anticoagulant Therapy Following Drug-Eluting Stenting (Isar-Triple). Fiedler, A. K., Byrne, R. A., Schulz, S., Sibbing, D., Mehili, J., Ibrahim, T., Maeng, M., Laugwitz, K.-L., Kastrati, A. & Sarafoff, N. Am Heart J, (2014). http://www.ahjonline.com/article/S0002-8703%2814%2900026-X/abstract

Paradoxical Effects on Force Generation after Efficient Beta1-Adrenoceptor Knockdown in Reconstituted Heart Tissue. Neuber, C., Muller, O. J., Hansen, F. C., Eder, A., Witten, A., Ruhle, F., Stoll, M., Katus, H. A., Eschenhagen, T. & El-Armouche, A. The Journal of pharmacology and experimental therapeutics, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24431469

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients with Paroxysmal Atrial Fibrillation. Voigt, N., Heijman, J., Wang, Q., Chiang, D. Y., Li, N., Karck, M., Wehrens, X. H., Nattel, S. & Dobrev, D. Circulation 129, 145-156, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24249718

Common Variation in Fatty Acid Metabolic Genes and Risk of Incident Sudden Cardiac Arrest. Lemaitre, R. N., Johnson, C. O., Hesselson, S., Sotoodhenia, N., McKnight, B., Sitlani, C. M., Rea, T. D., King, I. B., Kwok, P. Y., Mak, A., Li, G., Brody, J., Larson, E., Mozaffarian, D., Psaty, B. M., Huertas-Vazquez, A., Tardif, J. C., Albert, C. M., Lyytikainen, L. P., Arking, D. E. et al. Heart rhythm : the official journal of the Heart Rhythm Society, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24418166

How to Include Chromosome X in Your Genome-Wide Association Study. Konig, I. R., Loley, C., Erdmann, J. & Ziegler, A. Genet Epidemiol, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24408308

[Importance of Modern Genome-Wide Studies for the Risk of Myocardial Infarction.]. Kessler, T., Erdmann, J. & Schunkert, H. Der Internist, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24399470

Argonaute2 Mediates Compensatory Expansion of the Pancreatic Beta Cell. Tattikota, S. G., Rathjen, T., McAnulty, S. J., Wessels, H. H., Akerman, I., van de Bunt, M., Hausser, J., Esguerra, J. L., Musahl, A., Pandey, A. K., You, X., Chen, W., Herrera, P. L., Johnson, P. R., O'Carroll, D., Eliasson, L., Zavolan, M., Gloyn, A. L., Ferrer, J., Shalom-Feuerstein, R. et al. Cell metabolism 19, 122-134, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24361012

Endothelial Junctional Adhesion Molecule-a Guides Monocytes into Flow-Dependent Predilection Sites of Atherosclerosis. Schmitt, M. M., Megens, R. T., Zernecke, A., Bidzhekov, K., van den Akker, N. M., Rademakers, T., van Zandvoort, M. A., Hackeng, T. M., Koenen, R. R. & Weber, C. Circulation 129, 66-76, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24065611

Chemokines in Atherosclerosis: Proceedings Resumed. Zernecke, A. & Weber, C. Arteriosclerosis, thrombosis, and vascular biology, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24436368

The Beta3-Integrin Binding Protein Beta3-Endonexin Is a Novel Negative Regulator of Hypoxia-Inducible Factor-1 (Hif-1). Kracun, D., Riess, F., Kanchev, I., Gawaz, M. & Gorlach, A. Antioxidants & redox signaling, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24386901

Detection of Intracardiac Masses in Patients with Coronary Artery Disease Using Cardiac Magnetic Resonance Imaging: A Comparison with Transthoracic Echocardiography. Staab, W., Bergau, L., Schuster, A., Hinojar, R., Dorenkamp, M., Obenauer, S., Lotz, J. & Sohns, C. The international journal of cardiovascular imaging, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24384859

Atherosclerotic Plaque Destabilization: Mechanisms, Models, and Therapeutic Strategies. Silvestre-Roig, C., de Winther, M. P., Weber, C., Daemen, M. J., Lutgens, E. & Soehnlein, O. Circulation research 114, 214-226, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24385514

Cardiac Calcium Handling on Trial: Targeting the Failing Cardiomyocyte Signalosome. Pleger, S. T., Raake, P., Katus, H. A. & Most, P. Circulation research 114, 12-14, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24385502

Perspectives: The Ca2+-Dependent K+-Channel Kca3.1 as a Therapeutic Target in Cardiovascular Disease Windler, R. & de Wit, C. Eur Heart J Suppl 16, A30-A32, (2014).

Dopamine and Lipophilic Derivates Protect Cardiomyocytes against Cold Preservation Injury. Vettel, C., Hottenrott, M. C., Spindler, R., Benck, U., Schnuelle, P., Tsagogiorgas, C., Kramer, B. K., Hoeger, S., El-Armouche, A., Wieland, T. & Yard, B. A. The Journal of pharmacology and experimental therapeutics 348, 77-85, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24135075

Impact of Coronary Anatomy and Stenting Technique on Long-Term Outcome after Drug-Eluting Stent Implantation for Unprotected Left Main Coronary Artery Disease. Tiroch, K., Mehilli, J., Byrne, R. A., Schulz, S., Massberg, S., Laugwitz, K. L., Vorpahl, M., Seyfarth, M., Kastrati, A. & Investigators, I.-L. M. S. JACC. Cardiovascular interventions 7, 29-36, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24332416

Lxr Agonism Improves Tnf-Alpha-Induced Endothelial Dysfunction in the Absence of Its Cholesterol-Modulating Effects. Spillmann, F., Van Linthout, S., Miteva, K., Lorenz, M., Stangl, V., Schultheiss, H. P. & Tschope, C. Atherosclerosis 232, 1-9, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24401210

Simultaneous Flow Dynamics in Small and Great Thoracic Vessels During Physiological Stress Tests and Normal Breathing Using Real-Time Cardiac Magnetic-Resonance. Sohns, J. M., Fasshauer, M., Kowallick, J. T., Schuster, A., Staab, W., Joseph, A., Zhang, S., Voit, D., Schatz, S., Merboldt, K.-D., Steinmetz, M., Unterberg-Buchwald, C., Frahm, J. & Lotz, J. J Cardiov Magn Reson 16, (2014). http://link.springer.com/article/10.1186%2F1532-429X-16-S1-P9

Therapeutic Targeting of the Oncostatin M Receptor-Beta Prevents Inflammatory Heart Failure. Poling, J., Gajawada, P., Richter, M., Lorchner, H., Polyakova, V., Kostin, S., Shin, J., Boettger, T., Walther, T., Rees, W., Wietelmann, A., Warnecke, H., Kubin, T. & Braun, T. Basic research in cardiology 109, 396, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24292852

Benefits of Collaborative Care for Post-Cabg Depression Are Not Related to Adjustments in Antidepressant Pharmacotherapy. Meyer, T., Belnap, B. H., Herrmann-Lingen, C., He, F., Mazumdar, S. & Rollman, B. L. Journal of psychosomatic research 76, 28-33, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24360138

Hypertrophic Cardiomyopathy in Cardiac Ct: A Validation Study on the Detection of Intramyocardial Fibrosis in Consecutive Patients. Langer, C., Lutz, M., Eden, M., Ludde, M., Hohnhorst, M., Gierloff, C., Both, M., Burchert, W., Faber, L., Horstkotte, D., Frey, N. & Prinz, C. The international journal of cardiovascular imaging, (2014). http://link.springer.com/article/10.1007%2Fs10554-013-0358-8

Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants. Dichgans, M., Malik, R., Konig, I. R., Rosand, J., Clarke, R., Gretarsdottir, S., Thorleifsson, G., Mitchell, B. D., Assimes, T. L., Levi, C., O'Donnell, C. J., Fornage, M., Thorsteinsdottir, U., Psaty, B. M., Hengstenberg, C., Seshadri, S., Erdmann, J., Bis, J. C., Peters, A., Boncoraglio, G. B. et al. Stroke; a journal of cerebral circulation 45, 24-36, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24262325

Incidence and Predictors of Restenosis after Coronary Stenting in 10 004 Patients with Surveillance Angiography. Cassese, S., Byrne, R. A., Tada, T., Pinieck, S., Joner, M., Ibrahim, T., King, L. A., Fusaro, M., Laugwitz, K. L. & Kastrati, A. Heart 100, 153-159, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24270744

The Level of Hepatic Abcc6 Expression Determines the Severity of Calcification after Cardiac Injury. Brampton, C., Aherrahrou, Z., Chen, L. H., Martin, L., Bergen, A. A., Gorgels, T. G., Erdmann, J., Schunkert, H., Szabo, Z., Varadi, A. & Le Saux, O. The American journal of pathology 184, 159-170, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24479134

Stem Cell Factor Gene Therapy Attenuates Cardiac Dysfunction Postmyocardial Infarction. Heger, T., Lutz, M., Rosenberg, M., Will, R., Krebs, J., Katus, H. A. & Frey, N. Exp Clin Cardiol 2013, (2014). http://cardiologyacademicpress.com/soap/pdf/sept2013/15669_hege.pdf

Metabolite Profiling Reveals New Insights into the Regulation of Serum Urate in Humans. Albrecht, E., Waldenberger, M., Krumsiek, J., Evans, A. M., Jeratsch, U., Breier, M., Adamski, J., Koenig, W., Zeilinger, S., Fuchs, C., Klopp, N., Theis, F. J., Wichmann, H. E., Suhre, K., Illig, T., Strauch, K., Peters, A., Gieger, C., Kastenmuller, G., Doering, A. et al. Metabolomics : Official journal of the Metabolomic Society 10, 141-151, (2014). http://www.ncbi.nlm.nih.gov/pubmed/24482632