Myocardial RNA Therapy
- Funding ID
81Z3600431
- Project number
493
- Institution
- Technische Universität München
- Project leader
- Stefan Engelhardt
- Site
- München
- Short description
-
This project aims to develop RNA-based therapeutics that interfere with myocardial damage. For this purpose several cardiovascular microRNAs have been identified and functionally …
This project aims to develop RNA-based therapeutics that interfere with myocardial damage. For this purpose several cardiovascular microRNAs have been identified and functionally characterized with regard to their capacity to regulate key cellular signaling pathways. A subset of these miRNAs are being validated in mouse models of disease and approaches for their therapeutic manipulation are being developed. This involves studies that aim to optimize the pharmacokinetics and pharmacodynamics of miRNA inhibitor molecules.
- Project type
- Partner Site Projects
- Keywords
- miRNA-based therapy, microRNA, AntagomiR, anti-miR, AAV
- Topic
- DNA/RNA based, protein based therapy
- Funding
- € 2.107.648,12
- Begin
- 15.10.2011
- End
- 31.12.2018