Alternatives Spleißen als therapeutisches Target für Erkrankungen des Herzens
- Funding ID
81Z2100102
- Project number
450
- Institution
- Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
- Project leader
- Michael Gotthardt
- Site
- Berlin
- Short description
-
The project alternative splicing as a therapeutic target for cardiac diseases builds on our identification of RBM20 as a splice factor with substrates related to sarcomere function and …
The project alternative splicing as a therapeutic target for cardiac diseases builds on our identification of RBM20 as a splice factor with substrates related to sarcomere function and calcium homeostasis. We will study the regulation of RBM20 expression and function, as well as its interaction with other proteins to identify potential therapeutic targets. Through the coordinated interference with cardiac isoform expression, we will adapt the elastic and electrical properties of the heart.
- Project type
- Partner Site Projects
- Keywords
- RNA, splicing, therapy
- Topic
- cardiomyocyte function
- Funding
- € 357.275,80
- Begin
- 01.01.2015
- End
- 31.12.2018