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  • protein based therapy
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1701 total entries
Last update 10.12.2024

VAD-DZHK3: Early versus late left ventricular assist device implantation in patients awaiting cardiac transplantation
ID 81X1100301
Institution Deutsches Herzzentrum Berlin
Project leader Volkmar Falk
Site Berlin
Project type Clinical Studies
Funding 2007622.00€ 2.007.622,00
Begin 2013-06-0101.06.2013
End 2024-06-3030.06.2024
Projektdetails
end-stage heart disease, ventricular assist device (VAD)
https://vad.dzhk.de/

TransitionCHF-DZHK2: Systolische Dysfunktion / Systolic Dysfunction to Congestive Heart Failure Cohort Study
ID 81X1300102
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Gerd Hasenfuß
Site Göttingen
Project type Clinical Studies
Funding 1731738.90€ 1.731.738,90
Begin 2013-08-0101.08.2013
End 2027-12-3131.12.2027
Projektdetails
heart failure, asymptomatic systolic dysfunction
This cohort study explores ways of predicting when decreased cardiac performance without symptoms will develop into a clinically manifest disease. In many patients, decreased cardiac performance is detected during routine examinations without the patient showing any of the typical symptoms, such as a reduction in exercise tolerance or shortness of breath. This ‘hidden’ heart failure can be caused by high blood pressure, myocardial infarction or diseases of the heart muscle. Some 1,500 such patients are to be examined and followed over a period of at least five years at the DZHK partner sites and at other clinics. Within the scope of the study, blood markers, results from imaging studies and genetic profiles will be analysed in relation to the patients’ state of health and development of clinical symptoms. The emerging patterns and regularities could be used in the future to help predict when symptoms of heart failure will appear. Then therapeutic measures could be taken to counter the development of symptoms. This is all the more important because heart failure generally progresses gradually and clinicians have so far not found a way to prevent further deterioration of the condition.

VAD-DZHK3: Biometrie
ID 81X1300103
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 114959.00€ 114.959,00
Begin 2013-10-0101.10.2013
End 2024-09-3030.09.2024
Projektdetails
end-stage heart disease, ventricular assist device (VAD)
https://vad.dzhk.de/

TORCH-DZHK1: TranslatiOnal Registry for CardiomyopatHies
ID 81X1400102
Institution Universitätsmedizin Greifswald
Project leader Wolfgang Hoffmann
Site Greifswald
Project type Clinical Studies
Funding 311748.62€ 311.748,62
Begin 2013-08-0101.08.2013
End 2019-12-3131.12.2019
Projektdetails
hereditary cardiomyopathy, inflammatory cardiomyopathy, acute myocarditis
Data is to be collected from some 2,300 patients with heart muscle damage (cardiomyopathy) whose condition was not caused by myocardial infarction, i.e. narrowing of the arteries. Instead this study will include patients who have suffered heart muscle damage for other reasons, for instance, as a result of genetic disposition or inflammatory processes. Diseases of the heart muscle have myriad causes and clinical manifestations. Therefore, the researchers intend to carry out detailed clinical examinations including taking small tissue samples from the heart by means of myocardial biopsy. This is the first registry of its kind worldwide and by evaluating the data and biological material of a large number of patients over a long period of time researchers hope to find new evidence that will help them to identify the various causes of disease. Ultimately, earlier and more precise diagnosis of heart muscle diseases and better treatments could result.

TORCH-DZHK1: TranslatiOnal Registry for CardiomyopatHies
ID 81X1500101
Institution Universitätsklinikum Heidelberg
Project leader Hugo A. Katus
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 785702.72€ 785.702,72
Begin 2013-08-0101.08.2013
End 2019-12-3131.12.2019
Projektdetails
hereditary cardiomyopathy, inflammatory cardiomyopathy, acute myocarditis
Data is to be collected from some 2,300 patients with heart muscle damage (cardiomyopathy) whose condition was not caused by myocardial infarction, i.e. narrowing of the arteries. Instead this study will include patients who have suffered heart muscle damage for other reasons, for instance, as a result of genetic disposition or inflammatory processes. Diseases of the heart muscle have myriad causes and clinical manifestations. Therefore, the researchers intend to carry out detailed clinical examinations including taking small tissue samples from the heart by means of myocardial biopsy. This is the first registry of its kind worldwide and by evaluating the data and biological material of a large number of patients over a long period of time researchers hope to find new evidence that will help them to identify the various causes of disease. Ultimately, earlier and more precise diagnosis of heart muscle diseases and better treatments could result.

APPROACH-ACS-AF-DZHK7: Apixaban versus Phenprocoumon: Orale Antikoagulation plus antithrombozytäre Therapie bei Patienten mit akuten Koronarsyndrom und Vorhofflimmern
ID 81X1600203
Institution Klinikum der Universität München
Project leader Reza Wakili
Site München
Project type Clinical Studies
Funding 474076.69€ 474.076,69
Begin 2016-01-0101.01.2016
End 2021-06-3030.06.2021
Projektdetails
acute coronary syndrome, atrial fibrillation, triple therapy, oral anticoagulation, novel oral anticoagulants (NOAC)
https://approach.dzhk.de/

ISAR-REACT 5 - Prospektive, randomisierte, klinische Studie von Ticagrelor versus Prasugrel bei Patienten mit akutem Koronarsyndrom
ID 81X1600501
Institution Deutsches Herzzentrum München
Project leader Adnan Kastrati
Site München
Project type Clinical Studies
Funding 1085319.68€ 1.085.319,68
Begin 2014-08-1818.08.2014
End 2021-12-3131.12.2021
Projektdetails
ticagrelor, prasugrel, acute coronary syndrome, percutaneous coronary intervention
Cardiovascular diseases caused by a blockage or severe narrowing of the coronary artery fall into the category of acute coronary syndrome (ACS). ACS and the life-threatening disturbances of heart perfusion associated with it range from instable angina pectoris to myocardial infarction. Despite the fact that huge progress has been made in the treatment of ACS with the use of drugs that prevent blood clotting and targeted therapy, ACS-related morbidity and mortality remain high. In Germany, an estimated 350,000 new cases of ACS are diagnosed each year. This study compares two agents used to inhibit blood clotting - ticagrelor and prasugrel. It is designed to make a significant contribution to antithrombotic therapy in ACS patients so that clinical outcomes can be improved. The hypothesis that ticagrelor is superior to prasugrel for the treatment of patients with acute coronary syndrome will be examined in relation to clinical outcomes. This is based on: the possibility of pre-treatment independent of clinical presentation and coronary anatomy consistently positive results in the sub-group of patients with conservative treatment strategy potentially positive effects of ticagrelor as a result of its interaction with adenosine metabolism, which affects several genes To test this hypothesis 4,000 ACS patients are to receive either ticagrelor or prasugrel over a 12-month period and a comparative analysis of the two active agents will be performed.

ISAR-REACT 5 - Prospektive, randomisierte, klinische Studie von Ticagrelor versus Prasugrel bei Patienten mit akutem Koronarsyndrom - Bioatatistik
ID 81X1600601
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alexander Hapfelmeier
Site München
Project type Clinical Studies
Funding 13849.14€ 13.849,14
Begin 2014-06-2727.06.2014
End 2021-10-3131.10.2021
Projektdetails
ticagrelor, prasugrel, acute coronary syndrome, percutaneous coronary intervention
Cardiovascular diseases caused by a blockage or severe narrowing of the coronary artery fall into the category of acute coronary syndrome (ACS). ACS and the life-threatening disturbances of heart perfusion associated with it range from instable angina pectoris to myocardial infarction. Despite the fact that huge progress has been made in the treatment of ACS with the use of drugs that prevent blood clotting and targeted therapy, ACS-related morbidity and mortality remain high. In Germany, an estimated 350,000 new cases of ACS are diagnosed each year. This study compares two agents used to inhibit blood clotting - ticagrelor and prasugrel. It is designed to make a significant contribution to antithrombotic therapy in ACS patients so that clinical outcomes can be improved. The hypothesis that ticagrelor is superior to prasugrel for the treatment of patients with acute coronary syndrome will be examined in relation to clinical outcomes. This is based on: the possibility of pre-treatment independent of clinical presentation and coronary anatomy consistently positive results in the sub-group of patients with conservative treatment strategy potentially positive effects of ticagrelor as a result of its interaction with adenosine metabolism, which affects several genes To test this hypothesis 4,000 ACS patients are to receive either ticagrelor or prasugrel over a 12-month period and a comparative analysis of the two active agents will be performed.

APPROACH-ACS-AF-DZHK7: Projektmanagement
ID 81X1600603
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Silvia Egert
Site München
Project type Clinical Studies
Funding 246021.00€ 246.021,00
Begin 2016-01-0101.01.2016
End 2021-06-3030.06.2021
Projektdetails
acute coronary syndrome, atrial fibrillation, triple therapy, oral anticoagulation, novel oral anticoagulants (NOAC)
https://approach.dzhk.de/

APPROACH-ACS-AF-DZHK7: Biometrie
ID 81X1600701
Institution Ludwig-Maximilians-Universität München
Project leader Ulrich Mansmann
Site München
Project type Clinical Studies
Funding 54000.00€ 54.000,00
Begin 2016-01-0101.01.2016
End 2021-06-3030.06.2021
Projektdetails
acute coronary syndrome, atrial fibrillation, triple therapy, oral anticoagulation, novel oral anticoagulants (NOAC)
https://approach.dzhk.de/

TOMAHAWK-DZHK4: Sofortige Koronarangiographie versus verzögerte Triage bei Überlebenden eines außerklinischen Herzstillstandes ohne ST-Hebung
ID 81X1700102
Institution Universität zu Lübeck
Project leader Steffen Desch
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 1552988.84€ 1.552.988,84
Begin 2015-11-0101.11.2015
End 2022-12-3131.12.2022
Projektdetails
out-of-hospital cardiac arrest, myocardial infarction, percutaneous coronary intervention
https://tomahawk.dzhk.de/

Generation of a Lmcd1-deficient mouse model using the CRISPR (Cas9 system)
ID 81X2100112
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE001)
Funding 14000.00€ 14.000,00
Begin 2014-09-0101.09.2014
End 2017-12-3131.12.2017
Projektdetails

Mechanical and electrical remodeling in the developing and diseased cardiomyocyte
ID 81X2100113
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Gotthardt
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE018)
Funding 7000.00€ 7.000,00
Begin 2014-11-1515.11.2014
End 2016-01-3131.01.2016
Projektdetails

Analysis of circadian regulated gene expression in microvascular endothelial cells
ID 81X2100115
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 15970.80€ 15.970,80
Begin 2015-02-1515.02.2015
End 2016-07-3131.07.2016
Projektdetails

Gewichtsentwicklung nach unter AT1Rezeptorblockade in MAS knock out Mäusen
ID 81X2100116
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE001)
Funding 11100.00€ 11.100,00
Begin 2015-02-0101.02.2015
End 2016-12-3131.12.2016
Projektdetails

Generation of exon1A-renin knockout rats as a new model to study cardiac failure
ID 81X2100117
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE001)
Funding 24410.00€ 24.410,00
Begin 2015-02-0101.02.2015
End 2016-01-3131.01.2016
Projektdetails

Generation of a MD-2 transgenic mouse model
ID 81X2100118
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE001)
Funding 11644.92€ 11.644,92
Begin 2015-02-0101.02.2015
End 2016-01-3131.01.2016
Projektdetails

Screening of MYBPC3 gene for genetic variations in a panel of control individuals without diastolic dysfunction
ID 81X2100121
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 31428.00€ 31.428,00
Begin 2015-06-0101.06.2015
End 2016-05-3131.05.2016
Projektdetails

Elucidating the functions of evolutionary-conserved, cardiovascular-disease-related long noncording RNA
ID 81X2100122
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Sascha Sauer
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 29294.05€ 29.294,05
Begin 2016-01-0101.01.2016
End 2017-06-3030.06.2017
Projektdetails

Proteomic analysis of the resolving macrophage in cardiovascular inflammation
ID 81X2100123
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Hübner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 15000.00€ 15.000,00
Begin 2015-09-0101.09.2015
End 2018-04-3030.04.2018
Projektdetails

Identification of ischemic heart disease-regulated T-cell IncRNAs
ID 81X2100124
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Sascha Sauer
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 54526.82€ 54.526,82
Begin 2015-10-0101.10.2015
End 2017-12-3131.12.2017
Projektdetails

Spatial-temporal mathematical modeling of NCX function in ventricular myocytes
ID 81X2100125
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Martin Falcke
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE014)
Funding 24079.38€ 24.079,38
Begin 2015-11-1818.11.2015
End 2016-06-3030.06.2016
Projektdetails

The Role of serotonin in aortic calcification
ID 81X2100126
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Natalia Alenina
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE058)
Funding 15000.00€ 15.000,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Epigenetic factors in the pathogenesis of arterial hypertension
ID 81X2100127
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Natalia Alenina
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE139)
Funding 12000.00€ 12.000,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Defining individual amino acids mediating the interaction of basic leucine zipper and W2 domain (BZW2) protein and ß-catenin through peptide SPOT technology as a prerequisite for a novel approach towards the treatment of heart failure
ID 81X2100128
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Enno Klussmann
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE103)
Funding 15500.00€ 15.500,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Endothelial cell senescence and gene expression patterns promoting thrombosis
ID 81X2100129
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Hübner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 11327.70€ 11.327,70
Begin 2016-01-0101.01.2016
End 2017-06-3030.06.2017
Projektdetails

Role of the chemokine atypical receptor Darc in atherosclerosis
ID 81X2100130
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE049)
Funding 14000.00€ 14.000,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

NF-kB signalling in microvascular endothelial cells of the blood-brain barrier
ID 81X2100131
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 15400.00€ 15.400,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Genome-wide identification of estrogen receptor binding sites in rat cardiac fibroblasts from both sexes
ID 81X2100209
Institution Charité - Universitätsmedizin Berlin
Project leader Elke Dworatzek
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE101)
Funding 7079.04€ 7.079,04
Begin 2014-08-0101.08.2014
End 2016-12-3131.12.2016
Projektdetails

Blinded ECG analysis of the “HEart and BRain interfaces in Acute ischemic Stroke” (HEBRAS) Study
ID 81X2100212
Institution Charité - Universitätsmedizin Berlin
Project leader Karl Georg Häusler
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE078)
Funding 1289.68€ 1.289,68
Begin 2014-10-2020.10.2014
End 2016-12-3131.12.2016
Projektdetails

Specific contribution of vascular and macrophage cannabinoid receptor CB1 signaling to the cardiometabolic effects of endocannabinoids
ID 81X2100213
Institution Charité - Universitätsmedizin Berlin
Project leader Ulrich Kintscher
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE004)
Funding 12158.93€ 12.158,93
Begin 2015-01-0101.01.2015
End 2016-12-3131.12.2016
Projektdetails

Effects of oestrogen and Mylip on cardiac contractile function in zebrafish
ID 81X2100214
Institution Charité - Universitätsmedizin Berlin
Project leader Georgios Kararigas
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE034)
Funding 9988.90€ 9.988,90
Begin 2015-03-0101.03.2015
End 2017-12-3131.12.2017
Projektdetails

PRAS40/mTOR mediated signaling in smooth muscle cells – a potential therapeutic target in vascular disease
ID 81X2100215
Institution Charité - Universitätsmedizin Berlin
Project leader Till Althoff
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE117)
Funding 13440.12€ 13.440,12
Begin 2015-03-0101.03.2015
End 2016-09-3030.09.2016
Projektdetails

Effects of chronic dichloroacetate administration in the mouse heart
ID 81X2100216
Institution Charité - Universitätsmedizin Berlin
Project leader Georgios Kararigas
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE106)
Funding 8245.33€ 8.245,33
Begin 2015-03-0101.03.2015
End 2017-12-3131.12.2017
Projektdetails

The transcription factor TFEB mediates Ang II-induced pathological cardiac remodeling
ID 81X2100217
Institution Charité - Universitätsmedizin Berlin
Project leader Jens Fielitz
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 14037.92€ 14.037,92
Begin 2015-03-0101.03.2015
End 2016-04-1414.04.2016
Projektdetails

Studies on combined cardiac/skeletal muscle inflammatory and metabolic status in patients with infective myocarditis
ID 81X2100218
Institution Charité - Universitätsmedizin Berlin
Project leader Wolfram Döhner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE118)
Funding 14637.36€ 14.637,36
Begin 2015-05-0101.05.2015
End 2016-05-3131.05.2016
Projektdetails

NOVEL RNA-BASED CARDIOVASCULAR THERAPIES TARGETING IMMUNOREGULATORY LONG NONCODING RNAs
ID 81X2100219
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE097)
Funding 12790.89€ 12.790,89
Begin 2015-05-0101.05.2015
End 2016-04-3030.04.2016
Projektdetails

Investigation of ventricular tachycardia using patient-specific induced pluripotent stem cells
ID 81X2100220
Institution Charité - Universitätsmedizin Berlin
Project leader Silke Sperling
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE019)
Funding 5840.00€ 5.840,00
Begin 2015-05-0101.05.2015
End 2016-04-3030.04.2016
Projektdetails

mTOR modulation in atherosclerosis
ID 81X2100221
Institution Charité - Universitätsmedizin Berlin
Project leader Till Althoff
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE112)
Funding 27570.00€ 27.570,00
Begin 2015-05-0101.05.2015
End 2018-06-3030.06.2018
Projektdetails

In vivo Modulation of M-CSF in viral myocarditis using nanoparticle encapsulated siRNA.
ID 81X2100222
Institution Charité - Universitätsmedizin Berlin
Project leader Antje Voigt
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE121)
Funding 23905.76€ 23.905,76
Begin 2015-05-0101.05.2015
End 2016-12-3131.12.2016
Projektdetails

Proteome profiling of human umbilical vein endothelial cells from twin pairs of the opposite sex
ID 81X2100223
Institution Charité - Universitätsmedizin Berlin
Project leader Mario Lorenz
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 9512.00€ 9.512,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Mapping endothelial to mesenchymal transition by stage-specific marker genes
ID 81X2100224
Institution Charité - Universitätsmedizin Berlin
Project leader Sabine Klaassen
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE136)
Funding 12988.65€ 12.988,65
Begin 2016-01-0101.01.2016
End 2018-06-3030.06.2018
Projektdetails

Skeletal energetic metabolic characteristics of patients with HFpEF and HFrEF. Pilot project
ID 81X2100225
Institution Charité - Universitätsmedizin Berlin
Project leader Nadja Scherbakov
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE118)
Funding 13527.06€ 13.527,06
Begin 2016-01-0101.01.2016
End 2017-07-3131.07.2017
Projektdetails

Identification of pro-proliferative and anti-apoptotic microRNAs in adult human cardiomyocytes using a functional high-throughput screening
ID 81X2100226
Institution Charité - Universitätsmedizin Berlin
Project leader Philipp Jakob
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE019)
Funding 14157.71€ 14.157,71
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Role of CaV3.2, CaV1.2, and TRPV channels in local elementary calcium signaling
ID 81X2100227
Institution Charité - Universitätsmedizin Berlin
Project leader Mario Kaßmann
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE129)
Funding 11686.20€ 11.686,20
Begin 2016-01-0101.01.2016
End 2017-03-3131.03.2017
Projektdetails

Functional characterization of psiPSC-CMs derived from patients with Tetralogy of Fallot in comparison to healthy controls
ID 81X2100228
Institution Charité - Universitätsmedizin Berlin
Project leader Silke Sperling
Site Berlin
Project type Cooperation with External Partners
Funding 16453.16€ 16.453,16
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Analysis of PAR2 mouse mutants to specify the role of PAR2 in viral myocarditis
ID 81X2100229
Institution Charité - Universitätsmedizin Berlin
Project leader Antje Voigt
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE121)
Funding 29402.11€ 29.402,11
Begin 2016-01-0101.01.2016
End 2017-06-3030.06.2017
Projektdetails

Pediatric cardiomyopathy - screening for mutations and evaluation of their impact in iPSC-derived cardiomyocytes
ID 81X2100230
Institution Charité - Universitätsmedizin Berlin
Project leader Sabine Klaassen
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE136)
Funding 12713.94€ 12.713,94
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

MPI imaging capability to visualize inflammatory atherosclerotic plaques
ID 81X2100231
Institution Charité - Universitätsmedizin Berlin
Project leader Antje Ludwig
Site Berlin
Project type Cooperation with External Partners
Funding 7603.94€ 7.603,94
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Role of Sirt3 in the anti-inflammatory effects of estrogen receptors signaling
ID 81X2100232
Institution Charité - Universitätsmedizin Berlin
Project leader Maria Luisa Barcena de Arellano
Site Berlin
Project type Cooperation with External Partners
Funding 14992.31€ 14.992,31
Begin 2016-02-0101.02.2016
End 2017-12-3131.12.2017
Projektdetails

Defining the optimal temporal and spatial resolution for cardiac magnetic resonance feature tracking
ID 81X2100303
Institution Deutsches Herzzentrum Berlin
Project leader Sebastian Kelle
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE120)
Funding 14561.20€ 14.561,20
Begin 2016-02-0101.02.2016
End 2017-12-3131.12.2017
Projektdetails

Determination of arginine derivatives in the EPIC cohort
ID 81X2100501
Institution Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Project leader Matthias Schulze
Site Extern
Project type Cooperation with External Partners
Funding 16450.95€ 16.450,95
Begin 2014-09-1919.09.2014
End 2016-06-3030.06.2016
Projektdetails

Epigenetic Control of Endo-MT
ID 81X2200108
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE097)
Funding 13333.97€ 13.333,97
Begin 2014-06-0101.06.2014
End 2016-06-3030.06.2016
Projektdetails

Cardiac gene transfer of non-coding RNA
ID 81X2200112
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE042 und SE047)
Funding 15000.00€ 15.000,00
Begin 2014-09-1010.09.2014
End 2018-06-3030.06.2018
Projektdetails

Mechanisms of gap junction remodelling in health and diseases
ID 81X2200119
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE100)
Funding 11000.00€ 11.000,00
Begin 2014-10-0101.10.2014
End 2016-03-3131.03.2016
Projektdetails

Assessment of lncRNA functions in human engineered heart tissue
ID 81X2200121
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE024)
Funding 3999.92€ 3.999,92
Begin 2015-03-0101.03.2015
End 2017-12-3131.12.2017
Projektdetails

Development of miR-92a inhibitors for the treatment of cardiovascular disease
ID 81X2200122
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Stefanie Dimmeler
Site RheinMain
Project type Translational Research Project
Funding 2457576.20€ 2.457.576,20
Begin 2015-02-0101.02.2015
End 2019-12-3131.12.2019
Projektdetails
Based on own preliminary works that show that miR-92a inhibitors can improve cardiac function after infarction, the safety and optimisation studies necessary for an application in human beings are to be carried out in the context of the application. For this, the composition of the microRNA inhibitors is to be optimised and the necessary pharmacological and toxicological examinations are to be performed.

NOVEL RNA-BASED CARDIOVASCULAR THERAPIES TARGETING IMMUNOREGULATORY LONG NONCODING RNAs
ID 81X2200126
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE097)
Funding 15000.00€ 15.000,00
Begin 2015-05-0101.05.2015
End 2016-04-3030.04.2016
Projektdetails

Elucidating the functions of evolutionary-conserved, cardiovascular-disease-related long non-coding RNA
ID 81X2200127
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 29985.26€ 29.985,26
Begin 2016-01-0101.01.2016
End 2017-06-3030.06.2017
Projektdetails

Identification of ischemic heart disease-regulated T-cell lncRNAs
ID 81X2200128
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 5000.00€ 5.000,00
Begin 2015-10-0101.10.2015
End 2017-12-3131.12.2017
Projektdetails

BioID and complexome-remodelling analysis of cMyBP-C
ID 81X2200129
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE137)
Funding 23220.00€ 23.220,00
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Investigation of a redox-phosphorylation crosstalk in human hypertrophic cardiomyopathy
ID 81X2200130
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE137)
Funding 6999.16€ 6.999,16
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Generation of mouse models for the characterization of the cardiomyopathy- associated gene SARAF by nuclease-based genome editing methods
ID 81X2200306
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Nina Wettschureck
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE113)
Funding 35130.73€ 35.130,73
Begin 2015-04-0101.04.2015
End 2016-03-3131.03.2016
Projektdetails

Characterization of the role of Gq/11- and G12/13-mediated signaling cascades in the myogenic autoregulation of isolated murine mesenteric vessels
ID 81X2200307
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Stefan Offermanns
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE119)
Funding 12840.60€ 12.840,60
Begin 2015-03-0101.03.2015
End 2016-03-3131.03.2016
Projektdetails

Von Shared Expertises zu Core Facilities – Kompetitiver Austausch von Fähigkeiten und Fachkenntnissen, die ein Alleinstellungsmerkmal eines Partners/Standortes darstellen - Vorhaben siehe Projektbeschreibungen
ID 81X2210102
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Thomas Münzel
Site RheinMain
Project type Shared Expertise (SE)
Funding 68533.00€ 68.533,00
Begin 2013-11-0101.11.2013
End 2016-03-3131.03.2016
Projektdetails

Analyses on the impact of the intestinal microbiota on atherosclerotic plaque development, plaque rupture and atherothrombosis
ID 81X2210106
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Christoph Reinhardt
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE049)
Funding 10000.00€ 10.000,00
Begin 2014-10-2020.10.2014
End 2016-12-3131.12.2016
Projektdetails

Role of TLR4 signaling in platelet-induced thrombin generation and arterial platelet adhesion
ID 81X2210107
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Sven Jäckel
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE104)
Funding 10000.00€ 10.000,00
Begin 2015-06-0101.06.2015
End 2016-09-3030.09.2016
Projektdetails

Comprehensive evaluation of functional iron deficiency: Prognostic value and genetic evaluation in the Gutenberg Health Study
ID 81X2210108
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Karl Lackner
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE123)
Funding 7876.79€ 7.876,79
Begin 2015-09-0101.09.2015
End 2016-08-3131.08.2016
Projektdetails

Analysis of PAR2 mouse mutants to specify the role of PAR2 in viral myocarditis
ID 81X2210109
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Wolfram Ruf
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE121)
Funding 28294.22€ 28.294,22
Begin 2015-12-0101.12.2015
End 2017-06-3030.06.2017
Projektdetails

Endothelial cell senescence and gene expression patterns promoting thrombosis
ID 81X2210110
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Katrin Schäfer
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 12000.00€ 12.000,00
Begin 2015-12-0101.12.2015
End 2017-06-3030.06.2017
Projektdetails

Importance of p63RhoGEF for the vascular response to injury
ID 81X2210111
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Katrin Schäfer
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE094)
Funding 12466.97€ 12.466,97
Begin 2015-12-0101.12.2015
End 2018-01-3131.01.2018
Projektdetails

Von Shared Expertises zu Core Facilities – Kompetitiver Austausch von Fähigkeiten und Fachkenntnissen, die ein Alleinstellungsmerkmal eines Partners/Standortes darstellen.
ID 81X2300106
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Shared Expertise (SE)
Funding 152844.00€ 152.844,00
Begin 2013-07-0101.07.2013
End 2016-06-3030.06.2016
Projektdetails

Differentiation of human MEF2 reporter-iPS cells to cardiomyocytes
ID 81X2300111
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE019)
Funding 7498.46€ 7.498,46
Begin 2014-10-0101.10.2014
End 2017-03-3131.03.2017
Projektdetails

Cardiomyocytes derived from patient-specific induced pluripotent stem cells as a model system for individualized medicine
ID 81X2300112
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Kaomei Guan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE019)
Funding 15078.72€ 15.078,72
Begin 2014-10-1515.10.2014
End 2016-01-1414.01.2016
Projektdetails

Role of HCN channels for sinoatrial network synchronization and stable heart beat
ID 81X2300114
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE017)
Funding 10000.00€ 10.000,00
Begin 2014-10-1313.10.2014
End 2016-10-3131.10.2016
Projektdetails

Blinded ECG analysis of the “HEart and BRain interfaces in Acute ischemic Stroke” (HEBRAS) Study
ID 81X2300116
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Rolf Wachter
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE078)
Funding 15999.99€ 15.999,99
Begin 2014-10-1313.10.2014
End 2016-12-3131.12.2016
Projektdetails

Mechanical and electrical remodeling in the developing and diseased cardiomyocyte
ID 81X2300119
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE018)
Funding 26321.51€ 26.321,51
Begin 2014-11-1515.11.2014
End 2016-01-3131.01.2016
Projektdetails

Generation and transcriptional analysis of iPS-derived engineered heart muscle from patients with genetic cardiac disease and healthy donors
ID 81X2300122
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuß-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE031)
Funding 9375.00€ 9.375,00
Begin 2015-03-0101.03.2015
End 2016-05-3131.05.2016
Projektdetails

Characterization of the role of BZW2 in adult heart homoeostasis
ID 81X2300123
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayán
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 7650.00€ 7.650,00
Begin 2015-03-0101.03.2015
End 2016-08-3131.08.2016
Projektdetails

Effects of chronic dichloroacetate administration in the mouse heart
ID 81X2300124
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zalarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE106)
Funding 22498.69€ 22.498,69
Begin 2015-01-0101.01.2015
End 2017-12-3131.12.2017
Projektdetails

Studies on combined cardiac/skeletal muscle inflammatory and metabolic status in patients with infective myocarditis
ID 81X2300129
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Jochen Springer
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE118)
Funding 14621.54€ 14.621,54
Begin 2015-03-0101.03.2015
End 2016-09-3030.09.2016
Projektdetails

Investigation of ventricular tachycardia using patient-specific induced pluripotent stem cells
ID 81X2300130
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Kaomei Guan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE019)
Funding 23990.66€ 23.990,66
Begin 2015-05-0101.05.2015
End 2016-04-3030.04.2016
Projektdetails

Accomplishment of a split-ubiquitin yeast-two-hybrid screen to identify novel interaction partners of Junctophilin-1 and Junctophilin-2
ID 81X2300131
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Cooperation with External Partners
Funding 7850.00€ 7.850,00
Begin 2015-06-0101.06.2015
End 2016-08-3131.08.2016
Projektdetails

Role of Ca/Calmodulin-dependent protein kinase II in isolated cardiac fibroblasts
ID 81X2300132
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Samuel Sossalla
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE092)
Funding 3998.97€ 3.998,97
Begin 2015-06-0101.06.2015
End 2016-02-2929.02.2016
Projektdetails

New vascular keys to EndMT and cardiac fibrosis
ID 81X2300133
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Elisabeth Zeisberg
Site Göttingen
Project type Cooperation with External Partners
Funding 11450.00€ 11.450,00
Begin 2015-07-0101.07.2015
End 2016-04-3030.04.2016
Projektdetails

Targeting T. cruzi-specific STAT1 serine phosphatase in the treatment of chagasic cardiomyopathy
ID 81X2300134
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Christoph Herrmann-Lingen
Site Göttingen
Project type Cooperation with External Partners
Funding 9550.00€ 9.550,00
Begin 2015-07-0101.07.2015
End 2016-06-3030.06.2016
Projektdetails

Role of caspases and NADPH oxidases in hypoxia induced pulmonary hypertension
ID 81X2300135
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Jochen Springer
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE118)
Funding 13662.69€ 13.662,69
Begin 2015-07-1515.07.2015
End 2018-01-3131.01.2018
Projektdetails

Comprehensive evaluation of myocardial mechanics using cardiovascular magnetic resonance feature tracking in patients with myocardial infarction
ID 81X2300136
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Andreas Schuster
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE120)
Funding 15970.43€ 15.970,43
Begin 2015-09-0101.09.2015
End 2017-01-3131.01.2017
Projektdetails

Characterization of SCF-type Cullin-RING E3 ubiquitin ligases in cardiac hypertrophy
ID 81X2300137
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Michael Didié
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE108)
Funding 0.00€ 0,00
Begin 2015-10-0101.10.2015
End 2017-12-3131.12.2017
Projektdetails

AAV9-mediated rescue of TBX5KO mouse hearts from ventricular arrhythmias
ID 81X2300138
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Maria Patapia Zafeiriou
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 7613.49€ 7.613,49
Begin 2015-09-0101.09.2015
End 2017-03-3131.03.2017
Projektdetails

Role of killer cell immunoglobulin-like receptors in killing of induced pluripotent stem cell-derived cardiomyocytes
ID 81X2300139
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Ralf Dressel
Site Göttingen
Project type Cooperation with External Partners
Funding 18650.00€ 18.650,00
Begin 2016-01-0101.01.2016
End 2018-01-3131.01.2018
Projektdetails

Role of protein phosphatases in human cardiac pathology
ID 81X2300140
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Samuel Sossalla
Site Göttingen
Project type Cooperation with External Partners
Funding 9000.00€ 9.000,00
Begin 2015-11-0101.11.2015
End 2016-12-3131.12.2016
Projektdetails

Mapping endothelial to mesenchymal transition by stage-specific marker genes
ID 81X2300141
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Elisabeth Zeisberg
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE136)
Funding 15000.00€ 15.000,00
Begin 2016-01-0101.01.2016
End 2018-06-3030.06.2018
Projektdetails

Skeletal energetic metabolic characteristics of patients with HFpEF and HFrEF. Pilot project
ID 81X2300142
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Jochen Springer
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE118)
Funding 14332.88€ 14.332,88
Begin 2016-01-0101.01.2016
End 2017-07-3131.07.2017
Projektdetails

Identification of pro-proliferative and anti-apoptotic microRNAs in adult human cardiomyocytes using a functional high-throughput screening
ID 81X2300143
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuß-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE019)
Funding 14442.96€ 14.442,96
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Role of IGFBP5 in cardiac stress induced by pressure overload
ID 81X2300144
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Claudia Noack
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 15800.00€ 15.800,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Investigation of the role of long intergenic non-coding RNAs (lincRNAs) in the transition of human hypertrophy to heart failure using AAV mediated overexpression in human iPS cell--derived cardiomyocytes
ID 81X2300145
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Sara Khadjeh
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 16660.94€ 16.660,94
Begin 2016-01-0101.01.2016
End 2018-03-3131.03.2018
Projektdetails

Defining individual amino acids mediating the interaction of basic leucine zipper and W2 domain (BZW2) protein and ß-catenin through peptide SPOT technology as a prerequisite for a novel approach towards the treatment of heart failure
ID 81X2300146
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE103)
Funding 13869.32€ 13.869,32
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Functional and molecular analysis of NADPH-oxidases in iPSC-derived cardiomyocytes from anthacycline-induced cardiotoxicity patients
ID 81X2300147
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuß-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE040)
Funding 15234.00€ 15.234,00
Begin 2016-01-0101.01.2016
End 2017-09-3030.09.2017
Projektdetails

Importance of p63RhoGEF for the vascular response to injury
ID 81X2300148
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Susanne Lutz
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE094)
Funding 9512.05€ 9.512,05
Begin 2015-11-0101.11.2015
End 2018-01-3131.01.2018
Projektdetails

Defining the optimal temporal and spatial resolution for cardiac magnetic resonance feature tracking
ID 81X2300149
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Andreas Schuster
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE120)
Funding 11300.54€ 11.300,54
Begin 2016-02-0101.02.2016
End 2017-12-3131.12.2017
Projektdetails

RNA-guided gene de-methylation by Cas9-based methylcytosine dioxygenase
ID 81X2300150
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Elisabeth Zeisberg
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 15268.29€ 15.268,29
Begin 2016-02-0101.02.2016
End 2017-12-3131.12.2017
Projektdetails

Inotropy and Chronotropy Screens in Engineered Human Myocardium by Optical Analysis in Real Time
ID 81X2300151
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Cooperation with External Partners
Funding 25774.80€ 25.774,80
Begin 2016-02-0101.02.2016
End 2016-09-3030.09.2016
Projektdetails

LEAP termination of ventricular arrhythmias in a porcine myocard infarct model in vitro
ID 81X2300401
Institution Max-Planck-Institut für Dynamik und Selbstorganisation
Project leader Stefan Luther
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE048)
Funding 13320.86€ 13.320,86
Begin 2015-03-1515.03.2015
End 2016-12-3131.12.2016
Projektdetails

Spatial-temporal mathematical modeling of NCX function in ventricular myocytes
ID 81X2300402
Institution Max-Planck-Institut für Dynamik und Selbstorganisation
Project leader Stefan Luther
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE014)
Funding 6042.24€ 6.042,24
Begin 2016-01-0101.01.2016
End 2016-06-3030.06.2016
Projektdetails

Low-Energy Termination off Ventricular Fibrillation in a Porcine Heart Failure Model
ID 81X2300403
Institution Max-Planck-Institut für Dynamik und Selbstorganisation
Project leader Stefan Luther
Site Göttingen
Project type Translational Research Project
Funding 590585.86€ 590.585,86
Begin 2016-01-0101.01.2016
End 2019-09-3030.09.2019
Projektdetails
In previous studies run by the working group led by Stefan Luther it was shown that the energy applied in cardiac arrhythmias could be reduced by 80 to 90 percent compared to conventional defibrillations. In order to translate these results successfully into clinical application, the necessary proof of efficacy in an animal model is to be produced in the scope of this project: the termination of ventricular fibrillation by means of a novel defibrillator compared to conventional defibrillation will be examined in pigs used as an animal model for heart failure. The results will constitute the foundation for preparing a study for a first-in-human application.

Generation of a MD-2 transgenic mouse model
ID 81X2400107
Institution Universitätsmedizin Greifswald
Project leader Stephan B. Felix
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE001)
Funding 8967.37€ 8.967,37
Begin 2015-02-0101.02.2015
End 2016-01-3131.01.2016
Projektdetails

To investigate the role for S1P and its receptor subtypes in vascular thrombosis
ID 81X2400108
Institution Universitätsmedizin Greifswald
Project leader Bernhard Rauch
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE104)
Funding 13225.20€ 13.225,20
Begin 2015-02-0101.02.2015
End 2016-01-3131.01.2016
Projektdetails

The role of myeloid differentiation factor-2 (MD-2) during inflammatory processes in human monocytes and human cardiac fibroblasts
ID 81X2400109
Institution Universitätsmedizin Greifswald
Project leader Stephan B. Felix
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE092)
Funding 10752.98€ 10.752,98
Begin 2015-02-0101.02.2015
End 2016-03-3131.03.2016
Projektdetails

Generation of exon1A-renin knockout rats as a new model to study cardiac failure
ID 81X2400110
Institution Universitätsmedizin Greifswald
Project leader Jörg Peters
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE001)
Funding 9300.78€ 9.300,78
Begin 2015-02-0101.02.2015
End 2016-01-3131.01.2016
Projektdetails

Determination of S1P in the SHIP-TREND and GANI_MED cohorts
ID 81X2400111
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE057)
Funding 4391.44€ 4.391,44
Begin 2015-02-0101.02.2015
End 2017-01-3131.01.2017
Projektdetails

Single molecule force spectroscopy of the ß1 adrenergic receptor and autoantibodies
ID 81X2400112
Institution Universitätsmedizin Greifswald
Project leader Ricardo Pires
Site Greifswald
Project type Cooperation with External Partners
Funding 19137.22€ 19.137,22
Begin 2015-05-0101.05.2015
End 2016-12-3030.12.2016
Projektdetails

Promotion of positive images of ageing in elderly patients after myocardial infarction
ID 81X2400113
Institution Universitätsmedizin Greifswald
Project leader Sabina Ulbricht
Site Greifswald
Project type Cooperation with External Partners
Funding 11253.80€ 11.253,80
Begin 2015-06-0101.06.2015
End 2016-01-3131.01.2016
Projektdetails

Role of TLR4 signaling in platelet-induced thrombin generation and arterial platelet adhesion
ID 81X2400114
Institution Universitätsmedizin Greifswald
Project leader Bernhard Rauch
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE104)
Funding 10585.24€ 10.585,24
Begin 2015-06-0101.06.2015
End 2016-09-3030.09.2016
Projektdetails

Development of dietary intervention tools supported by motivational interviewing techniques
ID 81X2400115
Institution Universitätsmedizin Greifswald
Project leader Jennis Freyer-Adam
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE109)
Funding 4921.56€ 4.921,56
Begin 2015-07-1616.07.2015
End 2016-02-1515.02.2016
Projektdetails

European Meta-Analysis of Genome-Wide Association Studies of the Early Repolarization Pattern
ID 81X2400116
Institution Universitätsmedizin Greifswald
Project leader Alexander Teumer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE081)
Funding 14976.35€ 14.976,35
Begin 2015-07-1515.07.2015
End 2018-02-2828.02.2018
Projektdetails

Human Atrial Tissue Proteomics, Pilot Analysis
ID 81X2400118
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 20080.00€ 20.080,00
Begin 2015-09-0101.09.2015
End 2016-08-3131.08.2016
Projektdetails

Proteome profiling of human umbilical vein endothelial cells from twin pairs of the opposite sex
ID 81X2400119
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 20488.00€ 20.488,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Is autophagy flux altered in a mouse model of heart failure?
ID 81X2400120
Institution Universitätsmedizin Greifswald
Project leader Stephanie Könemann
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE102)
Funding 13235.68€ 13.235,68
Begin 2016-01-0101.01.2016
End 2017-06-3030.06.2017
Projektdetails

Charakterisierung der Lmcd1/Dyxin Knockout Maus - die Bedeutung der Inflammation
ID 81X2500101
Institution Universitätsklinikum Heidelberg
Project leader Hugo A. Katus
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 14907.52€ 14.907,52
Begin 2012-10-0808.10.2012
End 2016-05-3131.05.2016
Projektdetails

Epigenetic Control of Endo-MT
ID 81X2500114
Institution Universitätsklinikum Heidelberg
Project leader David Hassel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE097)
Funding 14628.94€ 14.628,94
Begin 2014-06-0101.06.2014
End 2016-06-3030.06.2016
Projektdetails

Mapping the cardiac methylome - towards new epigenetic diagnostics
ID 81X2500117
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 37500.00€ 37.500,00
Begin 2014-08-1414.08.2014
End 2016-12-3131.12.2016
Projektdetails

Beta2 Integrin Activation of T cells in Atherosclerosis
ID 81X2500118
Institution Universitätsklinikum Heidelberg
Project leader Mathias Konstandin
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE020)
Funding 18720.91€ 18.720,91
Begin 2014-09-0404.09.2014
End 2016-06-3030.06.2016
Projektdetails

Differentiation of human MEF2 reporter-iPS cells to cardiomyocytes
ID 81X2500122
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE019)
Funding 7406.29€ 7.406,29
Begin 2014-10-0101.10.2014
End 2017-03-3131.03.2017
Projektdetails

Generation and transcriptional analysis of iPS-derived engineered heart muscle from patients with genetic cardiac disease and healthy donors
ID 81X2500125
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 12371.31€ 12.371,31
Begin 2015-04-0101.04.2015
End 2016-05-3131.05.2016
Projektdetails

Characterization of the role of BZW2 in adult heart homoeostasis
ID 81X2500126
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 12254.58€ 12.254,58
Begin 2015-03-0101.03.2015
End 2016-08-3131.08.2016
Projektdetails

Effects of oestrogen and Mylip on cardiac contractile function in zebrafish
ID 81X2500127
Institution Universitätsklinikum Heidelberg
Project leader David Hassel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE034)
Funding 17637.90€ 17.637,90
Begin 2015-02-0101.02.2015
End 2017-12-3131.12.2017
Projektdetails

PRAS40/mTOR mediated signaling in smooth muscle cells – a potential therapeutic target in vascular disease
ID 81X2500128
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE117)
Funding 14713.48€ 14.713,48
Begin 2015-02-0101.02.2015
End 2016-09-3030.09.2016
Projektdetails

The transcription factor TFEB mediates Ang II-induced pathological cardiac remodeling
ID 81X2500129
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 14966.66€ 14.966,66
Begin 2015-03-0101.03.2015
End 2016-02-2929.02.2016
Projektdetails

Generation of mouse models for the characterization of the cardiomyopathy- associated gene SARAF by nuclease-based genome editing methods
ID 81X2500130
Institution Universitätsklinikum Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE113)
Funding 33955.61€ 33.955,61
Begin 2015-04-0101.04.2015
End 2016-04-0101.04.2016
Projektdetails

Regulation of lncRNAs in cardiac tissue from heart failure patients
ID 81X2500131
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 7927.57€ 7.927,57
Begin 2015-04-0101.04.2015
End 2016-01-3131.01.2016
Projektdetails

Characterization of the role of Gq/11- and G12/13-mediated signaling cascades in the myogenic autoregulation of isolated murine mesenteric vessels
ID 81X2500132
Institution Universitätsklinikum Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE119)
Funding 31409.33€ 31.409,33
Begin 2015-04-0101.04.2015
End 2016-03-3131.03.2016
Projektdetails

Modeling the genetic and molecular basis of cardiac arrhythmias with patient-specific iPS cells
ID 81X2500133
Institution Universitätsklinikum Heidelberg
Project leader Sandra Hoffmann
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE043)
Funding 18491.82€ 18.491,82
Begin 2015-05-0101.05.2015
End 2017-12-3131.12.2017
Projektdetails

mTOR modulation in atherosclerosis
ID 81X2500135
Institution Universitätsklinikum Heidelberg
Project leader Mirko Völkers
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE112)
Funding 29917.66€ 29.917,66
Begin 2015-05-0101.05.2015
End 2018-06-3030.06.2018
Projektdetails

In vivo Modulation of M-CSF in viral myocarditis using nanoparticle encapsulated siRNA.
ID 81X2500136
Institution Universitätsklinikum Heidelberg
Project leader Florian Leuschner
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE121)
Funding 20522.00€ 20.522,00
Begin 2015-05-0101.05.2015
End 2016-12-3131.12.2016
Projektdetails

Gene therapy of pathological hypertrophy by targeted downregulation of PPIA
ID 81X2500137
Institution Universitätsklinikum Heidelberg
Project leader Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE022)
Funding 24803.26€ 24.803,26
Begin 2015-08-0101.08.2015
End 2016-12-3131.12.2016
Projektdetails

Characterization and neurohumoral regulation of the newly identified membrane protein TRPML-like 2 in cardiomyocytes
ID 81X2500138
Institution Universitätsklinikum Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 37477.28€ 37.477,28
Begin 2015-07-0101.07.2015
End 2016-07-3131.07.2016
Projektdetails

Identification and detailed characterization of candidate miRNAs involved in cardiac development
ID 81X2500139
Institution Universitätsklinikum Heidelberg
Project leader David Hassel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE034)
Funding 14718.61€ 14.718,61
Begin 2015-08-0101.08.2015
End 2017-12-3131.12.2017
Projektdetails

AAV9-mediated rescue of TBX5KO mouse hearts from ventricular arrhythmias
ID 81X2500140
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 12811.02€ 12.811,02
Begin 2015-09-0101.09.2015
End 2017-03-3131.03.2017
Projektdetails

Generation and characterization of two adult knockout zebrafish models using the CRISPR/Cas9 technique
ID 81X2500141
Institution Universitätsklinikum Heidelberg
Project leader David Hassel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE034)
Funding 19700.25€ 19.700,25
Begin 2015-10-0101.10.2015
End 2017-12-3131.12.2017
Projektdetails

Role of miRNA-regulated lncRNAs in endothelial cells during atherosclerosis
ID 81X2500142
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 23490.04€ 23.490,04
Begin 2015-10-0101.10.2015
End 2016-03-3131.03.2016
Projektdetails

Generation and initial characterization of the adeno-associated virus (AAV) vector for the dominant negative Gs -protein GS226A
ID 81X2500143
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 20965.24€ 20.965,24
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Role of IGFBP5 in cardiac stress induced by pressure overload
ID 81X2500144
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 15157.51€ 15.157,51
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Investigation of the role of long intergenic non-coding RNAs (lincRNAs) in the transition of human hypertrophy to heart failure using AAV mediated overexpression in human iPS cell--derived cardiomyocytes
ID 81X2500145
Institution Universitätsklinikum Heidelberg
Project leader Hugo A. Katus
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 17185.39€ 17.185,39
Begin 2016-01-0101.01.2016
End 2018-03-3131.03.2018
Projektdetails

Role of CaV3.2, CaV1.2, and TRPV channels in local elementary calcium signaling
ID 81X2500203
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Rudolf Schubert
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE129)
Funding 16062.63€ 16.062,63
Begin 2016-01-0101.01.2016
End 2017-03-3131.03.2017
Projektdetails

Genome-wide identification of estrogen receptor binding sites in rat cardiac fibroblasts from both sexes
ID 81X2600105
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Nina Henriette Uhlenhaut
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE101)
Funding 21500.00€ 21.500,00
Begin 2014-08-0101.08.2014
End 2016-12-3131.12.2016
Projektdetails

Evaluation of potential atrial calcium handling abnormalities contributing to the atrial arrhythmogenic substrate in a porcine model of ischemic heart failure
ID 81X2600216
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site München
Project type Cooperation with External Partners
Funding 8130.07€ 8.130,07
Begin 2014-10-0101.10.2014
End 2017-05-3131.05.2017
Projektdetails

Organotypic slice cultures of human failing myocardium for mechanistic assessment of diastolic dysfunction
ID 81X2600217
Institution Klinikum der Universität München
Project leader Ulrich Pohl
Site München
Project type Cooperation with External Partners
Funding 9790.41€ 9.790,41
Begin 2014-10-0101.10.2014
End 2016-12-3131.12.2016
Projektdetails

Non-coding RNAs in human atherosclerotic lesions
ID 81X2600218
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE105)
Funding 59400.56€ 59.400,56
Begin 2014-09-1515.09.2014
End 2016-03-3131.03.2016
Projektdetails

Role of HCN channels for sinoatrial network synchronization and stable heart beat
ID 81X2600219
Institution Klinikum der Universität München
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE017)
Funding 8704.76€ 8.704,76
Begin 2014-05-2222.05.2014
End 2016-10-3131.10.2016
Projektdetails

Analyses on the impact of the intestinal microbiota on atherosclerotic plaque development, plaque rupture and atherothrombosis
ID 81X2600220
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE049)
Funding 10000.00€ 10.000,00
Begin 2014-10-1515.10.2014
End 2016-12-3131.12.2016
Projektdetails

The TROPICAL-ACS SPARTAN Substudy
ID 81X2600221
Institution Klinikum der Universität München
Project leader Steffen Massberg
Site München
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2014-09-0101.09.2014
End 2016-08-3131.08.2016
Projektdetails

Specific contribution of vascular and macrophage cannabinoid receptor CB1 signaling to the cardiometabolic effects of endocannabinoids
ID 81X2600222
Institution Klinikum der Universität München
Project leader Sabine Steffens
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE004)
Funding 14995.01€ 14.995,01
Begin 2015-01-0101.01.2015
End 2016-12-3131.12.2016
Projektdetails

AFNET-EORP Register für Vorhofflimmern. Langzeitregister für Patienten mit Vorhofflimmern in Deutschland
ID 81X2600223
Institution Klinikum der Universität München
Project leader Michael Näbauer
Site Extern
Project type Competence Networks
Funding 249394.50€ 249.394,50
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Annexin A1 prevents arterial leukocyte recruitment – mechanistic insights
ID 81X2600224
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Cooperation with External Partners
Funding 9992.91€ 9.992,91
Begin 2015-06-0101.06.2015
End 2016-06-3030.06.2016
Projektdetails

Role of miRNA-regulated lncRNAs in endothelial cells during atherosclerosis
ID 81X2600225
Institution Klinikum der Universität München
Project leader Andreas Schober
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE031)
Funding 6249.99€ 6.249,99
Begin 2015-09-0101.09.2015
End 2016-03-3131.03.2016
Projektdetails

Proteomic analysis of the resolving macrophage in cardiovascular inflammation
ID 81X2600226
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 15000.00€ 15.000,00
Begin 2015-10-0101.10.2015
End 2018-04-3030.04.2018
Projektdetails

Investigation of vascular function in endothelial cell-specific Txnrd2-deficient mice in vivo
ID 81X2600227
Institution Klinikum der Universität München
Project leader Ulrich Pohl
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE100)
Funding 9712.44€ 9.712,44
Begin 2015-10-0101.10.2015
End 2017-09-3030.09.2017
Projektdetails

Non-invasive Renal Volume and Lipid Quantification as Biomarkers in Patients with Cardiovascular Disease
ID 81X2600228
Institution Klinikum der Universität München
Project leader Maximilian Reiser
Site München
Project type Cooperation with External Partners
Funding 9917.10€ 9.917,10
Begin 2015-10-0101.10.2015
End 2016-12-3131.12.2016
Projektdetails

Role of the chemokine atypical receptor Darc in atherosclerosis
ID 81X2600229
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE049)
Funding 15999.88€ 15.999,88
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

The Role of CD40 in Endothelial and Smooth Muscle Cell on Atherogenesis
ID 81X2600230
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Cooperation with External Partners
Funding 9999.00€ 9.999,00
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Identification of hypertrophy-modulating Cullin-RING E3 ubiquitin ligases in primary cardiomyocytes
ID 81X2600402
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
Funding 10000.00€ 10.000,00
Begin 2012-11-0101.11.2012
End 2017-12-3131.12.2017
Projektdetails

Von Shared Expertises zu Core Facilities
ID 81X2600404
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
Funding 21896.00€ 21.896,00
Begin 2013-09-0101.09.2013
End 2016-03-3131.03.2016
Projektdetails

Cardiac gene transfer of non-coding RNA
ID 81X2600405
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE042 und SE047)
Funding 34975.54€ 34.975,54
Begin 2014-08-2121.08.2014
End 2018-06-3030.06.2018
Projektdetails

Cardiomyocytes derived from patient-specific induced pluripotent stem cells as a model system for individualized medicine
ID 81X2600406
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE019)
Funding 14876.00€ 14.876,00
Begin 2014-10-1515.10.2014
End 2016-01-1414.01.2016
Projektdetails

Characterization of SCF-type Cullin-RING E3 ubiquitin ligases in cardiac hypertrophy
ID 81X2600408
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE108)
Funding 15000.00€ 15.000,00
Begin 2015-10-0101.10.2015
End 2017-12-3131.12.2017
Projektdetails

Generation of viral vectors for the functional characterization of long non-coding RNA in vivo
ID 81X2600409
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Cooperation with External Partners
Funding 9966.40€ 9.966,40
Begin 2015-12-0101.12.2015
End 2016-09-3030.09.2016
Projektdetails

Determination of miR-29 subtypes in myocardial cell types and their regulation
ID 81X2600410
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2015-11-0101.11.2015
End 2017-05-1414.05.2017
Projektdetails

Role of NADPH oxidases in cardiac miRNA expression under normoxia and hypoxia
ID 81X2600507
Institution Deutsches Herzzentrum München
Project leader Agnes Görlach
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE063)
Funding 12350.00€ 12.350,00
Begin 2015-05-0101.05.2015
End 2017-08-3131.08.2017
Projektdetails

Epigenetic Profile of Cardiac Progenitor Cells – Global DNA Methylome
ID 81X2600508
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Cooperation with External Partners
Funding 8168.48€ 8.168,48
Begin 2015-07-0101.07.2015
End 2016-04-3030.04.2016
Projektdetails

Identification and detailed characterization of candidate miRNAs involved in cardiac development
ID 81X2600509
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE034)
Funding 14590.00€ 14.590,00
Begin 2015-07-1515.07.2015
End 2017-12-3131.12.2017
Projektdetails

Role of caspases and NADPH oxidases in hypoxia induced pulmonary hypertension
ID 81X2600510
Institution Deutsches Herzzentrum München
Project leader Andreas Petry
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE118)
Funding 13700.00€ 13.700,00
Begin 2015-07-1515.07.2015
End 2018-01-3131.01.2018
Projektdetails

European Meta-Analysis of Genome-Wide Association Studies of the Early Repolarization Pattern
ID 81X2600511
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE081)
Funding 14400.00€ 14.400,00
Begin 2015-07-1515.07.2015
End 2018-02-2828.02.2018
Projektdetails

Functional and molecular analysis of NADPH-oxidases in iPSC-derived cardiomyocytes from anthacycline-induced cardiotoxicity patients
ID 81X2600512
Institution Deutsches Herzzentrum München
Project leader Andreas Petry
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE040)
Funding 14551.17€ 14.551,17
Begin 2016-01-0101.01.2016
End 2017-09-3030.09.2017
Projektdetails

Functional role of ZC3HC1 in neointima formation
ID 81X2600513
Institution Deutsches Herzzentrum München
Project leader Thorsten Kessler
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE140)
Funding 17926.17€ 17.926,17
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Adipokines as biomarkers for dysfunction of retinal microvasculature
ID 81X2600604
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Cooperation with External Partners
Funding 10126.50€ 10.126,50
Begin 2014-09-0101.09.2014
End 2016-03-3131.03.2016
Projektdetails

LEAP termination of ventricular arrhythmias in a porcine myocard infarct model in vitro
ID 81X2600606
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE048)
Funding 14997.92€ 14.997,92
Begin 2015-03-1515.03.2015
End 2016-12-3131.12.2016
Projektdetails

Modeling the genetic and molecular basis of cardiac arrhythmias with patient-specific iPS cells
ID 81X2600607
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alessandra Moretti
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE043)
Funding 31485.88€ 31.485,88
Begin 2015-05-0101.05.2015
End 2017-12-3131.12.2017
Projektdetails

Optical action potential recordings for high-­-throughput cardiomyocytes subtype identification.
ID 81X2600608
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alessandra Moretti
Site München
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2015-09-0101.09.2015
End 2016-08-3131.08.2016
Projektdetails

Low-Energy Termination of Ventricular Fibrillation in a Porcine Heart Failure Model
ID 81X2600609
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Translational Research Project
Funding 430505.66€ 430.505,66
Begin 2016-01-0101.01.2016
End 2019-09-3030.09.2019
Projektdetails

Mechanisms of gap junction remodelling in health and diseases
ID 81X2700108
Institution Universität zu Lübeck
Project leader Cor de Wit
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE100)
Funding 15124.62€ 15.124,62
Begin 2014-10-0101.10.2014
End 2016-03-3131.03.2016
Projektdetails

Gewichtsentwicklung nach unter AT1Rezeptorblockade in MAS knock out Mäusen
ID 81X2700110
Institution Universität zu Lübeck
Project leader Walter Raasch
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE001)
Funding 10917.43€ 10.917,43
Begin 2015-03-0101.03.2015
End 2016-12-3131.12.2016
Projektdetails

Analysis of circadian regulated gene expression in microvascular endothelial cells
ID 81X2700111
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 1951.71€ 1.951,71
Begin 2015-03-0101.03.2015
End 2016-07-3131.07.2016
Projektdetails

Role of NADPH oxidases in cardiac miRNA Expression under normoxia and hypoxia
ID 81X2700112
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE063)
Funding 10559.39€ 10.559,39
Begin 2015-05-0101.05.2015
End 2017-08-3131.08.2017
Projektdetails

Generation and characterization of a novel zebrafish atherosclerotic model by overexpression of the humanized ApoE3-leiden protein
ID 81X2700113
Institution Universität zu Lübeck
Project leader Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 0.00€ 0,00
Begin 2015-07-0101.07.2015
End 2016-09-3030.09.2016
Projektdetails

Comprehensive evaluation of myocardial mechanics using cardiovascular magnetic resonance feature tracking in patients with myocardial infarction
ID 81X2700114
Institution Universität zu Lübeck
Project leader Holger Thiele
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE120)
Funding 16000.00€ 16.000,00
Begin 2015-08-0101.08.2015
End 2016-12-3131.12.2016
Projektdetails

Investigation of vascular function in endothelial cell-specific Txnrd2-deficient mice in vivo
ID 81X2700115
Institution Universität zu Lübeck
Project leader Cor de Wit
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE100)
Funding 14296.31€ 14.296,31
Begin 2015-10-0101.10.2015
End 2017-09-3030.09.2017
Projektdetails

The Role of serotonin in aortic calcification
ID 81X2700116
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE058)
Funding 15000.00€ 15.000,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Epigenetic factors in the pathogenesis of arterial hypertension
ID 81X2700117
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE139)
Funding 18000.00€ 18.000,00
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Cerebral blood flow changes after stroke in brain endothelial thrombomodulin knockout mice
ID 81X2700118
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 3381.26€ 3.381,26
Begin 2015-12-0101.12.2015
End 2016-05-3131.05.2016
Projektdetails

Treatment of mice with an AT1-receptor blocker reduces hypothalamic lipids which
ID 81X2700119
Institution Universität zu Lübeck
Project leader Walter Raasch
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 13800.00€ 13.800,00
Begin 2016-02-0101.02.2016
End 2018-08-3131.08.2018
Projektdetails

Functional role of ZC3HC1 in neointima formation
ID 81X2700121
Institution Universität zu Lübeck
Project leader Zouhair Aherrarhou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE140)
Funding 13543.22€ 13.543,22
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Charakterisierung der Lmcd1/Dyxin Knockout Maus - die Bedeutung der Inflammation
ID 81X2700201
Institution Universitätsklinikum Schleswig-Holstein
Project leader Norbert Frey
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 14551.94€ 14.551,94
Begin 2013-01-0101.01.2013
End 2016-05-3131.05.2016
Projektdetails

Generation of a Lmcd1-deficient mouse model using the CRISPR (Cas9 system)
ID 81X2700206
Institution Universitätsklinikum Schleswig-Holstein
Project leader Derk Frank
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE001)
Funding 13976.55€ 13.976,55
Begin 2014-09-2929.09.2014
End 2017-12-3131.12.2017
Projektdetails

NF-kB signalling in microvascular endothelial cells of the blood-brain barrier
ID 81X2700120
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 11246.12€ 11.246,12
Begin 2016-04-0101.04.2016
End 2016-12-3131.12.2016
Projektdetails

Gene therapy of pathological hypertrophy by targeted downregulation of PPIA
ID 81X2700207
Institution Universitätsklinikum Schleswig-Holstein
Project leader Frey
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE022)
Funding 24993.78€ 24.993,78
Begin 2015-09-0101.09.2015
End 2016-12-3131.12.2016
Projektdetails

Generation and characterization of two adult knockout zebrafish models using the CRISPR/Cas9 technique
ID 81X2700208
Institution Universitätsklinikum Schleswig-Holstein
Project leader Derk Frank
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE034)
Funding 20492.23€ 20.492,23
Begin 2015-10-0101.10.2015
End 2017-12-3131.12.2017
Projektdetails

Von Shared Expertises zu Core Facilities – Kompetitiver Austausch von Fähigkeiten und Fachkenntnissen, die ein Alleinstellungsmerkmal eines Partners/Standortes darstellen
ID 81X2710105
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 91738.92€ 91.738,92
Begin 2013-01-0101.01.2013
End 2016-12-3131.12.2016
Projektdetails

Von Shared Expertises zu Core Facilities – Beauftragung Externer Shared Expertises
ID 81X2710106
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 30529.50€ 30.529,50
Begin 2013-01-0101.01.2013
End 2016-03-3131.03.2016
Projektdetails

Identification of hypertrophy-modulating Cullin-RING E3 ubiquitin ligases in primary cardiomyocytes
ID 81X2710107
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 9928.33€ 9.928,33
Begin 2013-11-0101.11.2013
End 2017-12-3131.12.2017
Projektdetails

Determination of arginine derivatives in the EPIC cohort
ID 81X2710108
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 28316.87€ 28.316,87
Begin 2014-09-0101.09.2014
End 2016-06-3030.06.2016
Projektdetails

Beta2 Integrin Activation of T cells in Atherosclerosis
ID 81X2710109
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE020)
Funding 19055.16€ 19.055,16
Begin 2014-08-2727.08.2014
End 2016-06-3030.06.2016
Projektdetails

To investigate the role for S1P and its receptor subtypes in vascular thrombosis
ID 81X2710115
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE104)
Funding 2738.58€ 2.738,58
Begin 2015-01-0101.01.2015
End 2016-01-3131.01.2016
Projektdetails

Assessment of lncRNA functions in human engineered heart tissue
ID 81X2710116
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE024)
Funding 15727.99€ 15.727,99
Begin 2015-03-0101.03.2015
End 2017-12-3131.12.2017
Projektdetails

The role of myeloid differentiation factor-2 (MD-2) during inflammatory processes in human monocytes and human cardiac fibroblasts
ID 81X2710117
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE092)
Funding 21000.04€ 21.000,04
Begin 2015-02-0101.02.2015
End 2016-03-3131.03.2016
Projektdetails

Determination of S1P in the SHIP-TREND and GANI_MED cohorts
ID 81X2710121
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE057)
Funding 29789.16€ 29.789,16
Begin 2015-02-0101.02.2015
End 2017-01-3131.01.2017
Projektdetails

Role of Ca/Calmodulin-dependent protein kinase II in isolated cardiac fibroblasts
ID 81X2710124
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE092)
Funding 15932.00€ 15.932,00
Begin 2015-06-0101.06.2015
End 2016-02-2929.02.2016
Projektdetails

Screening of MYBPC3 gene for genetic variations in a panel of control individuals without diastolic dysfunction
ID 81X2710125
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Lucie Carrier
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 6909.59€ 6.909,59
Begin 2015-06-0101.06.2015
End 2016-05-3131.05.2016
Projektdetails

Development of dietary intervention tools supported by motivational interviewing techniques
ID 81X2710126
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Birgit-Christiane Zyriax
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE109)
Funding 4665.00€ 4.665,00
Begin 2015-07-1616.07.2015
End 2016-02-1515.02.2016
Projektdetails

Autophagy screening platform
ID 81X2710127
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Lucie Carrier
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 3667.74€ 3.667,74
Begin 2015-07-0101.07.2015
End 2016-06-3030.06.2016
Projektdetails

Human Atrial Tissue Proteomics, Pilot Analysis
ID 81X2710129
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 9966.64€ 9.966,64
Begin 2015-09-0101.09.2015
End 2016-08-3131.08.2016
Projektdetails

Comprehensive evaluation of functional iron deficiency: Prognostic value and genetic evaluation in the Gutenberg Health Study
ID 81X2710130
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Mahir Karakas
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE123)
Funding 1952.94€ 1.952,94
Begin 2015-10-0101.10.2015
End 2016-08-3131.08.2016
Projektdetails

Identification of differentially expressed proteins in the cardiac tissue of CRTC1 deficient mice and their wild-type littermates
ID 81X2710131
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Elke Oetjen
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 3242.92€ 3.242,92
Begin 2015-11-0101.11.2015
End 2016-12-3131.12.2016
Projektdetails

Role for microRNAs in calcineurin-mediated immunosuppression after solid organ transplantation
ID 81X2710132
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Sonja Schrepfer
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 8999.93€ 8.999,93
Begin 2015-11-0101.11.2015
End 2016-12-3131.12.2016
Projektdetails

Generation and initial characterization of the adeno-associated virus (AAV) vector for the dominant negative Gs -protein GS226A
ID 81X2710133
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Viacheslav Nicolaev
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 5180.43€ 5.180,43
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

BioID and complexome-remodelling analysis of cMyBP-C
ID 81X2710134
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Friederike Cuello
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE137)
Funding 10200.00€ 10.200,00
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Pediatric cardiomyopathy - screening for mutations and evaluation of their impact in iPSC-derived cardiomyocytes
ID 81X2710135
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Giulia Mearini
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE136)
Funding 17991.36€ 17.991,36
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Is autophagy flux altered in a mouse model of heart failure?
ID 81X2710136
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Lucie Carrier
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE102)
Funding 19033.78€ 19.033,78
Begin 2016-01-0101.01.2016
End 2017-06-3030.06.2017
Projektdetails

Investigation of a redox-phosphorylation crosstalk in human hypertrophic cardiomyopathy
ID 81X2710137
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Friederike Cuello
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE137)
Funding 2885.38€ 2.885,38
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Mapping the cardiac methylome - towards new epigenetic diagnostics
ID 81X2800105
Institution Albert-Ludwigs-Universität Freiburg
Project leader Lutz Hein
Site Extern
Project type Cooperation with External Partners
Funding 41667.00€ 41.667,00
Begin 2014-09-1616.09.2014
End 2016-12-3131.12.2016
Projektdetails

Organotypic slice cultures of human failing myocardium for mechanistic assessment of diastolic dysfunction
ID 81X2800106
Institution Ruhr-Universität Bochum Universitätsklinik Herz- und Diabeteszentrum Nordrhein-Westfalen
Project leader Hendrik Milting
Site Extern
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2014-10-0101.10.2014
End 2016-12-3131.12.2016
Projektdetails

Evaluation of potential atrial calcium handling abnormalities contributing to the atrial arrhythmogenic substrate in a porcine model of ischemic heart failure
ID 81X2800108
Institution Universitätsklinikum Essen
Project leader Dobromir Dobrev
Site Extern
Project type Cooperation with External Partners
Funding 10990.00€ 10.990,00
Begin 2014-11-1313.11.2014
End 2017-05-3131.05.2017
Projektdetails

The role of myeloid differentiation factor-2 (MD-2) in infectious inflammatory and non-infectious cardiomyopathy
ID 81X2800109
Institution Eberhard Karls Universität Tübingen
Project leader Karin Klingel
Site Extern
Project type Cooperation with External Partners
Funding 32640.82€ 32.640,82
Begin 2014-10-0101.10.2014
End 2017-01-3131.01.2017
Projektdetails

Klinische Studien des Kompetenznetzes Vorhofflimmern e.V.
ID 81X2800110
Institution Kompetenznetz Vorhofflimmern e. V.
Project leader Paulus Kirchhof
Site Extern
Project type Competence Networks
Funding 1273976.94€ 1.273.976,94
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Nationales Register für angeborene Herzfehler mit Biomaterialbank
ID 81X2800111
Institution Nationales Register für angeborene Herzfehler e.V.
Project leader Ulrike Bauer
Site Extern
Project type Competence Networks
Funding 3013196.01€ 3.013.196,01
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Geschäftstelle des Kompetenznetzes AHF e. V.
ID 81X2800112
Institution Kompetenznetz Angeborene Herzfehler e. V.
Project leader Ulrike Bauer
Site Extern
Project type Competence Networks
Funding 754578.72€ 754.578,72
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Kompetenznetz Herzinsuffizienz
ID 81X2800113
Institution Universitätsklinikum Würzburg
Project leader Stefan Störk
Site Extern
Project type Competence Networks
Funding 820627.65€ 820.627,65
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Adipokines as biomarkers for dysfunction of retinal microvasculature
ID 81X2800114
Institution Universitätsklinikum Ulm
Project leader Wolfgang Koenig
Site Extern
Project type Cooperation with External Partners
Funding 9796.80€ 9.796,80
Begin 2014-12-0101.12.2014
End 2016-03-3131.03.2016
Projektdetails

The TROPICAL-ACS SPARTAN Substudy
ID 81X2800115
Institution Eberhard Karls Universität Tübingen
Project leader Tobias Geisler
Site Extern
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2014-11-0101.11.2014
End 2016-08-3131.08.2016
Projektdetails

Single molecule force spectroscopy of the ß1 adrenergic receptor and autoantibodies
ID 81X2800117
Institution Heinrich-Heine-Universität Düsseldorf
Project leader Friedrich Boege
Site Extern
Project type Cooperation with External Partners
Funding 16999.39€ 16.999,39
Begin 2015-05-0101.05.2015
End 2016-12-3030.12.2016
Projektdetails

Annexin A1 prevents arterial leukocyte recruitment – mechanistic insights
ID 81X2800118
Institution Westfälische Wilhelms-Universität Münster
Project leader Alexander Zarbock
Site Extern
Project type Cooperation with External Partners
Funding 9692.43€ 9.692,43
Begin 2015-05-0101.05.2015
End 2016-04-3030.04.2016
Projektdetails

Zentrales Management der Kohortenstudie des Kompetenznetzes Herzinsuffizienz (KN HI) durch das Deutsche Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK)
ID 81X2800119
Institution Universität Leipzig
Project leader Markus Löffler
Site Extern
Project type Competence Networks
Funding 567036.88€ 567.036,88
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Accomplishment of a split-ubiquitin yeast-two-hybrid screen to identify novel interaction partners of Junctophilin-1 and Junctophilin-2
ID 81X2800120
Institution Universität Bielefeld
Project leader Michael Schwake
Site Extern
Project type Cooperation with External Partners
Funding 15305.43€ 15.305,43
Begin 2015-06-0101.06.2015
End 2016-08-3131.08.2016
Projektdetails

Promotion of positive images of ageing in elderly patients after myocardial infarction
ID 81X2800121
Institution Friedrich-Alexander-Universität Erlangen-Nürnberg
Project leader Susanne Wurm
Site Extern
Project type Cooperation with External Partners
Funding 10953.29€ 10.953,29
Begin 2015-06-0101.06.2015
End 2016-01-3131.01.2016
Projektdetails

Generation and characterization of a novel zebrafish atherosclerotic model by overexpression of the humanized ApoE3-leiden protein
ID 81X2800122
Institution Universität Potsdam
Project leader Salim Seyfried
Site Extern
Project type Cooperation with External Partners
Funding 10740.00€ 10.740,00
Begin 2015-09-0101.09.2015
End 2016-08-3131.08.2016
Projektdetails

New vascular keys to EndMT and cardiac fibrosis
ID 81X2800123
Institution Medizinische Hochschule Hannover - Zentrum Innere Medizin - Klinik für Nieren- und Hochdruckerkrankungen
Project leader Sibylle von Vietinghoff
Site Extern
Project type Cooperation with External Partners
Funding 14423.68€ 14.423,68
Begin 2015-07-0101.07.2015
End 2016-04-3030.04.2016
Projektdetails

Targeting T. cruzi-specific STAT1 serine phosphatase in the treatment of chagasic cardiomyopathy
ID 81X2800124
Institution Philipps-Universität Marburg
Project leader Ralph T. Schwarz
Site Extern
Project type Cooperation with External Partners
Funding 2237.79€ 2.237,79
Begin 2015-08-0101.08.2015
End 2016-06-3030.06.2016
Projektdetails

Epigenetic Profile of Cardiac Progenitor Cells – Global DNA Methylome
ID 81X2800125
Institution Albert-Ludwigs-Universität Freiburg
Project leader Lutz Hein
Site Extern
Project type Cooperation with External Partners
Funding 9900.00€ 9.900,00
Begin 2015-08-0101.08.2015
End 2016-04-3030.04.2016
Projektdetails

Autophagy screening platform
ID 81X2800126
Institution Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Project leader Ole Pleß
Site Extern
Project type Cooperation with External Partners
Funding 12785.22€ 12.785,22
Begin 2015-08-0101.08.2015
End 2016-06-3030.06.2016
Projektdetails

Optical action potential recordings for high---throughput cardiomyocytes subtype identification.
ID 81X2800127
Institution Universität des Saarlandes
Project leader Peter Lipp
Site Extern
Project type Cooperation with External Partners
Funding 8818.57€ 8.818,57
Begin 2015-09-0101.09.2015
End 2016-08-3131.08.2016
Projektdetails

Characterization and neurohumoral regulation of the newly identified membrane protein TRPML-like 2 in cardiomyocytes
ID 81X2800128
Institution Universität des Saarlandes
Project leader Peter Lipp
Site Extern
Project type Cooperation with External Partners
Funding 33395.79€ 33.395,79
Begin 2015-08-0101.08.2015
End 2016-07-3131.07.2016
Projektdetails

Non-invasive Renal Volume and Lipid Quantification as Biomarkers in Patients with Cardiovascular Disease
ID 81X2800129
Institution Universitätsklinikum Tübingen
Project leader Mike Notohamiprodjo
Site Extern
Project type Cooperation with External Partners
Funding 8688.90€ 8.688,90
Begin 2015-10-0101.10.2015
End 2016-12-3131.12.2016
Projektdetails

Generation of viral vectors for the functional characterization of long non-coding RNA in vivo
ID 81X2800130
Institution Medizinische Hochschule Hannover
Project leader Thomas Thum
Site Extern
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2015-10-0101.10.2015
End 2016-07-3030.07.2016
Projektdetails

ldentification of differentially expressed proteins in the cardiac tissue of CRTC1 deficient mice and their wildtype littermates
ID 81X2800131
Institution Universität zu Köln
Project leader Elke Oetjen
Site Extern
Project type Cooperation with External Partners
Funding 7149.98€ 7.149,98
Begin 2015-11-0101.11.2015
End 2016-12-3131.12.2016
Projektdetails

Role for microRNAs in calcineurin-mediated immunosuppression after solid organ transplantation
ID 81X2800132
Institution Universität zu Köln
Project leader Matti Adam
Site Extern
Project type Cooperation with External Partners
Funding 9880.27€ 9.880,27
Begin 2015-11-0101.11.2015
End 2016-12-3131.12.2016
Projektdetails

Role of killer cell immunoglobulin-like receptors in killing of induced pluripotent stem cell-derived cardiomyocytes
ID 81X2800133
Institution Heinrich-Heine-Universität Düsseldorf
Project leader Markus Uhrberg
Site Extern
Project type Cooperation with External Partners
Funding 11629.03€ 11.629,03
Begin 2016-01-0101.01.2016
End 2018-01-3131.01.2018
Projektdetails

Role of protein phosphatases in human cardiac pathology
ID 81X2800134
Institution Technische Universität Dresden
Project leader Ali El-Armouche
Site Extern
Project type Cooperation with External Partners
Funding 13999.99€ 13.999,99
Begin 2015-11-0101.11.2015
End 2016-12-3131.12.2016
Projektdetails

Determination of miR-29 subtypes in myocardial cell types and their regulation
ID 81X2800135
Institution Medizinische Hochschule Hannover
Project leader Thomas Thum
Site Extern
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2015-11-0101.11.2015
End 2017-05-1414.05.2017
Projektdetails

Functional characterization of psiPSC-CMs derived from patients with Tetralogy of Fallot in comparison to healthy controls.
ID 81X2800136
Institution Universitätsklinikum Essen
Project leader Dobromir Dobrev
Site Extern
Project type Cooperation with External Partners
Funding 12475.07€ 12.475,07
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Cerebral blood flow changes after stroke in brain endothelial thrombomodulin knockout mice
ID 81X2800137
Institution Medizinisches Laserzentrum Lübeck GmbH
Project leader Gereon Hüttmann
Site Extern
Project type Cooperation with External Partners
Funding 15975.00€ 15.975,00
Begin 2016-01-0101.01.2016
End 2016-05-3131.05.2016
Projektdetails

The Role of CD40 in Endothelial and Smooth Muscle Cell on Atherogenesis
ID 81X2800139
Institution Albert-Ludwigs-Universität Freiburg - Medizinische Fakultät
Project leader Andreas Zirlik
Site Extern
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Role of Sirt3 in the anti-inflammatory effects of estrogen receptors signaling
ID 81X2800140
Institution Justus-Liebig-Universität Gießen
Project leader Dursun Gündüz
Site Extern
Project type Cooperation with External Partners
Funding 13550.74€ 13.550,74
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails

Inotropy and Chronotropy Screens in Engineered Human Myocardium by Optical Analysis in Real Time. Teilvorhaben der HOCHSCHULE DARMSTADT
ID 81X2800141
Institution Hochschule Darmstadt
Project leader Ralf Blendowske
Site Extern
Project type Cooperation with External Partners
Funding 4702.76€ 4.702,76
Begin 2016-01-0101.01.2016
End 2016-09-3030.09.2016
Projektdetails

Research grant: Molecular aspects of the antiviral activity of ISG15 in CVB3-induced myocarditis
ID 81X3100202
Institution Charité - Universitätsmedizin Berlin
Project leader Nadine Althof
Site Berlin
Project type Excellence Programme
Funding 30761.12€ 30.761,12
Begin 2015-07-0101.07.2015
End 2017-06-2121.06.2017
Projektdetails

Rotation grant: Heart failure in children and adolescents
ID 81X3100302
Institution Deutsches Herzzentrum Berlin
Project leader Nadya Al-Wakeel
Site Berlin
Project type Excellence Programme
Funding 85635.56€ 85.635,56
Begin 2015-08-0101.08.2015
End 2018-09-3030.09.2018
Projektdetails

Postdoc start-up grant: The regulatory role of Reg3ß on neutrophil persistence and functionality after the onset myocardial infarction
ID 81X3200301
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Holger Lörchner
Site RheinMain
Project type Excellence Programme
Funding 58624.31€ 58.624,31
Begin 2015-10-0101.10.2015
End 2016-11-3030.11.2016
Projektdetails

Postdoc start-up grant: The role of sympathetic and parasympathetic innervation in heart development and regeneration
ID 81X3200302
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Ryota Matsuoka
Site RheinMain
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2015-10-0101.10.2015
End 2016-09-3030.09.2016
Projektdetails

Rotation grant: Catheter ablation for atrial fibrillation in hearth failure with preserved ejection fraction
ID 81X3500106
Institution Universitätsklinikum Heidelberg
Project leader Maura Magdalena Zylla
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 85468.57€ 85.468,57
Begin 2015-07-0101.07.2015
End 2016-12-3131.12.2016
Projektdetails

Rotation grant: Efficacy of ticagrelor after cardiopulmonary resuscitation in hypothermic patients with a myocardial infarction
ID 81X3500108
Institution Universitätsklinikum Heidelberg
Project leader Lisa Tilemann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 76778.00€ 76.778,00
Begin 2015-07-0101.07.2015
End 2016-08-3131.08.2016
Projektdetails

Postdoc start-up grant: Role of miR-147 in macrophages in atherosclerosis
ID 81X3600203
Institution Klinikum der Universität München
Project leader Maliheh Nazari-Jahantigh
Site München
Project type Excellence Programme
Funding 59981.00€ 59.981,00
Begin 2015-12-0101.12.2015
End 2017-03-3131.03.2017
Projektdetails

Rotation grant: Functional characterization of risk factor gene ADAMTS7 in vascular smooth muscle cells
ID 81X3600502
Institution Deutsches Herzzentrum München
Project leader Thorsten Kessler
Site München
Project type Excellence Programme
Funding 94000.00€ 94.000,00
Begin 2015-07-0101.07.2015
End 2016-09-3030.09.2016
Projektdetails

Rotation grant: Characterization of long noncoding RNAs as novel modulators of cardiac hypertrophy
ID 81X3700202
Institution Universitätsklinikum Schleswig-Holstein
Project leader Constantin Kühl
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 89513.69€ 89.513,69
Begin 2015-08-0101.08.2015
End 2016-08-3131.08.2016
Projektdetails

Rotation grant: Pressure-volume analysis in structural heart disease
ID 81X3710105
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Michael Schwarzl
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 87074.50€ 87.074,50
Begin 2015-11-0101.11.2015
End 2017-01-3131.01.2017
Projektdetails

Microbiome and cardiovascular disease
ID 81Z1100101
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Dominik Müller
Site Berlin
Project type Partner Site Projects
Topic inflammation/vascular inflammation
Funding 262364.36€ 262.364,36
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
microbiome, CVD
The microbiome includes a diverse community of bacteria in our gut and its impact on health has spawned the Human Microbiome Project. This immensely rich bacterial community, which is known to respond to fluctuations in lifestyle and diet, is increasingly recognized as an important factor that influences host health and disease. Several diseases have been shown to be influenced by gut microbiota, such as obesity, diabetes mellitus, inflammatory bowel disease and autoimmune disease. Even though the importance of the gut microbiome has been recognized, the role of environmental factors like high salt on the gut microbiome as well as the role for the gut microbiota in hypertension-induced target organ damage is not known. The project addresses these isuues.

Metabolic control of vascular diseases (Stammzellplattform)
ID 81Z1100102
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Thomas Willnow
Site Berlin
Project type Partner Site Projects
Topic iPSC
Funding 701111.28€ 701.111,28
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Stem cells, Genome editing, differentiation, reprogramming, disease modeling, screening
The Stem Cell platform of the DZHK in Berlin was established to provide stem cell specific services to scientists of the DZHK to overcome technical obstacles in a field of reprogramming, differentiation and genome editing rapidly growing and full of spectacular innovations.The stem cell platform already established feeder free cultivation system of hiPSC using homemade chemical defined media and different endothelial and cardiac, differentiation protocols in cooperation with the DZHK affiliated groups of Prof. Willnow, Hübner, Sperling, Gerhardt. The stem cell platform also performed genome engineering experiments using Crispr/Cas9 or TALEN mediated gene targeting and derived different disease and non- disease specific patient iPSC lines using different reprogramming techniques.

Heart prevention study
ID 81Z1100103
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Tobias Pischon
Site Berlin
Project type Partner Site Projects
Topic arteriosclerosis
Funding 250836.75€ 250.836,75
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
myocardial infarction, diet, nutrition, physical activity, patients
Current guidelines recommend a healthy diet and physical activity of at least moderate intensity for management of cardiovascular risk. Recent studies suggest that a Mediterranean diet reduces the risk of major cardiovascular events among persons at high cardiovascular risk. However, it is unclear whether in non-Mediterranean countries, diets similar to the Mediterranean diet have comparable effects. Further, preliminary evidence indicates that interval-based vigorous physical activity may be at least as beneficial as moderate activity. The aim of this project is therefore to study in a German population the association of diet, physical activity, lifestyle, and metabolic factors with prognosis of patients with history of myocardial infarction.

Endothelial cell dynamics in vascular remodelling
ID 81Z1100104
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Holger Gerhardt
Site Berlin
Project type Partner Site Projects
Topic vascular remodelling/altering
Funding 2301504.32€ 2.301.504,32
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
angiogenesis, imaging, blood flow, mouse, zebrafish
Our recent work on endothelial cell specification, competition, dynamic rearrangements, Notch signalling synchronization, and vessel regression established key principles in vascular patterning and malformations. Challenges ahead lie in the multiscale and multiphysics nature of vascular remodelling. Our project bridges across scales and disciplines to establish mechanisms of dynamic cell polarity establishment and regulation of endothelial cell shape in vascular remodelling, as well as transmission and integration of physical forces with signalling to influence shape and polarity of individual cells. We then ask how collective cell behaviour under the influence of the above-mentioned principles is coordinated with blood flow and tissue responses to achieve functional remodelling.

Development of microRNA therapeutics for vascular diseases
ID 81Z1100112
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Nikolaus Rajewski
Site Berlin
Project type Partner Site Projects
Funding 330046.67€ 330.046,67
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Metabolic control in cerebrovascular disease – Role of extracellu- lar matrix and junctional proteins for post-stroke regeneration
ID 81Z1100201
Institution Charité - Universitätsmedizin Berlin
Project leader Ulrich Dirnagl
Site Berlin
Project type Partner Site Projects
Topic angiogenesis
Funding 473143.09€ 473.143,09
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Ischemic stroke is a vascular disease affecting neuronal function. The ‘bimodal response’ of the neurovascular unit (NVU) to brain ischemia is characterized by an early blood-brain-barrier disruption followed later by vascular remodelling and, hence, a switch from brain injury to repair and recovery. The aim of this project is to target extracellular matrix (ECM) components essential for NVU integrity to protect from stroke and to identify novel biomarkers to translate these findings into clinical practice. Using a model of transient focal brain ischemia and a genetically modified mice, we investigate the role of key ECM components for stroke outcome and their potential use as biomarkers for the switch from injury to recovery.

RNA Therapeutics 1_5
ID 81Z1200101
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Stefanie Dimmeler
Site RheinMain
Project type Partner Site Projects
Topic miRNAS/IncRNA
Funding 1404260.50€ 1.404.260,50
Begin 2014-09-1010.09.2014
End 2018-12-3131.12.2018
Projektdetails
cardiovascular, RNA, miRNA, lncRNA, RNA therapeutics
In the last years, it has become evident that the majority of the genome is transcribed, while only about 2% codes for proteins. These so-called non-coding RNAs (ncRNAs) comprise microRNAs, long ncRNAs (>200 nt) and circular RNAs (circRNAs). The research groups of Prof. Dimmeler, Prof. Fleming and Prof. Brandes at RheinMain have extensive expertise in non-coding RNA research including the development of microRNA inhibitors in angiogenesis, cardiac aging and aneurysm formation as well as the characterization of the long non-coding RNAs in endothelial cell functions in vitro and in vivo. In frame of this common project we will join efforts to better understand the function of lncRNAs and circRNAs in the cardiovascular system in order to identify putative novel therapeutic targets.

Cell Therapy
ID 81Z1200102
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Andreas Zeiher
Site RheinMain
Project type Partner Site Projects
Topic stem cells/cardiac regeneration
Funding 239980.90€ 239.980,90
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
acute myocardial infarction, heart failure, stem cell therapy
Intracoronary therapy using autologous bone-marrow derived  cells (BMCs) has been shown to moderately improve left ventricular function in patients with acute myocardial infarction and chronic heart failure. One of the key factors influencing the efficacy of the application is certainly the heterogeneity of the cell products which varies depending on the genetic determinants and risk factors of the individual patients. Focus of this project is the establishment of fast and easy-to-perform in vitro methods to analyze the functionality of BMCs already before the re-application in the patient. Identification of factors determining the functionality of the applied cellular product might also enable ex-vivo modification by drugs or small molecules in order to further enhance the efficacy of cell therapy in patients with cardiovascular diseases.

Biomarker Research
ID 81Z1200201
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Christian Hamm
Site RheinMain
Project type Partner Site Projects
Funding 897561.16€ 897.561,16
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
biomarker, heart failure, microRNA
The Biomarker Research Group aims to identify and validate of cardiac biomarkers, which is the central area of clinical and basic research in this Project in order to improve diagnosis, decision on therapeutic strategies and prognosis of cardiovascular disease. Only a few Biomarkers (e.g. Troponin, CKMB) have made into daily clinical practice and are routinely measured in patients in a limited number of clinical settings (exclusion of myocardial infarction). Thus, there is an essential need for a broader range of biomarkers not only in the context of myocardial infarction but also for other cardiac and vascular diseases like heart failure (diastolic/systolic dysfunction), right/left ventricular insufficiency and for cardiac ischemia. Furthermore, new concepts of (bio)-markers (e.g. circulating micro-RNAs and molecular signature of circulating mononuclear cells) are investigated for their potential to act as therapeutic or prognostic indicators of cardiac pathologies.

Metabolic Response to Pharmacological and Non-pharmacological Interventions
ID 81Z1400101
Institution Universitätsmedizin Greifswald
Project leader Raila Busch
Site Greifswald
Project type Partner Site Projects
Topic endothelial cells/vascular function
Funding 560749.31€ 560.749,31
Begin 2014-08-1818.08.2014
End 2018-12-3131.12.2018
Projektdetails
exercise, lipid-lowering medication, interactive effects, endothelial function, animal models, cell culture and flow-chamber experiments
This project investigates the interaction between pharmacological therapies and life-style changes as non-pharmacological intervention. The current guidelines recommend a combination of pharmacological and non-pharmacological approaches. However, little is known at the current state e.g. how life-style interventions like exercise training and medication interact. For primary and secondary prevention interactions between exercise training and lipid lowering medication is of high interest. Up to now it is still unclear if the positive effects of exercise training or lipid lowering medication alone act additively/synergisticly or counteractively when applied in combination as recommended by the guidelines. The major aim of this project is to investigate the effects of lipid lowering medication on endothelial/vascular function in cell culture models. Furthermore animal models shall provide insights into the interaction of exercise training and lipid lowering medication on cardiopulmonary capacity, vascular and heart function.

Vascular Regeneration/Remodelling
ID 81Z1600211
Institution Klinikum der Universität München
Project leader Ulrich Pohl
Site München
Project type Partner Site Projects
Topic vascular remodelling/altering
Funding 718832.52€ 718.832,52
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
smooth muscle, AMPK, connexins, cell migration, cytoskelton, podosomes, mitochnodrial impairment
In this project we study the role of vascular connexins in remodelling processes. Using genetic connexin mutations their effect on of vascular on cell growth and migration and heterocellular communication are analyzed. We further study the role endothelial mitochondrial impairment, cytoskeletal reorganization and altered smooth muscle calcium homeostasis on cellular migration in isolated cultured microvessels and a model of arteriogenesis. One of the targets is the AMP-activated kinase (AMPK) which establishes a close link to metabolic and inflammatory diseases and microvascular remodelling

Immunotherapy of Vascular Disease
ID 81Z1600212
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Partner Site Projects
Topic inflammation/vascular inflammation
Funding 1849181.03€ 1.849.181,03
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
chemokine, heteromer, neutrophil, platelet, inflammation, recruitment
The newly established research group headed by the DZHK-Professor Oliver Soehnlein shall develop and pursue novel concepts for target identification and therapeutic exploitation in the context of the chemokine-interactome, leukocytic granule proteins, and costimulatory molecules for the treatment of inflammatory aspects of cardiovascular diseases. These are based on detailed structure-function analyses, modelling of molecular interactions, and synthetic peptide chemistry for generation of interceptors, which shall be validated and optimized for safety and efficacy during atherogenic immune cell recruitment. It is the aim to generate peptides for use in clinical studies which shall be realized in subsequent funding periods.

Clinical CHD - Clinical Platelet Therapy Research
ID 81Z1600214
Institution Klinikum der Universität München
Project leader Steffen Massberg
Site München
Project type Partner Site Projects
Topic platelet function/thrombosis mechanisms
Funding 1567485.72€ 1.567.485,72
Begin 2013-05-0101.05.2013
End 2018-12-3131.12.2018
Projektdetails
platelet, thrombosis, immune cells, coagulation
Platelets are central mediators of arterial thrombosis and the main target of treatment as well as prophylaxis of coronary heart disease. However, despite improvements in antiplatelet therapy thrombotic disorders a still a leading cause of mortality worldwide. Therefore, the central aim of this project is to pave the way for innovative therapeutic approaches targeting the prothrombotic functions of platelets. This is based on an improved understanding of the interactions of platelets with the coagulation as well as the immune system using state-of-the-art basic science approaches and reaching to clinical evaluation. The results of this project will provide valuable insight into the mechanisms of thrombotic disorders and will break new ground for the treatment of coronary heart disease.

Gender Medicine
ID 81Z1600215
Institution Klinikum der Universität München
Project leader Julinda Mehilli
Site München
Project type Partner Site Projects
Funding 573929.98€ 573.929,98
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails
gender, women, TAVI, TAVR, AS,HTx, heart transplantation,CAD, BRS, scaffold
gender-related analyses from different registries and ongoing randomized trials focused on clinical outcomes after trans-catheter aortic valve repair, after heart transplantation as well as after implantation of bioresorbable vascular scaffolds

Cell Adhesion in CHD
ID 81Z1600313
Institution Max-Planck-Institut für Biochemie
Project leader Reinhard Fässler
Site München
Project type Partner Site Projects
Topic endothelial cells/vascular function
Funding 775111.00€ 775.111,00
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
cell adhesion signaling, knock-out mice, parvin, integrin, cardiomyocytes, vascular smooth muscle cells, hypertrophy, proteomics
The project „cell adhesion in coronary heart diseases“ makes use of genetically modified mouse lines to analyze the role of integrin-mediated adhesion of vascular smooth muscle cell and cardiomyocyte to the extracellular matrix (cell-matrix adhesion) and neighboring cells (cell-cell adhesion) in vivo. We aim to characterize ?-Parvin and ?-Parvin-regulated signal pathways that control vascular and cardiomyocyte function and the progression of CHDs (such as aneurysms, hypertonia or hypertrophy) by a combination of genetic experiments in mice, cell biology and proteomic analysis. A second aim is the development of therapeutic strategies for the treatment of CHDs using synthetic peptides that bind to and inactivate cell adhesion proteins.

Experimental and integrative analysis of CAD
ID 81Z1600512
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 831297.87€ 831.297,87
Begin 2013-01-0101.01.2013
End 2018-12-3131.12.2018
Projektdetails
animal models, genome-wide association studies, coronary artery disease, myocardial infarction
Our group has significantly contributed to the discovery and functional analysis of a large number of genomic variants which were identified to be genome-wide significantly associated with coronary artery disease. Hence, several transgenic animal models as well as novel bioinformatics strategies have been established to enable the analysis of networks and signaling pathways. In the project “Experimental and integrative analysis of CAD” we aim to experimentally explore these tools of functional gene analysis. Furthermore, using OMICS datasets and animal models, which are based on the genome-wide significant coronary artery disease loci, we aim to improve the understanding of the molecular consequences of the identified variants for the development of coronary artery disease and myocardial infarction.

Clinical CHD Therapy - Early Clinical Trial Unit
ID 81Z1600514
Institution Deutsches Herzzentrum München
Project leader Adnan Kastrati
Site München
Project type Partner Site Projects
Funding 1262041.09€ 1.262.041,09
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
Coronary artery disease, thrombosis, restenosis, platelet, aggregation, stent, women,antiproliferative drug, antiplatelet drug, clinical trial, phase II
The objective is 2 fold: evaluation of new therapeutic concepts for the prevention of stent thrombosis and restenosis. A new substance, a glycoproten VI inhibitor, Revacept, which prevents the adhesion of platelets to the vessel wall injury site, is expected to protect against thrombosis without impacting significantly on bleeding. Preclinical and phase I studies have shown promise that Revacept might be an effective and safe drug for prevention of thrombotic events after percutaneous coronary intervention. This substance will be assessed in a phase II clinical trial. The second objective is the development of safer and effective drug-eluting stents. RGD peptide and novel fully resorbable polymers will be subject of pre-clinical and first-in-man studies. We are establishing an early clinical trial unit for the conductance of these studies.

From GWAS hits to novel treatment targets
ID 81Z1700101
Institution Universität zu Lübeck
Project leader Jeanette Erdmann
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 1840985.79€ 1.840.985,79
Begin 2014-11-0505.11.2014
End 2018-12-3131.12.2018
Projektdetails
myocardial infarction, coronary artery disease, genetics, GWAS, animal models, SNPs, NGS
The project aims to systematically explore the human genome in cardiovascular disease, as well as to study the functional consequences of genomic variations in human cell and animal models. We wish to enhance diagnostic and therapeutic options particularly in the context of atherosclerosis and myocardial infarction. We systematically explored genome-wide association as well as genome-wide sequencing data and contributed to the identification of most currently known alleles affecting risk of the disease. Transgenic animal models (mice), also based on these newly identified genes, are about to further refine the mechanistic understanding of these processes. We aim to utilize these resources for the benefit of patients in terms of improved risk prediction and individualized medical treatment.

Phenotypic evaluation of MI genes in mouse models
ID 81Z1700102
Institution Universität zu Lübeck
Project leader Cor de Wit
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 309685.98€ 309.685,98
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
endothelium, microcirculation, knockout-models
This project is aimed to analyse mouse models that carry identified CAD/MI genes with respect to flow regulation in the microcirculation, neointima formation in carotid artery, and platelet aggregation in arterioles. Flow regulation is studied by measuring arteriolar diameter changes in the in vivo setting before and after stimulation using vasoactive agents. Neointima formation is an in vivo model of atherosclerosis that induces a switch in smooth muscle phenotype. Thrombus formation is initiated in vivo in arterioles by mechanical or excitation of light-sensitive dyes to induce platelet activation. By these means we aim to obtain insight into pathophysiological mechanisms that are initiated by such genes of risk which ultimately may cause or promote CAD/MI.

Genetic epidemiology and clinical studies
ID 81Z1700103
Institution Universität zu Lübeck
Project leader Inke R. König
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 165000.00€ 165.000,00
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
biomarker, simulation, interaction, study design, randomise all, biomarker stratified, subgroup analysis
The first aim is to derive practical recommendations for identifying interactions between predictive biomarkers and treatments in different study designs via simulations based on distinct regression models. The first step is to design simulation scenarios based on effects and effect combinations described in literature. Next, transformations are developed to define equivalent effects in different regression models resulting in subsequent simulation runs. The second aim is to give recommendations how to analyse subgroup designs defined by multiple biomarkers. The first step here is again to design simulation scenarios by literature search. Practical recommendations arise from simulations based on these scenarios, and unbiased estimators for treatment and biomarker effects will be developed.

Functional investigationof mutations in cardiovascular disease
ID 81Z1700104
Institution Universität zu Lübeck
Project leader Frank Kaiser
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 182046.40€ 182.046,40
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
chromatin, SNP, transcription, mutation
To characterize genetic variants associated with cardiovascular disease two different analytic pipelines are used. The first one is focusing on variants affecting protein coding regions of the genome by a broad spectrum of different technologies (two hybrid assays, immunoprecipitation or ChIP) to investigate exchanges of selected amino acids on protein complex formation or protein DNA interaction. The second part of this project is focusing on variants within the non-coding part of the genome. Based on public or own databases variants are rated and listed regarding their predicted functional relevance. Selected variants will be analyzed by cellular in-vitro systems and chromatin conformation capture assays to investigate their effect on chromatin structure and gene expression.

Vascular end organ damage
ID 81Z1700105
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic endothelial cells/vascular function
Funding 248630.83€ 248.630,83
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
optical coherence tomography, diabetic complications, diabetic microvascular pathology, incontinentia pigmenti, small vessel diseases, NF-kB, gene therapy
Our project investigates vascular pruning and remodeling in mouse models of disease. We focus on (i) diabetes and (ii) incontinentia pigmenti, a genetic disease that leads to vascular pathology in the brain. Although diverse in etiology, the two conditions share an involvement of the proinflammatory transcription factor NF-?B. To explore whether interfering with NF-?B signaling offers therapeutic opportunities, we employ classical small-molecule pharmacology as well as gene therapy approaches. Optical coherence tomography and various physiological or morphological techniques are used to evaluate the vasculature.

Omics-based approaches in cardiovascular disease
ID 81Z1710101
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 1368872.73€ 1.368.872,73
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
OMICS, cardiovascular genetics, genomics, gene expression, candidate genes, translation, clinical application, systems medicine
Systems medince approaches to characterize candidate genes and networks of cardiovascular diseases such as myocardial infarction, heart failure and atrial fibrillation. As resources we use large-scale omics and phenotypic data sets as well as comprehensive biobanks of population-based and disease cohorts. Candidate genes are investigated at the molecular and cellular levels. Findings are translated into clinical disease models and tested for clinical application.

Modulation of the AGAT/homoarginine pathway in cardio - vascular diseases
ID 81Z1710102
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 368000.00€ 368.000,00
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
AGAT, CRTC1, homoarginine
L-arginine:glycine amidinotransferase (AGAT) is involved in creatine as well as homoarginine (hArg) synthesis. hArg is an amino acid identified as risk marker in cardiovascular (CV) and cerebrovascular diseases. Cardiac phenotyping of AGAT deficient, Mybpc3-targeted knock-in, and CREB-regulated transcription coactivator 1 deficient mice is part of the project for a better understanding of processes in CV diseases. The aim of the project is to investigate the potential relevance of the AGAT/hArg pathway as a new therapeutic approach in CV diseases, e.g. atrial fibrillation, stroke/transient ischemic attack, heart failure, and hypertrophic cardiomyopathy with AGAT modulators, identified by high throughput screening, and homoarginine supplementation in healthy and diseased patients.

Examination of novel risk markers for atrial fibrillation
ID 81Z1710103
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Renate B. Schnabel
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic other arrhythmias
Funding 208086.86€ 208.086,86
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
atrial fibrillation, risk prediction, outcome, epidemiology
At University Heart Centre Hamburg we have established obserational cohorts to investigate incidence and outcome of atrial fibrillation. Cohorts range from population-based individuals to patients at risk of developing atrial fibrillation, lone atrial fibrillation, and postoperative new-onset disease. In the DZHK project we perform epidemiological analyses that examine classical risk factors and novel risk markers for atrial fibrillation. Our aim is to improve the understanding of the disease pathophysiology and its natural history. In pre-defined subgroups we try to improve risk prediction beyond existing risk algorithms. In addition, by our well-characterized cohorts we provide a clinical-epidemiological basis for a fast translation of basic research findings into the clinical setting.

Integration of transcriptional and posttranscriptional regulation in dilated cardiomyopathy
ID 81Z2100101
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 189185.95€ 189.185,95
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Genetic variation, transcriptional and translational regulation
We investigate the molecular basis of cardiovascular diseases with a main focus on dilated cardiomyopathy (DCM), a major cause of congestive heart failure. Genetic factors are known to play an important role in disease etiology but the molecular mechanisms are largely unknown. In order to elucidate the impact of pathogenic variation, we perform RNA-seq and ribosome profiling of cardiac disease tissue. Ribosome profiling is a powerful and novel methodology to obtain qualitative and quantitative information about translation on a genome-wide scale. This technology provides a way to thoroughly investigate translational regulation and to significantly improve the estimate of protein levels compared to traditional gene expression approaches.

Alternatives Spleißen als therapeutisches Target für Erkrankungen des Herzens
ID 81Z2100102
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Gotthardt
Site Berlin
Project type Partner Site Projects
Topic cardiomyocyte function
Funding 357275.80€ 357.275,80
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
RNA, splicing, therapy
The project „alternative splicing as a therapeutic target for cardiac diseases“ builds on our identification of RBM20 as a splice factor with substrates related to sarcomere function and calcium homeostasis. We will study the regulation of RBM20 expression and function, as well as its interaction with other proteins to identify potential therapeutic targets. Through the coordinated interference with cardiac isoform expression, we will adapt the elastic and electrical properties of the heart.

Sex-specific use of estrogen pathway modulation in human heart failure
ID 81Z2100201
Institution Charité - Universitätsmedizin Berlin
Project leader Vera Regitz-Zagrosek
Site Berlin
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 887303.04€ 887.303,04
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
calcium, fibrosis, hormone, mitochondria, receptor
There are major sex differences in heart failure. The overall hypothesis is that female sex or sex hormones lead to better maintenance of mitochondrial function, calcium handling and reduced fibrosis and apoptosis under stress. To investigate these processes, we use animal models and tissues from male and female patients undergoing cardiac surgery in the following objectives: 1) sex-specific role of ER? and ER? on mitochondrial energy production in the human heart; 2) sex-specific role of ER? and ER? effects in cardiac fibrosis; 3) role of mitochondrial cAMP-signaling in the cardioprotective effects of ER; 4) sex differences in calcium-dependent cardiomyocyte death in heart failure; 5) integrative model of sex differences in cardiomyocyte function and testing of targets.

Translationale Studien zur Rolle der non-coding RNA (miR und long ncRNA) für die kardievaskuläre Repair- und Immunmodulationsprozesse beim akuten Koronarsyndrom
ID 81Z2100202
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Partner Site Projects
Topic inflammation/vascular inflammation
Funding 755163.91€ 755.163,91
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
non-coding RNA, inflammation, vascular, endothelium, repair, monocytes, mircoRNA
The project aims to better define mechanisms regulating vascular and cardiac immune and repair responses in cardiovascular diseases. We combine flow cytometric sorting of human monocyte populations and the characterization of their coding and non-coding RNA profiles in relation to monocyte functions. Furthermore, we assess the functional impact of each of the known 2000+ miR species for monocyte-endothelial cell interaction and for cardiomyocyte proliferation. Another sub-project investigates microvesicles and their miR cargo for the interaction between blood leukocyte populations and the endothelium in patients with acute and stable cardiovascular diseases. Finally, we assess the role of lipoproteins for the interaction between cells of the innate immunity and cells of the vascular wall.

Präventionsstudie/Risikomanagement
ID 81Z2100501
Institution Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Project leader Matthias Schulze
Site Berlin
Project type Partner Site Projects
Funding 255239.29€ 255.239,29
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Beobachtungsstudie, Ernährung, körperliche Aktivität, Mortalität, koronare Herzkrankheit
In einer Beobachtungsstudie werden Ernährung und körperliche Aktivität als Risikofaktoren für die Prognose und Mortalität von Patienten mit stabiler koronarer Herzkrankheit untersucht.")

W2 RNA Biology
ID 81Z2200101
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Stefanie Dimmeler
Site RheinMain
Project type Partner Site Projects
Topic miRNAS/IncRNA
Funding 1000001.20€ 1.000.001,20
Begin 2015-05-0101.05.2015
End 2019-01-3131.01.2019
Projektdetails
cardiovascular, RNA therapeutics, bioinformatics, biomarker
In frame of this project we would like to strengthen our extensive expertise in non-coding RNA research by appointing two new W2 professorships “RNA Therapeutics” and “Bioinformatics in Cardiovascular Disease” at the university hospital in Frankfurt. Dr. Reinier Boon has recently been appointed as professor in RNA Therapeutics and is mainly focusing on the establishment of in vitro and in vivo systems to unravel the role of newly discovered non-coding RNAs, especially lincRNAs, in cardiovascular diseases. The W2 professorship in “Bioinformatics in Cardiovascular Disease” will provide strong expertise in bioinformatics to support the analysis of large datasets (e.g. microarrays, ChIP and NGS) for the identification of new biomarker and to generate databases mainly focusing on the non-coding Genome.

MyoVasc-Kohortenstudie
ID 81Z2210101
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site RheinMain
Project type Partner Site Projects
Funding 2431414.02€ 2.431.414,02
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Heart Failure, vascular function, Biodatabanking, phenomics, cohort study
The Myovasc Study is a prospective cohort study investigating heart failure and its interactions with vascular disease. From January 2013 to January 2017 approximately 3000 participants with asymptomatic and symptomatic heart failure are eligible for the study. The primary outcome of interest is worsening of heart failure, defined as transition of cardiac dysfunction to symptomatic heart failure or cardiac death in asymptomatic individuals and hospitalization or cardiac death in symptomatic heart failure. Study participants start with a 5-hour baseline examination including comprehensive cardiovascular diagnostics. A follow up with the same examination program is performed after 2 and 4 years. A computer-assisted telephone interview with assessment of outcome is conducted yearly.

Genotyp/Phänotyp Analysen in 2D und 3D iPS-Modellen
ID 81Z2300121
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Gerd Hasenfuß
Site Göttingen
Project type Partner Site Projects
Funding 838625.00€ 838.625,00
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails

Personalized Medicine: Molecular Stratification of DCM patients
ID 81Z2400121
Institution Universitätsmedizin Greifswald
Project leader Stephan B. Felix
Site Greifswald
Project type Partner Site Projects
Topic Inflammatory heart diseases
Funding 557511.98€ 557.511,98
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails
dilated cardiomyopathy, risk profiles, biomarker, inflammatory processes, animal models, cell culture
The discovery of inflammatory processes involved in the development of cardiomyopathies has lead to the development of new therapies. The aim of this project is to use existing patient cohorts with dilated cardiomyopathy to investigate individual inflammatory risk profiles. Biomaterials will be investigated regarding new factors indicating an individual predisposition for developing the disease or factors influencing the progression of the disease. Generated hypotheses shall be further explored in experimental settings e.g. cell cultures or animal models. The major aim is to create new insights into the pathegenesis of DCM and to develop new diagnostic tools for dilated cardiomyopathy which may be also relevant for new therapeutic approaches.

Genomische und epigenomische Ursachen von Kardiomyopathien und ihre klinische Relevanz
ID 81Z2500101
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 2361099.02€ 2.361.099,02
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
cardiomyopathy, genetics, epigenetics
The project investigates the genetic and epigenetic mechanisms involved in the pathogenesis of cardiomyopathies. It further studies the connection of genetics and inflammatory heart disease on the clinical and molecular level.

Hereditäre und Inflammatorische Kardiomyophatien
ID 81Z2500102
Institution Universitätsklinikum Heidelberg
Project leader Hugo A. Katus
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 768615.15€ 768.615,15
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Molekulare und epigenetische Regulationsmechanismen bei dem pathologischen kardialen Remodeling
ID 81Z2500103
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 1812188.44€ 1.812.188,44
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Translational therapeutics: Therapeutic endpoints and diagnostic biomarker for advanced therapy medicinal products (ATMP) against heart failure
ID 81Z2500104
Institution Universitätsklinikum Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic DNA/RNA based, protein based therapy
Funding 525688.20€ 525.688,20
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Heart failure gene therapy efficacy parameter & biomarker, Disease- & ligand-controlled expression systems
To enable the design of meaningful clinical trial protocols for future heart failure gene therapy programs, this project aims to determine optimized parameters of therapeutic efficacy (work package 1), viral vectors (work package 2) and predictive biomarkers (work package 3) for DNA-based therapeutic targets/ATMP against chronic heart failure such as S100A1 and others. In addition, this project seeks development of disease- (work package 4) and ligand-controlled (work package 5) gene expression systems suitable for the human-sized heart to overcome limitations of currently used constitutive systems.

Pre-clinical evaluation of novel targets against cardiomyopathies
ID 81Z2500105
Institution Universitätsklinikum Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic DNA/RNA based, protein based therapy
Funding 555342.14€ 555.342,14
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Peptide- and mRNA-based therapeutic molecules, heart failure, Cor pulmonale
Unmet clinical needs such as heart failure or Cor pulmonale fuel our interest in pharmacological strategies that improve cardiac performance by bypassing cAMP signaling and extend to the mitigation of tachyarrhythmia susceptibility, energy defects and adverse remodeling. To this end, this project seeks to determine therapeutic efficacy and safety/toxicology of S100A1 synthetic peptide- (working package 1a/b) and in vitro transcribed mRNA-based (working package 2a/b) experimental therapies against disorders of the left and right ventricular chambers in in vitro and in vivo models.

From channelopathies to clinical arrhythmias
ID 81Z2500201
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Martin Borggrefe
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic iPSC
Funding 554176.29€ 554.176,29
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
iPS, arrhythmias, Patch-clamp
Investigation of underlying mechanisms and identification of new therapeutic targets: hiPSC-CMs possess characteristics similar to that of native human cardiomyocytes and can model the main features of some heart diseases. They provide a new platform to study the disease pathology and screen drugs. The aim of our study is to use the hiPSC-CMs modeling the arrhythmogenic heart diseases (SQTs, LQTs, Brugada syndrome, ARVC, HCM and DCM) for studying the underlying mechanisms and identifying new therapeutic targets for the treatment of the diseases. In addition, we will test effects of drugs on the “diseased” hiPSC-CMs and design better drug treatments for the diseases

Multimodal Image Fusion
ID 81Z2500202
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Martin Borggrefe
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic imaging
Funding 250319.60€ 250.319,60
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Detection of fibrosis, epicardial adipose tissue, Na+-Imaging
Detection of fibrosis using CMR: In patients with cardiomyopathies we want to investigate the diagnostic value of T1 mapping in comparision to late gadolinium enhancement imaging for the evaluation of fibrosis. Epicardial adipose tissue: In patients with cardiomyopathies we want to correlate changes in epicardial adipose tissue to morphological and functional parameters as well as outcome. Na+-Imaging: In cooperation with the Institute of Computer Assisted Clinical Medicine (Prof. Dr. rer. Nat L. Schad) we aime to examine the feasibility of 23Na+ heart imaging with a double-resonant 23Na-1H surface RF coil at 3 T.

Translational diagnostics of cardiomyopathies
ID 81Z2500203
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Martin Borggrefe
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic imaging
Funding 105710.16€ 105.710,16
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
outcome, CMR imaging, ICD implantation, benefits, risks
Identification of prognostic relevant risk factors In patients with cardiomyopathies and arrhythmias we aim to improve prognosis through clinical interventions. Therefore the identification of outcome-relevant parameters is crucial. In patients who underwent CMR-imaging prior to primary or secondary ICD implantation we aim to investigate which patient-specific and CMR parameters are relevant for reaching a primary or secondary endpoint. Besides, we want to find out in which patients the benefits of the lifesaving ICD implantations outweigh the risk of device associated complications.

Registry for primary electrical disease
ID 81Z2500204
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Martin Borggrefe
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic other arrhythmias
Funding 241543.78€ 241.543,78
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
primary electrical disease of the heart, channelopathies, risk stratification
Registry for primary electrical disease of the heart: Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all cells. Channelopathies are diseases that develop because of defects in ion channels caused by either genetic or acquired factors . In patients with inherited channelopathies phenotype, individual disease course and mechanisms of arrhythmogenesis are quite different among individual patients. While in some patients causes and genetic background of ventricular fibrillation are better understood, others will develop ventricular fibrillation of unknown cause. The clinical phenotype might be influenced by unknown genetic mutations, epigenetic modifiers, gender or other still unkown risk factors. Therefore, the aim of our registry for primary electrical disease of the heart, is to identify genetic and epigenetic factors which may cause lethal arrhythmias as a result of dysfunctioning cardiac ion channels.

Identification and Validation of Novel Inotropy-Enhancing Molecular Targets
ID 81Z2500205
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Thomas Wieland
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic cardiomyocyte function
Funding 609514.92€ 609.514,92
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
cardiac contractiliy,muscarinic receptors, RhoGTPases, RhoGTPase-activating proteins, RhoGTPase guanine nucleotide exchange factors,
In this project molecular targets in a novel positive inotropic pathway coupling M2 muscarinic receptors to RhoA/Rho-kinase in heart failure are characterized and validated. The so far identified targets are the Regulator of G-protein signaling RGS3, the RhoGTPase-actvating protein p190RhoGAP and the guanine nucleotide exchange factor Tiam1. Depending on the expression level of RGS3 this proteins allow for a switch of the coupling of M2 muscarinic receptors to a Rho-kinase dependent positive inotropic response in cardiac myocytes. Therefore, all three proteins are putative molecular targets for novel therapies in heart failure.

Experimental evaluation of cause specific personalized treatment options
ID 81Z2500206
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Jochen Utikal
Site Heidelberg/Mannheim
Project type Partner Site Projects
Topic iPSC
Funding 201473.50€ 201.473,50
Begin 2015-01-0101.01.2015
End 2018-05-3131.05.2018
Projektdetails
iPSC, repogramming, skin, fibroblast, cardiomyocyte
Generation of induced pluripotent stem cells (iPSCs) from patients with heart diseases, their differentiation in cardiomyocytes and their use in functional protocols

Kardiale Zelltyp- und Risikofaktor-spezifische DNA-Methylierung (DKFZ-PL-1)
ID 81Z2500301
Institution Deutsches Krebsforschungszentrum (DKFZ)
Project leader Christoph Plass
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 263917.41€ 263.917,41
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Kardiale Zelltyp- und Risikofaktor-spezifische Histonmodifikationen
ID 81Z2500401
Institution Europäisches Laboratorium für Molekularbiologie (EMBL)
Project leader Eileen Furlong
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 125505.72€ 125.505,72
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Functional role of nexilin in dilated cardiomyopathy
ID 81Z2700101
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 270000.00€ 270.000,00
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
Nexilin, Cardiomyopathy, Cardiomyocytes, iPS cells
Nexilin is one of the key genes, which have recently been identified by our group to play a critical role in cardiomyopathy. Our research interest is the evaluation of the functional role of nexilin in dilated cardiomyopathy (DCM) using constitutive and conditional mouse models as well as cardiomyocytes differentiated from human induced pluripotent stem cells (iPS cells).

The role of nexilin in dilated cardiomyopathy
ID 81Z2700121
Institution Universität zu Lübeck
Project leader Jeanette Erdmann
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 355455.45€ 355.455,45
Begin 2011-10-1515.10.2011
End 2016-03-3131.03.2016
Projektdetails

Non-coding RNAs in cardiac remodeling
ID 81Z2700201
Institution Universitätsklinikum Schleswig-Holstein
Project leader Norbert Frey
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 1231634.31€ 1.231.634,31
Begin 2014-11-0101.11.2014
End 2018-12-3131.12.2018
Projektdetails
non-coding RNAs, lncRNA, MicroRNA
Non-coding RNAs, including micro-RNAs and lncRNAs, have been shown to play a critical role in the regulation of gene expression. It is estimated that about 4.000 lncRNAs exist, yet little is known about the role of lncRNAs in cardiac remodeling and heart failure. We thus hypothesize that lncRNAs may significantly contribute to the pathogenesis and progression of heart failure. Specifically, we aim to identify differentially regulated lncRNAs in animal models as well as human heart failure. These data will be bioinformatically analyzed and correlated with cDNA and miRNA expression. In addition, we plan a comprehensive functional characterization of novel cardiac lncRNAs utilizing adenoviruses encoding for lncRNAs and inhibitors, respectively, as well as generation of transgenic animal models. Finally, we aim to explore novel therapeutic options via experimental manipulation of specific lncRNAs in vitro and in vivo

Molecular Mechnanismus of Hypoplastic Left Heart Syndrome (HLHS)
ID 81Z2700202
Institution Universitätsklinikum Schleswig-Holstein
Project leader Hans-Heiner Kramer
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 445266.19€ 445.266,19
Begin 2014-11-0101.11.2014
End 2018-12-3131.12.2018
Projektdetails
hypoplastic left heart syndrome, DNA methylation, whole exome sequencing, zebrafish
Hypoplastic left heart syndrome (HLHS) displays one of the most severe cardiac malformations that encompasses a spectrum of structural defects characterized by atresia or stenosis of the aortic and mitral valve, as well as a hypoplasia of the left ventricle and aorta. In order to analyze genetic and transcriptomic changes potentially involved in the pathogenesis of HLHS, whole exome sequencing and RNA sequencing is performed on heart tissue samples from independent cases. To evaluate epigenetic alterations, DNA methylation profiles are being analyzed. Identified candidate genes are characterized using zebrafish model organism and furthermore, patient-specific inducible pluripotent stem cells are analyzed to provide a contribution for a better understanding of the etiology of HLHS.

Minimally invasive valve resection and replacement: polycarbonateurethane valved stent implantation
ID 81Z2700203
Institution Universitätsklinikum Schleswig-Holstein
Project leader Georg Lutter
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic stem cells/cardiac regeneration
Funding 280000.00€ 280.000,00
Begin 2014-11-0101.11.2014
End 2018-12-3131.12.2018
Projektdetails
tissue engineering, endothelial progenitor cells, cell seeding, polymeric scaffolds
Tissue engineering is an upcoming technique for heart valve replacement, providing a living valve, capable of growth and biological integration. Heart valves made of synthetic polymers such as polyurethanes exhibit biocompatibility, bioresorbability and excellent mechanical properties with high durability. Endothelial progenitor cells (EPCs) are ideal candidates for vascular regenerative therapy, as they participate in blood vessel formation and incorporate into damaged vascular structure. In this project, the optimal conditions for administration of EPCs on polymeric scaffolds will be improved. Functionality, biocompatibility, inflammatory capacity and biological integrity of these engineered valved stents will be analysed in vivo (sheep model) for human cardiovascular application.

Cardiac tissue engineering
ID 81Z2710101
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic stem cells/cardiac regeneration
Funding 1556334.48€ 1.556.334,48
Begin 2014-10-2929.10.2014
End 2019-02-2828.02.2019
Projektdetails
Engineered heart tissue, guinea pig kryo injury model, cardiac repair
The project aims to unravel mechanisms of human engineered heart tissue (EHT) mediated cardiac repair. The project is based on a guinea pig kryo injury EHT transplant model and addresses coupling, EHT morphology after tranplantation, cardiomyocyte proliferation among others.

Hypertrophic cardiomyopathy: from gene identification to individualized therapy
ID 81Z2710102
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Lucie Carrier
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 692627.97€ 692.627,97
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
Cardiomyopathy, Hypertrophy, iPSC, CRISPR/Cas9, disease modeling
Goals of this project are : i) to search for mutations in patients with HCM and to evaluate the molecular pathways in several human samples (blood, septal myectomies, skin biopsy); ii) to model HCM in the dish in both 2D culture of cardiac myocytes and 3D engineered heart tissues (EHT) obtained from iPSC-derived from HCM patients’ skin biopsy. Evaluation of contractile function and electrophysiological properties. iii) to evaluate different molecular therapies in human cardiac myocytes and EHT. Therefore, we also plan to use the CRISPR-Cas9 technology to remove the mutation in iPSC, which will be then used as controls for disease phenotype and molecular therapy.

Reverse cardiac remodeling
ID 81Z2710103
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Heimo Ehmke
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic cardiomyocyte function
Funding 307489.08€ 307.489,08
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
acute mechanical unloading, Ca2+ cycling, phospholamban, Ca2+ channel, cardiac arrhythmias, SERCA2, heart transplantation
Cardiac mechanical unloading is associated with an increased risk of ventricular arrhythmias. Underlying pathophysiological mechanisms are still poorly understood. Recent studies indicate that unloading causes a remodeling of Ca2+ homeostasis in ventricular cardiomyocytes leading to a reduced contribution of sarcoplasmic reticulum (SR) Ca2+ release to the systolic Ca2+ transient. Using pharmacological and genetic interventions in a rodent model of cardiac unloading, this project tests the hypothesis that reestablishing the dominance of SR Ca2+ release will stabilize cardiac repolarization and therefore reduce the occurrence of arrhythmias.

Inflammation in atrial fibrillation
ID 81Z2710104
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Stephan Willems
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic other arrhythmias
Funding 386990.40€ 386.990,40
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
arrythmias, atrial fibrillation, Hypertension, Left ventricular hypertrophy, cardiac nervous system
The development of cardiac fibrosis and a higher susceptibility of atrial fibrillation (AF) have been shown in an animal model of long-term hypertension. However, the causal relationship between hypertension, fibrosis and AF remains unclear. Using Angiotensin II, we have established a long-term hypertension model in sheep in order to elucidate structural and electrophysiological changes as a prerequisite for AF. Since the intrinsic cardiac nervous system (ICANS) is known affect AF and other arrhythmias and might present a potential target for catheter-based interventions, we additionally characterise the role of the ICANS in arrhythmias using our sheep model.

Immunobiology of pluripotent stem cells
ID 81Z2710105
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Sonja Schrepfer
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic stem cells/cardiac regeneration
Funding 320582.89€ 320.582,89
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
cardiac regeneration; islet cell regeneration; regenerative medicine; immunobiology of pluripotent stem cells; stem cell rejection
Due to ethical concerns, the derivation of induced pluripotent stem (iPS) cells seems to be a novel, promising tool. However, the generation, validation, differentiation and puri-fication of iPS cells takes weeks to months and therefore, patient-specific iPS cells will not be readily available for acute diseases such as myocardial infarction or stroke. For this purpose, off-the-shelf cell products (e.g., iPS cell-derived cardiac and neuronal cells) will be required to be administered in a timely fashion. These cells, however, would not be patient-specific, but allogeneic. Since systemic immunosuppression for iPS cell recipients is not justifiable and feasible for cell therapy, we are aiming to understand their immune rejection and subsequent generate hypo-immunogenic cells that allow universal allogeneic transplantation without inducing immune activation, thereby evading rejection.

Oxidative post-translational modifications in cardiovascular disease
ID 81Z2710106
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Friederike Cuello
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic cardiomyocyte function
Funding 340241.71€ 340.241,71
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
Signalling pathways in cardiovascular disease, Protein kinase, Redox regulation
The group‘s research aims to increase the understanding of the molecular mechanisms of heart failure. In particular, we study how signals from the sympathetic nervous system are transduced into the cardiac myocyte, which processes are subsequently triggered and what molecular alterations occur during heart failure development. Over the past years, we have concentrated our attention on the redox-regulation of protein kinase signalling and the effect on posttranslational regulation of kinases and their substrates. Through this, we have recently established disease-specific posttranslational fingerprints of the myofilament proteome in human heart failure tissue by combining interdisciplinary techniques such as molecular biology and redox-proteomics analyses.

Molecular mechanisms of HF
ID 81Z2710107
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 292596.06€ 292.596,06
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
Heart failure, extracellular matrix, inflammation
Our goal is to describe molecular mechanisms involved in heart failure pathology. Therefore, our research is focused on the extracellular matrix remodelling and the regulation of cardiac inflammation in different types of heart failure. Different animal models were used to induce heart failure. Furthermore, we combine in vivo animal models with in vitro cell culture experiments as well as the analysis of human samples to describe molecular mechanisms involved in heart failure pathology. Special focus will be on cardiac remodeling and changes in the extracellular matrix.

Modulation of cAMP microdomains to treat heart failure
ID 81Z2710108
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Viacheslav Nikolaev
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 491801.84€ 491.801,84
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
cAMP, microdomains, hypertrophy, beta-blocker, AAV, genetherapy
The ubiquitous second messenger cAMP plays central roles in the regulation of cardiac function and diseases such as hypertrophy and heart failure. Especially the stimulation of cardiomyocyte ?-adrenoceptors leads to strong contractile response and disease progression, while other membrane receptors coupled to the stimulatory G-protein (Gs) play less prominent role. Beta-blockers are therefore central to the therapy but lead to non-cardiac side-effects which limit patient compliance. This project will test the hypothesis that cardiomyocyte-specific delivery of a dominant negative Gs mutant should provide beneficial antihypertrophic effect without systemic side-effects. This mutant will be studied in mouse diseased models and introduced into AAV for gene therapy studies.

Systolic and diastolic heart failure - Collagen regulation
ID 81Z3100231
Institution Charité - Universitätsmedizin Berlin
Project leader Carsten Tschöpe
Site Berlin
Project type Partner Site Projects
Topic Inflammatory heart diseases
Funding 397144.32€ 397.144,32
Begin 2014-01-0101.01.2014
End 2018-12-3131.12.2018
Projektdetails
collagen, LoxL-2
Left ventricular stiffness and diastolic dysfunction are besides a raise in collagen/matrix also due to an increased crosslinking of the matrix. Lysyloxidases (LOX) are a family of extracellular matrix crosslinking enzymes and critical contributors to the development of cardiac fibrosis. Besides LOX1, particularly LOX-like (LOXL)-2 is an important target since inhibition of LOXL2 has been shown to result in a marked reduction in activated fibroblasts (myofibroblasts), decreased production of cytokines, and decreased TGF-? pathway signaling. Furthermore, higher serum LOXL2 levels have been shown to be associated with increased risk for idiopatic pulmonary fibrosis disease progression. Importantly, LOXL2 is besides the heart expressed in the spleen and the thymus. Given the importance of the cardiosplenic axis in heart failure, linking inflammation with cardiac fibrosis on the one hand, and the expression of LOXL2 in the spleen/thymus and their antifibrotic features on the other hand, a role of LOXL2 in the inflammation and fibrosis process in heart failure is suggested. This project is focused at evaluating the role of LOXL2 in heart failure with preserved ejection fraction (HFpEF). Therefore, cardiac expression of LOXL2 will be evaluated in HFpEF and heart failure with reduced ejection fraction (HFrEF) patients and the effect of LOXL2 on TGF-ß signaling in cardiac fibroblasts from HFpEF and HFrEF patients analyzed. There will be evaluated whether serum LOXL2 levels are a predictive biomarker for cardiac LOXL2 expression and HFpEF, and whether LOXL2 inhibition may abrograte the progression of cardiac fibrosis.

Systolic heart failure and diastolic heart failure
ID 81Z3100331
Institution Deutsches Herzzentrum Berlin
Project leader Volkmar Falk
Site Berlin
Project type Partner Site Projects
Funding 2194941.80€ 2.194.941,80
Begin 2011-10-0101.10.2011
End 2020-12-3131.12.2020
Projektdetails

Mechanisms of heart failure in congenital heart disease
ID 81Z3100333
Institution Deutsches Herzzentrum Berlin
Project leader Felix Berger
Site Berlin
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 681214.79€ 681.214,79
Begin 2013-01-0101.01.2013
End 2018-12-3131.12.2018
Projektdetails
cardiomyopathy, heart failure, MRI, genetic analysis, disease mechanisms
Pediatric cardiomyopathies are genetically heterogeneous and information on the epidemiology and outcomes of cardiomyopathy in children is limited by disease diversity and small case series. In order to specifically identify patients that would profit from early intervention such as an implantable cardioverter defibrillator (ICD) or specific pharmacologic treatment for heart failure we study individuals <= 18 years and their first-degree relatives with the following phenotypes: Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Left ventricular noncompaction cardiomyopathy (LVNC), and Arrhythmogenic right ventricular cardiomyopathy (ARVC). Detailed phenotyping including MRI and genotyping with a Next Generation Sequencing Panel of 170 candidate genes is performed.

Herzinsuffizienz - Transition GOE MD 1 UMG
ID 81Z3300131
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stefan Anker
Site Göttingen
Project type Partner Site Projects
Funding 2448242.69€ 2.448.242,69
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails

Herzinsuffizienz - Regeneration
ID 81Z3300132
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Partner Site Projects
Funding 1255543.47€ 1.255.543,47
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails

Herzinsuffizienz – Regeneration
ID 81Z3300232
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rüdiger Behr
Site Göttingen
Project type Partner Site Projects
Funding 1629344.24€ 1.629.344,24
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails

Risk factor patterns associated with systolic and diastolic left ventricular dysfunction
ID 81Z3400131
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Partner Site Projects
Topic cardiomyocyte function
Funding 1475849.35€ 1.475.849,35
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails
heart failure, HFrEF, HFpEF, risk profiles biomarker, animal models, TAC, cell culture
The aim of this project is to identify risk profiles which are associated with the development of systolic and diastolic left ventricular dysfunction (HFrEF/ HFpEF). Based on populations-based data new knowledge should be generated regarding the general population. Furthermore patient cohorts (GANI_MED) in an early asymptomatic disease stage shall be investigated to identify factors and mechanisms which indicate or lead to the transition to symptomatic heart failure. Generated hypotheses will be validated and further investigated by cell and animal model based experimental approaches. The major aim is to identify new targets and mechanisms that can be tackled in new prevention and therapeutic approaches in early stages of heart failure to inhibit disease progression.

Myocardial RNA Therapy
ID 81Z3600431
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Partner Site Projects
Topic DNA/RNA based, protein based therapy
Funding 2107648.12€ 2.107.648,12
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
miRNA-based therapy, microRNA, AntagomiR, anti-miR, AAV
This project aims to develop RNA-based therapeutics that interfere with myocardial damage. For this purpose several cardiovascular microRNAs have been identified and functionally characterized with regard to their capacity to regulate key cellular signaling pathways. A subset of these miRNAs are being validated in mouse models of disease and approaches for their therapeutic manipulation are being developed. This involves studies that aim to optimize the pharmacokinetics and pharmacodynamics of miRNA inhibitor molecules.

Arrhythmia Modelling
ID 81Z4300141
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Partner Site Projects
Funding 1445283.03€ 1.445.283,03
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Arrhythmia Modelling
ID 81Z4300441
Institution Max-Planck-Institut für Dynamik und Selbstorganisation
Project leader Stefan Luther
Site Göttingen
Project type Partner Site Projects
Funding 1582022.06€ 1.582.022,06
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Early Clinical Trials with Focus Arrhythmia
ID 81Z4600241
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site München
Project type Partner Site Projects
Funding 632804.55€ 632.804,55
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails

Metabolic mechanisms of cardiovascular disease and the German Prevention Study
ID 81Z5100251
Institution Charité - Universitätsmedizin Berlin
Project leader Joachim Spranger
Site Berlin
Project type Partner Site Projects
Topic arteriosclerosis
Funding 1206113.23€ 1.206.113,23
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails
Metabolism, brain-heart axis, diabetes, NAFLD, prevention
We aim to identify novel and further elucidate known endogenous metabolic modifiers of cardiovascular health. We analyze the interrelation between environment, novel metabolic targets and CVD in relation to age and pre-existing CVD to finally translate those findings into preventive practice. We use established mouse models of metabolic disease (obesity, insulin resistance, NAFLD) and analyse the role of specific molecular targets in rodents. We particularly test selected interventional strategies (incl. pharmacology). This is combined with clinical studies in cohorts with impaired metabolism and increased cardiovascular risk (e.g. obesity, diabetes, insulin resistance)

Nutritional Pharmacology
ID 81Z5100254
Institution Charité - Universitätsmedizin Berlin
Project leader Ulrich Kintscher
Site Berlin
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 554977.80€ 554.977,80
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
lipids, metabolism, heart failure
This study aims to investigate the preventive actions of new lipid mediators on myocardial hypertrophy and heart failure. We could recently show that palmitoleic acid (C16:1n7) promotes the development of physiological cardiac remodeling (Foryst-Ludwig A, J Biol Chem 2015). In continuation of this, we are now focusing on new ?-3 fatty acids. We will test the anti-hypertrophic/ anti-fibrotic potential of anti-inflammatory lipid mediators such as resolvins, protectins und maresins in different disease models such as TAC or isoprenalin injection.

Psychosoziale und Verhaltens-Interventionen
ID 81Z5300151
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Christoph Herrmann-Lingen
Site Göttingen
Project type Partner Site Projects
Funding 474744.45€ 474.744,45
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Establishment of a Cardiovascular Examination Centre
ID 81Z5400151
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Partner Site Projects
Topic Inflammatory heart diseases
Funding 2430579.10€ 2.430.579,10
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
deep phenotyping, standarized phenotyping, examination centre, exercise training centre
This project aims to create a new infrastructure for conducting clinical trials by establishing a cardiovascular examination and training centre. This centre will carry out the standardized and quality controlled phenotyping of probands and patients. This includes algorithms for standardized data export and analysis. Methods for phenotyping include: standardized interviews and questionnaires, anthropometry, digital ECG, echocardiography, resting and 24 h blood pressure measurement, bodyplethysmography, spiroergometry, IMT measurements, peripheral endothelial function (FMD, EndoPAT), ankle-brachial-index measurements, pulse wave measurements (Vascular Explorer). Furthermore, training facilities will be established for conductiong cardiovascular prevention studies with life-style intervention programmes e.g. exercise.

Development of individualized intervention tools for primary prevention programmes
ID 81Z5400152
Institution Universitätsmedizin Greifswald
Project leader Ulrich John
Site Greifswald
Project type Partner Site Projects
Topic Inflammatory heart diseases
Funding 1344543.01€ 1.344.543,01
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
expert feedback systems, behavioural changes, primary prevention, physical activity, motivation, adherence life-style changes
The aim of this project is to investigate how to reach relevant patient groups for primary prevention of cardiovascular diseases. Furthermore, automated intervention tools and feedback systems shall be developed which can be easily used in CVD prevention studies to increase motivation and adherence to life-style changes. Additionally, pilot studies and RCTs will be conducted to reduce sedentary behaviour as one major cardiovascular risk factor and to increase daily physical activity. A W2 professorship will be established to provide profound knowledge for prevention and behavioural change approaches e.g. exercise training and to support the other partner side projects especially those dealing with heart failure and coronary heart disease.

Individualized Tools for Life style Intervention in Patients with Chronic Heart Failure [Secondary Prevention]
ID 81Z5400153
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Partner Site Projects
Topic Inflammatory heart diseases
Funding 1317560.22€ 1.317.560,22
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails
exercise training, secondary prevention, biomarker profiles, heart failure, molecular cardiology
This projects aims to develop new life-style intervention approaches for secondary prevention of heart failure (HFrEF/HFpEF) and coronary heart disease. Pilotstudies will investigate the effects of life-style changes mainly exercise training on cardiovascular surrogate parameters and disease progression. Additionally, intervention-related biomarkers shall be investigated using transcriptomics, proteomics and metabolomics (urine, plasma, whole blood) which can be used as monitoring factors during intervention or as predictive factors for disease progression. The major aim is to find suitable surrogate paramters which can be easily implemented into large prevention RCTs and can be used to amplify the positive effects of life-style changes by increasing motivation and therapy complience and adherence. A W2 professorship for molecular cardiology will be established to support the investigation of prevention approaches and to interact with and support the other partner site projects.

Cardiovascular Population Studies
ID 81Z5600151
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Annette Peters
Site München
Project type Partner Site Projects
Topic arteriosclerosis
Funding 895595.21€ 895.595,21
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
changes in cardiovascular risk factors, epigenetics, environmental factors, system biology
The aim of the DZHK project Cardiovascular Population Studies (MHA 5.1) is to identify novel risk factors to improve individual risk prediction. The last years showed that especially epigenetics and metabolic processes have great potential to elicit so far unknown pathomechanisms. The focus is on short-term triggers of myocardial infarction as well as long-term risk factors that influence arteriosclerosis. A junior research group was established to integrate life-style factors, environmental factors, epigenetic markers and blood biomarkers from the KORA study. Their relative impact are investigated using innovative methods. All data is available via KORA.PASST. Tasks: 1. Risk factors for coronary heart disease – which changes occurred in the last 30 years? 2. OMICs and novel methods from system medicine to investigate the etiology of coronary heart disease. 3. Environmental factors and coronary heart disease.

Zelluläre Netzwerke bei kardiovaskulären Erkrankungen
ID 81Z5600153
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Partner Site Projects
Funding 621714.66€ 621.714,66
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails

Clinical genomics, risk prediction
ID 81Z5600551
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 882711.61€ 882.711,61
Begin 2013-01-0101.01.2013
End 2018-12-3131.12.2018
Projektdetails
coronary artery disease, myocardial infarction, networks, pathway analysis, risk prediction
Our group has substantially contributed to the discovery of numerous genomic variants, which increase the risk of coronary artery disease. Based on these variants, we were able to evaluate the prospective value of a genetic risk score in a large sample set. Using novel bioinformatics techniques, we identified novel networks and pathways influencing the pathophysiology of coronary artery disease and myocardial infarction. The goal of the project “Clinical genomics, risk prediction“ is to explore the interaction of known and yet to be identified coronary artery disease risk loci as well as the interaction of coronary artery disease risk loci with environmental factors to ultimately improve risk prediction.

Development of novel methodology and technology for cardiovascular MR
ID 81Z6100161
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Thoralf Niendorf
Site Berlin
Project type Partner Site Projects
Topic imaging
Funding 261522.15€ 261.522,15
Begin 2014-01-0101.01.2014
End 2018-12-3131.12.2018
Projektdetails
ultrhahigh field MRI, human studies
This project builds on the achievements of our previous GCCR project. It focuses on the development of enabling radiofrequency (RF) antenna technology tailored for high spatial resolution cardiac magnetic resonance imaging (MRI) at a magnetic field strength of 7.0 Tesla. To meet this objective multi-channel transmission RF antenna arrays will be designed. For this purpose novel dipole antenna building blocks will be developed, implemented and validated. The clinical feasibility of the novel technology will be evaluated in a volunteer study at 7.0 Tesla with the ultimate goal to enable sub-millimeter spatial resolution cardiac MR imaging that supports visualization of subtle cardiac anatomy, high fidelity cardiac chamber quantification and imaging based myocardial tissue characterization.

Noninvasive characterization of myocardial tissue
ID 81Z6100162
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Thoralf Niendorf
Site Berlin
Project type Partner Site Projects
Topic imaging
Funding 188439.49€ 188.439,49
Begin 2014-01-0101.01.2014
End 2018-12-3131.12.2018
Projektdetails
CMR imaging, experimental and human studies
CMR has the capability to differentiate myocardial injury applying different techniques. There are increasing numbers of quantitative approaches but an integrative quantitative covering various pathologies is missing. A a non-rigid registration method to superimpose focal images and diffuse fibrosis imaging allowing for pixel-wise comparison could already be developed. Further efforts are focusing on the integration of other pathologies in fused images. The project is based on theoretical phantoms, in vitro phantoms leading to human studies.

Clinical imaging
ID 81Z6200161
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Eike Nagel
Site RheinMain
Project type Partner Site Projects
Topic imaging
Funding 2765542.01€ 2.765.542,01
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
magnetic resonance, computed tomography, myocardial ischaemia, heart failure, inflammation, fibrosis
The Imaging Project at the University Hospital Frankfurt (Rhein-Main) is represented by a DZHK-Professor for Cardiovascular Imaging and equipped with a state-of-the art 3T MR scanner dedicated for cardiovascular research since May 2016. In October 2016 a state-of-the art CT scanner dedicated for cardiovascular research will be installed. The projects focus on the main areas of cardiovascular disease, such as ischaemia, inflammation, fibrosis and heart failure as well as the prediction and substrate for arrhythmia. Novel diagnostic strategies (such as real time imaging, fully quantitative perfusion imaging and tissue characterisation) are developed, validated for accuracy, reproducibility, transferability, outcome and reversibility the effects of therapeutic interventions are assessed.

Echtzeit MRI
ID 81Z6300161
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Joachim Lotz
Site Göttingen
Project type Partner Site Projects
Funding 1101795.14€ 1.101.795,14
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Nanopathologie
ID 81Z6300162
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Partner Site Projects
Funding 712655.25€ 712.655,25
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Echtzeit-MRT
ID 81Z6300561
Institution Max-Planck-Institut für Biophysikalische Chemie
Project leader Jens Frahm
Site Göttingen
Project type Partner Site Projects
Funding 605859.47€ 605.859,47
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Live-Nanopathology
ID 81Z6300562
Institution Max-Planck-Institut für Biophysikalische Chemie
Project leader Stefan W. Hell
Site Göttingen
Project type Partner Site Projects
Funding 822288.33€ 822.288,33
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Biomarker Imaging
ID 81Z6600262
Institution Klinikum der Universität München
Project leader Reiser
Site München
Project type Partner Site Projects
Topic imaging
Funding 655059.11€ 655.059,11
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
MRI, CT, 4D-flow MRI, T1-mapping, large vessel vasculitis, 3D-Blackblood, OSAS, TAVI
Biomarker Imaging develops diagnostic, prognostic and predictive CT and MRI biomarkers for heart disease and establishes them in clinical routine. This includes: • Validation and standardization of recording and evaluation techniques of 4D flow MRI in children • Characterization of diffuse myocardial fibrosis in hereditary cardiomyopathy using pre- and post-contrast T1-mapping • Contrast dose optimization in CT angiography for determining the size of the aortic annulus before TAVI • Evaluation of non-invasive imaging methods without radiation exposure for primary diagnostic imaging and assessment of large vessel vasculitis • Evaluation of the effect of obstructive sleep apnea syndrome (OSAS) on cardiac function as determined by MRI

Multimodal Cardiovascular Imaging
ID 81Z6600661
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Markus Schwaiger
Site München
Project type Partner Site Projects
Topic imaging
Funding 392617.58€ 392.617,58
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
imaging atherosclerotic plaques, macrophage infiltration, Tilmanocept plaque inflammation, tracer development, CXCR4, Ga-68-pentixafor, acute myocardial infarction, post-ischemic inflammation, FDG-PET/MRI
The aim of this project is to develop multimodal imaging strategies with a focus on inflammatory processes in atherosclerosis and in the sub-acute phase after myocardial infarction. For this purpose tracers targeting inflammatory processes (such as activated macrophages) are being developed. One such example is the tracer “Tilmanocept” which binds specifically to mannose-receptors on the surface of macrophages. “Tilmanocept” has originally been developed to image sentinel lymph nodes and was therefore labeled with radionuclides ideal for conventional gamma cameras. In our research group “Tilmanocept” is being modified so that positron emitting radionuclides, particularly Gallium-68, can be attached to “Tilmanocept”. Furthermore, the structure of “Tilmanocept” is being adapted to improve the affinity and biodistribution of this tracer. First biodistribution data in Apo-E-mice demonstrated an increased uptake in atherosclerotic plaques. Another focus of our research is the evaluation of Ga-68-pentixafor – a PET-tracer binding with nanomolar affinity to the chemokine receptor 4 (CXCR4). CXCR4 is known to be overexpressed on activated, hypoxic macrophages – therefor CXCR4 seems to be a very promising target to image inflammatory processes in atherosclerosis. In a rabbit model of atherosclerosis this approach has already been evaluated. New Zealand White rabbits fed with a high cholesterol diet received an endothelial abrasion of the right carotid artery and of the abdominal aorta to induce atherosclerotic plaque formation. Studies were performed using Ga-68-pentixafor (for imaging studies) and I-125-pentixafor (for biodistribution studies). We were able to demonstrate that tracer uptake was increased in atherosclerotic lesions and could be blocked efficiently by AMD3100 – a CXCR4-inhibitor. CXCR4-immunohistochemistry staining showed a high correlation with tracer uptake in autoradiography. These results are the basis for a DZHK-funded project with the aim to evaluate Ga-68-pentixafor in humans with carotid plaques in comparison to F-18-FDG. Besides these experiments to study inflammatory processes in atherosclerotic plaques, a large number of clinical studies to investigate the post-ischemic inflammatory response after myocardial infarction have been conducted. Patients were imaged in the first few days after myocardial infarction on an integrated PET/MR scanner using F-18-FDG as radiotracer. Patients had to fast for >12 hours and received heparin before tracer injection in order to suppress physiological F-18 FDG uptake in remote myocardium. The area of F-18 FDG uptake showed a high correlation with the area at risk and was significantly larger than the infarcted area (the latter was determined by late gadolinium enhancement MRI). Interestingly, the intensity of F-18 FDG uptake – as a measure of post-ischemic inflammation – correlated inversely with left ventricular function after 6 months, i.e. the higher the inflammatory signal the more likely an increase in endsystolic/end-diastolic volume and a decrease in ejection fraction was observed. While preclinical rodent studies clearly suggest that the F-18 FDG uptake reflects the invasion of inflammatory cells into the post-ischemic myocardium, no large animal study has proven this hypothesis. That is the reason why our group initiated first large animal studies with the aim to further breakdown this novel biosignal.

Establishment DZHK Core Facility
ID 81Z7100201
Institution Charité - Universitätsmedizin Berlin
Project leader Vera Regitz-Zagrosek
Site Berlin
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 407195.97€ 407.195,97
Begin 2014-08-0101.08.2014
End 2018-12-3131.12.2018
Projektdetails
mouse models, echocardiography (mice, rats), training
Establishment of DZHK-core facility for imaging, telemetric and metabolic measurements of rodents

Experimental Core Facility
ID 81Z7200101
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Ralf Brandes
Site RheinMain
Project type Partner Site Projects
Topic Mechanisms in ischemia/reperfusion
Funding 1129114.89€ 1.129.114,89
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
mouse imaging, mouse Phenotyping
The core facility provides a platform for animal phenotyping within the DZHK. SOPs for angiogenesis assays, animal imaging, myocardial infarct models are provided and novel Assays are developed such as virtual histology and xenograph angiogenesis models.

IT: Novel statistical tools (FFM I.5)
ID 81Z7200175
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Project leader Eva Herrmann
Site RheinMain
Project type Partner Site Projects
Funding 104966.38€ 104.966,38
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails
biostatistics, mathematical modelling, survival analysis, sample size calculation
The aim of this project is the development of new statistical tools, especially in form of easy to use R package with a graphical user interface. These tools should especially comprise sample size calculation tools, survival analysis tools and graphical illustrations of the analysis of longitudinal data which directly refer to needs of basic science and clinical projects in the DZHK. These packages will be available under the GNU licence for open software products.

Proteomics
ID 81Z7200301
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Thomas Braun
Site RheinMain
Project type Partner Site Projects
Funding 1943239.54€ 1.943.239,54
Begin 2015-01-0101.01.2015
End 2018-12-3131.12.2018
Projektdetails
cardiovascular research, mass spectrometry-based proteomics, protein quantification, post-translational modificationv
Biomolecular mass spectrometry facility in Bad Nauheim provides service in state-of-the-art liquid chromatography and tandem mass spectrometry for all members of the DZHK. Cardiovascular diseases are multicausal and result from altered cellular processes. Therefore, changes within the proteome or incorrect signaling pathways need to be characterized to understand the molecular mechanisms of heart failure. Our facility enables proteomic approaches to identify and quantify protein expression, post-translational modifications and protein-protein interactions. Furthermore, we aim for establishing new methods to optimize proteomics for cardiovascular research.

Experimentelle Stammzellbank
ID 81Z7300171
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Partner Site Projects
Funding 2090025.26€ 2.090.025,26
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails

Informations-und Datenmanagement
ID 81Z7300173
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Partner Site Projects
Funding 578972.98€ 578.972,98
Begin 2012-01-0101.01.2012
End 2018-12-3131.12.2018
Projektdetails

Metabolomics
ID 81Z7400171
Institution Universitätsmedizin Greifswald
Project leader Matthias Nauck
Site Greifswald
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 832828.34€ 832.828,34
Begin 2013-01-0101.01.2013
End 2018-12-3131.12.2018
Projektdetails
metabolomics, metabolic profiles, risk stratification, molecular intervention monitoring
Changes in individual metabolic profiles can give hints on subcliinical deseases and might be a source for the discovery of new biomarkers. Furthermore, metabolic profiles can provide information on specific food consumption habits or environmental exposures. Therefore, measurements of metabolic profiles are the basis for individualized diagnostics and therapy in patients. NMR and mass pectroscopy provide deep insights into metabolom changes in urine or blood plasma samples. The major aim of this project is to provide a platform for investigating metabolic changes due to prevention measure in cardiovascular diseases and to generate new hypotheses for the investigation and development of new diagnostic and theraputic approaches. Data from population-based studies like SHIP or Inter99 will complement these investigations by comparing patient cohorts to the general population. Furthermore, metabolic profiles that can be used as intervention (e.g. exercise training) monitoring tools will be investigated. Finally, a comprehensive data analysis of transcriptome, proteome and metabolome data will be carried out for risk stratification and therapeutic prognosis in DCM and heart failure.

Proteomics
ID 81Z7400172
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 1427830.24€ 1.427.830,24
Begin 2013-01-0101.01.2013
End 2018-12-3131.12.2018
Projektdetails
proteomics, transcriptomics, integrated data analysis, risk stratification, molecular intervention monitoring
The identification of new biomarkers from easily obtainable biomaterials like blood or urine is a key in individualized approaches for diagnostics and therapy. Proteomics provides promising approaches that are ivestigated worldwide for many different diseases. The major aim of this project is analyse unique population-based cohorts in Greifswald which can be used as control groups for investigations in patients. Furthermore, proteomics shall provide characterictic proteome profiles for primary and secondary prevention approaches of cardiovascular diseases that can be used for intervention monitoring or as prognostic factors. Complementary transcriptome analyses to baseline and during the intervention (follow-up) will be done and a comprehensive data analysis of transcriptome, proteome and metabolome data will be carried out for risk stratification and therapeutic prognosis in DCM and heart failure.

Biobanking
ID 81Z7400173
Institution Universitätsmedizin Greifswald
Project leader Matthias Nauck
Site Greifswald
Project type Partner Site Projects
Topic genetics of cardiovascular diseases
Funding 512493.38€ 512.493,38
Begin 2014-01-0101.01.2014
End 2018-12-3131.12.2018
Projektdetails
biobanking, clinical chemistry, biomarker, integrated molecular approaches
This project provides the platform for longtime storage of biomaterials (blood, urine, DNA) for investigations regarding the discovery of new biomarkers or biomarker profiles with genomic, transcriptomic, proteomic and metabolomic approaches. A fully automated biobank will be used for storage of biomaterials at -80°C. Furthermore, this project provides standardized and quality controlled workflows for obtaining and processing of biomaterials. Finally, all laboratory diagnostic measurements will be carried in this project as interface to the other partner site projects.

Integrated Data Management and Telemedical Monitoring
ID 81Z7400174
Institution Universitätsmedizin Greifswald
Project leader Wolfgang Hoffmann
Site Greifswald
Project type Partner Site Projects
Topic Health services/health systems research
Funding 477719.96€ 477.719,96
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
telemedicine, telemonitoring, IT systems, integrated data management, quality assurance
This project supports the investigation of primary and secondary prevention approaches. The major aim of this project is to develop an integrated IT system for documentation, quality assurance, and data storage and provision for population-based field studies and clinical trials regarding cardiovascular disease prevention. Telemedical approaches like monitoring of physical activity and personalized feedback systems will also be investigated.

Sequenzierplattform: Resources for deep-sequencing/genomics
ID 81Z7600173
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Partner Site Projects
Funding 885175.24€ 885.175,24
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails

Phenotyping Mouse Models
ID 81Z7600174
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Martin Hrabé de Angelis
Site München
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 212627.90€ 212.627,90
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
phenoytping, mouse models, echocardiography, electrocardiography, cardiovascular screening
Engineered mouse models are essential tools for cardiovascular research because they facilitate studies of the phenotypic consequences of genetic alterations in a large-scale fashion. We established a cardiovascular screen to investigate such mouse models. We aimed at establishing non-invasive echocardiography of the left and right ventricle, Doppler echocardiography and electrocardiography in awake mice. Our protocol allows the diagnosis of biventricular cardiac pathologies and to study symptom occurrence and disease progression non-invasively in high throughput. Many new cardiac phenotypes have been successfully identified in mice.

Large Animal Models
ID 81Z7600274
Institution Klinikum der Universität München
Project leader Christian Kupatt
Site München
Project type Partner Site Projects
Topic cardiac hypertrophy/remodeling
Funding 464116.00€ 464.116,00
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
Large animal, pig, acute myocardial ischemia, chronic myocardial ischemia, cardiovascular risk factors
The Large Animal platform offers preclinical models of acute or chronic myocardial ischemia (including cardiovascular risk factors) as well as hypertensive / hypertrophic heart failure in pigs. Besides an ischemia-reperfusion model (60-120min occlusion of a coronary artery, up to 8 weeks follow-up) a model of hibernating myocardium (reducing stent gradual coronary occlusion, loss of function in the target area) and a model of hypertrophic heart failure (percutaneous aortic constriction) is available. These models allow for patient care techniques, instrumentation and catheterization. Therapeutic agents (drugs, viral vectors, microRNA inhibitors and cell therapy) can be tested in systemic or regional (intravascular/intra-myocardial) applications. Besides morphological changes, global and regional myocardial function, myocardial perfusion, inflammation and vascular changes can be analyzed.

Platform Reprogramming
ID 81Z7600671
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Laugwitz/Moretti
Site München
Project type Partner Site Projects
Topic iPSC
Funding 707459.52€ 707.459,52
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
induced pluripotent stem cells, disease modelling, drug/intervention testing
The focus of this project is the generation of patient-specific models of monogenic and complex cardiovascular diseases using induced pluripotent stem cells (iPSCs) in order to study the molecular pathways that drive the disease and screen for both genes and drugs that can block the disease onset or progression at a cellular level. We work on optimization of reprogramming methods and differentiation protocols into the cardiovascular lineages as well as the development of high-throughput functional assays and CRISPR/Cas9-based genome editing in iPSCs.

Platform Biomedical Informatics
ID 81Z7600672
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Klaus Kuhn
Site München
Project type Partner Site Projects
Topic Health services/health systems research
Funding 143336.45€ 143.336,45
Begin 2011-10-1515.10.2011
End 2018-12-3131.12.2018
Projektdetails
information technology, data integration, biobanking
This project has focused on supporting the integration of databases of the Munich Heart Alliance in order to improve shared access to data. Specific aspects are management of biobank data, integration of data into registers, secondary use of clinical data for research questions, and security/privacy issues in compliance with TMF concepts. Existing software modules have been further developed, and an open source solution will be established.

CVRC Echo Core Facility
ID 81Z7710101
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Topic imaging
Funding 243335.92€ 243.335,92
Begin 2014-10-2929.10.2014
End 2018-12-3131.12.2018
Projektdetails
small animal experimentation, echocardiography, core facility
The CVRC Echo Core Facility at the UKE offers all members of the DZHK access to a Visualsonics Vevo 2100® high frequency ultrasonograph for small animals. Transthoracic echocardiography is performed by trained staff. They provide a strong background in the evaluation of animal models and can help design protocols to answer research questions. Researchers are introduced into the handling of the technique and receive support for their individual scientific projects.

SMART-MI-DZHK9: DZHK-Biobanking
ID 81X1600205
Institution Klinikum der Universität München
Project leader Axel Bauer
Site München
Project type Clinical Studies
Funding 59624.23€ 59.624,23
Begin 2016-02-0101.02.2016
End 2021-07-3131.07.2021
Projektdetails
https://smart-mi.dzhk.de/

SMART-MI-DZHK9: Biometrie
ID 81X1600702
Institution Ludwig-Maximilians-Universität München
Project leader Ulrich Mansmann
Site München
Project type Clinical Studies
Funding 42000.00€ 42.000,00
Begin 2016-05-0101.05.2016
End 2021-07-3131.07.2021
Projektdetails
https://smart-mi.dzhk.de/

FAIR-HF2-DZHK5: Biometrie
ID 81X1300106
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 116018.80€ 116.018,80
Begin 2016-04-0101.04.2016
End 2024-09-3030.09.2024
Projektdetails
https://fair-hf2.dzhk.de/

FAIR-HF2-DZHK5: Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity & mortality
ID 81X1710102
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Mahir Karakas
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 6514115.02€ 6.514.115,02
Begin 2016-05-0101.05.2016
End 2024-09-3030.09.2024
Projektdetails
https://fair-hf2.dzhk.de/

FAIR-HF2-DZHK5: DZHK-Biobanking
ID 81X1710103
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Mahir Karakas
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 37088.48€ 37.088,48
Begin 2016-07-0101.07.2016
End 2024-09-3030.09.2024
Projektdetails
https://fair-hf2.dzhk.de/

IPSC-EHT transplantation for cardiac repair - towards first-in-patient
ID 81X2600702
Institution Ludwig-Maximilians-Universität München
Project leader Eckhard Wolf
Site München
Project type Translational Research Project
Funding 170759.26€ 170.759,26
Begin 2016-10-0101.10.2016
End 2021-11-3030.11.2021
Projektdetails

IPSC-EHT transplantation for cardiac repair - towards first-in-patient
ID 81X2600613
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Translational Research Project
Funding 293688.26€ 293.688,26
Begin 2016-10-0101.10.2016
End 2021-11-3030.11.2021
Projektdetails

IPSC-EHT transplantation for cardiac repair – towards first-in-patient
ID 81X2710146
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Translational Research Project
Funding 1118692.96€ 1.118.692,96
Begin 2016-09-0101.09.2016
End 2021-11-3030.11.2021
Projektdetails
End-stage heart failure patients suffer from high mortality rates and have very limited treatment options. The availability of cardiomyocytes from human induced pluripotent stem cells (hiPSC) opens the possibility of allogeneic transplantation of new heart muscle mass. A recent study gives compelling evidence that transplantation of hiPSC-derived cardiomyocytes in the form of engineered heart tissue (EHT) improves cardiac function in a guinea pig myocardial infarction model. To pave the way for a first clinical trial, two critical issues will be addressed: 1) determination of the minimal effective dose/size in guinea pig and 2) translation to a large animal model (minipig myocardial infarction). Major endpoints are the therapeutic efficacy of small doses/sizes of EHTs in guinea pig myocardial infarction model, survival and growth of EHT in minipig under optimized immunosuppression and therapeutic efficacy in minipig.

Gene therapy for neonatal sacromeric cardiomyopathies: towards first-in-patient.
ID 81X2600413
Institution Technische Universität München
Project leader Angelika Schnieke
Site München
Project type Translational Research Project
Funding 132507.00€ 132.507,00
Begin 2016-10-0101.10.2016
End 2019-12-3131.12.2019
Projektdetails

Gene therapy for neonatal sacromeric cardiomyopathies: towards first-in-patient.
ID 81X2600614
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Translational Research Project
Funding 199110.23€ 199.110,23
Begin 2016-10-0101.10.2016
End 2019-12-3131.12.2019
Projektdetails

Gene therapy for neonatal sacromeric cardiomyopathies: towards first-in-patient.
ID 81X2600703
Institution Ludwig-Maximilians-Universität München
Project leader Eckhard Wolf
Site München
Project type Translational Research Project
Funding 92430.00€ 92.430,00
Begin 2016-10-0101.10.2016
End 2019-12-3131.12.2019
Projektdetails

Gene therapy for neonatal sarcomeric cardiomyopathies: towards first-in-patient
ID 81X2710148
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Lucie Carrier
Site Hamburg/Kiel/Lübeck
Project type Translational Research Project
Funding 19656.12€ 19.656,12
Begin 2016-10-0101.10.2016
End 2019-12-3131.12.2019
Projektdetails
Homozygous or compound heterozygous truncating mutations in MYBPC3 encoding cardiac myosin-binding protein C (cMyBP?C) cause neonatal cardiomyopathy, which rapidly evolves into systolic heart failure and death within the first year of life. We recently provided evidence of longterm disease prevention by Mybpc3 gene therapy in homozygous Mybpc3?targeted knock?in mice, which genetically mimic human neonatal cardiomyopathies. In the absence of alternative treatment options except heart transplantation, gene therapy is a realistic treatment option for this subset of infants with severe and fatal neonatal cardiomyopathy. Our main objective towards clinical application is to reproduce our mouse findings in a larger animal model. Our gene therapy medicinal product is a recombinant adeno?associated virus serotype 9, which contains the human MYBPC3 cDNA under the control of human cardiac troponin T promoter. The project aims at the generation of a pig model of neonatal cardiomyopathy carrying bi?allelic truncating MYBPC3 mutations with the combination of CRISPR/Cas9 RNA?guide nuclease, somatic cell nuclear transfer and embryo transfer. We expect to produce bi?allelic truncating mutations that will result in a severe, fatal neonatal cardiomyopathy in pigs.

Off-pump transapical mitral valved stent implantation
ID 81X2700209
Institution Universitätsklinikum Schleswig-Holstein
Project leader Georg Lutter
Site Hamburg/Kiel/Lübeck
Project type Translational Research Project
Funding 325107.48€ 325.107,48
Begin 2016-01-0101.01.2016
End 2017-12-3131.12.2017
Projektdetails
The aim of this project is to develop and verify a new mitral valved stent, fully adapted to the anatomy of mitral regurgitation of diseased hearts by means of a transapical mitral-valve stent implantation in the beating heart without using a heart-lung machine. Focus of this project will be the evaluation in the mitral regurgitation animal model. The design of the stent is supposed to be further developed for the mitral position, so that a greater match with the natural anatomy is attained with a new oval shape. In addition to the apical fixation, another fixation system shall also be developed. The additional anchorage shall ensure the correct anatomical position of the stent.

GPR32 in arterial myeloid cell recruitment - Koop. mit Externen Partner
ID 81X2600242
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2017-01-0101.01.2017
End 2019-12-3131.12.2019
Projektdetails

GPR32 in arterial myeloid cell recruitment - Koop. mit Externen Partner
ID 81X2800164
Institution Westfälische Wilhelms-Universität Münster
Project leader Alexander Zarbock
Site Extern
Project type Cooperation with External Partners
Funding 11696.07€ 11.696,07
Begin 2017-01-0101.01.2017
End 2019-12-3131.12.2019
Projektdetails

The inflammasome Aim2 links arterial inflammation and lipid metabolism
ID 81X2800156
Institution Technische Universität Dresden
Project leader Triantafyllos Chavakis
Site Extern
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2016-09-0101.09.2016
End 2018-08-3131.08.2018
Projektdetails

The inflammasome Aim2 links arterial inflammation and lipid metabolism
ID 81X2600238
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2016-09-0101.09.2016
End 2018-06-3030.06.2018
Projektdetails

Characterization of HCN-Channels in neural heart rate control
ID 81X2710149
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Christian Meyer
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 13781.69€ 13.781,69
Begin 2016-10-0101.10.2016
End 2019-01-3131.01.2019
Projektdetails

Characterization of HCN-Channels in neural heart rate control
ID 81X2800159
Institution Heinrich-Heine-Universität Düsseldorf
Project leader Nikolaj Klöcker
Site Extern
Project type Cooperation with External Partners
Funding 11711.92€ 11.711,92
Begin 2016-10-0101.10.2016
End 2019-01-3131.01.2019
Projektdetails

Elucidating the role of DENND5B in congenital heart disease -
ID 81X2800168
Institution Universitätsklinikum Ulm
Project leader Michael Kühl
Site Extern
Project type Cooperation with External Partners
Funding 13870.01€ 13.870,01
Begin 2017-02-0101.02.2017
End 2018-01-3131.01.2018
Projektdetails

Elucidating the role of DENND5B in congenital heart disease - Koop. mit Externen Partner
ID 81X2600619
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Karl-Ludwig Laugwitz
Site München
Project type Cooperation with External Partners
Funding 14991.20€ 14.991,20
Begin 2017-01-0101.01.2017
End 2018-01-3131.01.2018
Projektdetails

Analysis of Rho/actin-mediated regulation of MRTF and WT1 in the pathogenesis of ARVC using iPSC-derived CMs - Koop. mit Externen Partner
ID 81X2600618
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alessandra Moretti
Site München
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Analysis of Rho/actin-mediated regulation of MRTF and WT1 in the pathogenesis of ARVC using iPSC-derived CMs - Koop. mit Externen Partner
ID 81X2800167
Institution Philipps-Universität Marburg
Project leader Robert Grosse
Site Extern
Project type Cooperation with External Partners
Funding 14985.49€ 14.985,49
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

In vivo monitoring of brain hypoxia in cerebrovascular disease
ID 81X2200133
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Cooperation with External Partners
Funding 5998.42€ 5.998,42
Begin 2016-04-0101.04.2016
End 2017-12-3131.12.2017
Projektdetails

In vivo monitoring of brain hypoxia in cerebrovascular disease
ID 81X2800146
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (MPG)
Project leader Friedemann Kiefer
Site Extern
Project type Cooperation with External Partners
Funding 14000.00€ 14.000,00
Begin 2016-04-0101.04.2016
End 2017-12-3131.12.2017
Projektdetails

Genotype-dependent effects of smoking on atherosclerotic plaque formation in an in vivo-model
ID 81X2600517
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Cooperation with External Partners
Funding 4808.45€ 4.808,45
Begin 2017-03-0101.03.2017
End 2019-12-3131.12.2019
Projektdetails

Genotype-dependent effects of smoking on atherosclerotic plaque formation in an in vivo-model
ID 81X2800170
Institution Justus-Liebig-Universität Gießen
Project leader Norbert Weißmann
Site Extern
Project type Cooperation with External Partners
Funding 20995.61€ 20.995,61
Begin 2017-03-0101.03.2017
End 2019-12-3131.12.2019
Projektdetails

Message in a micro-bottle: Extracellular vesicles as transmitters of HDL’s immunomodulatory capacity - Koop. mit Ext
ID 81X2600244
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2017-01-0101.01.2017
End 2018-04-3030.04.2018
Projektdetails

Message in a micro-bottle: Extracellular vesicles as transmitters of HDL’s immunomodulatory capacity - Koop. mit Ext
ID 81X2800169
Institution Universitätsklinikum Aachen
Project leader Joachim Jankowski
Site Extern
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2017-01-0101.01.2017
End 2018-04-3030.04.2018
Projektdetails

Molecular mechanisms involved in apoptotic cell death in T. cruzi-infected cardiomyocytes
ID 81X2300157
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Thomas Meyer
Site Göttingen
Project type Cooperation with External Partners
Funding 9391.20€ 9.391,20
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

Molecular mechanisms involved in apoptotic cell death in T. cruzi-infected cardiomyocytes
ID 81X2800160
Institution Philipps-Universität Marburg
Project leader Ralph T. Schwarz
Site Extern
Project type Cooperation with External Partners
Funding 10738.58€ 10.738,58
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

Quantitative pluripotency assessment of selected human induced pluripotent stem cell (hiPSC) lines and analysis of correlation to their cardiac differentiation potential
ID 81X2710153
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Bärbel Ulmer
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 15881.54€ 15.881,54
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Quantitative pluripotency assessment of selected human induced pluripotent stem cell (hiPSC) lines and analysis of correlation to their cardiac differentiation potential
ID 81X2800163
Institution Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Project leader Ole Pleß
Site Extern
Project type Cooperation with External Partners
Funding 19000.00€ 19.000,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

STAT1 regulierte miRNAs als diagnostische Biomarker und putative Targets für die Behandlung des Myokardinfarkts
ID 81X2800166
Institution Philipps-Universität Marburg
Project leader Volker Ruppert
Site Extern
Project type Cooperation with External Partners
Funding 38806.00€ 38.806,00
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

STAT1-regulated microRNAs as diagnostic biomarkers and putative targets for the treatment of myocardial infarction
ID 81X2300166
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Thomas Meyer
Site Göttingen
Project type Cooperation with External Partners
Funding 32215.17€ 32.215,17
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

Understanding key gene regulatory nodes programming vertebrate cardiac regeneration
ID 81X2500156
Institution Universitätsklinikum Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 31938.76€ 31.938,76
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Understanding key gene regulatory nodes programming vertebrate cardiac regeneration
ID 81X2800165
Institution Universität zu Köln
Project leader Leo Kurian
Site Extern
Project type Cooperation with External Partners
Funding 31939.46€ 31.939,46
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Identification of novel arrhythmia susceptibility genes in survivors of sudden cardiac arrest using next generation sequencing
ID 81X2500204
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Martin Borggrefe
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 2834.85€ 2.834,85
Begin 2016-09-0101.09.2016
End 2017-12-3131.12.2017
Projektdetails

Identification of novel arrhythmia susceptibility genes in survivors of sudden cardiac arrest using next generation sequencing
ID 81X2800157
Institution Westfälische Wilhelms-Universität Münster
Project leader Eric Schulze-Bahr
Site Extern
Project type Cooperation with External Partners
Funding 39667.85€ 39.667,85
Begin 2016-11-0101.11.2016
End 2017-12-3131.12.2017
Projektdetails

Characterization of inward rectifying potassium current (IK1) as a potential contributor to atrial arrhythmias in a porcine model of ischemic heart failure.
ID 81X2600232
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site München
Project type Cooperation with External Partners
Funding 9934.00€ 9.934,00
Begin 2016-04-0101.04.2016
End 2019-07-3131.07.2019
Projektdetails

Characterization of inward rectifying potassium current (IK1) as a potential contributor to atrial arrhythmias in a porcine model of ischemic heart failure. DZHK B 15-015 Ext
ID 81X2800145
Institution Universitätsklinikum Regensburg
Project leader Lars Maier
Site Extern
Project type Cooperation with External Partners
Funding 10175.82€ 10.175,82
Begin 2016-04-0101.04.2016
End 2019-07-3131.07.2019
Projektdetails

Identification and characterization of proteins that regulate cardiac gene expression through interference with microRNA precursor processing.
ID 81X2600411
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2016-04-0101.04.2016
End 2017-09-3030.09.2017
Projektdetails

Identification and characterization of proteins that regulate cardiac gene expression through interference with microRNA precursor processing.
ID 81X2800147
Institution Universitätsklinikum Regensburg
Project leader Gunter Meister
Site Extern
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2016-03-0101.03.2016
End 2017-09-3030.09.2017
Projektdetails

Role of Nucleoside Diphosphate Kinases in Clinical and Experimental Atrial Fibrillation
ID 81X2500205
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Thomas Wieland
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 18453.76€ 18.453,76
Begin 2016-10-0101.10.2016
End 2017-12-3131.12.2017
Projektdetails

Establishing of a recombinant Zebrafish line carrying the New Foundland mutation TMEM43 p.S358L for drug screening and evaluation of the underlying pathomechanism
ID 81X2700210
Institution Universitätsklinikum Schleswig-Holstein
Project leader Hans-Heiner Kramer
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 25000.00€ 25.000,00
Begin 2016-09-0101.09.2016
End 2017-08-3131.08.2017
Projektdetails

Role of Nucleoside Diphosphate Kinases in Clinical and Experimental Atrial Fibrillation
ID 81X2800161
Institution Universitätsklinikum Essen
Project leader Dobromir Dobrev
Site Extern
Project type Cooperation with External Partners
Funding 18500.00€ 18.500,00
Begin 2016-09-0101.09.2016
End 2017-08-3131.08.2017
Projektdetails

Establishing of a recombinant Zebrafish line carrying the New Foundland mutation TMEM43 p.S358L for drug screening and evaluation of the underlying pathomechanism
ID 81X2800158
Institution Krankenhausbetriebsgesellschaft Bad Oeynhausen mbH
Project leader Hendrik Milting
Site Extern
Project type Cooperation with External Partners
Funding 23609.30€ 23.609,30
Begin 2016-08-0101.08.2016
End 2017-07-3131.07.2017
Projektdetails

Evaluation of functional calcium handling abnormalities contributing to the atrial arrhythmogenic substrate in a porcine model of ischemic heart failure.
ID 81X2600234
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site München
Project type Cooperation with External Partners
Funding 9681.00€ 9.681,00
Begin 2016-04-0101.04.2016
End 2019-07-3131.07.2019
Projektdetails

Evaluation of functional calcium handling abnormalities contributing to the atrial arrhythmogenic substrate in a porcine model of ischemic heart failure.
ID 81X2800150
Institution Universitätsklinikum Regensburg
Project leader Lars Maier
Site Extern
Project type Cooperation with External Partners
Funding 10675.00€ 10.675,00
Begin 2016-04-0101.04.2016
End 2019-07-3131.07.2019
Projektdetails

Development of a physical activity program for patients 65 years of age or older after myocardial infarction
ID 81X2800154
Institution Friedrich-Alexander-Universität Erlangen-Nürnberg
Project leader Susanne Wurm
Site Extern
Project type Cooperation with External Partners
Funding 21715.92€ 21.715,92
Begin 2016-05-0101.05.2016
End 2017-12-3131.12.2017
Projektdetails

Development of a physical activity program for patients 65 years of age or older after myocardial infarction DZHK B 16-010 Ext
ID 81X2400127
Institution Universitätsmedizin Greifswald
Project leader Sabina Ulbricht
Site Greifswald
Project type Cooperation with External Partners
Funding 18785.56€ 18.785,56
Begin 2016-05-0101.05.2016
End 2017-12-3131.12.2017
Projektdetails

Nanomedical approach for generating arterial ‘teflon’ endothelium
ID 81X2600236
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Cooperation with External Partners
Funding 9999.81€ 9.999,81
Begin 2016-04-0101.04.2016
End 2017-06-3030.06.2017
Projektdetails

Nanomedical approach for generating arterial ‘teflon’ endothelium
ID 81X2800152
Institution Universitätsklinikum Aachen
Project leader Twan Lammers
Site Extern
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2016-04-0101.04.2016
End 2017-06-3030.06.2017
Projektdetails

Role of the cardiac inflammasome in Coxsackievirus B3-induced myocarditis
ID 81X2100235
Institution Charité - Universitätsmedizin Berlin
Project leader Sophie Van Linthout
Site Berlin
Project type Cooperation with External Partners
Funding 9445.06€ 9.445,06
Begin 2016-01-0101.01.2016
End 2018-03-3131.03.2018
Projektdetails

Role of the cardiac inflammasome in coxsackievirus B3-induced myocarditis
ID 81X2800143
Institution Technische Universität Berlin
Project leader Jens Kurreck
Site Extern
Project type Cooperation with External Partners
Funding 14000.00€ 14.000,00
Begin 2016-01-0101.01.2016
End 2018-03-3131.03.2018
Projektdetails

Die Rolle von TRPC-Kanälen für die Regulation der Ca2+ Homöostase beim kardialen Remodeling in kardialen Fibroblasten in vitro und in vivo
ID 81X2500148
Institution Universitätsklinikum Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 17004.92€ 17.004,92
Begin 2016-03-0101.03.2016
End 2017-05-3131.05.2017
Projektdetails

Die Rolle von TRPC-Kanälen für die Regulation der Ca2+ Homöostase beim kardialen Remodeling in kardialen Fibroblasten in vitro und in vivo
ID 81X2800142
Institution Universität des Saarlandes
Project leader Peter Lipp
Site Extern
Project type Cooperation with External Partners
Funding 20500.00€ 20.500,00
Begin 2016-03-0101.03.2016
End 2017-05-3131.05.2017
Projektdetails

Does Aerobic Exercise provide a safe and effective Therapy for Arterial Hypertension?
ID 81X2800155
Institution Justus-Liebig-Universität Gießen
Project leader Klaus-Dieter Schlüter
Site Extern
Project type Cooperation with External Partners
Funding 11962.48€ 11.962,48
Begin 2016-06-0101.06.2016
End 2017-12-3131.12.2017
Projektdetails

Does Aerobic Exercise provide and effective Therapy for Arterilal Hypertension?
ID 81X2200201
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Christian Hamm
Site RheinMain
Project type Cooperation with External Partners
Funding 7752.19€ 7.752,19
Begin 2016-06-0101.06.2016
End 2017-12-3131.12.2017
Projektdetails

Functional analysis of heart failure-regulated lncRNAs (lnc-FAIL)
ID 81X2200134
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Cooperation with External Partners
Funding 4000.00€ 4.000,00
Begin 2016-04-0101.04.2016
End 2017-05-3131.05.2017
Projektdetails

Functional analysis of heart failure-regulated lncRNAs (lnc-FAIL)
ID 81X2800148
Institution Medizinische Hochschule Hannover
Project leader Thomas Thum
Site Extern
Project type Cooperation with External Partners
Funding 16000.00€ 16.000,00
Begin 2016-04-0101.04.2016
End 2017-05-3131.05.2017
Projektdetails

Heart failure with preserved ejection fraction – Improvement of diagnosis and risk prediction
ID 81X2300162
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Rolf Wachter
Site Göttingen
Project type Cooperation with External Partners
Funding 7247.41€ 7.247,41
Begin 2016-12-0101.12.2016
End 2018-12-3131.12.2018
Projektdetails

Assessment of heart function and injury-induced hypertrophy in a guinea-pig model of engineered cardiac repair
ID 81X2800149
Institution Medizinische Hochschule Hannover
Project leader Sandor Batkai
Site Extern
Project type Cooperation with External Partners
Funding 8247.16€ 8.247,16
Begin 2016-03-0101.03.2016
End 2017-02-2828.02.2017
Projektdetails

Elucidation of mechanotransducing elements and of the role of AT1 receptors in renin secreting cells.
ID 81X2600701
Institution Ludwig-Maximilians-Universität München
Project leader Thomas Gudermann
Site München
Project type Cooperation with External Partners
Funding 14988.78€ 14.988,78
Begin 2016-04-0101.04.2016
End 2018-10-0101.10.2018
Projektdetails

Elucidation of mechanotransducing elements and of the role of AT1 receptors in renin secreting cells.
ID 81X2800144
Institution Universität Regensburg
Project leader Armin Kurtz
Site Extern
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2016-01-0101.01.2016
End 2018-10-0101.10.2018
Projektdetails

Assessment of heart function and injury-induced hypertrophy in a guinea-pig model of tissue engineered cardiac repair
ID 81X2710143
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 0.00€ 0,00
Begin 2016-04-0101.04.2016
End 2016-11-3030.11.2016
Projektdetails

Study of the role of endothelial CXCR4 in vascular permeability
ID 81X2600235
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Cooperation with External Partners
Funding 9676.96€ 9.676,96
Begin 2016-04-0101.04.2016
End 2016-11-3030.11.2016
Projektdetails

Study of the role of endothelial CXCR4 in vascular permeability
ID 81X2800151
Institution Universitätsklinikum Aachen
Project leader Heidi Noels
Site Extern
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2016-04-0101.04.2016
End 2016-11-3030.11.2016
Projektdetails

Generation of Phactr1 Knockout mice on an atherogenic Apoe Knockout background using Crispr/Cas technology
ID 81X2100135
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE001)
Funding 15000.00€ 15.000,00
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Generation of Phactr1 Knockout mice on an atherogenic Apoe Knockout background using Crispr/Cas technology
ID 81X2700125
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE001)
Funding 14452.55€ 14.452,55
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Pooled analysis of three prospective stroke trials focusing on the prevalence of paroxysmal atrial fibrillation
ID 81X2100251
Institution Charité - Universitätsmedizin Berlin
Project leader Matthias Endres
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE159)
Funding 37847.90€ 37.847,90
Begin 2017-03-0101.03.2017
End 2020-06-3030.06.2020
Projektdetails

Pooled analysis of three prospective stroke trials focusing on the prevalence of paroxysmal atrial fibrillation in
ID 81X2300168
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Rolf Wachter
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE159)
Funding 41041.39€ 41.041,39
Begin 2017-03-0101.03.2017
End 2020-06-3030.06.2020
Projektdetails

Circadian control of atherosclerosis
ID 81X2710145
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE062)
Funding 20000.00€ 20.000,00
Begin 2016-08-0101.08.2016
End 2019-06-3030.06.2019
Projektdetails

Changes in circulating microparticles after cardiopulmonary exercise testing in patients with reduced ejection fraction
ID 81X2100243
Institution Charité - Universitätsmedizin Berlin
Project leader Nicolle Kränkel
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE124)
Funding 14000.00€ 14.000,00
Begin 2017-04-0101.04.2017
End 2020-12-3131.12.2020
Projektdetails

Changes in circulating microparticles after cardiopulmonary exercise testing in patients with reduced ejection fraction
ID 81X2400129
Institution Universitätsmedizin Greifswald
Project leader Martin Bahls
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE124)
Funding 13889.50€ 13.889,50
Begin 2017-04-0101.04.2017
End 2020-12-3131.12.2020
Projektdetails

Circadian control of atherosclerosis
ID 81X2600237
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE062)
Funding 20000.00€ 20.000,00
Begin 2016-09-0101.09.2016
End 2019-06-3030.06.2019
Projektdetails

Effects of 17ß-Estradiol on collagen I and III in human 3D-dimensional connective heart tissues
ID 81X2100241
Institution Charité - Universitätsmedizin Berlin
Project leader Elke Dworatzek
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE017)
Funding 15515.20€ 15.515,20
Begin 2017-01-0101.01.2017
End 2019-07-3131.07.2019
Projektdetails

Effects of 17ß-Estradiol on collagen I and III in human 3D-dimensional connective heart tissues
ID 81X2300160
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Malte Tiburcy
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE017)
Funding 23706.42€ 23.706,42
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Epigenetic control of endothelial phenotype and atherosclerosis in response to atherogenic blood flow
ID 81X2100248
Institution Charité - Universitätsmedizin Berlin
Project leader Till Althoff
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE060)
Funding 24946.77€ 24.946,77
Begin 2017-01-0101.01.2017
End 2020-09-3030.09.2020
Projektdetails

Epigenetic control of endothelial phenotype and atherosclerosis in response to atherogenic blood flow
ID 81X2500164
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE060)
Funding 23291.77€ 23.291,77
Begin 2017-01-0101.01.2017
End 2020-09-3030.09.2020
Projektdetails

Hypercholesterolemia generates splenic neutrophils with a distinct phenotype and function
ID 81X2100136
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 20000.00€ 20.000,00
Begin 2017-01-0101.01.2017
End 2020-12-3131.12.2020
Projektdetails

Hypercholesterolemia generates splenic neutrophils with a distinct phenotype and function - Koop. mit SE
ID 81X2600241
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 20000.00€ 20.000,00
Begin 2017-01-0101.01.2017
End 2020-12-3131.12.2020
Projektdetails

Validation of CMR indices for interstitial fibrosis, inflammation and water content with endomyocardial biopsies in patients with nonischaemic cardiomyopathies
ID 81X2100247
Institution Charité - Universitätsmedizin Berlin
Project leader Felicitas Escher
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE005)
Funding 19241.23€ 19.241,23
Begin 2017-01-0101.01.2017
End 2020-12-3131.12.2020
Projektdetails

Validation of CMR indices for interstitial fibrosis, inflammation and water content with endomyocardial biopsies in patients with nonischaemic cardiomyopathies
ID 81X2200141
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE005)
Funding 19923.07€ 19.923,07
Begin 2017-01-0101.01.2017
End 2020-12-3131.12.2020
Projektdetails

Role of Carboxypeptidase-X, member 2 in left ventricle hypertrophy
ID 81X2300169
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Samuel Sossalla
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE095)
Funding 16228.72€ 16.228,72
Begin 2017-03-0101.03.2017
End 2018-12-3131.12.2018
Projektdetails

Does a combination of Valsartan and Sacubitril modulate autophagy in a mouse model of transverse aortic banding?
ID 81X2400131
Institution Universitätsmedizin Greifswald
Project leader Stephanie Könemann
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE102)
Funding 38031.95€ 38.031,95
Begin 2017-05-0101.05.2017
End 2019-06-3030.06.2019
Projektdetails

Does a combination of Valsartan and Sacubitril modulate autophagy in a mouse model of transverse aortic banding?
ID 81X2710154
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Lucie Carrier
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE102)
Funding 38534.23€ 38.534,23
Begin 2017-05-0101.05.2017
End 2019-06-3030.06.2019
Projektdetails

Mechanobiology of iPSC-derived cardiomyocytes on 3D substrates towards improved implant surfaces
ID 81X2300158
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE019)
Funding 33241.00€ 33.241,00
Begin 2017-01-0101.01.2017
End 2018-10-3131.10.2018
Projektdetails

Mechanobiology of iPSC-derived cardiomyocytes on 3D substrates towards improved implant surfaces
ID 81X2400128
Institution Universitätsmedizin Greifswald
Project leader Mihaela Delcea
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE019)
Funding 31644.44€ 31.644,44
Begin 2017-01-0101.01.2017
End 2018-10-3131.10.2018
Projektdetails

Role of Carboxypeptidase-X, member 2 in left ventricle hypertrophy
ID 81X2710164
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE095)
Funding 18000.00€ 18.000,00
Begin 2017-03-0101.03.2017
End 2018-12-3131.12.2018
Projektdetails

PKD regulation of epigenetic pathways in septic cardiomyopathy
ID 81X2500161
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider + SE user  (SE080)
Funding 19659.17€ 19.659,17
Begin 2017-02-0101.02.2017
End 2019-01-3131.01.2019
Projektdetails

PKD regulation of epigenetic pathways in septic cardiomyopathy
ID 81X2710161
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Konstantina Stathopoulou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider + SE user  (SE060)
Funding 12491.80€ 12.491,80
Begin 2017-01-0101.01.2017
End 2019-01-3131.01.2019
Projektdetails

Unraveling the genetic origin of the hypoplastic left heart syndrome by whole-genome sequencing approaches
ID 81X2300167
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Bernd Wollnik
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 7472.21€ 7.472,21
Begin 2017-02-0101.02.2017
End 2018-09-3030.09.2018
Projektdetails

Unraveling the genetic origin of the hypoplastic left heart syndrome by whole-genome sequencing approaches
ID 81X2600112
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 63963.11€ 63.963,11
Begin 2017-02-0101.02.2017
End 2018-09-3030.09.2018
Projektdetails

A combined intravascular imaging and miRNA-profiling approach for different plaque phenotypes
ID 81X2100244
Institution Charité - Universitätsmedizin Berlin
Project leader Philipp Jakob
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 20723.45€ 20.723,45
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

A combined intravascular imaging and miRNA-profiling approach for different plaque phenotypes
ID 81X2400130
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 25587.00€ 25.587,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Acute and chronic impact of exercise on arterial stiffness and biomarkers of endothelial function in cardiometabolic diseases
ID 81X2710156
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE057)
Funding 14937.47€ 14.937,47
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Acute and chronic impact of exercise on arterial stiffness and biomarkers of endothelial function in cardiometabolic diseases - Koop. mit SE
ID 81X2600617
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Flavia Baldassarri
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE057)
Funding 14998.66€ 14.998,66
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Atrial remodeling in heart failure with preserved ejection fraction: the role of cardiomyocyte / cardiac fibroblast-interaction.
ID 81X2710151
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE092)
Funding 24999.93€ 24.999,93
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Atrial remodeling in heart failure with preserved ejection fraction: the role of cardiomyocyte/ cardiac fibroblast-interaction
ID 81X2100240
Institution Charité - Universitätsmedizin Berlin
Project leader Felix Hohendanner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE092)
Funding 24996.15€ 24.996,15
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Characterization of homeostatic coagulation protease-specific enhancer landscapes in macrophages
ID 81X2100140
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 8400.00€ 8.400,00
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Characterization of homeostatic coagulation protease-specific enhancer landscapes in macrophages
ID 81X2100250
Institution Charité - Universitätsmedizin Berlin
Project leader Silke Rickert-Sperling
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE134)
Funding 15216.00€ 15.216,00
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Characterization of murine heterozygous Shox2 Cardiomyocytes as a Model for Atrial Fibrillation
ID 81X2100245
Institution Charité - Universitätsmedizin Berlin
Project leader Felix Hohendanner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE150)
Funding 34176.99€ 34.176,99
Begin 2017-01-0101.01.2017
End 2018-02-2828.02.2018
Projektdetails

Characterization of murine heterozygous Shox2 Cardiomyocytes as a Model for Atrial Fibrillation
ID 81X2500160
Institution Universitätsklinikum Heidelberg
Project leader Anna-Eliane Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE150)
Funding 43093.19€ 43.093,19
Begin 2017-01-0101.01.2017
End 2018-02-2828.02.2018
Projektdetails

Endogenous Reprogramming of Cardiac Fatty Acid Metabolism to Treat Diabetic Cardiomyopathy
ID 81X2100249
Institution Charité - Universitätsmedizin Berlin
Project leader Ulrich Kintscher
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 21833.11€ 21.833,11
Begin 2017-01-0101.01.2017
End 2019-01-3131.01.2019
Projektdetails

EP3 receptor-dependent epigenetic pathways in septic cardiomyopathy
ID 81X2500159
Institution Universitätsklinikum Heidelberg
Project leader Richard Schell
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE060/SE080)
Funding 40207.96€ 40.207,96
Begin 2017-01-0101.01.2017
End 2020-01-3131.01.2020
Projektdetails

EP3 receptor-dependent epigenetic pathways in septic cardiomyopathy
ID 81X2710155
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Konstantina Stathopoulou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE060/SE080)
Funding 40197.19€ 40.197,19
Begin 2017-01-0101.01.2017
End 2020-01-3131.01.2020
Projektdetails

Evaluation of diagnostic and prognostic value of microRNAs
ID 81X2700126
Institution Universität zu Lübeck
Project leader Holger Thiele
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE063)
Funding 50110.80€ 50.110,80
Begin 2017-03-0101.03.2017
End 2018-02-2828.02.2018
Projektdetails

Evaluation of diagnostic and prognostic value of microRNAs - Koop mit SE -
ID 81X2200202
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Christian Hamm
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE063)
Funding 28914.80€ 28.914,80
Begin 2017-01-0101.01.2017
End 2019-12-3131.12.2019
Projektdetails

Gene profiling in hypothalami and cerebral vessels of HFD-fed mice under AT1 blockade
ID 81X2100141
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 18000.00€ 18.000,00
Begin 2017-01-0101.01.2017
End 2018-06-3030.06.2018
Projektdetails

Gene profiling in hypothalami and cerebral vessels of HFD-fed mice under AT1 blockade
ID 81X2700128
Institution Universität zu Lübeck
Project leader Walter Raasch
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 7507.71€ 7.507,71
Begin 2017-03-0101.03.2017
End 2018-06-3030.06.2018
Projektdetails

Generation and cardiac phenotyping of miR-365-deficient mice
ID 81X2100138
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE001)
Funding 15735.87€ 15.735,87
Begin 2017-01-0101.01.2017
End 2020-12-3131.12.2020
Projektdetails

Generation and cardiac phenotyping of miR-365-deficient mice - Koop. mit SE
ID 81X2600414
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE001)
Funding 15669.85€ 15.669,85
Begin 2017-01-0101.01.2017
End 2020-12-3131.12.2020
Projektdetails

Generierung und Charakterisierung von TLR2-Mutant IPS Zellen und davon abgeleiteten Endothelzellen und Kardiomyozyten
ID 81X2200138
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE025)
Funding 8000.00€ 8.000,00
Begin 2016-06-0101.06.2016
End 2018-12-3131.12.2018
Projektdetails

Generierung und Charakterisierung von TLR2-Mutant IPS Zellen und davon abgeleiteten Endothelzellen und Kardiomyozyten
ID 81X2710144
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Sandra Laufer
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE025)
Funding 12000.00€ 12.000,00
Begin 2016-06-0101.06.2016
End 2018-12-3131.12.2018
Projektdetails

Identifikation von zirkulären RNA Molekülen im kardiovaskulären System
ID 81X2200132
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 14973.34€ 14.973,34
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Identifikation von zirkulären RNA Molekülen im kardiovaskulären System
ID 81X2500153
Institution Universitätsklinikum Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 31635.29€ 31.635,29
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

In vivo characterization of the role of HectD3 via AAV9-mediated transient, heart-specific gene transfer in mice
ID 81X2500154
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 29411.85€ 29.411,85
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

In vivo characterization of the role of HectD3 via AAV9-mediated transient, heart-specific gene transfer in mice
ID 81X2700211
Institution Universitätsklinikum Schleswig-Holstein
Project leader Ashraf Yusuf Rangrez
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 28976.95€ 28.976,95
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

In vivo characterization of the role of STRIPAK protein complex via AAV9-mediated transient, heart- specific gene transfer in mice.
ID 81X2500158
Institution Universitätsklinikum Heidelberg
Project leader Hugo A. Katus
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 28963.71€ 28.963,71
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

In vivo characterization of the role of STRIPAK protein complex via AAV9-mediated transient, heart-specific gene transfer in mice
ID 81X2700212
Institution Universitätsklinikum Schleswig-Holstein
Project leader Matthias Eden
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 19989.34€ 19.989,34
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Influence of interaction between sex and cytotoxic cell-mediated immunomodulation in outcome of patients with inflammatory cardiomyopathy.
ID 81X2100246
Institution Charité - Universitätsmedizin Berlin
Project leader Felicitas Escher
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE092)
Funding 4405.14€ 4.405,14
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Influence of interaction between sex and cytotoxic cell-mediated immunomodulation in outcome of patients with inflammatory cardiomyopathy.
ID 81X2710157
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE092)
Funding 20000.00€ 20.000,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Investigation of protein changes that underlie and determine the maturation of rat and human engineered heart tissue.
ID 81X2400132
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 15000.00€ 15.000,00
Begin 2017-01-0101.01.2017
End 2019-12-3131.12.2019
Projektdetails

Investigation of protein changes that underlie and determine the maturation of rat and human engineered heart tissue.
ID 81X2710159
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Marc Hirt
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 14678.87€ 14.678,87
Begin 2017-01-0101.01.2017
End 2019-12-3131.12.2019
Projektdetails

Mathematical modeling of cardiac rhythm control by mitochondria
ID 81X2100137
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Martin Falcke
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE014)
Funding 21700.00€ 21.700,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Mathematical modeling of cardiac rhythm control by mitochondria
ID 81X2600704
Institution Ludwig-Maximilians-Universität München
Project leader Thomas Gudermann
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE014)
Funding 7475.79€ 7.475,79
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Migration of T cells from the intestine to the heart in autoimmune myocarditis
ID 81X2500155
Institution Universitätsklinikum Heidelberg
Project leader Ziya Kaya
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE127)
Funding 39947.64€ 39.947,64
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

Migration of T cells from the intestine to the heart in autoimmune myocarditis
ID 81X2710150
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Ulrich Wenzel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE127)
Funding 35361.13€ 35.361,13
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

Modeling the Electrophysiological Basis of Cardiac Arrhythmias with Patients-specific iPSCs
ID 81X2300164
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE019)
Funding 43668.00€ 43.668,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Modeling the Electrophysiological Basis of Cardiac Arrhythmias with Patients-specific iPSCs
ID 81X2500206
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Ibrahim El-Battrawy
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE019)
Funding 19800.00€ 19.800,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Next-generation sequencing and susceptibility phenotyping for arrhythmia risk analysis in patients
ID 81X2300163
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE031)
Funding 30660.00€ 30.660,00
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Next-generation sequencing and susceptibility phenotyping for arrhythmia risk analysis in patients
ID 81X2500157
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 49850.75€ 49.850,75
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Novel insights in the development of takotsubo cardiomyopathy using patient-specific iPSCs
ID 81X2300165
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuß-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 34279.24€ 34.279,24
Begin 2017-01-0101.01.2017
End 2019-12-3131.12.2019
Projektdetails

Proteomic screening for neutrophil-derived mediators promoting myocardial infarction repair
ID 81X2200308
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Thomas Braun
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE056)
Funding 20000.00€ 20.000,00
Begin 2016-10-0101.10.2016
End 2017-12-3131.12.2017
Projektdetails

Proteomic screening for neutrophil-derived mediators promoting myocardial infarction repair
ID 81X2600239
Institution Klinikum der Universität München
Project leader Sabine Steffens
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE056)
Funding 19923.25€ 19.923,25
Begin 2016-10-0101.10.2016
End 2017-12-3131.12.2017
Projektdetails

Regulation and function of cardiac fibroblast-derived factors differentially expressed in men and women with aortic stenosis
ID 81X2100242
Institution Charité - Universitätsmedizin Berlin
Project leader Elke Dworatzek
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE012)
Funding 37997.30€ 37.997,30
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Regulation and function of cardiac fibroblast-derived factors differentially expressed in men and women with aortic stenosis
ID 81X2300161
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Susanne Lutz
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE012)
Funding 33752.41€ 33.752,41
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

RNAseq transcriptomic analysis in a redox-dead RSK mouse model of angiotensin II-induced hypertrophy
ID 81X2100143
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 24300.00€ 24.300,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

RNAseq transcriptomic analysis in a redox-dead RSK mouse model of angiotensin II-induced hypertrophy
ID 81X2710162
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Friederike Cuello
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 10321.55€ 10.321,55
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Role of complement in autoimmune myocarditis
ID 81X2500163
Institution Universitätsklinikum Heidelberg
Project leader Ziya Kaya
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE068)
Funding 9997.55€ 9.997,55
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Role of complement in autoimmune myocarditis
ID 81X2710158
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Ulrich Wenzel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE068)
Funding 10000.00€ 10.000,00
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Die Rolle der Rezeptor-regulierten Kalziumhomöostase in kardialen Fibroblasten und Endothelzellen für das pathologische Remodeling.
ID 81X2500165
Institution Universitätsklinikum Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE158)
Funding 36840.45€ 36.840,45
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Die Rolle der Rezeptor-regulierten Kalziumhomöostase in kardialen Fibroblasten und Endothelzellen für das pathologische Remodeling.
ID 81X2700213
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Matthias Lutz
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE158)
Funding 36995.00€ 36.995,00
Begin 2017-01-0101.01.2017
End 2018-12-3131.12.2018
Projektdetails

Serotonergic drugs for atherosclerosis in the zebrafish model
ID 81X2100142
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Natalia Alenina
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 22382.31€ 22.382,31
Begin 2017-01-0101.01.2017
End 2018-02-2828.02.2018
Projektdetails

Serotonergic drugs for atherosclerosis in the zebrafish model
ID 81X2700129
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 22886.65€ 22.886,65
Begin 2017-03-0101.03.2017
End 2018-02-2828.02.2018
Projektdetails

Sex hormone-binding globulin and Testosterone as Risk Factors for Incident Cardiovascular Diseases – Results from the Population-based KORA F4 Cohort Study
ID 81X2600110
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Annette Peters
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE062)
Funding 14875.00€ 14.875,00
Begin 2017-02-0101.02.2017
End 2018-07-3131.07.2018
Projektdetails

Sex hormone-binding globulin and Testosterone as Risk Factors for Incident Cardiovascular Diseases – Results from the Population-based KORA F4 Cohort Study
ID 81X2710160
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE062)
Funding 10563.58€ 10.563,58
Begin 2017-01-0101.01.2017
End 2018-07-3131.07.2018
Projektdetails

Spatially Resolved Gene Expression Analysis in Chronic Thromboembolic Pulmonary Hypertension
ID 81X2210115
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Katrin Schäfer
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE105)
Funding 17640.68€ 17.640,68
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

Spatially Resolved Gene Expression Analysis in Chronic Thromboembolic Pulmonary Hypertension
ID 81X2600243
Institution Klinikum der Universität München
Project leader Andreas Schober
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE105)
Funding 20920.80€ 20.920,80
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

The role of monocytic CRIP1 of renal function and blood pressure regulation
ID 81X2210114
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wenzel
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE062)
Funding 20000.00€ 20.000,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

The role of monocytic CRIP1 of renal function and blood pressure regulation
ID 81X2210116
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Wolfram Ruf
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE062)
Funding 16300.00€ 16.300,00
Begin 2017-01-0101.01.2017
End 2019-06-3030.06.2019
Projektdetails

The role of monocytic CRIP1 of renal function and blood pressure regulation
ID 81X2710152
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE062)
Funding 19484.85€ 19.484,85
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Transcriptional compensation of impaired CO2-vasoreactivity
ID 81X2100139
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 20000.00€ 20.000,00
Begin 2017-01-0101.01.2017
End 2018-06-3030.06.2018
Projektdetails

Transcriptional compensation of impaired CO2-vasoreactivity
ID 81X2700127
Institution Universität zu Lübeck
Project leader Jan Wenzel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 10000.00€ 10.000,00
Begin 2017-01-0101.01.2017
End 2018-06-3030.06.2018
Projektdetails

Genome-wide association study of stent thrombosis after coronary stenting - bioinformatic analysis and replication
ID 81X2700124
Institution Universität zu Lübeck
Project leader Jeanette Erdmann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE139)
Funding 16577.74€ 16.577,74
Begin 2016-11-0101.11.2016
End 2018-10-3131.10.2018
Projektdetails

Bioinformatic comparison of two different cardiomyocyte maturation platforms for the identification of cardiomyogenic transcription factor networks
ID 81X2100239
Institution Charité - Universitätsmedizin Berlin
Project leader Silke Rickert-Sperling
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE134)
Funding 14558.75€ 14.558,75
Begin 2016-10-0101.10.2016
End 2017-09-3030.09.2017
Projektdetails

Bioinformatic comparison of two different cardiomyocyte maturation platforms for the identification of cardiomyogenic transcription factor networks.
ID 81X2300159
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Edgar Wingender
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE134)
Funding 13748.55€ 13.748,55
Begin 2016-10-0101.10.2016
End 2017-09-3030.09.2017
Projektdetails

Evaluation of contractile dysfunctions in engineered heart tissues derived from HLHS patient-specific iPS cells
ID 81X2600514
Institution Deutsches Herzzentrum München
Project leader Markus Krane
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE024)
Funding 18438.00€ 18.438,00
Begin 2016-03-0101.03.2016
End 2017-12-3131.12.2017
Projektdetails

Evaluation of contractile dysfunctions in engineered heart tissues derived from HLHS patient-specific iPS cells
ID 81X2710140
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE024)
Funding 18246.97€ 18.246,97
Begin 2016-04-0101.04.2016
End 2017-12-3131.12.2017
Projektdetails

Genome-wide association study of stent thrombosis after coronary stenting - bioinformatic analysis and replication
ID 81X2600516
Institution Deutsches Herzzentrum München
Project leader Adnan Kastrati
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE139)
Funding 12160.12€ 12.160,12
Begin 2016-10-0101.10.2016
End 2018-10-3131.10.2018
Projektdetails

Genotyping of samples of DCM patients and analysis of correlation of genetic variation with disease phenotypes and molecular data
ID 81X2400124
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 9900.00€ 9.900,00
Begin 2016-05-0101.05.2016
End 2017-09-3030.09.2017
Projektdetails

Genotyping of samples of DCM patients and analysis of correlation of genetic variation with disease phenotypes and molecular data
ID 81X2600107
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 30620.25€ 30.620,25
Begin 2016-05-0101.05.2016
End 2017-09-3030.09.2017
Projektdetails

Impact of the chemokine receptor Ccr5 on NO signaling in atherosclerosis
ID 81X2710141
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE057)
Funding 19805.18€ 19.805,18
Begin 2016-04-0101.04.2016
End 2017-09-3030.09.2017
Projektdetails

Impact of the chemokine receptor Ccr5 on NO signaling in atherosclerosis.
ID 81X2600231
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE057)
Funding 19925.43€ 19.925,43
Begin 2016-04-0101.04.2016
End 2017-09-3030.09.2017
Projektdetails

Effect of exercise intensity on circulating inflammatory parameters in metabolic syndrome
ID 81X2100238
Institution Charité - Universitätsmedizin Berlin
Project leader Nicolle Kränkel
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE124)
Funding 11789.18€ 11.789,18
Begin 2016-09-0101.09.2016
End 2018-08-3131.08.2018
Projektdetails

Effect of exercise intensity on circulating inflammatory parameters in metabolic syndrome
ID 81X2600612
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE124)
Funding 15000.00€ 15.000,00
Begin 2016-09-0101.09.2016
End 2018-08-3131.08.2018
Projektdetails

Gene therapy of cardiomyopathy in a large animal model
ID 81X2500152
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE048)
Funding 5604.99€ 5.604,99
Begin 2016-09-0101.09.2016
End 2017-08-3131.08.2017
Projektdetails

Gene therapy of cardiomyopathy in a large animal model
ID 81X2600616
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE048)
Funding 28611€ 28611
Begin 2016-09-0101.09.2016
End 2019-08-3131.08.2019
Projektdetails

Role of microRNA-regulated mitochondrial energy metabolism in macrophages during atherosclerosis
ID 81X2500151
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 19014.58€ 19.014,58
Begin 2016-09-0101.09.2016
End 2018-02-2828.02.2018
Projektdetails

Role of microRNA-regulated mitochondrial energy metabolism in macrophages during atherosclerosis.
ID 81X2600240
Institution Klinikum der Universität München
Project leader Yuanyuan Wei
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE031)
Funding 10745.74€ 10.745,74
Begin 2016-09-0101.09.2016
End 2018-02-2828.02.2018
Projektdetails

To investigate the role of vessel wall PAR1 and its inhibition for atherosclerotic lesion formation
ID 81X2400126
Institution Universitätsmedizin Greifswald
Project leader Bernhard Rauch
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE122)
Funding 17850.00€ 17.850,00
Begin 2016-05-0101.05.2016
End 2018-01-3131.01.2018
Projektdetails

To investigate the role of vessel wall PAR1 and its inhibition for atherosclerotic lesion formation DZHK B 16-020SE
ID 81X2100237
Institution Charité - Universitätsmedizin Berlin
Project leader Ursula Rauch-Kröhnert
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE122)
Funding 21483.19€ 21.483,19
Begin 2016-05-0101.05.2016
End 2018-01-3131.01.2018
Projektdetails

Assessment of the Value of Quantitative Analysis of Dobutamine Stress MR and Adenosine Perfusion MR for the Prediction of Outcomes
ID 81X2100304
Institution Deutsches Herzzentrum Berlin
Project leader Sebastian Kelle
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE144)
Funding 9999.99€ 9.999,99
Begin 2016-08-0101.08.2016
End 2018-03-3131.03.2018
Projektdetails

Assessment of the Value of Quantitative Analysis of Dobutamine Stress MR and Adenosine Perfusion MR for the Prediction of Outcomes
ID 81X2200139
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eike Nagel
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE144)
Funding 9423.40€ 9.423,40
Begin 2016-08-0101.08.2016
End 2018-03-3131.03.2018
Projektdetails

Analyse differentieller Genexpression durch unterschiedliche rezeptorgesteuerte Kalziumkanäle in kardialen Zellen
ID 81X2100134
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 66400.00€ 66.400,00
Begin 2016-08-0101.08.2016
End 2017-07-3131.07.2017
Projektdetails

Analyse differentieller Genexpression durch unterschiedliche rezeptorgesteuerte Kalziumkanäle in kardialen Zellen
ID 81X2500150
Institution Universitätsklinikum Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 45367.00€ 45.367,00
Begin 2016-08-0101.08.2016
End 2017-07-3131.07.2017
Projektdetails

AAV mediated transgene expression of recombinant JP2 constructs for nanodomain proteomics
ID 81X2600412
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE047)
Funding 13000.00€ 13.000,00
Begin 2016-07-0101.07.2016
End 2017-06-3030.06.2017
Projektdetails

Characterization of human iPS cell-derived endothelial cells, part II
ID 81X2200140
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE097)
Funding 16000.00€ 16.000,00
Begin 2016-09-0101.09.2016
End 2017-06-3030.06.2017
Projektdetails

Characterization of human iPS cell-derived endothelial cells, part II
ID 81X2710147
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE097)
Funding 3998.93€ 3.998,93
Begin 2016-09-0101.09.2016
End 2017-06-3030.06.2017
Projektdetails

Detection of mutated TITIN and evaluation of isoform expression in a hiPSC-based model of DCM.
ID 81X2300156
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfgang Linke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE155)
Funding 20000.02€ 20.000,02
Begin 2016-06-0101.06.2016
End 2017-11-3030.11.2017
Projektdetails

Detection of mutated TITIN and evaluation of isoform expression in a hiPSC-based model of DCM.
ID 81X2600611
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alexander Goedel
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE155)
Funding 20000.00€ 20.000,00
Begin 2016-06-0101.06.2016
End 2017-11-3030.11.2017
Projektdetails

Relation of GPR15 cg19859270 methylation and GPR15 expression
ID 81X2710163
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Tina Haase
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 7433.40€ 7.433,40
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Relation of GPR15 cg19859270 methylation and GPR15 expression - Koop. mit SE
ID 81X2600111
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 25493.29€ 25.493,29
Begin 2017-02-0101.02.2017
End 2017-12-3131.12.2017
Projektdetails

SNP Genotyping and bioinformatic evaluation of the Myovasc Cohort to determine genetic risk factors of systolic and diastolic heart failure
ID 81X2210113
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE141)
Funding 6160.00€ 6.160,00
Begin 2016-04-0101.04.2016
End 2018-12-3131.12.2018
Projektdetails

SNP Genotyping and bioinformatic evaluation of the Myovasc Cohort to determine genetic risk factors of systolic and diastolic heart failure
ID 81X2700122
Institution Universität zu Lübeck
Project leader Inke König
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE141)
Funding 23100.00€ 23.100,00
Begin 2016-04-0101.04.2016
End 2018-12-3131.12.2018
Projektdetails

AAV mediated transgene expression of recombinant JP2 constructs for nanodomain proteomics
ID 81X2300153
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE047)
Funding 7100.00€ 7.100,00
Begin 2016-06-0101.06.2016
End 2017-05-3131.05.2017
Projektdetails

Genotyping and whole blood expression analysis of samples from cardiovascular cohorts of GANI_MED for OMICS analyses of cardiovascular phenotypes
ID 81X2600108
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 35029.01€ 35.029,01
Begin 2016-05-0101.05.2016
End 2017-09-3030.09.2017
Projektdetails

Genotyping and whole blood expression analysis of samples from cardiovascular cohorts of GANI_MED for OMICS analyses of cardiovascular phenotypes DZHK B16-019SE
ID 81X2400123
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 19778.62€ 19.778,62
Begin 2016-05-0101.05.2016
End 2017-09-3030.09.2017
Projektdetails

Impact of a standardised psychotherapy intervention on procoagulant markers in depressed patients with coronary artery disease (CAD)
ID 81X2100236
Institution Charité - Universitätsmedizin Berlin
Project leader Hans-Christian Deter
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE122)
Funding 20648.35€ 20.648,35
Begin 2016-02-0101.02.2016
End 2018-12-3131.12.2018
Projektdetails

Impact of a standardised psychotherapy intervention on procoagulant markers in depressed patients with coronary artery disease (CAD)
ID 81X2300152
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Christoph Herrmann-Lingen
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE122)
Funding 6260.00€ 6.260,00
Begin 2016-03-0101.03.2016
End 2018-12-3131.12.2018
Projektdetails

Soluble guanylate cyclase dependent RNA and protein alterations in a murine heart failure model
ID 81X2400125
Institution Universitätsmedizin Greifswald
Project leader Karina Grube
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 11618.83€ 11.618,83
Begin 2016-05-0101.05.2016
End 2018-03-3131.03.2018
Projektdetails

Soluble guanylate cyclase dependent RNA and protein alterations in a murine heart failure model
ID 81X2600109
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 41584.68€ 41.584,68
Begin 2016-05-0101.05.2016
End 2018-03-3131.03.2018
Projektdetails

Analysis of the composition of the T-cell secretome and its impact on the expression and protein secretion pattern of human cardiac fibroblasts
ID 81X2710142
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE092)
Funding 14655.94€ 14.655,94
Begin 2016-04-0101.04.2016
End 2017-10-3131.10.2017
Projektdetails

Analysis of the composition of the T-cell secretome and its impact on the expression and protein secretion pattern of human cardiac fibroblasts DZHK B 16-012 SE
ID 81X2400121
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE092)
Funding 13428.79€ 13.428,79
Begin 2016-04-0101.04.2016
End 2017-10-3131.10.2017
Projektdetails

Regulation of calpains and calpastatin by histone modifications
ID 81X2100234
Institution Charité - Universitätsmedizin Berlin
Project leader Silke Sperling
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE134)
Funding 13553.39€ 13.553,39
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

Regulation of calpains and calpastatin by histone modifications
ID 81X2200131
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE134)
Funding 4935.92€ 4.935,92
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

Role of ADAR2 in recruitment of circulating inflammatory cells in ischemic muscle tissues.
ID 81X2200136
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE050)
Funding 1501.12€ 1.501,12
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

Role of ADAR2 in recruitment of circulating inflammatory cells in ischemic muscle tissues.
ID 81X2600233
Institution Klinikum der Universität München
Project leader Oliver Söhnlein
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE050)
Funding 6499.50€ 6.499,50
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

Role of endothelial cell RNA editing in noncoding RNAs under hypoxic and interleukin-6-induced pro-inflammatory conditions
ID 81X2100132
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Sascha Sauer
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 19800.00€ 19.800,00
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

Role of endothelial cell RNA editing in noncoding RNAs under hypoxic and interleukin-6-­induced pro-­inflammatory conditions
ID 81X2200137
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 4725.58€ 4.725,58
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

The role of C3a and its association with the Th17 axis in the development of endorgan damage in arterial hypertension
ID 81X2210112
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wenzel
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE127)
Funding 14755.63€ 14.755,63
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

The role of C3a and its association with the Th17 axis in the development of endorgan damage in arterial hypertension
ID 81X2710139
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Ulrich Wenzel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE127)
Funding 15000.00€ 15.000,00
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

The role of the aging-regulated protein PNUTS in cardiac myocytes
ID 81X2200135
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 10000.00€ 10.000,00
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

The role of the aging-regulated protein PNUTS in cardiac myocytes DZHK B 16-011 SE
ID 81X2500149
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 9774.82€ 9.774,82
Begin 2016-04-0101.04.2016
End 2017-03-3131.03.2017
Projektdetails

Validation of non-invasive inverse body surface mapping using Langendorff-perfused porcine hearts in vitro
ID 81X2300404
Institution Max-Planck-Institut für Dynamik und Selbstorganisation
Project leader Stefan Luther
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE138)
Funding 24460.74€ 24.460,74
Begin 2016-06-0101.06.2016
End 2017-03-3131.03.2017
Projektdetails

Validation of non-invasive inverse body surface mapping using Langendorff-perfused porcine hearts in vitro
ID 81X2710201
Institution Asklepios Kliniken Hamburg GmbH
Project leader Karl-Heinz Kuck
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE138)
Funding 0.00€ 0,00
Begin 2016-07-0101.07.2016
End 2017-03-3131.03.2017
Projektdetails

Contribution of the proteasome system to the pathogenesis of inflammatory cardiomyopathy
ID 81X2500147
Institution Universitätsklinikum Heidelberg
Project leader Ziya Kaya
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE067)
Funding 36702.31€ 36.702,31
Begin 2016-03-0101.03.2016
End 2017-02-2828.02.2017
Projektdetails

Contribution of the proteasome system to the pathogenesis of inflammatory cardiomyopathy
ID 81X2100233
Institution Charité - Universitätsmedizin Berlin
Project leader Antje Voigt
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE067)
Funding 39826.44€ 39.826,44
Begin 2016-01-0101.01.2016
End 2016-12-3131.12.2016
Projektdetails

Identification and functional characterization of a ROCK-specific phosphorylation sites in cardiac myosin binding protein C
ID 81X2300154
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Susanne Lutz
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE080)
Funding 9349.01€ 9.349,01
Begin 2016-03-0101.03.2016
End 2016-12-3131.12.2016
Projektdetails

Identification and functional characterization of a ROCK-specific phosphorylation sites in cardiac myosin binding protein C
ID 81X2710138
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Friederike Cuello
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE080)
Funding 12381.84€ 12.381,84
Begin 2016-02-0101.02.2016
End 2016-12-3131.12.2016
Projektdetails

Developing new interventions for disease prevention – integration of psychosocial and exercise modalities.
ID 81X2600610
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE126)
Funding 8499.39€ 8.499,39
Begin 2016-04-0101.04.2016
End 2016-07-3131.07.2016
Projektdetails

Developing new interventions for disease prevention – integration of psychosocial and exercise modalities. DZHK B 16-016 SE
ID 81X2400122
Institution Universitätsmedizin Greifswald
Project leader Martin Bahls
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE126)
Funding 9381.64€ 9.381,64
Begin 2016-04-0101.04.2016
End 2016-07-3131.07.2016
Projektdetails

W2-Professur "Epigenetics in Cardiac Hypertrophy"
ID 81Z2700204
Institution Universitätsklinikum Schleswig-Holstein
Project leader Norbert Frey
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 399067.39€ 399.067,39
Begin 2016-09-0101.09.2016
End 2018-12-3131.12.2018
Projektdetails

Experimental evaluation of cause specific personalized treatment options (HD/MA 2.4 HIC)
ID 81Z2500224
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Jochen Utikal
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 212438.13€ 212.438,13
Begin 2011-10-1515.10.2011
End 2016-06-3030.06.2016
Projektdetails

Junior research group: Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular diseases
ID 81X3600604
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Lars Maegdefessel
Site München
Project type Excellence Programme
Funding 1249800.00€ 1.249.800,00
Begin 2016-09-0101.09.2016
End 2021-12-3131.12.2021
Projektdetails

Junior research group: Sarco/endoplasmic reticulum-associated protein degradation in proteostasis and cardiac function
ID 81X3500109
Institution Universitätsklinikum Heidelberg
Project leader Shirin Doroudgar
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 1274491.14€ 1.274.491,14
Begin 2015-10-0101.10.2015
End 2020-12-3131.12.2020
Projektdetails

Treatment of mice with an AT1-receptor blocker reduces hypothalamic lipids which contributes to weight loss and improvement of energy homeostasis
ID 81X2800138
Institution Rheinische Friedrich-Wilhelms-Universität Bonn
Project leader Lars Kuerschner
Site Extern
Project type Cooperation with External Partners
Funding 13726.89€ 13.726,89
Begin 2016-02-0101.02.2016
End 2018-08-3131.08.2018
Projektdetails

RNA-guided gene de-methylation by Cas9-based methylcytosine dioxygenase DZHK B 15-076SE
ID 81X2500146
Institution Universitätsklinikum Heidelberg
Project leader Oliver Müller
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 19399.73€ 19.399,73
Begin 2016-03-0101.03.2016
End 2017-12-3131.12.2017
Projektdetails

Non-invasive evaluation of oxygenation in the pulmonary artery, coronary sinus and left ventricular myocardium using BOLD-MRI
ID 81X2100305
Institution Deutsches Herzzentrum Berlin
Project leader Sebastian Kelle
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE131)
Funding 24686.68€ 24.686,68
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

Non-invasive evaluation of oxygenation in the pulmonary artery, coronary sinus and left ventricular myocardium using BOLD-MRI
ID 81X2200142
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum
Project leader Eike Nagel
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE131)
Funding 24400.00€ 24.400,00
Begin 2017-01-0101.01.2017
End 2018-09-3030.09.2018
Projektdetails

The role of myeloid differentiation factor-2 (MD-2) in infectious inflammatory and non-infectious cardiomyopathy (Greifswald part)
ID 81X2400106
Institution Universitätsmedizin Greifswald
Project leader Stepahn B. Felix
Site Greifswald
Project type Cooperation with External Partners
Funding 26724.41€ 26.724,41
Begin 2014-10-1717.10.2014
End 2017-01-3131.01.2017
Projektdetails

Pilot Study for Tissue Engineered Heart Repair in Pigs
ID 81X2300126
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Malte Tiburcy
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE048)
Funding 5997.53€ 5.997,53
Begin 2015-03-0101.03.2015
End 2019-12-3131.12.2019
Projektdetails

Pilot Study for Tissue Engineered Heart Repair in Pigs
ID 81X2600605
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE048)
Funding 23000.00€ 23.000,00
Begin 2015-03-0101.03.2015
End 2019-12-3131.12.2019
Projektdetails

Reintegration grant: The role of YAP/TAZ signaling in retinal angiogenesis
ID 81X3100102
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Alexandra Klaus-Bergmann
Site Berlin
Project type Excellence Programme
Funding 33000.00€ 33.000,00
Begin 2016-06-0101.06.2016
End 2016-12-3131.12.2016
Projektdetails

Research grant: Characterization of the PHF8 splicing target sHLA-G
ID 81X3200104
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Christian Fork
Site RheinMain
Project type Excellence Programme
Funding 12579.14€ 12.579,14
Begin 2016-10-0101.10.2016
End 2017-04-3030.04.2017
Projektdetails

Postdoc start-up grant: Identification of ischemic heart disease-regulated T-cell lncRNAs
ID 81X3200105
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Jedrzej Hoffmann
Site RheinMain
Project type Excellence Programme
Funding 55624.28€ 55.624,28
Begin 2016-09-0101.09.2016
End 2017-12-3131.12.2017
Projektdetails

Postdoc start-up grant: Elucidating the cellular mechanism driving asymmetric patterning of the cardiovascular system
ID 81X3200304
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Michelle Collins
Site RheinMain
Project type Excellence Programme
Funding 55500.00€ 55.500,00
Begin 2016-09-0101.09.2016
End 2017-08-3131.08.2017
Projektdetails

Postdoc start-up grant: The role of long non coding RNA in gene-specific promoter methylation during cardiac fibrogenesis
ID 81X3300103
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Xingbo Xu
Site Göttingen
Project type Excellence Programme
Funding 59398.60€ 59.398,60
Begin 2016-10-0101.10.2016
End 2018-01-3131.01.2018
Projektdetails

Rotation grant: Arterial stiffness in type 2 diabetes: Therapeutic potential of microRNA miR-29b
ID 81X3300104
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Uwe Raaz
Site Göttingen
Project type Excellence Programme
Funding 91971.60€ 91.971,60
Begin 2016-11-0101.11.2016
End 2018-04-3030.04.2018
Projektdetails

Postdoc start-up grant: Epigenome-wide association study on platelet count and platelet volume
ID 81X3400104
Institution Universitätsmedizin Greifswald
Project leader Alexander Teumer
Site Greifswald
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2017-02-0101.02.2017
End 2018-01-3131.01.2018
Projektdetails

Postdoc start-up grant: Dissection of molecular disease mechanisms in non-compaction cardiomyopathy (NCCM)
ID 81X3500107
Institution Universitätsklinikum Heidelberg
Project leader Jan Haas
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 53890.96€ 53.890,96
Begin 2015-08-0101.08.2015
End 2016-12-3131.12.2016
Projektdetails

Postdoc start-up grant: Specific K2P channel remodeling in atrial fibrillation and heart failure - implications for therapy
ID 81X3500110
Institution Universitätsklinikum Heidelberg
Project leader Constanze Schmidt
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2016-10-0101.10.2016
End 2017-09-3030.09.2017
Projektdetails

Rotation grant: Enhancer regulation in metabolic cardiac stress
ID 81X3500111
Institution Universitätsklinikum Heidelberg
Project leader Lorenz Lehmann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 65545.27€ 65.545,27
Begin 2016-10-0101.10.2016
End 2017-07-3030.07.2017
Projektdetails

Postdoc start-up grant: Role of the myeloid cell compartment in cardiac hypertrophy
ID 81X3500112
Institution Universitätsklinikum Heidelberg
Project leader Shabana Din
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 55516.24€ 55.516,24
Begin 2016-09-0101.09.2016
End 2017-08-3131.08.2017
Projektdetails

Postdoc start-up grant: YY1 associated factor 2 (Yaf2) as an epigenetic regulator of the cardiac cell cycle
ID 81X3500113
Institution Universitätsklinikum Heidelberg
Project leader Lorenz Lehmann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 59750.00€ 59.750,00
Begin 2016-12-0101.12.2016
End 2017-11-3030.11.2017
Projektdetails

Rotation grant: Antibodies as central mediators of thrombosis and hemostasis
ID 81X3600204
Institution Klinikum der Universität München
Project leader Konstantin Stark
Site München
Project type Excellence Programme
Funding 66110.16€ 66.110,16
Begin 2016-10-0101.10.2016
End 2017-09-3030.09.2017
Projektdetails

Postdoc start-up grant: The role of formyl peptide receptor 1 (FPR1) and DAMPs in myocardial infarction
ID 81X3600205
Institution Klinikum der Universität München
Project leader Maik Drechsler
Site München
Project type Excellence Programme
Funding 59240.00€ 59.240,00
Begin 2017-01-0101.01.2017
End 2017-12-3131.12.2017
Projektdetails

Postdoc start-up grant: Myocardial HMGB1 as mediator of increased atherosclerosis and thrombosis in the post-myocardial infarction period
ID 81X3600206
Institution Klinikum der Universität München
Project leader Konstantin Stark
Site München
Project type Excellence Programme
Funding 57814.33€ 57.814,33
Begin 2016-12-0101.12.2016
End 2018-03-3131.03.2018
Projektdetails

Postdoc start-up grant: The function of microRNA-365 in cardiac arrhythmia
ID 81X3600402
Institution Technische Universität München
Project leader Yassine Sassi
Site München
Project type Excellence Programme
Funding 55894.81€ 55.894,81
Begin 2015-08-0101.08.2015
End 2016-10-3131.10.2016
Projektdetails

Rotation grant: Therapeutic targeting of the NLRP3-inflammasome in atherosclerosis
ID 81X3600503
Institution Deutsches Herzzentrum München
Project leader Hendrik Sager
Site München
Project type Excellence Programme
Funding 98200.00€ 98.200,00
Begin 2016-10-0101.10.2016
End 2017-09-3030.09.2017
Projektdetails

Reintegration grant: Identification of potential drugs abolishing the effect of specific mutations in soluble guanyl cyclase for risk management in myocardial infarction
ID 81X3700103
Institution Universität zu Lübeck
Project leader Stephanie Tennstedt
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 27499.98€ 27.499,98
Begin 2016-07-0101.07.2016
End 2016-12-3131.12.2016
Projektdetails

Reintegration grant: Role of novel microRNAs in cardiac autophagy
ID 81X3700204
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Simone Martini
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 35000.00€ 35.000,00
Begin 2017-03-0101.03.2017
End 2017-08-3131.08.2017
Projektdetails

Rotation grant: Electrophysiological characterisation of a HCM-causing ACTN2 mutation in human iPSC-cardiomyocytes
ID 81X3710106
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Marc Daniel Lemoine
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 74956.63€ 74.956,63
Begin 2016-10-0101.10.2016
End 2017-09-3030.09.2017
Projektdetails

Genetic variation in miRNA networks and its implications for coronary artery disease
ID 81X2100144
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
Funding 47810.00€ 47.810,00
Begin 2018-01-0101.01.2018
End 2021-06-3030.06.2021
Projektdetails

Role of serotonin in cardiac development
ID 81X2100145
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Michael Bader
Site Berlin
Project type Cooperation with External Partners
Funding 33000.00€ 33.000,00
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Proteomic profiling of macrophages
ID 81X2400133
Institution Universitätsmedizin Greifswald
Project leader Uwe Völker
Site Greifswald
Project type Shared Expertise (SE)
Funding 25800.00€ 25.800,00
Begin 2017-05-0101.05.2017
End 2018-04-3030.04.2018
Projektdetails

Gene expression profiling of human monocytes during myocardial infarction.
ID 81X2500167
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 20294.46€ 20.294,46
Begin 2017-05-0101.05.2017
End 2019-04-3030.04.2019
Projektdetails

Analysis of the role of Matr3 for heart-specific alternative splicing and in dilative cardiomyopathy
ID 81X2500169
Institution Universitätsklinikum Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 31032.43€ 31.032,43
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Elucidating cis-regulating function of SNPs associated with atherosclerosis in human iPSCs
ID 81X2600113
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 65708.00€ 65.708,00
Begin 2018-01-0101.01.2018
End 2020-03-3131.03.2020
Projektdetails

Generation and functional characterization of macrophage cell lines from yolk sac precursors
ID 81X2600245
Institution Klinikum der Universität München
Project leader Christian Schulz
Site München
Project type Translational Research Project
Funding 249713.84€ 249.713,84
Begin 2017-04-0101.04.2017
End 2019-03-3131.03.2019
Projektdetails
Macrophage cell lines represent a very useful tool for the study of macrophage functions with high throughput. However, existing cell lines mostly derive from peripheral blood mononuclear cells or leukemic cells, which significantly limits the significance and validity of experiments. However, we and others have recently shown that tissue macrophages in adult organs, including cardiovascular tissues, mostly originate from embryonic precursors located in the yolk sac. These findings have strong implications for our understanding of the immune system and of macrophage biology in general. It also suggests that existing macrophage cell lines are insufficient to study tissue macrophage functions under culture conditions. We therefore aim to generate cell lines of bona fide yolk sac-derived macrophage progenitors, which can be expanded and differentiated into tissue macrophages as needed. This will allow scientists to conduct high throughput screening in disease-relevant cell culture models in vitro and to determine the macrophage potential to promote tissue regeneration in vivo.

Proteomic profiling of macrophages
ID 81X2600246
Institution Klinikum der Universität München
Project leader Christian Schulz
Site München
Project type Shared Expertise (SE)
Funding 14200.00€ 14.200,00
Begin 2017-05-0101.05.2017
End 2018-04-3030.04.2018
Projektdetails

Late pre-clinical developement of CD40-TRAF6 inhibitors (TRAF-STOPs) part I: Go - No Go project
ID 81X2600247
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Translational Research Project
Funding 396944.08€ 396.944,08
Begin 2017-07-0101.07.2017
End 2019-03-3131.03.2019
Projektdetails
Blocking the co-stimulatory CD40L-CD40 dyad reduces atherosclerosis. We found that the interaction between CD40 and TNF-receptor-associated factor 6 (TRAF6) is the driving force for atherosclerosis. Using virtual ligand screening, we identified several small molecule inhibitors termed TRAF-STOPs that were modeled to bind to the CD40-binding domain of TRAF6. Two TRAF-STOPs significantly reduce existing atherosclerosis, improve glucose tolerance and insulin sensitivity in mice, and ameliorate multiple sclerosis. Here we pursue the hypothesis that these TRAF-STOPs are candidates to pass the translational pipeline towards a clinical application to treat chronic inflammatory diseases, including atherosclerosis. Dose finding studies, toxicity and pharmacological safety studies as well as pharmacodynamic studies will be performed, the pharmacological properties will be improved and the proof of the specificity of these small molecule inhibitors will be established.

A novel oxidized MIF isoform: mechanism of formation, neutrophil-specificity, and role in cardiac ischemia
ID 81X2600248
Institution Klinikum der Universität München
Project leader Jürgen Bernhagen
Site München
Project type Cooperation with External Partners
Funding 37251.88€ 37.251,88
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Gene expression profiling of human monocytes during myocardial infarction
ID 81X2600518
Institution Deutsches Herzzentrum München
Project leader Hendrik Sager
Site München
Project type Shared Expertise (SE)
Funding 19599.39€ 19.599,39
Begin 2017-03-0101.03.2017
End 2019-04-3030.04.2019
Projektdetails

Genetic variation in miRNA networks and its implications for coronary artery disease
ID 81X2600519
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Shared Expertise (SE)
Funding 27190.00€ 27.190,00
Begin 2018-01-0101.01.2018
End 2021-06-3030.06.2021
Projektdetails

Elucidating cis-regulating function of SNPs associated with atherosclerosis in human iPSCs
ID 81X2700130
Institution Universität zu Lübeck
Project leader Jeanette Erdmann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 62756.57€ 62.756,57
Begin 2018-01-0101.01.2018
End 2020-03-3131.03.2020
Projektdetails

Endogenous Reprogramming of Cardiac Fatty Acid Metabolism to Treat Diabetic Cardiomyopathy
ID 81X2700214
Institution Christian-Albrechts-Universität zu Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 24999.46€ 24.999,46
Begin 2017-09-0101.09.2017
End 2019-01-3131.01.2019
Projektdetails

Novel insights in the development of Takotsubo cardiomyopathy using patient-specific induced pluripotent stem cells
ID 81X2700215
Institution Christian-Albrechts-Universität zu Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38900.00€ 38.900,00
Begin 2017-09-0101.09.2017
End 2019-12-3131.12.2019
Projektdetails

A novel oxidized MIF isoform: mechanism of formation, neutrophil-specificity, and role in cardiac ischemia
ID 81X2800172
Institution Universität Duisburg-Essen
Project leader Tienush Rassaf
Site Extern
Project type Cooperation with External Partners
Funding 37120.00€ 37.120,00
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

DZHK OMICs Ressource Projekt Teilprojekt RNA-Sequenzierung
ID 81X1100101
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader Norbert Huebner
Site Berlin
Project type OMICs
Funding 439744.92€ 439.744,92
Begin 2016-07-0101.07.2016
End 2019-03-3131.03.2019
Projektdetails

SPIRIT-HF-DZHK8: SPIRonolactone In the Treatment for Heart Failure
ID 81X1100205
Institution Charité - Universitätsmedizin Berlin
Project leader Frank Edelmann
Site Berlin
Project type Clinical Studies
Funding 6892323.49€ 6.892.323,49
Begin 2016-04-0101.04.2016
End 2025-08-3131.08.2025
Projektdetails

SPIRIT-HF-DZHK8: DZHK-Biobanking
ID 81X1100206
Institution Charité - Universitätsmedizin Berlin
Project leader Frank Edelmann
Site Berlin
Project type Clinical Studies
Funding 86471.82€ 86.471,82
Begin 2016-04-0101.04.2016
End 2024-12-3131.12.2024
Projektdetails

Decipher HFpEF-DZHK12: Clinical Project Management
ID 81X1100207
Institution Charité - Universitätsmedizin Berlin
Project leader Burkert Pieske
Site Berlin
Project type Clinical Studies
Funding 66538.14€ 66.538,14
Begin 2017-02-0101.02.2017
End 2019-12-3131.12.2019
Projektdetails
https://www.cardiac-imaging.org/decipher--hfpef.html

Ex-VAD-DZHK11: Exercise Training in Patients with Left Ventricular Assist Device
ID 81X1100208
Institution Charité - Universitätsmedizin Berlin
Project leader Frank Edelmann
Site Berlin
Project type Clinical Studies
Funding 513129.15€ 513.129,15
Begin 2017-04-0101.04.2017
End 2020-12-3131.12.2020
Projektdetails
https://ex-vad.dzhk.de/

Ex-VAD-DZHK11: DZHK-Biobanking
ID 81X1100209
Institution Charité - Universitätsmedizin Berlin
Project leader Frank Edelmann
Site Berlin
Project type Clinical Studies
Funding 10516.22€ 10.516,22
Begin 2017-04-0101.04.2017
End 2020-12-3131.12.2020
Projektdetails
https://ex-vad.dzhk.de/

DYNAMIC-MR: Basis Biobanking
ID 81X1100210
Institution Charité - Universitätsmedizin Berlin
Project leader Burkert Pieske
Site Berlin
Project type Clinical Studies
Funding 0.00€ 0,00
Begin 2017-07-0101.07.2017
End 2018-12-3131.12.2018
Projektdetails

DYNAMIC-MR: Stress testing and echocardiography to identify significant DYNAMIC Mitral valve Regurgitation amenable to MitraClip mitral valve repair in patients with heart failure with reduced ejection fraction (DYNAMIC-MR)
ID 81X1100211
Institution Charité - Universitätsmedizin Berlin
Project leader Burkert Pieske
Site Berlin
Project type Clinical Studies
Funding 24115.68€ 24.115,68
Begin 2017-07-0101.07.2017
End 2018-12-3131.12.2018
Projektdetails

CLOSURE-AF-DZHK16: DZHK-Biobanking
ID 81X1100212
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Clinical Studies
Funding 111765.28€ 111.765,28
Begin 2017-06-0101.06.2017
End 2025-12-3131.12.2025
Projektdetails
https://closure-af.dzhk.de/

VAD-DZHK3: DZHK-Biobanking
ID 81X1100302
Institution Deutsches Herzzentrum Berlin
Project leader Christoph Knosalla
Site Berlin
Project type Clinical Studies
Funding 37823.61€ 37.823,61
Begin 2015-01-0101.01.2015
End 2023-03-3131.03.2023
Projektdetails
https://vad.dzhk.de/

Decipher HFpEF-DZHK12: Validation of Cardiovascular Magnetic Resonance against Invasive haemodynamics in patients with Heart Failure with Preserved Ejection Fraction
ID 81X1200102
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eike Nagel
Site RheinMain
Project type Clinical Studies
Funding 579125.26€ 579.125,26
Begin 2017-02-0101.02.2017
End 2022-12-3131.12.2022
Projektdetails
https://www.cardiac-imaging.org/decipher--hfpef.html

Decipher HFpEF-DZHK12: DZHK-Biobanking
ID 81X1200103
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eike Nagel
Site RheinMain
Project type Clinical Studies
Funding 16180.45€ 16.180,45
Begin 2017-02-0101.02.2017
End 2022-12-3131.12.2022
Projektdetails
https://www.cardiac-imaging.org/decipher--hfpef.html

GARY-Register (German Aortic Valve Registry) Auswertungen
ID 81X1200104
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eva Herrmann
Site RheinMain
Project type Clinical Studies
Funding 285658.18€ 285.658,18
Begin 2017-03-0101.03.2017
End 2019-02-2828.02.2019
Projektdetails

GARY-Register (German Aortic Valve Registry) Auswertungen
ID 81X1200202
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Christian Hamm
Site RheinMain
Project type Clinical Studies
Funding 41856.83€ 41.856,83
Begin 2017-02-0101.02.2017
End 2019-01-3131.01.2019
Projektdetails

TransitionCHF-DZHK2: DZHK-Biobanking
ID 81X1300105
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Gerd Hasenfuß
Site Göttingen
Project type Clinical Studies
Funding 55133.37€ 55.133,37
Begin 2014-11-0101.11.2014
End 2023-12-3131.12.2023
Projektdetails

SPIRIT-HF-DZHK8: Biometrie
ID 81X1300107
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 90000.00€ 90.000,00
Begin 2016-07-0101.07.2016
End 2025-08-3131.08.2025
Projektdetails

Decipher HFpEF-DZHK12: Clinical Project Management
ID 81X1300108
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Gerd Hasenfuß
Site Göttingen
Project type Clinical Studies
Funding 74862.85€ 74.862,85
Begin 2017-02-0101.02.2017
End 2021-02-2828.02.2021
Projektdetails

Ex-VAD-DZHK11: Biometrie
ID 81X1300109
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 64886.24€ 64.886,24
Begin 2017-04-0101.04.2017
End 2020-12-3131.12.2020
Projektdetails
https://ex-vad.dzhk.de/

DYNAMIC-MR: Biometrie
ID 81X1300110
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 2563.12€ 2.563,12
Begin 2017-07-0101.07.2017
End 2018-12-3131.12.2018
Projektdetails

HFpEF-stress-DZHK17: Cardiovascular magnetic resonance real time exercise stress testing in heart failure with preserved ejection fraction
ID 81X1300113
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Andreas Schuster
Site Göttingen
Project type Clinical Studies
Funding 305002.06€ 305.002,06
Begin 2017-06-0101.06.2017
End 2020-09-3030.09.2020
Projektdetails

HFpEF-stress-DZHK17: DZHK-Biobanking
ID 81X1300114
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Andreas Schuster
Site Göttingen
Project type Clinical Studies
Funding 1053.19€ 1.053,19
Begin 2017-06-0101.06.2017
End 2020-09-3030.09.2020
Projektdetails

CLOSURE-AF-DZHK16: Biometrie Göttingen
ID 81X1300115
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 69224.00€ 69.224,00
Begin 2017-06-0101.06.2017
End 2025-12-3131.12.2025
Projektdetails
https://closure-af.dzhk.de/

Studienbiobanking diverse DZHK-Studien
ID 81X1400104
Institution Universitätsmedizin Greifswald
Project leader Matthias Nauck
Site Greifswald
Project type Clinical Studies
Funding 519351.09€ 519.351,09
Begin 2014-11-2525.11.2014
End 2024-09-3030.09.2024
Projektdetails

Umsetzung und Finanzierung des DZHK-Biobankings in der Anfangsphase
ID 81X1400105
Institution Universitätsmedizin Greifswald
Project leader Matthias Nauck
Site Greifswald
Project type Clinical Studies
Funding 394064.79€ 394.064,79
Begin 2014-11-0101.11.2014
End 2024-12-3131.12.2024
Projektdetails

HFpEF-stress-DZHK17: Laboranalyse
ID 81X1400106
Institution Universitätsmedizin Greifswald
Project leader Matthias Nauck
Site Greifswald
Project type Clinical Studies
Funding 10127.93€ 10.127,93
Begin 2018-01-0101.01.2018
End 2020-09-3030.09.2020
Projektdetails

TORCH-DZHK1: DZHK-Biobanking
ID 81X1500103
Institution Universitätsklinikum Heidelberg
Project leader Hugo A. Katus
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 189240.38€ 189.240,38
Begin 2014-11-0101.11.2014
End 2018-02-2828.02.2018
Projektdetails

Hauptstudie zum OMICs Ressource Projekt
ID 81X1500104
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type OMICs
Funding 15167.94€ 15.167,94
Begin 2016-07-0101.07.2016
End 2019-03-3131.03.2019
Projektdetails

Decipher HFpEF-DZHK12: Clinical Project Management
ID 81X1500105
Institution Universitätsklinikum Heidelberg
Project leader Johannes Riffel
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 73917.45€ 73.917,45
Begin 2017-08-0101.08.2017
End 2019-12-3131.12.2019
Projektdetails
https://www.cardiac-imaging.org/decipher--hfpef.html

Vorstudie zum OMICs Resource Projekt als technischer und methodischer Validierungslauf zu Ganzgenom-Sequenzierungen
ID 81X1500301
Institution Deutsches Krebsforschungszentrum (DKFZ)
Project leader Stephan / Stefan Wolf / Wiemann
Site Heidelberg/Mannheim
Project type OMICs
Funding 59400.00€ 59.400,00
Begin 2016-03-0101.03.2016
End 2016-10-3131.10.2016
Projektdetails

Hauptstudie zum OMICs Ressource Projekt
ID 81X1500302
Institution Deutsches Krebsforschungszentrum (DKFZ)
Project leader Stephan / Stefan Wolf / Wiemann
Site Heidelberg/Mannheim
Project type OMICs
Funding 2017224.00€ 2.017.224,00
Begin 2016-07-0101.07.2016
End 2019-03-3131.03.2019
Projektdetails

OMICs Ressource Project - Hauptstudie - Datenhaltung München
ID 81X1600102
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Tim M. Strom
Site München
Project type OMICs
Funding 264979.57€ 264.979,57
Begin 2016-07-0101.07.2016
End 2019-03-3131.03.2019
Projektdetails

APPROACH-ACS-AF-DZHK7: DZHK-Biobanking
ID 81X1600204
Institution Klinikum der Universität München
Project leader Reza Wakili
Site München
Project type Clinical Studies
Funding 64520.00€ 64.520,00
Begin 2016-01-0101.01.2016
End 2021-06-3030.06.2021
Projektdetails
https://approach.dzhk.de/

SMART-MI-DZHK9: Implantierbare kardiale Monitore bei Hochrisiko-­Postinfarkt-­Patienten mit kardialer autonomer Dysfunktion und mittelgradig reduzierter linksventrikulärer Pumpfunktion
ID 81X1600206
Institution Klinikum der Universität München
Project leader Axel Bauer
Site München
Project type Clinical Studies
Funding 1555573.84€ 1.555.573,84
Begin 2016-02-0101.02.2016
End 2021-07-3131.07.2021
Projektdetails
https://smart-mi.dzhk.de/

REVACEPT/CAD/02 - Revacept, ein neuartiger Inhibitor der Thrombozytenadhäsion für Patienten mit stabiler koronarer Herzkrankheit, die sich einer elektiven perkutanen Koronarintervention unterziehen: eine randomisierte, doppelblinde, placebokontrollierte P
ID 81X1600207
Institution Klinikum der Universität München
Project leader Steffen Massberg
Site München
Project type Clinical Studies
Funding 178601.39€ 178.601,39
Begin 2016-09-0101.09.2016
End 2020-07-3131.07.2020
Projektdetails

REVACEPT/CAD/02 - Revacept, ein neuartiger Inhibitor der Thrombozytenadhäsion für Patienten mit stabiler koronarer Herzkrankheit, die sich einer elektiven perkutanen Koronarintervention unterziehen: eine randomisierte, doppelblinde, placebokontrollierte P
ID 81X1600503
Institution Deutsches Herzzentrum München
Project leader Adnan Kastrati
Site München
Project type Clinical Studies
Funding 780429.13€ 780.429,13
Begin 2016-09-0101.09.2016
End 2020-08-3131.08.2020
Projektdetails

SMART-MI-DZHK9: Projektmanagement
ID 81X1600604
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Silvia Egert
Site München
Project type Clinical Studies
Funding 468898.44€ 468.898,44
Begin 2016-06-0101.06.2016
End 2021-07-3131.07.2021
Projektdetails
https://smart-mi.dzhk.de/

REVACEPT/CAD/02 - Statistische Beratung
ID 81X1600605
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alexander Hapfelmeier
Site München
Project type Clinical Studies
Funding 16322.56€ 16.322,56
Begin 2016-09-0101.09.2016
End 2020-07-3131.07.2020
Projektdetails

Ex-VAD-DZHK11: Training Core Lab
ID 81X1600606
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Clinical Studies
Funding 25000.00€ 25.000,00
Begin 2017-04-0101.04.2017
End 2020-12-3131.12.2020
Projektdetails
https://ex-vad.dzhk.de/

Hauptstudie zum OMICs Ressource Projekt
ID 81X1700104
Institution Universität zu Lübeck
Project leader Inke König
Site Hamburg/Kiel/Lübeck
Project type OMICs
Funding 129493.52€ 129.493,52
Begin 2016-07-0101.07.2016
End 2019-03-3131.03.2019
Projektdetails

Hauptstudie zum OMICs Ressource Projekt
ID 81X1700105
Institution Universität zu Lübeck
Project leader Jeanette Erdmann
Site Hamburg/Kiel/Lübeck
Project type OMICs
Funding 127709.27€ 127.709,27
Begin 2016-07-0101.07.2016
End 2019-03-3131.03.2019
Projektdetails

CAVA-ADHF-DZHK10: Zusätzliche Ultraschalluntersuchung der Vena cava inferior zur Steuerung der Rekompensationstherapie der akut-dekompensierten Herzinsuffizienz
ID 81X1700106
Institution Universität zu Lübeck
Project leader Alexander Jobs
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 921014.95€ 921.014,95
Begin 2016-12-0101.12.2016
End 2023-03-3131.03.2023
Projektdetails
https://cava-adhf.dzhk.de/

CAVA-ADHF-DZHK10: DZHK-Biobanking
ID 81X1700107
Institution Universität zu Lübeck
Project leader Alexander Jobs
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 37171.61€ 37.171,61
Begin 2016-12-0101.12.2016
End 2023-03-3131.03.2023
Projektdetails
https://cava-adhf.dzhk.de/

Hauptstudie zum OMICs Ressource Projekt
ID 81X1710104
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type OMICs
Funding 33597.69€ 33.597,69
Begin 2016-07-0101.07.2016
End 2019-03-3131.03.2019
Projektdetails

DEDICATE-DZHK6: DZHK-Biobanking
ID 81X1710105
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Stefan Blankenberg
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 73117.00€ 73.117,00
Begin 2017-02-0101.02.2017
End 2023-03-3131.03.2023
Projektdetails
https://dedicate.dzhk.de/

DEDICATE-DZHK6: Randomized, Observer-Blinded, Multi-Center, Event-Driven Trial of TAVI versus SAVR in Patients with Symptomatic Severe Aortic Valve Stenosis and Intermediate Risk of Mortality, as assessed by STS-Score
ID 81X1710106
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Stefan Blankenberg
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 3732785.61€ 3.732.785,61
Begin 2017-02-0101.02.2017
End 2028-07-3131.07.2028
Projektdetails
https://dedicate.dzhk.de/

SCREEN-AF-DZHK15: Projektmanagement
ID 81X1710107
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Martin Scherer
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 66805.07€ 66.805,07
Begin 2017-04-0101.04.2017
End 2024-06-3030.06.2024
Projektdetails

Postdoc start-up grant: Regulation of endothelial FOXO signaling by deubiquitinating enzymes
ID 81X3200305
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Toshiya Sugino
Site RheinMain
Project type Excellence Programme
Funding 59480.94€ 59.480,94
Begin 2017-01-0101.01.2017
End 2018-06-3030.06.2018
Projektdetails

Rotation grant: The role of the gut-microbiome for the development of vulnerable coronary plaque
ID 81X3100204
Institution Charité - Universitätsmedizin Berlin
Project leader Arash Haghikia
Site Berlin
Project type Excellence Programme
Funding 82933.31€ 82.933,31
Begin 2017-10-0101.10.2017
End 2018-11-3030.11.2018
Projektdetails

Postdoc start-up grant: GPCR signaling in smooth muscle dedifferentiation: From single-cell expression to new therepeutic strategies
ID 81X3200306
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Harmandeep Kaur
Site RheinMain
Project type Excellence Programme
Funding 56933.83€ 56.933,83
Begin 2017-12-0101.12.2017
End 2018-11-3030.11.2018
Projektdetails

Contribution of skeletal muscle to inflammation-induced heart failure
ID 81X2500168
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE060)
Funding 49080.90€ 49.080,90
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

CLOSURE-AF-DZHK16: Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy: a prospective randomized clinical tria
ID 81X1100213
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Clinical Studies
Funding 6251873.49€ 6.251.873,49
Begin 2017-06-0101.06.2017
End 2025-12-3131.12.2025
Projektdetails
https://closure-af.dzhk.de/

CLOSURE-AF-DZHK16: Klinisches Projektmanagement & SAE Management
ID 81X1700109
Institution Universität zu Lübeck
Project leader Ingo Eitel
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 458657.46€ 458.657,46
Begin 2017-07-0101.07.2017
End 2025-12-3131.12.2025
Projektdetails
https://closure-af.dzhk.de/

CLOSURE-AF-DZHK16: Biometrie Hamburg
ID 81X1710108
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Karl Wegscheider
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 229699.01€ 229.699,01
Begin 2017-06-0101.06.2017
End 2025-12-3131.12.2025
Projektdetails
https://closure-af.dzhk.de/

CTSN-TVR-DZHK14: DZHK-Biobanking
ID 81X1100304
Institution Deutsches Herzzentrum Berlin
Project leader Volkmar Falk
Site Berlin
Project type Clinical Studies
Funding 6044.79€ 6.044,79
Begin 2017-05-0101.05.2017
End 2023-12-3131.12.2023
Projektdetails

CTSN-TVR-DZHK14: Evaluating the benefit of concurrent tricuspid valve repair during mitral surgery
ID 81X1100305
Institution Deutsches Herzzentrum Berlin
Project leader Volkmar Falk
Site Berlin
Project type Clinical Studies
Funding 716818.00€ 716.818,00
Begin 2017-05-0101.05.2017
End 2024-10-3131.10.2024
Projektdetails

DEDICATE-DZHK6: Biometrie
ID 81X1700108
Institution Universität zu Lübeck
Project leader Inke König
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 98586.00€ 98.586,00
Begin 2017-03-0101.03.2017
End 2028-07-3131.07.2028
Projektdetails
https://dedicate.dzhk.de/

SCREEN-AF-DZHK15: Projektmanagement
ID 81X1200105
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Christiane Muth
Site RheinMain
Project type Clinical Studies
Funding 7815.84€ 7.815,84
Begin 2017-04-0101.04.2017
End 2020-02-2929.02.2020
Projektdetails

SCREEN-AF-DZHK15: DZHK-Biobanking
ID 81X1300112
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Rolf Wachter
Site Göttingen
Project type Clinical Studies
Funding 27907.52€ 27.907,52
Begin 2017-05-0101.05.2017
End 2022-02-2828.02.2022
Projektdetails

SCREEN-AF-DZHK15: Program for Identification of "Actionable" Atrial Fibrillation (PIAFF): Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care
ID 81X1300111
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Rolf Wachter
Site Göttingen
Project type Clinical Studies
Funding 452291.19€ 452.291,19
Begin 2017-05-0101.05.2017
End 2024-06-3030.06.2024
Projektdetails

Novel inotropic/lusitropic biologics against decompensated chronic heart failure
ID 81X2500173
Institution Universitätsklinikum Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Translational Research Project
Funding 475370.35€ 475.370,35
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails
The objectives of this proposal are the preclinical development of a cardiac-targeted peptide drug with inotropic and lusitropic effects for the short-term intravenous treatment of decompensated chronic heart failure (CHF) and its clinical translation into a first-in-human clinical trial. The life-threatening complication of the clinical syndrome presents a significant unmet medical need given its high mortality and severe adverse effects of clinical drugs to reconstitute cardiac performance. The proposed therapeutic innovation seeks to exploit a novel regulatory principle to improve cardiac contraction and relaxation by the molecular factor S100A1 and utilizes cell-permeable peptide technology that is derived from the molecule’s C-terminal domain. The translational research project originates from comprehensive preclinical data showing the ability of S100A1ct peptide for a reversible short-term improvement and protection of cardiac performance in vivo and in vitro. In its funded first developmental module, the project seeks to define the therapeutically effective dose-range of S100A1ct in clinically relevant large animal disease models as well as demonstration of toxicological and immunological safety to conclude regulatory steps on ultimate GMP/GLP pre-clinical and clinical development.

GMP-Production of Engineered Human Myocardium for Heart Failure Repair
ID 81X2300176
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Translational Research Project
Funding 2654615.00€ 2.654.615,00
Begin 2018-01-0808.01.2018
End 2022-06-3030.06.2022
Projektdetails
Irreversible and progressive loss of cardiomyocytes is the underlying cause of heart failure. Remuscularization of the failing heart can be achieved by epicardial implantation of tissue engineered myocardium. A major procedural challenge for the translation of cell based therapies is the set-up and validation of a cGMP-production process. This should be done early during the translation process to reduce costs and variability/inconsistency already in preclinical studies and facilitate clinical translation into first-in patient studies. We have developed a versatile protocol for the construction of engineered human myocardium from ESCs and iPSCs to meet cGMP demands. The objectives of this project are to now set-up a GMP production pipeline and obtain a manufacturing authorization from the local competent authority for the preparation of EHM for a first in patient safety study with an anticipated number of 10 patients with end-stage heart failure.

METRIS-HF-DZHK18: Effect of Metformin in Insulin resistant patients with heart failure with reduced ejection fraction
ID 81X1100215
Institution Charité - Universitätsmedizin Berlin
Project leader Wolfram Döhner
Site Berlin
Project type Clinical Studies
Funding 936007.40€ 936.007,40
Begin 2018-02-0101.02.2018
End 2024-07-3131.07.2024
Projektdetails

METRIS-HF-DZHK18: DZHK-Biobanking
ID 81X1100216
Institution Charité - Universitätsmedizin Berlin
Project leader Wolfram Döhner
Site Berlin
Project type Clinical Studies
Funding 16565.84€ 16.565,84
Begin 2018-02-0101.02.2018
End 2024-02-2828.02.2024
Projektdetails

PRAISE-DZHK19|DZNEB001: Prediction of Acute coronary syndrome in acute Ischemic StrokE
ID 81X1100217
Institution Charité - Universitätsmedizin Berlin
Project leader Matthias Endres
Site Berlin
Project type Clinical Studies
Funding 445715.72€ 445.715,72
Begin 2018-08-0101.08.2018
End 2022-12-3131.12.2022
Projektdetails

PRAISE-DZHK19|DZNEB001: DZHK-Biobanking
ID 81X1100218
Institution Charité - Universitätsmedizin Berlin
Project leader Matthias Endres
Site Berlin
Project type Clinical Studies
Funding 40428.19€ 40.428,19
Begin 2018-08-0101.08.2018
End 2022-07-3131.07.2022
Projektdetails

METRIS-HF-DZHK18: Biometrie
ID 81X1300116
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 39999.00€ 39.999,00
Begin 2018-02-0101.02.2018
End 2024-07-3131.07.2024
Projektdetails

CAVA-ADHF-DZHK10: Studien Biobanking CAVA ADHF-Analyse
ID 81X1400107
Institution Universitätsmedizin Greifswald
Project leader Matthias Nauck
Site Greifswald
Project type Clinical Studies
Funding 67998.88€ 67.998,88
Begin 2018-07-0101.07.2018
End 2023-03-3131.03.2023
Projektdetails

PRAISE-DZHK19|DZNEB001: Biometrie
ID 81X1710109
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Karl Wegscheider
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 56501.00€ 56.501,00
Begin 2018-07-0101.07.2018
End 2022-06-3030.06.2022
Projektdetails

Serotonin in Vascular function and disease
ID 81Z0100102
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Bader
Site Berlin
Project type Partner Site Projects
Funding 110000.00€ 110.000,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

PCP-SRF Zusammenspiel in der myokardiale Remodeling während der Herzreparatur
ID 81Z0100103
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Daniela Panakova
Site Berlin
Project type Partner Site Projects
Funding 107095.90€ 107.095,90
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Regenerative role of cardiac macrophage in response to high fat diet
ID 81Z0100104
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Suphansa Sawamiphak
Site Berlin
Project type Partner Site Projects
Funding 110000.00€ 110.000,00
Begin 2019-01-0101.01.2019
End 2022-06-3030.06.2022
Projektdetails

A single cell phenomics approach to cardiac remodelling in development and disease
ID 81Z0100105
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Huebner
Site Berlin
Project type Partner Site Projects
Funding 1365909.00€ 1.365.909,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Einfluss von Metformin auf das Darmmikrobiom bei salzempfindlichen CMD
ID 81Z0100106
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Dominik Müller
Site Berlin
Project type Partner Site Projects
Funding 223481.28€ 223.481,28
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

DZHK Professorship Project: Principles, regulation and treatment options of endothelial maladaptation in acute and chronic vascular disease (EndoAdapt)
ID 81Z0100108
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Holger Gerhardt
Site Berlin
Project type Partner Site Projects
Funding 3108448.00€ 3.108.448,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Metabolic mechanisms of in Heart Failure with reduced ejection fraction (HFrEF)
ID 81Z0100203
Institution Charité - Universitätsmedizin Berlin
Project leader Anna Foryst Ludwig
Site Berlin
Project type Partner Site Projects
Funding 1119489.09€ 1.119.489,09
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Zelluläre Mechanotransduktion in der Behandlung und Diagnostik kardiovaskulärer Erkrankungen
ID 81Z0100205
Institution Charité - Universitätsmedizin Berlin
Project leader Antje Ludwig
Site Berlin
Project type Partner Site Projects
Funding 676063.42€ 676.063,42
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Voltage-mapping- and MRI-guided endomyocardial biopsy in myocarditis and DCMi
ID 81Z0100206
Institution Charité - Universitätsmedizin Berlin
Project leader Carsten Tschöpe
Site Berlin
Project type Partner Site Projects
Funding 158732.77€ 158.732,77
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Sex and gender differences in frailty and muscle wast-ing as complication of elderly heart failure patients, Networking
ID 81Z0100207
Institution Charité - Universitätsmedizin Berlin
Project leader Stefan Anker
Site Berlin
Project type Partner Site Projects
Funding 302052.23€ 302.052,23
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Noninvasive hemodynamica and myocardial tissue differ-entiation applying Cardiovascular MR
ID 81Z0100208
Institution Charité - Universitätsmedizin Berlin
Project leader Jeanette Schulz-Menger
Site Berlin
Project type Partner Site Projects
Funding 672355.62€ 672.355,62
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Endotheliales Re-arrangement und die neurovaskuläre Einheit beim ischämischen Schlaganfall
ID 81Z0100209
Institution Charité - Universitätsmedizin Berlin
Project leader Matthias Endres
Site Berlin
Project type Partner Site Projects
Funding 647085.96€ 647.085,96
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Mechanisms of heart failure in pediatric primary cardiomyopathies
ID 81Z0100301
Institution Deutsches Herzzentrum Berlin
Project leader Felix Berger
Site Berlin
Project type Partner Site Projects
Funding 169987.20€ 169.987,20
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Targeted modification of MSC-derived exosomes for intravascular therapeutic application
ID 81Z0100302
Institution Deutsches Herzzentrum Berlin
Project leader Volkmar Falk
Site Berlin
Project type Partner Site Projects
Funding 157800.00€ 157.800,00
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

Pulmonary vascular stiffening in pulmonary Hypertension due to left heart disease
ID 81Z0100303
Institution Deutsches Herzzentrum Berlin
Project leader Volkmar Falk
Site Berlin
Project type Partner Site Projects
Funding 1571978.26€ 1.571.978,26
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

RNA Therapeutics 2.0
ID 81Z0200103
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Partner Site Projects
Funding 922872.36€ 922.872,36
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Cellular Heterogeneity
ID 81Z0200104
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Partner Site Projects
Funding 1757564.00€ 1.757.564,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

W2v RNA Biology
ID 81Z0200105
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Partner Site Projects
Funding 1196370.00€ 1.196.370,00
Begin 2019-01-1717.01.2019
End 2025-12-3131.12.2025
Projektdetails

IT Novel statistical tools
ID 81Z0200107
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eva Herrmann
Site RheinMain
Project type Partner Site Projects
Funding 52228.11€ 52.228,11
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Untersuchung zum Langzeit Follow-up bei Herzinsuffizienz
ID 81Z0210102
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site Göttingen
Project type Partner Site Projects
Funding 3397301.19€ 3.397.301,19
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Allianz zur Regeneration des Herzens
ID 81Z0300103
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Partner Site Projects
Funding 457020.00€ 457.020,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Nanopathologie
ID 81Z0300104
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stefan Lehnart
Site Göttingen
Project type Partner Site Projects
Funding 389185.64€ 389.185,64
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Epigenetische Biomarker-stratifizierte Therapie der Herzfibrose
ID 81Z0300106
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Elisabeth Zeisberg
Site Göttingen
Project type Partner Site Projects
Funding 120000.00€ 120.000,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Entwicklung einer dynamischen Plattform mobiler Apps zur Unterstützung verhaltensbezogener Interventionen in der Sekundärprävention der Herzinsuffizienz
ID 81Z0300107
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Christoph Herrmann-Lingen
Site Göttingen
Project type Partner Site Projects
Funding 516739.62€ 516.739,62
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Informations- und Datenmanagement
ID 81Z0300108
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Tim Friede
Site Göttingen
Project type Partner Site Projects
Funding 543059.71€ 543.059,71
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Metabolische Kardiologie und Kardio-Onkologie
ID 81Z0300109
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Stephan von Haehling
Site Göttingen
Project type Partner Site Projects
Funding 654923.87€ 654.923,87
Begin 2019-01-0101.01.2019
End 2021-03-3131.03.2021
Projektdetails

Identifikation und Validierung von Targets bei Herzinsuffizienz
ID 81Z0300301
Institution Georg-August-Universität Göttingen
Project leader Lutz Ackermann
Site Göttingen
Project type Partner Site Projects
Funding 169566.51€ 169.566,51
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Allianz zur Regeneration des Herzens
ID 81Z0300401
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (MPG)
Project leader Eberhard Bodenschatz
Site Göttingen
Project type Partner Site Projects
Funding 88019.32€ 88.019,32
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

L-Typ Ca2+-Kanäle (LCC) Lebendzell-Markierung.
ID 81Z0300501
Institution Max-Planck-Gesellschaft (MPG), vertreten durch das Max-Planck-Institut für biophysikalische Chemie
Project leader Stefan Hell
Site Göttingen
Project type Partner Site Projects
Funding 259314.00€ 259.314,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Molecular mechanisms of heart failure and cardiac cachexia
ID 81Z0400103
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Partner Site Projects
Funding 4337607.13€ 4.337.607,13
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Die Rolle von Lamin A bei Kardiomyopathien
ID 81Z0500202
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Gergana Dobreva
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 1239313.28€ 1.239.313,28
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Einfluss von Endothelzellen auf das kardiale Remodeling
ID 81Z0500203
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Jörg Heineke
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 939514.20€ 939.514,20
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Von der Kanalerkrankung zur Klinischen Arrhythmie
ID 81Z0500204
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Martin Borggrefe
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 1244614.20€ 1.244.614,20
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Integrierte Omicsanalysen bei kardiovaskulären Erkrankungen (Förderphase 2019-2020)
ID 81Z0600102
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 179661.93€ 179.661,93
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Cardiometabolism
ID 81Z0600103
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Stephan Herzig
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 766248.00€ 766.248,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Molecular determinants of atherosclerotic plaque destabilization
ID 81Z0600203
Institution Klinikum der Universität München
Project leader Christian Weber
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 2073735.20€ 2.073.735,20
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Regulation of innate immune responses in cardiovascular injury
ID 81Z0600204
Institution Klinikum der Universität München
Project leader Christian Schulz
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 784919.00€ 784.919,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Pericardial immune cell cross talk in cardiac repair and remodelling
ID 81Z0600205
Institution Klinikum der Universität München
Project leader Sabine Steffens
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 846819.00€ 846.819,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Translational Arrhythmia Research Group (Förderphase 2019-2020)
ID 81Z0600206
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 784919.00€ 784.919,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Vascular regeneration/remodeling (Förderphase 2019-2020)
ID 81Z0600207
Institution Klinikum der Universität München
Project leader Daphne Merkus
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 784919.00€ 784.919,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Gender Medicine (Förderphase 2019-2020)
ID 81Z0600208
Institution Klinikum der Universität München
Project leader Julinda Mehilli
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 311665.00€ 311.665,00
Begin 2019-01-0101.01.2019
End 2022-01-3131.01.2022
Projektdetails

Cell adhesion in CHD (Förderphase 2019-2020)
ID 81Z0600301
Institution Max-Planck-Institut für Biochemie
Project leader Reinhard Fässler
Site München
Project type Partner Site Projects
Funding 178524.76€ 178.524,76
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

A translational approach to improve vascular healing after coronary intervention
ID 81Z0600502
Institution Deutsches Herzzentrum München
Project leader Michael Joner
Site München
Project type Partner Site Projects
Funding 1915618.00€ 1.915.618,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Coronary Artery Disease Clinical Study Unit (Förderphase 2019-2020)
ID 81Z0600503
Institution Deutsches Herzzentrum München
Project leader Adnan Kastrati
Site München
Project type Partner Site Projects
Funding 792387.00€ 792.387,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Large Animal Models (Förderphase 2019-2020)
ID 81Z0600602
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Partner Site Projects
Funding 792387.00€ 792.387,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Exercise intervention in heart failure
ID 81Z0600603
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Partner Site Projects
Funding 416233.00€ 416.233,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Funktionelle Analyse transkriptioneller Dysregulation und der Chromatin-Organisation
ID 81Z0700103
Institution Universität zu Lübeck
Project leader Frank Kaiser
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 136800.00€ 136.800,00
Begin 2019-01-0101.01.2019
End 2021-04-3030.04.2021
Projektdetails

Generation of autologous, biodegradable, tissue-engineered heart valves for minimally invasive stent implantation
ID 81Z0700202
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Georg Lutter
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 150000.00€ 150.000,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Molecular Mechanisms of structural heart defects.
ID 81Z0700204
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Daniela Panakova
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 652920.58€ 652.920,58
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Targeting mechanotransduction in cardiac hypertrophy and failure
ID 81Z0700205
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Derk Frank
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 2079171.00€ 2.079.171,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

CVRC Echokardiographie Core Facility für Kleintiere
ID 81Z0710103
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 284420.00€ 284.420,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Mikrodomänen-spezifische Modulation des adrenergen Signalings im Myokard
ID 81Z0710104
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Viacheslav Nikolaev
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 1342353.02€ 1.342.353,02
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails
Co-Projektleitung: Prof. Heimo Ehmke

Intimal hyperplasia and vascular restenosis
ID 81Z0710105
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 756026.00€ 756.026,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Mikrodomänen-spezifische Modulation des adrenergen Signalings im Myokard
ID 81Z0710106
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Heimo Ehmke
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 167624.00€ 167.624,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Oxidative post-translationale Modifikationen bei kardi-ovaskulären Erkrankungen: Regulationsmechanismen von Proteinkinasen
ID 81Z0710107
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Friederike Cuello
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 167624.00€ 167.624,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Molecular characterization of target genes in heart failure
ID 81Z0710108
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Dirk Westermann
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 268863.74€ 268.863,74
Begin 2019-01-0101.01.2019
End 2022-06-3030.06.2022
Projektdetails

Untersuchung neuer Risikomarker für Vorhofflimmern und Verbesserung von Risikoalgorithmen
ID 81Z0710109
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Renate Schnabel
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 112204.31€ 112.204,31
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Hypertrophic cardiomyopathy: from gene identification to individualized therapy
ID 81Z0710111
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Lucie Carrier
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 225261.15€ 225.261,15
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Die Rolle des intrakardialen autonomen Nervensystems bei der Entstehung und Behandlung von kardialen Arrhythmien
ID 81Z0710112
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Christian Meyer
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 182186.98€ 182.186,98
Begin 2019-01-0101.01.2019
End 2021-06-3030.06.2021
Projektdetails

Cardiac repair with hypo-immunogeneic iPSC-derived heart tissue tissue
ID 81Z0710113
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Sonja Schrepfer
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 156285.78€ 156.285,78
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

Postdoc start-up grant: Decoding genetic and functional endothelial heterogeneity in vascular regeneration.
ID 81X3100103
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Baptiste Coxam
Site Berlin
Project type Excellence Programme
Funding 59315.46€ 59.315,46
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Postdoc start-up grant: Metabolic and cardiovascular consequences of the human gut microbiota in gnotobiotic mice
ID 81X3100205
Institution Charité - Universitätsmedizin Berlin
Project leader Reiner Jumpertz-von Schwartzenberg
Site Berlin
Project type Excellence Programme
Funding 55613.29€ 55.613,29
Begin 2018-02-0101.02.2018
End 2019-01-3131.01.2019
Projektdetails

Postdoc start-up grant: Ca homeostasis, metabolism and impaired mechanics during heart failure with preserved ejection fraction.
ID 81X3100206
Institution Charité - Universitätsmedizin Berlin
Project leader Felix Hohendanner
Site Berlin
Project type Excellence Programme
Funding 59995.72€ 59.995,72
Begin 2018-08-0101.08.2018
End 2020-12-3131.12.2020
Projektdetails

Clinician scientist programme: Cardiovascular phenotyping in patients with cancer: impact of arrhythmias and altered cardiac function on prognosis
ID 81X3100207
Institution Charité - Universitätsmedizin Berlin
Project leader Markus Anker
Site Berlin
Project type Excellence Programme
Funding 245267.36€ 245.267,36
Begin 2018-12-0101.12.2018
End 2024-02-2929.02.2024
Projektdetails

Junior research group: Deciphering transcriptional networks regulated by TBX18 in cardiovascular disease
ID 81X3200108
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Nuno Miguel Guimarães Camboa
Site RheinMain
Project type Excellence Programme
Funding 1497133.00€ 1.497.133,00
Begin 2018-08-0101.08.2018
End 2025-02-2828.02.2025
Projektdetails

Postdoc start-up grant: Impact of endothelial cell clonal expansion during neonatal heart regeneration
ID 81X3200109
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Yosif Manavski
Site RheinMain
Project type Excellence Programme
Funding 59999.00€ 59.999,00
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Postdoc start-up grant: Metabolic reprogramming in aged endothelial cells
ID 81X3200110
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Sofia Iris Bibli
Site RheinMain
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2019-07-1515.07.2019
End 2020-08-3131.08.2020
Projektdetails

Postdoc start-up grant: Regulation of cardiac lymphatics in heart disease
ID 81X3200307
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (MPG)
Project leader Kerstin Wilhelm
Site RheinMain
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2018-06-0101.06.2018
End 2019-07-3131.07.2019
Projektdetails

Rotation grant: Cardiac magnetic resonance imaging of the atria: multiparametric assessment of atrial fibrillation
ID 81X3300106
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wieland Staab
Site Göttingen
Project type Excellence Programme
Funding 75066.53€ 75.066,53
Begin 2018-09-0101.09.2018
End 2019-10-3131.10.2019
Projektdetails

Postdoc start-up grant: Ultraschall-basiertes 3D Mapping von ventrikulären Arrhtyhmien im Zusammenspiel mit funktioneller und struktureller Heterogenität
ID 81X3300107
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Jan Christoph
Site Göttingen
Project type Excellence Programme
Funding 55238.57€ 55.238,57
Begin 2019-01-0101.01.2019
End 2020-01-3131.01.2020
Projektdetails

Postdoc start-up grant: Role of Cand2 in mTOR-dependent myocardial remodeling
ID 81X3500115
Institution Universitätsklinikum Heidelberg
Project leader Agniezka Anna Gorska
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 59094.58€ 59.094,58
Begin 2018-02-0101.02.2018
End 2019-01-3131.01.2019
Projektdetails

Postdoc start-up grant: Investigating roles of dynamic RNA editing in the endoplasmic reticulum stress response in the heart
ID 81X3500116
Institution Universitätsklinikum Heidelberg
Project leader Tobias Jakobi
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 58376.32€ 58.376,32
Begin 2018-06-0101.06.2018
End 2019-05-3131.05.2019
Projektdetails

Clinician scientist programme: Clonal hematopoiesis and the relevance of DNMT3a in Heart Failure
ID 81X3500118
Institution Universitätsklinikum Heidelberg
Project leader Inga Hemmerling
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 215467.26€ 215.467,26
Begin 2019-01-0101.01.2019
End 2023-06-3030.06.2023
Projektdetails

Postdoc start-up grant: The role of FAM129B in monocytes during myocardial infarction
ID 81X3500119
Institution Universitätsklinikum Heidelberg
Project leader Sören Meyer
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 37724.51€ 37.724,51
Begin 2019-07-0101.07.2019
End 2020-09-3030.09.2020
Projektdetails

Postdoc start-up grant: Modelling short QT syndrome using human-induced pluripotent stem cell derived cardiomyocytes: Drug screening and carnitine as a therapeutic target
ID 81X3500204
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Ibrahim El-Battrawy
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 56061.97€ 56.061,97
Begin 2018-02-0101.02.2018
End 2019-01-3131.01.2019
Projektdetails

Rotation grant: Detection of electromechanical dispersion in patients with Brugada Syndrome using phase-contrast magnet resonance imaging
ID 81X3500205
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Anna Lena Hohneck
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 84375.41€ 84.375,41
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Postdoc start-up grant: Evaluation of ZFHX3 in the pathogenesis of atrial fibrillation
ID 81X3600208
Institution Klinikum der Universität München
Project leader Sebastian Clauß
Site München
Project type Excellence Programme
Funding 58825.11€ 58.825,11
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Postdoc start-up grant: Prevention of bioprosthetic heart valve dysfunction - a multimodal approach
ID 81X3600209
Institution Klinikum der Universität München
Project leader David Jochheim
Site München
Project type Excellence Programme
Funding 57763.79€ 57.763,79
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Postdoc start-up grant: The Calcium-Sensing Receptor, a crucial link between obesity and atherosclerosis?
ID 81X3600210
Institution Klinikum der Universität München
Project leader Emiel Van der Vorst
Site München
Project type Excellence Programme
Funding 59976.00€ 59.976,00
Begin 2018-04-0101.04.2018
End 2019-03-3131.03.2019
Projektdetails

Rotation grant: Mechanisms of early thrombopoiesis and the role of embryonic platelets in vasculogenesis
ID 81X3600211
Institution Klinikum der Universität München
Project leader Mathias Orban
Site München
Project type Excellence Programme
Funding 69049.96€ 69.049,96
Begin 2018-05-0101.05.2018
End 2019-06-3030.06.2019
Projektdetails

Junior research group: Nfe2l1-mediated proteasomal activity in heart function and cardiovascular disease
ID 81X3600212
Institution Klinikum der Universität München
Project leader Alexander Bartelt
Site München
Project type Excellence Programme
Funding 1647898.70€ 1.647.898,70
Begin 2018-08-0101.08.2018
End 2024-07-3131.07.2024
Projektdetails

Postdoc start-up grant: The role of platelet migration in biofilm formation and infective endocarditis
ID 81X3600213
Institution Klinikum der Universität München
Project leader Florian Gärtner
Site München
Project type Excellence Programme
Funding 58936.28€ 58.936,28
Begin 2018-09-0101.09.2018
End 2019-08-3131.08.2019
Projektdetails

Clinician scientist programme: The role of platelet migration in thrombosis and atherosclerosis
ID 81X3600214
Institution Klinikum der Universität München
Project leader Leo Nicolai
Site München
Project type Excellence Programme
Funding 199758.78€ 199.758,78
Begin 2018-09-0101.09.2018
End 2024-08-3131.08.2024
Projektdetails

Postdoc start-up grant: Role of oral FXa inhibitor on platelet function and arterial thrombosis
ID 81X3600215
Institution Klinikum der Universität München
Project leader Tobias Petzold
Site München
Project type Excellence Programme
Funding 57800.44€ 57.800,44
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Promotion of women scientists: Establishing a new interplay between PCSK9 and chemokine receptors in chronic vascular inflammation
ID 81X3600216
Institution Klinikum der Universität München
Project leader Yvonne Döring
Site München
Project type Excellence Programme
Funding 63000.00€ 63.000,00
Begin 2019-07-0101.07.2019
End 2020-06-3030.06.2020
Projektdetails

Postdoc start-up grant: LncRNA function in cardiac resident macrophages
ID 81X3600404
Institution Technische Universität München
Project leader Anne Dueck
Site München
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2018-06-0101.06.2018
End 2019-05-3131.05.2019
Projektdetails

Postdoc start-up grant: Sympathetic control of resident macrophages in the adult heart
ID 81X3600405
Institution Technische Universität München
Project leader Andrea Lang
Site München
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2019-03-0101.03.2019
End 2020-02-2828.02.2020
Projektdetails

Rotation grant: Molecular pathways of right heart failure in patients with complex congenital heart disease
ID 81X3600505
Institution Deutsches Herzzentrum München
Project leader Cordula Wolf
Site München
Project type Excellence Programme
Funding 82240.00€ 82.240,00
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Clinician scientist programme: Identification and validation of key driver genes in atherosclerosis relevant networks
ID 81X3600506
Institution Deutsches Herzzentrum München
Project leader Moritz von Scheidt
Site München
Project type Excellence Programme
Funding 226730.33€ 226.730,33
Begin 2018-12-0101.12.2018
End 2024-08-3131.08.2024
Projektdetails

Postdoc start-up grant: Maturing hiPSC-cardiomyocytes: the role of CSQ2 in automaticity and arrhythmia
ID 81X3710108
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Marc Lemoine
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 58739.35€ 58.739,35
Begin 2019-06-0101.06.2019
End 2020-05-3131.05.2020
Projektdetails

Mononuclear cell tracking by magnetic resonance imaging in atherosclerotic lesions using SPION-labelled autologous peripheral blood mononuclear cells.
ID 81X2800184
Institution Friedrich-Alexander-Universität Erlangen-Nürnberg
Project leader Christoph Alexiou
Site Extern
Project type Cooperation with External Partners
Funding 24976.97€ 24.976,97
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

AAVs for genetic manipulation of cardiovascular phenotypes
ID 81X2200147
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Jiong Hu
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE028)
Funding 15000.00€ 15.000,00
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

AAVs for genetic manipulation of cardiovascular phenotypes
ID 81X2700221
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE028)
Funding 44000.00€ 44.000,00
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

Analysis of cAMP dynamics in a patient-specific iPSC Takotsubo syndrome model
ID 81X2710165
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Viacheslav Nikolaev
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE157)
Funding 39400.00€ 39.400,00
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Analysis of cAMP dynamics in a patient-specific iPSC Takotsubo syndrome model
ID 81X2300170
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuß-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE157)
Funding 39390.00€ 39.390,00
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Analysis of DCM-driving mutations in a patient-specific iPSC-CM model
ID 81X2300178
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuss-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE174)
Funding 30450.00€ 30.450,00
Begin 2019-01-0101.01.2019
End 2020-06-3030.06.2020
Projektdetails

Analysis of DCM-driving mutations in a patient-specific iPSC-CM model.
ID 81X2500401
Institution Europäisches Laboratorium für Molekularbiologie (EMBL)
Project leader Lars Steinmetz
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE174)
Funding 23613.21€ 23.613,21
Begin 2019-01-0101.01.2019
End 2020-06-3030.06.2020
Projektdetails

Analysis of the role of Matr3 for heart-specific alternative splicing and in dilative cardiomyopathy
ID 81X2200309
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Thomas Braun
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 33357.44€ 33.357,44
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Artificial intelligence for diagnosis of myocardial infarction
ID 81X2800185
Institution Technische Universität Darmstadt
Project leader Kristian Kersting
Site Extern
Project type Cooperation with External Partners
Funding 19281.18€ 19.281,18
Begin 2019-01-0101.01.2019
End 2020-01-3131.01.2020
Projektdetails

Artificial intelligence for diagnosis of myocardial infarction
ID 81X2710172
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Johannes Neumann
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 24910.00€ 24.910,00
Begin 2019-01-0101.01.2019
End 2020-01-3131.01.2020
Projektdetails

Characterization of the cardiac function and potential targets of E3 ubiquitin ligase TRIM24 and TRIM32
ID 81X2400137
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 33575.00€ 33.575,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Characterization of the cardiac function and potential targets of E3 ubiquitin ligase TRIM24 and TRIM32
ID 81X2700223
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Ashraf Rangrez
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 32120.35€ 32.120,35
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Comparison and genetic rescue of diastolic dysfunction phenotypes - towards a personalized therapy of heart failure with preserved ejection fraction (HFpEF)
ID 81X2100151
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Gotthardt
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 37500.00€ 37.500,00
Begin 2019-01-0101.01.2019
End 2022-12-3131.12.2022
Projektdetails

Comparison and genetic rescue of diastolic dysfunction phenotypes - towards a personalized therapy of heart failure with preserved ejection fraction (HFpEF)
ID 81X2500178
Institution Universitätsklinikum Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 33370.20€ 33.370,20
Begin 2019-01-0101.01.2019
End 2022-12-3131.12.2022
Projektdetails

Contribution of skeletal muscle to inflammation-induced heart failure
ID 81X2400134
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE060)
Funding 49857.65€ 49.857,65
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Coronary heterogeneity in heart regeneration: finding common traits using a comparative approach
ID 81X2500210
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Jörg Heineke
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE173)
Funding 14734.55€ 14.734,55
Begin 2019-02-0101.02.2019
End 2020-01-3131.01.2020
Projektdetails

Coronary heterogeneity in heart regeneration: finding common traits using a comparative approach
ID 81X2200311
Institution Max-Planck-Institut für Herz- und Lungenforschung (W.G. Kerckhoff-Institut)
Project leader Didier Yves Stainier
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE173)
Funding 15221.25€ 15.221,25
Begin 2019-02-0101.02.2019
End 2020-01-3131.01.2020
Projektdetails

CRISPR/Cas9-medited reactivation of Krueppel like factor (KLF) 15 in the hypertrophic heart in vivo
ID 81X2700219
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 31148.03€ 31.148,03
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

CRISPR/Cas9-medited reactivation of Krueppel like factor (KLF) 15 in the hypertrophic heart in vivo
ID 81X2300180
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 28900.00€ 28.900,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Detection of gene regulatory networks in the cardiovascular system in health, disease and aging
ID 81X2200143
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 98574.00€ 98.574,00
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

First-milestone-funding: Development of heart-specific adeno-associated viruses (AAVs) prototypes via genetic capsid engineering for intravenous cardiac gene delivery
ID 81X2600622
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Kupatt Christian
Site München
Project type Innovation Cluster
Funding 22000.00€ 22.000,00
Begin 2018-10-0101.10.2018
End 2019-11-3030.11.2019
Projektdetails

First-milestone-funding: Development of heart-specific adeno-associated viruses (AAVs) prototypes via genetic capsid engineering for intravenous cardiac gene delivery
ID 81X2500174
Institution Universitätsklinikum Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 90564.01€ 90.564,01
Begin 2018-10-0101.10.2018
End 2019-11-3030.11.2019
Projektdetails

Discovery of blood pressure regulating genes by genetic analysis of inbred mouse strains
ID 81X2700131
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE139)
Funding 38000.00€ 38.000,00
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

Discovery of blood pressure regulating genes by genetic analysis of inbred mouse strains
ID 81X2100150
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Natalia Alenina
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE139)
Funding 37000.00€ 37.000,00
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

Effects of acylcarnitine treatment and CRTC1 knock-out on mitochondrial function in cardiomyocytes
ID 81X2710174
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Julia Krause
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 22142.35€ 22.142,35
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Effects of acylcarnitine treatment and CRTC1 knock-out on mitochondrial function in cardiomyocytes
ID 81X2800186
Institution Universitätsklinikum Würzburg
Project leader Alexander Nickel
Site Extern
Project type Cooperation with External Partners
Funding 22500.00€ 22.500,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Elucidation of a novel mediator of monocyte recruitment: the calcium-sensing receptor.
ID 81X2600251
Institution Klinikum der Universität München
Project leader Emiel Van der Vorst
Site München
Project type Cooperation with External Partners
Funding 24999.97€ 24.999,97
Begin 2019-01-0101.01.2019
End 2020-04-3030.04.2020
Projektdetails

Elucidation of a novel mediator of monocyte recruitment: the calcium-sensing receptor.
ID 81X2800183
Institution Universität Leipzig
Project leader Ulf Wagner
Site Extern
Project type Cooperation with External Partners
Funding 25000.00€ 25.000,00
Begin 2019-05-0101.05.2019
End 2020-04-3030.04.2020
Projektdetails

Endocannabinoid and related lipid profiling in cardiovascular disease mouse models
ID 81X2210118
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Beat Lutz
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE166)
Funding 38899.98€ 38.899,98
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Endocannabinoid and related lipid profiling in cardiovascular disease mouse models
ID 81X2600250
Institution Klinikum der Universität München
Project leader Sabine Steffens
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE166)
Funding 36100.00€ 36.100,00
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Estrogen-dependent activation of the sAC-AMPK pathway as a new strategy to protect coronary endothelial cell function
ID 81X2100256
Institution Charité - Universitätsmedizin Berlin
Project leader Yury Ladilov
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE165)
Funding 11448.02€ 11.448,02
Begin 2018-04-0101.04.2018
End 2019-03-3131.03.2019
Projektdetails

Estrogen-dependent activation of the sAC-AMPK pathway as a new strategy to protect coronary endothelial cell function_SE
ID 81X2200203
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Christian Hamm
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE165)
Funding 14046.30€ 14.046,30
Begin 2018-06-0101.06.2018
End 2019-05-3131.05.2019
Projektdetails

Evaluation of cardiomyocyte characteristics and dysfunction in engineered heart tissues derived from a patient-specific Holt-Oram-Syndrome human iPS model
ID 81X2710173
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE024)
Funding 24475.00€ 24.475,00
Begin 2019-01-0101.01.2019
End 2022-06-3030.06.2022
Projektdetails

Evaluation of cardiomyocyte characteristics and dysfunction in engineered heart tissues derived from a patient-specific Holt-Oram-Syndrome human iPS model
ID 81X2600521
Institution Deutsches Herzzentrum München
Project leader Markus Krane
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE024)
Funding 24318.85€ 24.318,85
Begin 2019-01-0101.01.2019
End 2022-06-3030.06.2022
Projektdetails

Fine mapping of the differential m6A RNA methylome in cardiac hypertrophy by miCLIP and LAIC-seq
ID 81X2500180
Institution Universitätsklinikum Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 37818.00€ 37.818,00
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Fine mapping of the differential m6A RNA methylome in cardiac hypertrophy by miCLIP and LIAC-seq
ID 81X2800187
Institution Institut für Molekulare Biologie gGmbH
Project leader Julian König
Site Extern
Project type Cooperation with External Partners
Funding 38000.00€ 38.000,00
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

First-milestone-funding: Development of heart-specific adeno-associated viruses (AAVs) prototypes via genetic capsid engineering for intravenous cardiac gene delivery
ID 81X2710168
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 21983.10€ 21.983,10
Begin 2018-10-0101.10.2018
End 2019-11-3030.11.2019
Projektdetails

First-milestone-funding: Development of heart-specific adeno-associated viruses (AAVs) prototypes via genetic capsid engineering for intravenous cardiac gene delivery
ID 81X2700218
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 14985.75€ 14.985,75
Begin 2018-10-0101.10.2018
End 2019-11-3030.11.2019
Projektdetails

Functional Analysis of Extracellular Vesicles in Heart Failure and Critically Ill Patients
ID 81X2700216
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Martina-Elisabeth Spehlmann
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 50000.00€ 50.000,00
Begin 2018-01-0101.01.2018
End 2021-06-3030.06.2021
Projektdetails

Functional Analysis of Extracellular Vesicles in Heart Failure and Critically Ill Patients
ID 81X2800175
Institution Universitätsklinikum Aachen
Project leader Christoph Roderburg
Site Extern
Project type Cooperation with External Partners
Funding 50000.00€ 50.000,00
Begin 2018-01-0101.01.2018
End 2021-06-3030.06.2021
Projektdetails

Functional role and therapeutic potential of the long noncoding RNA NEAT1-MALAT1 genomic region in cardiovascular inflammation control and atheropathogenesis
ID 81X2100253
Institution Charité - Universitätsmedizin Berlin
Project leader Wolfgang Poller
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE169)
Funding 34965.00€ 34.965,00
Begin 2018-01-0101.01.2018
End 2019-02-2828.02.2019
Projektdetails

Functional role and therapeutic potential of the long noncoding RNA NEAT1-MALAT1 genomic region in cardiovascular inflammation control and atheropathogenesis
ID 81X2710167
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE169)
Funding 35002.96€ 35.002,96
Begin 2018-01-0101.01.2018
End 2019-02-2828.02.2019
Projektdetails

Gene therapy of cardiomyopathy in a large animal model
ID 81X2700217
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 23259.42€ 23259,42
Begin 2018-01-0101.01.2018
End 2019-08-3131.08.2019
Projektdetails

Generation and initial characterization of three conditional knockout mouse models for cardiac research
ID 81X2710166
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Viacheslav Nikolaev
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 56881.69€ 56.881,69
Begin 2018-01-0101.01.2018
End 2020-01-3131.01.2020
Projektdetails

Generation and initial characterization of three conditional knockout mouse models for cardiac research
ID 81X2800174
Institution Westfälische Wilhelms-Universität Münster
Project leader Boris Skryabin
Site Extern
Project type Cooperation with External Partners
Funding 86026.84€ 86.026,84
Begin 2018-01-0101.01.2018
End 2020-01-3131.01.2020
Projektdetails

Heart-specific modeling of the ß-catenin/TCF7L2 chromatin protein complex for targeting genes promoting maladaptive heart remodelling
ID 81X2100146
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Enno Klußmann
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE103)
Funding 39998.60€ 39.998,60
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Heart-specific modeling of the ß-catenin/TCF7L2 chromatin protein complex for targeting genes promoting maladaptive heart remodelling
ID 81X2300172
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE103)
Funding 36570.79€ 36.570,79
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Herzinsuffizienz mit erhaltener und eingeschränkter LV-Funktion - Evaluation der bevölkerungsbasierten DIAST-CHF Studie und der Interventionsstudien Ex-DHF (P) und Aldo-DHF
ID 81X2800181
Institution Universität Leipzig
Project leader Oana Brosteanu
Site Extern
Project type Cooperation with External Partners
Funding 21210.92€ 21.210,92
Begin 2018-10-0101.10.2018
End 2019-03-3131.03.2019
Projektdetails

Identification of novel disease-causing mutations in hypertrophic cardiomyopathy via patient-specific iPSCs
ID 81X2300171
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE029)
Funding 39700.00€ 39.700,00
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Identification of novel disease-causing mutations in hypertrophic cardiomyopathy via patient-specific iPSCs
ID 81X2500207
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Ibrahim El-Battrawy
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE029)
Funding 37951.12€ 37.951,12
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Identification of therapeutic targets in vascular calcification by untargeted metabolomic profiling
ID 81X2600114
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Silke Heinzmann
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE170)
Funding 35085.00€ 35.085,00
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Identification of therapeutic targets in vascular calcification by untargeted metabolomic profiling
ID 81X2100254
Institution Charité - Universitätsmedizin Berlin
Project leader Jakob Voelkl
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE170)
Funding 31250.48€ 31.250,48
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Identifying signaling pathways of Brugada syndrome phenotype in patients with SCN10A mutations
ID 81X2300187
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 36666.76€ 36.666,76
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Identifying signaling pathways of Brugada syndrome phenotype in patients with SCN10A mutations
ID 81X2500209
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Ibrahim El-Battrawy
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 37447.45€ 37.447,45
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

In vivo characterization of 3632451O06Rik function in the adult mouse heart
ID 81X2500177
Institution Universitätsklinikum Heidelberg
Project leader Mirko Völkers
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE117)
Funding 29986.35€ 29.986,35
Begin 2019-01-0101.01.2019
End 2020-11-3030.11.2020
Projektdetails

In vivo characterization of 3632451O06Rik function in the adult mouse heart.
ID 81X2300183
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Maria Patapia Zafeiriou
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE117)
Funding 30560.00€ 30.560,00
Begin 2019-01-0101.01.2019
End 2020-11-3030.11.2020
Projektdetails

In vivo characterization of heterozygous Shox2 knockout mice
ID 81X2600249
Institution Klinikum der Universität München
Project leader Sebastian Clauß
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE163)
Funding 54700.00€ 54.700,00
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

In vivo characterization of heterozygous Shox2 knockout mice
ID 81X2500171
Institution Universitätsklinikum Heidelberg
Project leader Sandra Hoffmann
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE163)
Funding 21715.98€ 21.715,98
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Influence of heart failure drugs on cardiomyocyte proliferation
ID 81X2710171
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE024)
Funding 29466.69€ 29.466,69
Begin 2019-01-0101.01.2019
End 2020-06-3030.06.2020
Projektdetails

Influence of heart failure drugs on cardiomyocyte proliferation
ID 81X2300179
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Karl Toischer
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE024)
Funding 30406.17€ 30.406,17
Begin 2019-01-0101.01.2019
End 2020-06-3030.06.2020
Projektdetails

Inhibition of Integrins as target for the treatment of heart failure
ID 81X2500179
Institution Universitätsklinikum Heidelberg
Project leader Mathias Konstandin
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 35654.82€ 35.654,82
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Inhibition of Integrins as target for the treatment of heart failure.
ID 81X2700222
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38000.00€ 38.000,00
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

First-milestone-funding: Innovative approaches to precision medicine: impact of clonal hematopoiesis on cardiovascular disease
ID 81X2500175
Institution Universitätsklinikum Heidelberg
Project leader Hugo A. Katus
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 22949.99€ 22.949,99
Begin 2018-10-0101.10.2018
End 2019-11-3030.11.2019
Projektdetails

First-milestone-funding: Innovative approaches to precision medicine: impact of clonal hematopoiesis on cardiovascular disease
ID 81X2600520
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Innovation Cluster
Funding 21991.20€ 21.991,20
Begin 2018-10-0101.10.2018
End 2019-11-3030.11.2019
Projektdetails

Long non-coding RNA profiling in patients with acute coronary syndromes with different vulnerable plaque phenotypes as determined by near-field high-resolution intracoronary imaging
ID 81X2200144
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE097)
Funding 35285.12€ 35.285,12
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Long non-coding RNA profiling in patients with acute coronary syndromes with different vulnerable plaque phenotypes as determined by near-field high-resolution intracoronary imaging
ID 81X2100255
Institution Charité - Universitätsmedizin Berlin
Project leader David Leistner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE097)
Funding 29983.06€ 29.983,06
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Mapping RXR-dependent transcription regulatory networks in yolk sac and bone marrow macrophages
ID 81X2300184
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Martin Haubrock
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE066)
Funding 25430.20€ 25.430,20
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Mapping RXR-dependent transcription regulatory networks in yolk sac and bone marrow macrophages
ID 81X2600252
Institution Klinikum der Universität München
Project leader Tobias Weinberger
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE066)
Funding 24570.38€ 24.570,38
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails

Mechanisms of lysosphingolipid-mediated genome instability and senescence in the aging heart
ID 81X2800179
Institution Universität zu Köln
Project leader Leo Kurian
Site Extern
Project type Cooperation with External Partners
Funding 38542.56€ 38.542,56
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Mechanisms of lysosphingolipid-mediated genome instability and senescence in the aging heart
ID 81X2500172
Institution Universitätsklinikum Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 37233.04€ 37.233,04
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Microvascular shear stress-mediated NF-¿B activation and its role in activity-induced hyperemia
ID 81X2200310
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (MPG)
Project leader Stefan Offermanns
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE177)
Funding 40000.00€ 40.000,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Microvascular shear stress-mediated NF-¿B activation and its role in activity-induced hyperemia
ID 81X2700132
Institution Universität zu Lübeck
Project leader Jan Wenzel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE177)
Funding 40000.00€ 40.000,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Mononuclear cell tracking by magnetic resonance imaging in atherosclerotic lesions using SPION-labelled autologous peripheral blood mononuclear cells
ID 81X2600623
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Tobias Koppara
Site München
Project type Cooperation with External Partners
Funding 14567.74€ 14.567,74
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Nuclear mechanotransduction in the pathophysiological mechanisms of congenital heart disease
ID 81X2100152
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Daniela Panáková
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE106)
Funding 37500.00€ 37.500,00
Begin 2019-01-0101.01.2019
End 2020-02-2828.02.2020
Projektdetails

Nuclear mechanotransduction in the pathophysiological mechanisms of congenital heart disease
ID 81X2300182
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE106)
Funding 36850.83€ 36.850,83
Begin 2019-01-0101.01.2019
End 2020-02-2828.02.2020
Projektdetails

Optimized AAV vectors for cardiac gene transfer into NHPs
ID 81X2300203
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rüdiger Behr
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 26055.00€ 26.055,00
Begin 2019-01-0101.01.2019
End 2021-12-3131.12.2021
Projektdetails

Optimized AAV vectors for cardiac gene transfer into NHPs
ID 81X2700220
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 35065.00€ 35.065,00
Begin 2019-01-0101.01.2019
End 2021-12-3131.12.2021
Projektdetails

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Elucidate Single-Cell Phenotype in Brugada Syndrome and Short QT Syndrome
ID 81X2300175
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 24412.79€ 24.412,79
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Elucidate Single-Cell Phenotype in Brugada Syndrome and Short QT Syndrome
ID 81X2100149
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sebastian Diecke
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 30500.00€ 30.500,00
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Elucidate Single-Cell Phenotype in Brugada Syndrome and Short QT Syndrome
ID 81X2500208
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Ibrahim El-Battrawy
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 21268.56€ 21.268,56
Begin 2018-01-0101.01.2018
End 2018-12-3131.12.2018
Projektdetails

Platelet signatures and psoriasis in cardiac dysfunction
ID 81X2800176
Institution Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V.
Project leader Albert Sickmann
Site Extern
Project type Cooperation with External Partners
SE Trait SE user  (SE006/SE160)
Funding 75000.00€ 75.000,00
Begin 2018-01-0101.01.2018
End 2020-12-3131.12.2020
Projektdetails

Platelet signatures and psoriasis in cardiac dysfunction
ID 81X2100147
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Huebner
Site Berlin
Project type Cooperation with External Partners
SE Trait SE provider  (SE006/SE160)
Funding 65600.00€ 65.600,00
Begin 2018-01-0101.01.2018
End 2020-12-3131.12.2020
Projektdetails

Platelet signatures and psoriasis in cardiac dysfunction
ID 81X2210117
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Marina Panova-Noeva
Site RheinMain
Project type Cooperation with External Partners
SE Trait SE user  (SE006/SE160)
Funding 63160.28€ 63.160,28
Begin 2018-01-0101.01.2018
End 2020-12-3131.12.2020
Projektdetails

Proteomic profiling of inherited cardiomyopathies cultured in 2D and 3D models of human induced pluripotent stem cell-derived cardiomyocytes
ID 81X2400135
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 24485.00€ 24.485,00
Begin 2019-01-0101.01.2019
End 2020-01-3131.01.2020
Projektdetails

Proteomic profiling of inherited cardiomyopathies cultured in 2D and 3D models of human induced pluripotent stem cell-derived cardiomyocytes
ID 81X2710175
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Maksymilian Prondzynski
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 20474.29€ 20.474,29
Begin 2019-01-0101.01.2019
End 2020-01-3131.01.2020
Projektdetails

Reverse remodeling in tissue slices from failing human hearts
ID 81X2600253
Institution Klinikum der Universität München
Project leader Andreas Dendorfer
Site München
Project type Cooperation with External Partners
Funding 22600.00€ 22.600,00
Begin 2019-01-0101.01.2019
End 2020-05-3131.05.2020
Projektdetails

Reverse remodeling in tissue slices from failing human hearts
ID 81X2800188
Institution Friedrich-Alexander-Universität Erlangen-Nürnberg
Project leader Thomas Seidel
Site Extern
Project type Cooperation with External Partners
Funding 24166.26€ 24.166,26
Begin 2019-02-0101.02.2019
End 2020-05-3131.05.2020
Projektdetails

Robot-assisted 3D extrusion bioprinting of engineered human myocardium with defined force pattern
ID 81X2300173
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Meyer
Site Göttingen
Project type Cooperation with External Partners
Funding 37123.10€ 37.123,10
Begin 2018-01-0101.01.2018
End 2020-06-3030.06.2020
Projektdetails

Robot-assisted 3D extrusion bioprinting of engineered human myocardium with defined force pattern
ID 81X2800177
Institution Leibniz Universität Hannover
Project leader Tobias Ortmaier
Site Extern
Project type Cooperation with External Partners
Funding 34370.85€ 34.370,85
Begin 2018-01-0101.01.2018
End 2020-06-3030.06.2020
Projektdetails

Role of atrial metabolism dysfunction and cAMP remodelling in arrhythmogenesis in type 2 diabetes
ID 81X2710169
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Cristina Molina
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE095)
Funding 21037.00€ 21.037,00
Begin 2019-01-0101.01.2019
End 2020-01-3131.01.2020
Projektdetails

Role of atrial metabolism dysfunction and cAMP remodelling in arrhythmogenesis in type 2 diabetes
ID 81X2300185
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Samuel Sossalla
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE095)
Funding 21483.95€ 21.483,95
Begin 2019-01-0101.01.2019
End 2020-01-3131.01.2020
Projektdetails

Role of serotonin in cardiac development
ID 81X2800173
Institution Universität Potsdam
Project leader Salim Seyfried
Site Extern
Project type Cooperation with External Partners
Funding 37000.00€ 37.000,00
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

Roles for the ER stress sensor, ATF6, in iPSC-cardiomyocyte and engineered heart muscle function
ID 81X2500170
Institution Universitätsklinikum Heidelberg
Project leader Shirin Doroudgar
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 30729.19€ 30.729,19
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

Roles for the ER stress sensor, ATF6, in iPSC-cardiomyocyte and engineered heart muscle function
ID 81X2300174
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Malte Tiburcy
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 40500.00€ 40.500,00
Begin 2018-01-0101.01.2018
End 2019-06-3030.06.2019
Projektdetails

TOMAHAWK-DZHK4: Sofortige Koronarangiographie versus verzögerte Triage bei Überlebenden eines außerklinischen Herzstillstandes ohne ST-Hebung - Projektmanagement
ID 81X2800180
Institution Herzzentrum Leipzig GmbH
Project leader Steffen Desch
Site Extern
Project type Clinical Studies
Funding 122136.87€ 122.136,87
Begin 2018-03-0101.03.2018
End 2022-12-3131.12.2022
Projektdetails

Sulfur containing amino acids and polyunsaturated fatty acids and their effects on stem cell specification to cardiomyocytes, cardiomyocyte maturation and heart repair
ID 81X2300181
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Malte Tiburcy
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 73329.93€ 73.329,93
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Sulfur containing amino acids and polyunsaturated fatty acids and their effects on stem cell specification to cardiomyocytes, cardiomyocyte maturation and heart repair.
ID 81X2200146
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Sofia Iris Bibli
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 19428.65€ 19.428,65
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Temporal and spatial dynamics of immune cell infiltration, accumulation and resolution following myocardial infarction/ cardiac injury
ID 81X2200312
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Thomas Braun
Site RheinMain
Project type Cooperation with External Partners
Funding 15000.00€ 15.000,00
Begin 2019-02-0101.02.2019
End 2020-04-3030.04.2020
Projektdetails

Temporal and spatial dynamics of immune cell infiltration, accumulation and resolution following myocardial infarction/cardiac injury
ID 81X2800190
Institution Universitätsklinikum Essen
Project leader Matthias Totzeck
Site Extern
Project type Cooperation with External Partners
Funding 15442.50€ 15.442,50
Begin 2019-02-0101.02.2019
End 2020-04-3030.04.2020
Projektdetails

TFEB dependent gene expression in cardiomyocytes during heart failure
ID 81X2400138
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 61959.06€ 61.959,06
Begin 2019-01-0101.01.2019
End 2022-03-3131.03.2022
Projektdetails

TFEB dependent gene expression in cardiomyocytes during heart failure
ID 81X2100153
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Tatiana A. Borodina
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 81362.51€ 81.362,51
Begin 2019-01-0101.01.2019
End 2022-03-3131.03.2022
Projektdetails

The effect of Meis1 on proliferation and cell differentiation in monogenic congenital heart disease
ID 81X2800178
Institution Rheinische Friedrich-Wilhelms-Universität Bonn
Project leader Bernd K. Fleischmann
Site Extern
Project type Cooperation with External Partners
Funding 34803.96€ 34.803,96
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

The effect of Meis1 on proliferation and cell differentiation in monogenic congenital heart disease
ID 81X2600621
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Karl-Ludwig Laugwitz
Site München
Project type Cooperation with External Partners
Funding 37500.00€ 37.500,00
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

The validation of protein biomarkers for atherosclerotic diseases
ID 81X2400136
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 28358.51€ 28.358,51
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

The validation of protein biomarkers for atherosclerotic diseases.
ID 81X2600115
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Melanie Waldenberger
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 19056.00€ 19.056,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Transcriptome analysis of circulating immune cells to improve the assessment of prognosis and the response to novel anti-inflammatory treatments after myocardial infarction
ID 81X2100257
Institution Charité - Universitätsmedizin Berlin
Project leader Wolfgang Poller
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE062)
Funding 36888.20€ 36.888,20
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

Transcriptome analysis of circulating immune cells to improve the assessment of prognosis and the response to novel anti-inflammatory treatments after myocardial infarction
ID 81X2710170
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE062)
Funding 34608.50€ 34.608,50
Begin 2019-01-0101.01.2019
End 2021-02-2828.02.2021
Projektdetails

Uncovering mechanisms underlying mis-splicing in dilated cardiomyopathy (DCM) using an induced pluripotent stem cell model of DCM
ID 81X2500402
Institution Europäisches Laboratorium für Molekularbiologie (EMBL)
Project leader Lars Steinmetz
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 25494.01€ 25.494,01
Begin 2019-01-0101.01.2019
End 2020-06-3030.06.2020
Projektdetails

Uncovering mechanisms underlying mis-splicing in dilated cardiomyopathy (DCM) using an induced pluripotent stem cell model of DCM
ID 81X2300186
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuß-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 38477.15€ 38.477,15
Begin 2019-01-0101.01.2019
End 2020-06-3030.06.2020
Projektdetails

Zebrafish as a screening model to evaluate novel candidate genes with a potential role in the process of angiogenesis during thrombosis and thrombus non-resolution
ID 81X2210119
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Magdalena Bochenek
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE030)
Funding 39715.60€ 39.715,60
Begin 2019-01-0101.01.2019
End 2020-08-3131.08.2020
Projektdetails

Zebrafish as a screening model to evaluate novel candidate genes with a potential role in the process of angiogenesis during thrombosis and thrombus non-resolution
ID 81X2500176
Institution Universitätsklinikum Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE030)
Funding 34042.82€ 34.042,82
Begin 2019-01-0101.01.2019
End 2020-08-3131.08.2020
Projektdetails

CAR inhibitors to treat myocardial infarction (CARTI)
ID 81X2100154
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Gotthardt
Site Berlin
Project type Translational Research Project
Funding 254619.91€ 254.619,91
Begin 2019-01-0101.01.2019
End 2023-12-3131.12.2023
Projektdetails
The Coxsackievirus- and Adenovirus-Receptor (CAR) is a cell contact protein that also mediates virus entry. It is essential for early cardiac development. CAR-deficient mice are protected from Coxsackievirus infection at the expense of only minor health related issues. Here, we will use a translational approach, to evaluate CAR as a therapeutic target and to develop CAR inhibitors to treat cardiac disease. Building on our preliminary evaluation of different CAR inhibitors, we will focus on the development and validation of a human Anti CAR antibody. With this tool, we aim to improve cardiomyocyte survival after actute myocardial infarction, remodeling, and contractile function. This includes primarily work in tissue culture, which will subsequently be validated in suitable animal models. We are convinced that CAR is an excellent therapeutic target for myocardial infarction based on (1) the protective effect of CAR deficiency on myocardial infarction, (2) Access to inhibitors, and (3) the minor extend of undesired side effects of CAR-deficiency.

Detection of gene regulatory networks in the cardiovascular system in health, disease and aging
ID 81X2100148
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sascha Sauer
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 225936.94€ 225.936,94
Begin 2018-01-0101.01.2018
End 2019-12-3131.12.2019
Projektdetails

First-milestone-funding: Therapeutic strategies based on biosensitive telomere imaging
ID 81X2300177
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Innovation Cluster
Funding 149714.66€ 149.714,66
Begin 2018-10-0101.10.2018
End 2019-12-0101.12.2019
Projektdetails

First-milestone-funding: Innovative approaches to precision medicine: impact of clonal hematopoiesis on cardiovascular disease
ID 81X2200145
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Innovation Cluster
Funding 104200.00€ 104.200,00
Begin 2018-10-0101.10.2018
End 2019-11-3030.11.2019
Projektdetails

Local miR-29b inhibition using drug eluting balloons to block abdominal aortic aneurysm progression
ID 81X2600624
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Lars Maegdefessel
Site München
Project type Translational Research Project
Funding 1035040.00€ 1.035.040,00
Begin 2019-08-0101.08.2019
End 2023-12-3131.12.2023
Projektdetails

Real-time MRI-guided targeted endomyocardial biopsy of radiofrequency ablation lesions in a porcine model
ID 81X2300188
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Christina Unterberg-Buchwald
Site Göttingen
Project type Translational Research Project
Funding 118653.00€ 118.653,00
Begin 2019-09-0101.09.2019
End 2021-06-3030.06.2021
Projektdetails
The diagnostic success of endomyocardial biopsy (EMB) under X-ray guidance is limited. In a proof-of-concept study we confirmed that targeted endomyocardial biopsy under real-time imaging improves diagnostic accuracy of EMB in localized myocardial lesions. Our goal is to further develop real-time MRI-guided EMB into a diagnostic tool that is superior to today`s clinical practice and ready to enter clinical application. In the first milestone, we now aim to demonstrate that a newly developed prototype for an MR-compatible bioptome addresses the technical problems encountered during our proof-of-principle study and has procedural success rates similar to conventional steel bioptomes that are routinely used under fluoroscopic guidance. If such procedural success rates can be achieved (milestone 1) we will continue with the entire project (2020-2023) to develop a procedure that is clinically relevant and applicable.

Hit-to-lead development of CaMKII-HDAC4 inhibitory compounds to treat heart failure
ID 81X2500184
Institution Universitätsklinikum Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Translational Research Project
Funding 1237084.83€ 1.237.084,83
Begin 2019-11-0101.11.2019
End 2022-12-3131.12.2022
Projektdetails

Spatially resolved cellular and molecular drivers of cardiac remodeling in healthy and failing human hearts (DZHK-BHF Cooperation)
ID 81X2100155
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Hübner
Site Berlin
Project type Internationale Kooperation
Funding 615765.00€ 615.765,00
Begin 2019-06-0101.06.2019
End 2023-05-3131.05.2023
Projektdetails
Heart failure is a severe disease with a defective pump function that often results in heart transplantation. A heart is made of billions of cells which must properly work together. During heart failure functional changes arise due to modifications of cells that form the heart. We want to apply new leading-edge technologies to analyze thousands of individual cells at once to study the precise cell composition of different heart compartments and, importantly, the changes leading to heart failure. We expect to identify new disease markers and therapeutic targets for enlarged (dilated cardiomyopathy, DCM) and thickened (hypertrophic cardiomyopathy, HCM) failing hearts. Project partner: Dr Michela Noseda, Imperial College London (The British heart Foundation provides funding of £864,825 over three years)

Genetic discovery-based targeting of the vascular interface in atherosclerosis (DZHK-BHF Cooperation)
ID 81X2600254
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Internationale Kooperation
Funding 366883.27€ 366.883,27
Begin 2019-09-0101.09.2019
End 2023-08-3131.08.2023
Projektdetails
This collaborative project aims to help understand how our genes affect our risk of heart disease. Studies involving large groups of people with and without heart disease have identified changes in the DNA code that are more frequent in people with the disease. We found many of these DNA changes are in genes involved in the wall of our blood vessels, an important biological system in the development for heart disease. We will combine innovative computational and experimental methods to investigate these genes in great detail to understand how exactly they affect disease risk, and to translate this knowledge into new treatments. Project partner: Professor Hugh Watkins, University of Oxford (The British Heart Foundation provides funding of £1,077,114 over four years)

Genetic discovery-based targeting of the vascular interface in atherosclerosis (DZHK-BHF Cooperation)
ID 81X2600522
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site Hamburg/Kiel/Lübeck
Project type Internationale Kooperation
Funding 367000.00€ 367.000,00
Begin 2019-09-0101.09.2019
End 2023-08-3131.08.2023
Projektdetails
This collaborative project aims to help understand how our genes affect our risk of heart disease. Studies involving large groups of people with and without heart disease have identified changes in the DNA code that are more frequent in people with the disease. We found many of these DNA changes are in genes involved in the wall of our blood vessels, an important biological system in the development for heart disease. We will combine innovative computational and experimental methods to investigate these genes in great detail to understand how exactly they affect disease risk, and to translate this knowledge into new treatments. Project partner: Professor Hugh Watkins, University of Oxford (The British Heart Foundation provides funding of £1,077,114 over four years)

Spatially resolved cellular and molecular drivers of cardiac remodeling in healthy and failing human hearts (DZHK-BHF Cooperation)
ID 81X2710176
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Internationale Kooperation
Funding 274239.35€ 274.239,35
Begin 2019-07-0101.07.2019
End 2023-05-3131.05.2023
Projektdetails
Heart failure is a severe disease with a defective pump function that often results in heart transplantation. A heart is made of billions of cells which must properly work together. During heart failure functional changes arise due to modifications of cells that form the heart. We want to apply new leading-edge technologies to analyze thousands of individual cells at once to study the precise cell composition of different heart compartments and, importantly, the changes leading to heart failure. We expect to identify new disease markers and therapeutic targets for enlarged (dilated cardiomyopathy, DCM) and thickened (hypertrophic cardiomyopathy, HCM) failing hearts. Project partner: Dr Michela Noseda, Imperial College London (The British heart Foundation provides funding of £864,825 over three years)

BioVAT-HF-DZHK20: DZHK-Biobanking
ID 81X1300120
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Clinical Studies
Funding 8789.42€ 8.789,42
Begin 2019-07-0101.07.2019
End 2026-04-3030.04.2026
Projektdetails

BioVAT-HF-DZHK20: Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Device in Terminal Heart Failure
ID 81X1300119
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Clinical Studies
Funding 1176657.23€ 1.176.657,23
Begin 2019-07-0101.07.2019
End 2026-04-3030.04.2026
Projektdetails

TORCH-Plus-DZHK21: DZHK-Biobanking
ID 81X1500108
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 165457.82€ 165.457,82
Begin 2020-01-0101.01.2020
End 2027-12-3131.12.2027
Projektdetails

TORCH-Plus-DZHK21: TranslatiOnal Registry for CardiomyopatHies-Plus - Data Quality Centre
ID 81X1400111
Institution Universitätsmedizin Greifswald
Project leader Wolfgang Hoffmann
Site Greifswald
Project type Clinical Studies
Funding 494958.76€ 494.958,76
Begin 2020-01-0101.01.2020
End 2027-12-3131.12.2027
Projektdetails

TORCH-Plus-DZHK21: TranslatiOnal Registry for CardiomyopatHies-Plus
ID 81X1500107
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 2509046.58€ 2.509.046,58
Begin 2020-01-0101.01.2020
End 2027-12-3131.12.2027
Projektdetails

Clinician scientist programme: Mechanisms and clinical relevance of angiogenesis modulation through the platelet C5a receptor
ID 81X3700105
Institution Universität zu Lübeck
Project leader Henry Nording
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 234512.46€ 234.512,46
Begin 2019-10-0101.10.2019
End 2023-11-3030.11.2023
Projektdetails

Clinician scientist programme: Reticulated platelet biology in patients with coronary artery disease
ID 81X3600606
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Dario Bongiovanni
Site München
Project type Excellence Programme
Funding 149000.00€ 149.000,00
Begin 2019-11-0101.11.2019
End 2022-03-3131.03.2022
Projektdetails

Postdoc start-up grant: Effects of antimicrobial peptides on blood coagulation and venous thrombosis
ID 81X3600218
Institution Klinikum der Universität München
Project leader Joachim Pircher
Site München
Project type Excellence Programme
Funding 57204.01€ 57.204,01
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

Postdoc start-up grant: B-Cell Mediated Autoimmunity in Pulmonary Hypertension Associated to Left Heart Disease
ID 81X3100209
Institution Charité - Universitätsmedizin Berlin
Project leader Jana Grune
Site Berlin
Project type Excellence Programme
Funding 63463.61€ 63.463,61
Begin 2019-07-0101.07.2019
End 2022-02-2828.02.2022
Projektdetails

Postdoc start-up grant: Characterizing the role of adenosine-to-inosine RNA editing in atrial cardiomyopathy
ID 81X3500124
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Felix Wiedmann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2020-01-0101.01.2020
End 2021-04-3030.04.2021
Projektdetails

Postdoc start-up grant: Deciphering the role of novel mitochondrial microproteins in the human heart
ID 81X3100106
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sebastiaan van Heesch
Site Berlin
Project type Excellence Programme
Funding 59154.00€ 59.154,00
Begin 2019-10-0101.10.2019
End 2020-09-3030.09.2020
Projektdetails

Postdoc start-up grant: Gender-dependent disease severity in RBM20-cardiomyopathy - is there a role for CamkIId?
ID 81X3500122
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Maarten M.G. van den Hoogenhof
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2019-10-0101.10.2019
End 2021-03-3131.03.2021
Projektdetails

Postdoc start-up grant: Relevance and mechanistic role of hematopoietic KMD6A mutations in Ischemic Heart Failure
ID 81X3200113
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Sebastian Cremer
Site RheinMain
Project type Excellence Programme
Funding 56641.58€ 56.641,58
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

Postdoc start-up grant: Role of ChemR23 on macrophages in perivascular adipose tissue in atherosclerosis
ID 81X3600217
Institution Klinikum der Universität München
Project leader Yvonne Döring
Site München
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2019-10-0101.10.2019
End 2020-09-3030.09.2020
Projektdetails

Postdoc start-up grant: Role of circulating monocytes in heart failure subjects with mutations driving clonal haemotopoiesis
ID 81X3200114
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Wesley Abplanalp
Site RheinMain
Project type Excellence Programme
Funding 59475.00€ 59.475,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Promotion of women scientists: Dynamics of endothelial cadhesome in growing blood vessels
ID 81X3100105
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Anna Szymborska-Mell
Site Berlin
Project type Excellence Programme
Funding 72548.00€ 72.548,00
Begin 2019-08-0101.08.2019
End 2020-10-3131.10.2020
Projektdetails

Promotion of women scientists: Exercise-induced cardiomyogenesis in the aged mammalian heart
ID 81X3500120
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Carolin Lerchenmueller
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 62960.24€ 62.960,24
Begin 2019-07-1515.07.2019
End 2020-07-1414.07.2020
Projektdetails

Rotation grant: Cardiac midkine, a diet dependent cytokine as a regulator in cancer induced cardiac cachexia
ID 81X3500123
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Markus Heckmann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 103738.36€ 103.738,36
Begin 2019-12-0101.12.2019
End 2021-04-3030.04.2021
Projektdetails

Rotation grant: Impact of a skeletal muscle derived myokine on right ventricular failure and pulmonary hypertension
ID 81X3200112
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Badder Kattih
Site RheinMain
Project type Excellence Programme
Funding 92659.47€ 92.659,47
Begin 2019-11-0101.11.2019
End 2020-10-3131.10.2020
Projektdetails

Rotation grant: ITGA3 knockout attenuates pathological remodelling and fibrosis upon myocardial infarction
ID 81X3500121
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Nicolai Bogert
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 97060.33€ 97.060,33
Begin 2019-10-0101.10.2019
End 2020-09-3030.09.2020
Projektdetails

Rotation grant: Validation of myocardial perfusion analysis for detection of regional ischemia in an experimental pig model
ID 81X3200111
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Christophe Arendt
Site RheinMain
Project type Excellence Programme
Funding 76699.24€ 76.699,24
Begin 2019-12-0101.12.2019
End 2020-11-3030.11.2020
Projektdetails

Hit-to-lead development of CaMKII-HDAC4 inhibitory compounds to treat heart failure
ID 81X2300199
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Translational Research Project
Funding 42744.99€ 42.744,99
Begin 2019-11-0101.11.2019
End 2021-02-2828.02.2021
Projektdetails

Bestimmung des tolerogenen Levels der HLA-E-Expression für ein optimiertes Engineering allogener Kardiomyozyten
ID 81X2300204
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Lutz Walter
Site Göttingen
Project type Cooperation with External Partners
Funding 33837.63€ 33.837,63
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

Bestimmung des tolerogenen Levels der HLA-E-Expression für ein optimiertes Engineering allogener Kardiomyozyten
ID 81X2800194
Institution Heinrich-Heine-Universität Düsseldorf
Project leader Markus Uhrberg
Site Extern
Project type Cooperation with External Partners
Funding 39880.00€ 39.880,00
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

Link between DAMPs and MIF proteins in cardiac remodeling after I/R injury and relevance for heart failure
ID 81X2600258
Institution Klinikum der Universität München
Project leader Jürgen Bernhagen
Site München
Project type Cooperation with External Partners
Funding 31559.35€ 31.559,35
Begin 2020-01-0101.01.2020
End 2023-12-3131.12.2023
Projektdetails

Link between DAMPs and MIF proteins in cardiac remodeling after I/R injury and relevance for heart failure.
ID 81X2800195
Institution Universitätsklinikum Essen
Project leader Tienush Rassaf
Site Extern
Project type Cooperation with External Partners
Funding 23920.00€ 23.920,00
Begin 2020-01-0101.01.2020
End 2023-12-3131.12.2023
Projektdetails

Spatial and temporal proteomic mapping of translational regulation during ischemia/reperfusion injury
ID 81X2500190
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Mirko Völkers
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 15340.29€ 15.340,29
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

Spatial and temporal proteomic mapping of translational regulation during ischemia/reperfusion injury
ID 81X2800193
Institution Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e. V. (FLI)
Project leader Alessandro Ori
Site Extern
Project type Cooperation with External Partners
Funding 37600.00€ 37.600,00
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

The role of intraluminal thrombus derived non-coding RNAs in the hypoxic micromilieu of the growing abdominal aortic aneurysm wall
ID 81X2600626
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Albert Busch
Site München
Project type Cooperation with External Partners
Funding 23953.12€ 23.953,12
Begin 2020-01-0101.01.2020
End 2022-03-3131.03.2022
Projektdetails

The role of intraluminal thrombus derived non-coding RNAs in the hypoxic micromilieu of the growing abdominal aortic aneurysm wall
ID 81X2800192
Institution Heinrich-Heine-Universität Düsseldorf
Project leader Markus Wagenhäuser
Site Extern
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2020-01-0101.01.2020
End 2022-03-3131.03.2022
Projektdetails

Identification of noncoding regulatory variants in coronary artery disease
ID 81X2200151
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Marcel Schulz
Site RheinMain
Project type Shared Expertise (SE)
Funding 5506.00€ 5.506,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

AAV mediated transgenic regulation of the long non coding RNA- MALAT1 and the role in neonatal heart regeneration
ID 81X2200149
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 20000.00€ 20.000,00
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

AAV mediated transgenic regulation of the long non coding RNA- MALAT1 and the role in neonatal heart regeneration
ID 81X2700228
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 18842.22€ 18.842,22
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

Adapting cardiac splicing via PTBP1 as a therapeutic strategy in patients with RBM20 mutations
ID 81X2100160
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Gotthardt
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE079)
Funding 37500.00€ 37.500,00
Begin 2020-01-0101.01.2020
End 2022-12-3131.12.2022
Projektdetails

Adapting cardiac splicing via PTBP1 as a therapeutic strategy in patients with RBM20 mutations
ID 81X2500191
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE079)
Funding 37500.00€ 37.500,00
Begin 2020-01-0101.01.2020
End 2022-12-3131.12.2022
Projektdetails

Analysis of NMIIB function during cardiac lineage specification
ID 81X2500182
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 23999.76€ 23.999,76
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Analysis of NMIIB function during cardiac lineage specification
ID 81X2600625
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alessandra Moretti
Site München
Project type Shared Expertise (SE)
Funding 23999.70€ 23.999,70
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Cardiac myosin-binding protein C in comparison to highly sensitive troponin I and B-type natriuretic peptide to identify an obstructive coronary artery disease in stable patients
ID 81X2200204
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Till Keller
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user
Funding 4959.35€ 4.959,35
Begin 2019-07-0101.07.2019
End 2020-12-3131.12.2020
Projektdetails

Cardiac myosin-binding protein C in comparison to highly sensitive troponin I and B-type natriuretic peptide to identify an obstructive coronary artery disease in stable patients
ID 81X2710177
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider
Funding 6080.88€ 6.080,88
Begin 2019-07-0101.07.2019
End 2020-12-3131.12.2020
Projektdetails

Cardiac toxicity screening with swine myocardial tissue slices
ID 81X2300196
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tobias Brügmann
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE046)
Funding 12385.00€ 12.385,00
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

Cardiac toxicity screening with swine myocardial tissue slices
ID 81X2600257
Institution Klinikum der Universität München
Project leader Andreas Dendorfer
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE046)
Funding 13400.00€ 13.400,00
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

Characterization of the immune-modulatory function of selected IncRNAs in plaque erosion
ID 81X2200152
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Shared Expertise (SE)
Funding 9752.56€ 9.752,56
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Characterization of the immune-modulatory function of selected lncRNAs in plaque erosion.
ID 81X2100260
Institution Charité-Universitätsmedizin Berlin
Project leader David Leistner
Site Berlin
Project type Shared Expertise (SE)
Funding 29984.55€ 29.984,55
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Combinatorial metabolic and electromechanical maturation of stem cell-derived cardiomyocytes and engineered human myocardium
ID 81X2200148
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ingrid Fleming
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider
Funding 30633.52€ 30.633,52
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Combinatorial metabolic and electromechanical maturation of stem cell-derived cardiomyocytes and engineered human myocardium
ID 81X2300193
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Norman Liaw
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user
Funding 30632.00€ 30.632,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Contribution of lactate dehydrogenase B to the pathogenesis of an experimental autoimmune myocarditis
ID 81X2500185
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Ziya Kaya
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 38200.00€ 38.200,00
Begin 2020-01-0101.01.2020
End 2022-02-2828.02.2022
Projektdetails

Contribution of lactate dehydrogenase B to the pathogenesis of an experimental autoimmune myocarditis
ID 81X2700227
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 38200.00€ 38.200,00
Begin 2020-01-0101.01.2020
End 2022-02-2828.02.2022
Projektdetails

CRISPR/Cas9-mediated Activation of Endogenous Ribosome-binding Protein 1 (RRBP1) in the Ischemic Heart in Vivo
ID 81X2300195
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayán
Site Göttingen
Project type Shared Expertise (SE)
Funding 44719.09€ 44.719,09
Begin 2020-01-0101.01.2020
End 2021-07-3131.07.2021
Projektdetails

CRISPR/Cas9-mediated Activation of Endogenous Ribosome-binding Protein 1 (RRBP1) in the Ischemic Heart in Vivo
ID 81X2500188
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Shirin Doroudgar
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 36800.00€ 36.800,00
Begin 2020-01-0101.01.2020
End 2021-07-3131.07.2021
Projektdetails

Deciphering heterogeneity of spicing events of adult murine cardiomyocytes on single cell level
ID 81X2500192
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 35000.00€ 35.000,00
Begin 2020-01-0101.01.2020
End 2021-06-3030.06.2021
Projektdetails

Deciphering heterogeneity of spicing events of adult murine cardiomyocytes on single cell level.
ID 81X2200313
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Stefan Günther
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 35000.00€ 35.000,00
Begin 2020-01-0101.01.2020
End 2021-06-3030.06.2021
Projektdetails

Die Rolle von OCaR2, einem neuen Regulator der Ca2+ Freisetzung aus intrazellulären Organellen, für Katecholamin-induzierte diastolische Ca2+ Transienten in von hiPSC-Zellen abgeleiteten Kardiomyozyten
ID 81X2500181
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 23530.12€ 23.530,12
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

Die Rolle von OCaR2, einem neuen Regulator der Ca2+ Freisetzung aus intrazellulären Organellen, für Katecholamin-induzierte diastolische Ca2+ Transienten in von hiPSC-Zellen abgeleiteten Kardiomyozyten
ID 81X2710179
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 25000.00€ 25.000,00
Begin 2020-01-0101.01.2020
End 2020-12-3131.12.2020
Projektdetails

Endogenous Reprogramming of Cardiac Fatty Acid Metabolism to Treat Diabetic Cardiomyopathy
ID 81X2400142
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Shared Expertise (SE)
Funding 77694.49€ 77.694,49
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

Endogenous Reprogramming of Cardiac Fatty Acid Metabolism to Treat Diabetic Cardiomyopathy
ID 81X2700229
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 86335.33€ 86.335,33
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

Functional characterization of calcium-handling proteins in a porcine model of atrial fibrillation
ID 81X2300189
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Niels Voigt
Site Göttingen
Project type Shared Expertise (SE)
Funding 29586.22€ 29.586,22
Begin 2020-01-0101.01.2020
End 2021-06-3030.06.2021
Projektdetails

Functional characterization of calcium-handling proteins in a porcine model of atrial fibrillation
ID 81X2600255
Institution Klinikum der Universität München
Project leader Sebastian Clauß
Site München
Project type Shared Expertise (SE)
Funding 39632.55€ 39.632,55
Begin 2020-01-0101.01.2020
End 2021-06-3030.06.2021
Projektdetails

Genetic discovery-based targeting of the vascular interface in atherosclerosis (DZHK-BHF Cooperation)
ID 81X2700133
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Internationale Kooperation
Funding 375995.65€ 375.995,65
Begin 2019-09-0101.09.2019
End 2023-08-3131.08.2023
Projektdetails
This collaborative project aims to help understand how our genes affect our risk of heart disease. Studies involving large groups of people with and without heart disease have identified changes in the DNA code that are more frequent in people with the disease. We found many of these DNA changes are in genes involved in the wall of our blood vessels, an important biological system in the development for heart disease. We will combine innovative computational and experimental methods to investigate these genes in great detail to understand how exactly they affect disease risk, and to translate this knowledge into new treatments. Project partner: Professor Hugh Watkins, University of Oxford (The British Heart Foundation provides funding of £1,077,114 over four years)

Genotype-phenotype mapping of quantitative cardiac traits by integrated gen-transcript-proteomics
ID 81X2100158
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
Funding 38200.00€ 38.200,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Genotype-phenotype mapping of quantitative cardiac traits by integrated gen-transcript-proteomics
ID 81X2500189
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Jakob Gierten
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 38200.00€ 38.200,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Gut microbiome alterations in atrial fibrillation (AF)
ID 81X2100159
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sofia Forslund
Site Berlin
Project type Shared Expertise (SE)
Funding 35000.00€ 35.000,00
Begin 2020-01-0101.01.2020
End 2021-04-3030.04.2021
Projektdetails

Gut microbiome alterations in atrial fibrillation (AF).
ID 81X2710182
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Christin S. Börschel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 34300.00€ 34.300,00
Begin 2020-01-0101.01.2020
End 2021-04-3030.04.2021
Projektdetails

Identification of noncoding regulatory variants in coronary artery disease
ID 81X2200314
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Stefan Guenther
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 11200.00€ 11.200,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Identification of noncoding regulatory variants in coronary artery disease
ID 81X2600525
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Shared Expertise (SE)
Funding 17750.00€ 17.750,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Immunophenotyping to predict individual cardiovascular and metabolic response to exercise training
ID 81X2100262
Institution Charité-Universitätsmedizin Berlin
Project leader Nicolle Kränkel
Site Berlin
Project type Shared Expertise (SE)
Funding 33445.24€ 33.445,24
Begin 2020-01-0101.01.2020
End 2024-06-3030.06.2024
Projektdetails

Immunophenotyping to predict individual cardiovascular and metabolic response to exercise training
ID 81X2400143
Institution Universitätsmedizin Greifswald
Project leader Martin Bahls
Site Greifswald
Project type Shared Expertise (SE)
Funding 40000.00€ 40.000,00
Begin 2020-01-0101.01.2020
End 2024-06-3030.06.2024
Projektdetails

Impact of systemic versus cardiomyocyte-specific alarmin S100A9 expression on heart failure
ID 81X2100261
Institution Charité-Universitätsmedizin Berlin
Project leader Sophie Van Linthout
Site Berlin
Project type Shared Expertise (SE)
Funding 37290.01€ 37.290,01
Begin 2020-01-0101.01.2020
End 2022-03-3131.03.2022
Projektdetails

Impact of systemic versus cardiomyocyte-specific alarmin S100A9 expression on heart failure
ID 81X2500193
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 37500.00€ 37.500,00
Begin 2020-01-0101.01.2020
End 2022-03-3131.03.2022
Projektdetails

Influence of hypertension on Dnmt3a and Tet2 mutations driving clonal hematopoiesis
ID 81X2200150
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Shared Expertise (SE)
Funding 20550.00€ 20.550,00
Begin 2020-01-0101.01.2020
End 2021-09-3030.09.2021
Projektdetails

Influence of hypertension on Dnmt3a and Tet2 mutations driving clonal hematopoiesis
ID 81X2600116
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Annette Peters
Site München
Project type Shared Expertise (SE)
Funding 68854.36€ 68.854,36
Begin 2020-01-0101.01.2020
End 2021-09-3030.09.2021
Projektdetails

Morphological and Functional Characterization of Early Repolarization
ID 81X2400141
Institution Universitätsmedizin Greifswald
Project leader Alexander Teumer
Site Greifswald
Project type Shared Expertise (SE)
Funding 30300.00€ 30.300,00
Begin 2020-01-0101.01.2020
End 2023-09-3030.09.2023
Projektdetails

Morphological and Functional Characterization of Early Repolarization
ID 81X2600524
Institution Deutsches Herzzentrum München
Project leader Teresa Trenkwalder
Site München
Project type Shared Expertise (SE)
Funding 17700.00€ 17.700,00
Begin 2020-01-0101.01.2020
End 2023-09-3030.09.2023
Projektdetails

Proteomic analysis in valvular cardiomyopathy: aortic regurgitation vs. aortic stenosis
ID 81X2400139
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
Funding 35576.64€ 35.576,64
Begin 2020-01-0101.01.2020
End 2022-12-3131.12.2022
Projektdetails

Proteomic analysis in valvular cardiomyopathy: aortic regurgitation vs. aortic stenosis
ID 81X2710178
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Evaldas Girdauskas
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 7012.80€ 7.012,80
Begin 2020-01-0101.01.2020
End 2022-12-3131.12.2022
Projektdetails

Proteomic characterization of peroxisomes from the human heart
ID 81X2300198
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Sven Thoms
Site Göttingen
Project type Shared Expertise (SE)
Funding 38460.00€ 38.460,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Proteomic characterization of peroxisomes from the human heart
ID 81X2500211
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Markus Islinger
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 41460.00€ 41.460,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Regulatory elements involved in metabolic remodeling
ID 81X2500183
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Lorenz Lehmann
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 21000.00€ 21.000,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Regulatory elements involved in metabolic remodeling
ID 81X2700225
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 21000.00€ 21.000,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Regulatory role of gut microbiota dependent metabolites on maladaptive cardiac remodelling
ID 81X2100259
Institution Charité-Universitätsmedizin Berlin
Project leader Arash Haghikia
Site Berlin
Project type Shared Expertise (SE)
Funding 35507.03€ 35.507,03
Begin 2020-01-0101.01.2020
End 2022-02-2828.02.2022
Projektdetails

Regulatory role of gut microbiota dependent metabolites on maladaptive cardiac remodelling
ID 81X2500212
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Jörg Heineke
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 36160.00€ 36.160,00
Begin 2020-01-0101.01.2020
End 2022-02-2828.02.2022
Projektdetails

Role of CD40L in hyperglycemia (metabolic syndrome) and Hypertension induced vascular complications
ID 81X2100306
Institution Deutsches Herzzentrum Berlin
Project leader Christoph Knosalla
Site Berlin
Project type Shared Expertise (SE)
Funding 8000.00€ 8.000,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Role of CD40L in hyperglycemia (metabolic syndrome) and hypertension induced vascular complications
ID 81X2210121
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Andreas Daiber
Site RheinMain
Project type Shared Expertise (SE)
Funding 21000.00€ 21.000,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Role of CD40L in hyperglycemia (metabolic syndrome) and hypertension induced vascular complications
ID 81X2600259
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Shared Expertise (SE)
Funding 21000.00€ 21.000,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Role of epigenetic alterations and ROS in hypoxia-induced fetal programming of cardiac remodeling
ID 81X2300197
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayán
Site Göttingen
Project type Shared Expertise (SE)
Funding 21643.66€ 21.643,66
Begin 2020-01-0101.01.2020
End 2023-09-3030.09.2023
Projektdetails

Role of epigenetic alterations and ROS in hypoxia-induced fetal programming of cardiac remodeling
ID 81X2600523
Institution Deutsches Herzzentrum München
Project leader Agnes Görlach
Site München
Project type Shared Expertise (SE)
Funding 23800.00€ 23.800,00
Begin 2020-01-0101.01.2020
End 2023-09-3030.09.2023
Projektdetails

Role of Regnase-3 in viral myocarditis
ID 81X2100258
Institution Charité-Universitätsmedizin Berlin
Project leader Antje Beling
Site Berlin
Project type Shared Expertise (SE)
Funding 35000.00€ 35.000,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Role of Regnase-3 in viral myocarditis
ID 81X2600256
Institution Klinikum der Universität München
Project leader Maximilian Fischer
Site München
Project type Shared Expertise (SE)
Funding 13000.00€ 13.000,00
Begin 2020-01-0101.01.2020
End 2022-06-3030.06.2022
Projektdetails

Single nuclei RNA sequencing of injured arteries in mice
ID 81X2500187
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 28800.00€ 28.800,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Single nuclei RNA sequencing of injured arteries in mice
ID 81X2710181
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Justus Stenzig
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 25564.66€ 25.564,66
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Sympathetic control of cardiac macrophages
ID 81X2100156
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
Funding 23852.00€ 23.852,00
Begin 2020-01-0101.01.2020
End 2023-12-3131.12.2023
Projektdetails

Sympathetic control of cardiac macrophages
ID 81X2600415
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
Funding 23000.00€ 23.000,00
Begin 2020-01-0101.01.2020
End 2023-12-3131.12.2023
Projektdetails

T M V R ( Transcatheter mitral valve replacement ) in chronic mitral regurgitation
ID 81X2600627
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
Funding 20680.00€ 20.680,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

T M V R ( Transcatheter mitral valve replacement ) in chronic mitral regurgitation
ID 81X2700224
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Georg Lutter
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 19087.73€ 19.087,73
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

The effects of tissue specific Mas expression on development of obesity and atherosclerosis
ID 81X2100157
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
Funding 27500.00€ 27.500,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

The effects of tissue specific Mas expression on development of obesity and atherosclerosis
ID 81X2700134
Institution Universität zu Lübeck
Project leader Walter Raasch
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 24159.76€ 24.159,76
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Thrombo-inflammatory responses of monocytes in antiphospholipid syndrome
ID 81X2210120
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Wolfram Ruf
Site RheinMain
Project type Shared Expertise (SE)
Funding 28000.00€ 28.000,00
Begin 2020-02-0101.02.2020
End 2021-12-3131.12.2021
Projektdetails

Thrombo-inflammatoty responses of monocytes in antiphospholipid syndrome
ID 81X2100161
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
Funding 29250.00€ 29.250,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Titin cleavage by AAV9-mediated gene transfer to establish a mouse model of acute titin dysfunction
ID 81X2300190
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfgang Linke
Site Göttingen
Project type Shared Expertise (SE)
Funding 15000.00€ 15.000,00
Begin 2020-01-0101.01.2020
End 2021-01-3131.01.2021
Projektdetails

Titin cleavage by AAV9-mediated gene transfer to establish a mouse model of acute titin dysfunction.
ID 81X2700226
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 15000.00€ 15.000,00
Begin 2020-01-0101.01.2020
End 2021-01-3131.01.2021
Projektdetails

Ultrasound-based electro-mechanical mapping of ventricular tachycardia in human
ID 81X2300192
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Jan Christoph
Site Göttingen
Project type Shared Expertise (SE)
Funding 42311.50€ 42.311,50
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Ultrasound-based electro-mechanical mapping of ventricular tachycardia in human.
ID 81X2710180
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Paula Münkler
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 9407.00€ 9.407,00
Begin 2020-01-0101.01.2020
End 2021-12-3131.12.2021
Projektdetails

Utility of patient-specific human iPSC-derived nodal- and working-type ventricular cardiomyocytes to model a novel combined electromechanical cardiac disorder caused by mutations in HCN4
ID 81X2300194
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Antje Ebert
Site Göttingen
Project type Shared Expertise (SE)
Funding 38136.72€ 38.136,72
Begin 2020-01-0101.01.2020
End 2022-12-3131.12.2022
Projektdetails

Utility of patient-specific human iPSC-derived nodal- and working-type ventricular cardiomyocytes to model a novel combined electromechanical cardiac disorder caused by mutations in HCN4
ID 81X2500186
Institution Ruprecht-Karls-Universität Heidelberg
Project leader Patrick Schweizer
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
Funding 38200.00€ 38.200,00
Begin 2020-01-0101.01.2020
End 2022-12-3131.12.2022
Projektdetails

When Cardio meets Cancer: drug screening in iPSC-CMs from Noonan syndrome patients
ID 81X2300191
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
Funding 30624.96€ 30.624,96
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

When Cardio meets Cancer: drug screening in iPSC-CMs from Noonan syndrome patients
ID 81X2400140
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
Funding 30593.95€ 30.593,95
Begin 2020-01-0101.01.2020
End 2021-03-3131.03.2021
Projektdetails

Fünf-Jahres Follow-up Studie v.Teilnehmerinnen der Berliner Frauen Risikoevaluations-(BEFRI-)Studie
ID 81Z0100211
Institution Charité - Universitätsmedizin Berlin
Project leader Anna Brand
Site Berlin
Project type Partner Site Projects
Funding 86364.87€ 86.364,87
Begin 2019-07-0101.07.2019
End 2021-01-3131.01.2021
Projektdetails

CULPRIT-SHOCK: substudies
ID 81X2800191
Institution Stiftung Institut für Herzinfarktforschung
Project leader Steffen Schneider
Site Extern
Project type Clinical Studies
Funding 66809.10€ 66.809,10
Begin 2019-07-0101.07.2019
End 2020-06-3030.06.2020
Projektdetails
Das Projekt wertet die bestehenden Datenbanken der randomisierten CULPRIT-SHOCK Studie sowie des begleitenden Registers (Patienten mit akutem Myokardinfarkt und kardiogenem Schock) hinsichtlich sechs relevanter Themengebiete biometrisch aus.

COVID-PREVENT - Effect of anticoagulation therapy on clinical outcomes in COVID-19
ID 81X1100222
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Clinical Studies
Funding 321476.19€ 321.476,19
Begin 2020-07-0101.07.2020
End 2022-12-3131.12.2022
Projektdetails

EXAMINE-CAD-DZHK22: First prospective randomized trial to examine a differential therapeutic response in symptomatic patients with non-obstructive coronary artery disease after coronary physiological testing
ID 81X1100223
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Clinical Studies
Funding 1118101.00€ 1.118.101,00
Begin 2020-08-1515.08.2020
End 2024-03-3131.03.2024
Projektdetails

EXAMINE-CAD-DZHK22: DZHK-Biobanking
ID 81X1100224
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Clinical Studies
Funding 9652.00€ 9.652,00
Begin 2020-08-1515.08.2020
End 2024-01-3131.01.2024
Projektdetails

GARY: Statistical Data Analysis of the German Aortic Valve Registry 2020-2022
ID 81X1200107
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eva Herrmann
Site RheinMain
Project type Clinical Studies
Funding 198900.00€ 198.900,00
Begin 2020-11-0101.11.2020
End 2022-10-3131.10.2022
Projektdetails

GARY: Statistical Data Analyse of the German Aortic Valve Registry 2020-2022
ID 81X1200204
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Christian Hamm
Site RheinMain
Project type Clinical Studies
Funding 49500.00€ 49.500,00
Begin 2020-11-0101.11.2020
End 2022-10-3131.10.2022
Projektdetails

MR SPOC - Munich Remote SpO2 and Heart Rate Assessment in Covid-19 patients
ID 81X1600211
Institution Klinikum der Universität München
Project leader Moritz Sinner
Site München
Project type Clinical Studies
Funding 146031.56€ 146.031,56
Begin 2020-07-0101.07.2020
End 2023-06-3030.06.2023
Projektdetails

ACEI-COVID-19: Stopping ACE-inhibitors in COVID-19
ID 81X1600212
Institution Klinikum der Universität München
Project leader Steffen Massberg
Site München
Project type Clinical Studies
Funding 179861.00€ 179.861,00
Begin 2020-10-0101.10.2020
End 2022-02-2828.02.2022
Projektdetails

ACEI-COVID-19: Stopping ACE-inhibitors in COVID-19 - Biometrie
ID 81X1600703
Institution Ludwig-Maximilians-Universität München
Project leader Ulrich Mansmann
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 15249.99€ 15.249,99
Begin 2020-09-0101.09.2020
End 2022-02-2828.02.2022
Projektdetails

CMR-ICD-DZHK23: DZHK-Biobanking
ID 81X1700111
Institution Universität zu Lübeck
Project leader Ingo Eitel
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 125400.00€ 125.400,00
Begin 2020-10-0101.10.2020
End 2026-09-3030.09.2026
Projektdetails

CMR-ICD-DZHK23: Cardiac Magnetic Resonance guidance of Implantable Cardioverter Defibrillator implantation in non-ischaemic dilated cardiomyopathy
ID 81X1700112
Institution Universität zu Lübeck
Project leader Ingo Eitel
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 2913388.64€ 2.913.388,64
Begin 2020-10-0101.10.2020
End 2028-09-3030.09.2028
Projektdetails

EXAMINE-CAD-DZHK22: Biometrie
ID 81X1710111
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Karl Wegscheider
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 51465.50€ 51.465,50
Begin 2020-08-0101.08.2020
End 2024-03-3131.03.2024
Projektdetails

Postdoc start-up grant: Anpassung der interzellulären Kommunikation zur Verbesserung der Herzfunktion und der Reaktion auf Hypoxie
ID 81X3100107
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Felizia Voß
Site Berlin
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2020-04-0101.04.2020
End 2021-12-3131.12.2021
Projektdetails
Eine effiziente Kommunikation zwischen Kardiomyozyten ist die Voraussetzung für die korrekte Leitung der elektrischen Signale, die synchronisierte Kontraktion und ihre koordinierte Reaktion auf physiologische Anforderungen. Sie hängt von Zellkontaktproteinen wie dem Coxsackievirus und Adenovirusrezeptor (CAR) ab, der nicht nur für die Virusaufnahme bei der Myokarditis, sondern auch für die richtige Entwicklung des Herzens, den Umbau und die atrioventrikuläre Leitung wichtig ist. CAR bildet Homo- und Heterodimere über die Glanzstreifen und ist mit dem Zytoskelett und dem AKT-Signalweg assoziiert. Das Verständnis seiner Rolle bei menschlichen Erkrankungen auf molekularer Ebene wurde durch den begrenzten Zugang zu seiner Proteinumgebung und durch das Fehlen funktioneller Assays zur Analyse seiner Rolle in der Endozytose, Signaltransduktion und Zellkommunikation beeinträchtigt. Das Ziel dieser Studie ist es zu bestimmen, wie CAR die Glanzstreifen kompartmentalisiert, um Arrhythmie zu verhindern, den Herzumbau zu verbessern und die Kommunikation in einer hypoxischen Umgebung zu erleichtern, um das Ergebnis nach einer Ischämie-Reperfusionsverletzung zu verbessern. Deshalb werden wir etablierte humane iPSC-abgeleitete Kardiomyozyten (iPSC-CM) verwenden, um i) die CAR-Proteinumgebung mit Hilfe eines etablierten Lokalisationsproteomik-Ansatzes zu charakterisieren, ii) die Rolle von CAR bei der Reaktion auf Hypoxie und Zelltod zu evaluieren und zu untersuchen, wie CAR Endozytose, Zellkontaktbildung und Signaltransduktion integriert. Wir sind zuversichtlich, die vorgeschlagenen Arbeiten in der geplanten Zeit abzuschließen, um die mechanistische Basis für zukünftige CAR-gerichtete Therapien zu schaffen.

Junior research group: Regulation of Lipid Alterations and Metabolic Inflammation in Heart Failure with Preserved Ejection Fraction
ID 81X3100210
Institution Charité - Universitätsmedizin Berlin
Project leader Gabriele Schiattarella
Site Berlin
Project type Excellence Programme
Funding 1568687.00€ 1.568.687,00
Begin 2020-10-0101.10.2020
End 2026-09-3030.09.2026
Projektdetails

Postdoc start-up grant: Impact of DNMT3A and TET2 mutations on immune-inflammatory pathways in patients undergoing TAVI for aortic stenosis
ID 81X3200115
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Silvia Mas-Peiro
Site RheinMain
Project type Excellence Programme
Funding 59992.00€ 59.992,00
Begin 2020-05-0101.05.2020
End 2021-04-3030.04.2021
Projektdetails

Promotion of women scientists: Assembling a multi-level molecular roadmap of cardiomyocyte maturation for cardiac regeneration
ID 81X3200116
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Paola Cattaneo
Site RheinMain
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2020-11-0101.11.2020
End 2021-12-3131.12.2021
Projektdetails

Clinician scientist programme: Interplay of systemic inflammation, vascular inflammation and microvascular function
ID 81X3200117
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Simon Martin
Site RheinMain
Project type Excellence Programme
Funding 119988.00€ 119.988,00
Begin 2020-12-0101.12.2020
End 2023-06-3030.06.2023
Projektdetails

Postdoc start-up grant: Mitochondrial redox stress and maladaptive Ca2+ release unit remodelling as therapeutic targets in atrial fibrillation
ID 81X3300108
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Sören Brandenburg
Site Göttingen
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2020-07-0101.07.2020
End 2021-06-3030.06.2021
Projektdetails

Promotion of women scientists: Defining the beta-catenin-dependent posttranscriptional regulation during heart failure progression
ID 81X3300109
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayán
Site Göttingen
Project type Excellence Programme
Funding 106006.52€ 106.006,52
Begin 2020-08-0101.08.2020
End 2022-08-3131.08.2022
Projektdetails

Postdoc start-up grant: Viskoelastische Eigenschaften peripherer Blutzellen als markierungsfreier Indikator für in-vitro Immunzellaktivierung bei kardiovaskulären Erkrankungen
ID 81X3400107
Institution Universitätsmedizin Greifswald
Project leader Oiver Otto
Site Greifswald
Project type Excellence Programme
Funding 71205.55€ 71.205,55
Begin 2020-04-0101.04.2020
End 2021-12-3131.12.2021
Projektdetails
Das geplante Projekt beabsichtigt die viskoelastischen Eigenschaften von peripheren Blutzellen vor und nach Aktivierung mittels dynamic Real-Time Deformability Cytometry zu untersuchen. Die Ergebnisse der Studie bilden die Grundlage für einen TRP Antrag beim DZHK.

Postdoc start-up grant: ATGL cardiomyopathy: From mechanism to a new epigenetic therapy approach
ID 81X3500125
Institution Universität Heidelberg
Project leader Xuemin Gong
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 58950.00€ 58.950,00
Begin 2020-04-0101.04.2020
End 2021-12-3131.12.2021
Projektdetails

Rotation grant: Targeting MEF2D-dependent transcription to treat sepsis-induced acute heart failure
ID 81X3500126
Institution Universität Heidelberg
Project leader Richard Schell
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 108600.00€ 108.600,00
Begin 2020-12-0101.12.2020
End 2023-10-3131.10.2023
Projektdetails

Promotion of women scientists: The role of endothelial TGF-ß/BMP signaling pathway in heart remodeling and homeostasis
ID 81X3500206
Institution Universität Heidelberg
Project leader Roxana Ola
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-02-0101.02.2021
End 2022-05-3131.05.2022
Projektdetails
Das multifunktionelle Zytokin "Transforming Growth Factor beta (TGFß)" ist nach dem derzeitigen Erkenntnisstand einer der zentralen Regulatoren der kardialen Fibrose, der zudem die Apoptose von Kardiomyozyten und eine kardiale Hypertrophie initiieren kann. Es ist aber bis dato unklar, welche Bedeutung dabei die Einwirkung von TGFß auf vaskuläre Endothelzellen (EZ) und die in diesen Zellen angeworfenen Signalwege für Kardiomyopathien haben. Es ist dagegen bekannt, dass Mutationen in SMAD4, einem durch TGFß kontrolliertem Transkriptionsfaktor, Gefäßschäden hervorrufen, die letztendlich zu arteriovenösen Fehlbildungen, Aortenaneurysmen und anderen kardiovaskulären Anomalien, z. B. in Patienten, die an einem Myhre-Syndrom leiden, führen. Um die Bedeutung der durch TGFß-regulierten Signalwege in EZ für das kardiovaskuläre System besser verstehen zu können, wurde ein Mausmodell generiert, dass eine EZ-spezifische Deletion des SMAD4-Gens erlaubt. Durch die spezifische Inaktivierung von SMAD4 in EZ nach der Geburt entwickeln Mäuse eine kardiale Hypertrophie und versterben innerhalb kurzer Zeit. Deshalb soll in dem vorliegenden Forschungsprojekt 1. die molekularen und zellulären Mechanismen aufgeklärt werden, durch die TGFß-induzierte Signalwege in EZ zur kardialen Homöostase und Umbauprozessen im Herzen beitragen und 2. neue, SMAD4 nachgeschaltete Zielgene identifiziert werden, die diese Prozesse steuern und deshalb Ansatzpunkte für neue Therapiestrategien zur Behandlung von Kardiomyopathien, aber auch von Bindegewebserkrankungen wie dem Myrhe-Syndrom, darstellen könnten. In diesem Projekt, werden deshalb klassische Methoden wie morphometrische Analyse der Herzen der Mutanten nach gezielter Inaktivierung der Gene mit modernen Verfahren wie der Kokultur von Kardiomyozyten und Endothelzelle, Analysen des Transkriptoms und Proteoms, und Zeitraffermikrospkopie kombiniert werden, um diese Ziele zu erreichen.

Promotion of women scientists: Immuno-metabolic phenotyping of the amino acid homoarginine in atherosclerosis
ID 81X3600219
Institution Klinikum der Universität München
Project leader Dorothee Atzler
Site München
Project type Excellence Programme
Funding 78399.96€ 78.399,96
Begin 2020-10-0101.10.2020
End 2022-03-3131.03.2022
Projektdetails

Postdoc start-up grant: The aryl hydrocarbon receptor (AhR), a friend that turns out to be a foe?
ID 81X3600220
Institution Klinikum der Universität München
Project leader Emiel van der Vorst
Site München
Project type Excellence Programme
Funding 79660.90€ 79.660,90
Begin 2020-10-0101.10.2020
End 2021-12-3131.12.2021
Projektdetails

Clinician scientist programme: Contribution of SVEP1 and CD209 to vascular and cardiac inflammation - new mechanistic insights and therapeutic avenues
ID 81X3600507
Institution Deutsches Herzzentrum München
Project leader Alexander Dutsch
Site München
Project type Excellence Programme
Funding 180381.13€ 180.381,13
Begin 2020-10-0101.10.2020
End 2023-12-3131.12.2023
Projektdetails

Postdoc start-up grant: Molecular and morphological characterization of coronary neoatherosclerosis
ID 81X3600508
Institution Deutsches Herzzentrum München
Project leader Jens Wiebe
Site München
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2020-11-0101.11.2020
End 2022-03-3131.03.2022
Projektdetails

Postdoc start-up grant: Human-Mouse Chimera for Characterization of Human Cardiac Progenitors during Embryonic Development
ID 81X3600607
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Jessica Kornherr
Site München
Project type Excellence Programme
Funding 60000.00€ 60.000,00
Begin 2020-04-0101.04.2020
End 2021-03-3131.03.2021
Projektdetails

Clinician scientist programme: Inherited aortic diseases: Identification and functional analysis of novel disease-causing genes
ID 81X3710109
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Till Demal
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 148546.00€ 148.546,00
Begin 2020-09-0101.09.2020
End 2024-03-3131.03.2024
Projektdetails

Evaluation of the C5aR1-CXLC4-CXCR3 axis for ischemia-induced vessel growth by AAV-vector mediated gene transfer
ID 81X2700135
Institution Universität zu Lübeck
Project leader Harald Langer
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 27649.15€ 27.649,15
Begin 2020-03-0101.03.2020
End 2021-12-3131.12.2021
Projektdetails

Bewertung der C5aR1-CXLC4-CXCR3-Achse für Ischämie-induziertes Gefäßwachstum durch AAV-Vektor-vermittelten Gentransfer
ID 81X2300205
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rabea Hinkel
Site Göttingen
Project type Shared Expertise (SE)
Funding 27750.00€ 27.750,00
Begin 2020-03-0101.03.2020
End 2021-12-3131.12.2021
Projektdetails
Thrombozyten sind primäre Zelle in der Blutstillung und als solche "Wächter" der Gefäßintegrität. Kürzlich haben wir eine hemmende Rolle des Thrombozyten-C5a-Rezeptors C5aR1 in der durch Ischämie induzierten Angiogenese durch Sekretion von CXCL4 beschrieben. Interessanterweise ging eine geringere CXCL4-Konzentration mit einer verbesserten Perizytenzahl im ischämischen Muskelgewebe von Plättchen-spezifischen C5aR1-defizienten Mäusen einher. In einem nächsten Schritt wollen wir nun die Rolle dieser C5aR1-CXCL4-Achse und deren Einfluss auf das Perizyten- und Gefäßwachstum untersuchen. Zu diesem Zweck verwenden wir zwei transgene Mausslinien, die C5ar1floxPf4cre-Maus und die C5ar1-/- Cxcl4-/- Maus im Modell der Hinterlaufischämie. Durch die Einkreuzung eines Cxcr3flox-Stammes in unsere C5ar1-/- Cxcl4-/- Mauslinien, können wir sodann mittels AAV-cre-Vektor diese spezifisch ausschalten. Zusätzlich werden wir einen shRNA-basierten Ansatz zur Reduktion des CSCR3 verwenden. Abschließend wird der Einfluss einer möglichen C5aR1-CXCL4-CXCR3-Achse auf die Revaskularisierung durch eine Mikro-CT-Visualisierung des Gefäßbaums bewertet. Zur erfolgreichen Umsetzung dieses Projektes bringen wir unser Know-how optimal zusammen: Komplementvermitteltes Gefäßwachstum (H. Langer, Lübeck) und virales Vektor-Targeting von Ischämie-induziertem Gefäßwachstum (R. Hinkel, Göttingen). Zusammenfassend hoffen wir den Mechanismus aufzudecken, durch den Thrombozyten C5aR1 das Gefäßwachstum mittels CXLC4 beeinflusst.

Analysis of the biomechanical properties of induced pluripotent stem cells from patients with congenital heart disease induced by titin mutations
ID 81X2400144
Institution Universitätsmedizin Greifswald
Project leader Mihaela Delcea
Site Greifswald
Project type Shared Expertise (SE)
Funding 25193.87€ 25.193,87
Begin 2020-04-0101.04.2020
End 2021-06-3030.06.2021
Projektdetails
The goal of this project is to investigate the biomechanical properties (e.g. cell elasticity, contractility and organization of the cytoskeleton) of patient-specific and CRISPR-engineered induced pluripotent stem cells (iPSCs) with cardiac impairments induced by titin mutations. These properties will be analyzed under physiological and pharmacological conditions in diseased as well as in isogenic control cardiomyocytes using biophysical techniques. The results will serve to better understand the basic functionality of the respective cardiac cells, the disease mechanisms and potentially, to lead to targeted therapies. Stem Cell Unit at DZHK partner site Göttingen possesses numerous iPSC lines with various genetically caused cardiac diseases and a long-lasting experience in generation of iPSC-derived functional cardiomyocytes and in developing tissue engineered heart muscles as a potential treatment option in heart failure. The biophysical tools available in Greifswald (e.g. atomic force microscopy, colloidal probe techniques, confocal microscopy), together with the iPSC expertise of our cooperation partners in Göttingen provide all the premises for the successful implementation of this project.

Investigating the cardio-metabolic functions of the coagulation factor receptors PAR1 and PAR2
ID 81X2400145
Institution Universitätsmedizin Greifswald
Project leader Bernhard Rauch
Site Greifswald
Project type Shared Expertise (SE)
Funding 29782.06€ 29.782,06
Begin 2020-04-0101.04.2020
End 2022-06-3030.06.2022
Projektdetails
In addition to their key role in haemostasis, the coagulation factors thrombin and the activated factor-X (FXa) exert direct effects in various cell types via activation of the protease-activated-receptors PAR1 and PAR2. In previous studies, we have shown that reduced levels of cardiac PAR2 expression in patients with heart failure with preserved ejection fraction (HFpEF) are associated with aggravated diastolic dysfunction and myocardial fibrosis. Consistently, the lack of PAR2 expression in a murine model of genetic PAR2-deficiency resulted in cardiac fibrosis and diastolic dysfunction (Friebel et al., 2019). Interestingly, PAR2-deficiency was associated with increased cardiac expression of PAR1 and treatment with the PAR1 antagonist vorapaxar significantly reduced cardiac fibrosis and inflammation in the metabolic disease model of apolipoprotein E (ApoE)-deficient mice. However, to date unknown is the role and functional interaction of both PAR1 and PAR2 under conditions of metabolic challenge. Therefore, we generated an ApoE-PAR2-double deficient mouse model. Goal of the contracted research is to investigate if a pharmacological PAR1 inhibition can modify metabolic and cardiac functions in this model. The specific aims of the project are to determine: 1) any effect of PAR1 antagonism on lipid metabolism and glucose parameters in ApoE and ApoE-PAR2 mice, 2) if expression profiles of proinflammatory and prothrombotic genes are modified, and 3) if PAR-1 inhibition modulates cardiac and characteristic metabolic parameters as well as thrombus formation in these disease models.

Deciphering the transcriptional profile of the dilated left ventricle from remodeled hearts by single nucleus RNA sequencing
ID 81X2100263
Institution Charité - Universitätsmedizin Berlin
Project leader Malte Spielmann
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE197)
Funding 30000.00€ 30.000,00
Begin 2020-04-0101.04.2020
End 2021-03-3131.03.2021
Projektdetails

Investigating the cardio-metabolic functions of the coagulation factor receptors PAR1 and PAR2
ID 81X2100264
Institution Charité - Universitätsmedizin Berlin
Project leader Ursula Rauch-Kröhnert
Site Berlin
Project type Shared Expertise (SE)
Funding 29281.42€ 29.281,42
Begin 2020-04-0101.04.2020
End 2022-06-3030.06.2022
Projektdetails

Detection of plaque vulnerability with a novel hybrid intravascular NIRF-IVUS imaging system
ID 81X2600526
Institution Deutsches Herzzentrum München
Project leader Michael Joner
Site München
Project type Translational Research Project
Funding 339767.56€ 339.767,56
Begin 2020-05-0101.05.2020
End 2023-08-3131.08.2023
Projektdetails

Detection of plaque vulnerability with a novel hybrid intravascular NIRF-IVUS imaging system
ID 81X2600416
Institution Technische Universität München
Project leader Vasilis Ntziachristos
Site München
Project type Translational Research Project
Funding 416351.01€ 416.351,01
Begin 2020-06-0101.06.2020
End 2023-08-3131.08.2023
Projektdetails

CMR-ICD-DZHK23: Biometrie
ID 81X2800196
Institution Stiftung Institut für Herzinfarktforschung
Project leader Steffen Schneider
Site Extern
Project type Clinical Studies
Funding 120695.20€ 120.695,20
Begin 2020-09-0101.09.2020
End 2028-09-3030.09.2028
Projektdetails

Clonal haematopoiesis: Innovative approaches to precision medicine: impact of clonal hematopoiesis on cardiovascular disease
ID 81X2200153
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Innovation Cluster
Funding 797534.10€ 797.534,10
Begin 2020-10-0101.10.2020
End 2024-12-3131.12.2024
Projektdetails

Clonal haematopoiesis: Innovative approaches to precision medicine: impact of clonal hematopoiesis on cardiovascular disease
ID 81X2100265
Institution Charité - Universitätsmedizin Berlin
Project leader Lukas Zanders
Site Berlin
Project type Innovation Cluster
Funding 72000.00€ 72.000,00
Begin 2020-10-0101.10.2020
End 2024-03-3131.03.2024
Projektdetails

Clonal haematopoiesis: Innovative approaches to precision medicine: impact of clonal hematopoiesis on cardiovascular disease
ID 81X2600527
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Innovation Cluster
Funding 155000.00€ 155.000,00
Begin 2020-10-0101.10.2020
End 2024-12-3131.12.2024
Projektdetails

Clonal haematopoiesis: Innovative approaches to precision medicine: impact of clonal hematopoiesis on cardiovascular disease
ID 81X2500194
Institution Universität Heidelberg
Project leader Florian Leuschner
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 95115.00€ 95.115,00
Begin 2020-11-0101.11.2020
End 2024-12-3131.12.2024
Projektdetails

Allianz für die Identifizierung und Validierung von Targets bei Herzinsuffizienz
ID 81Z0300116
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Partner Site Projects
Funding 2988574.85€ 2.988.574,85
Begin 2020-07-0101.07.2020
End 2025-12-3131.12.2025
Projektdetails

Cardiovascular function in advanced cancer patients
ID 81Z0100212
Institution Charité - Universitätsmedizin Berlin
Project leader Stefan Anker
Site Berlin
Project type Partner Site Projects
Funding 1058735.25€ 1.058.735,25
Begin 2020-07-0101.07.2020
End 2025-12-3131.12.2025
Projektdetails
Wir nehmen an, dass fortgeschrittener Krebs die Entwicklung eines kardiovaskulären Phänotyps aufgrund von a) Schwächung des Herzens und b) abnormaler Homöostase des Herzgewebes verursacht, was zur Entwicklung einer signifikanten arrhythmischen Belastung und Herzfunktionsstörung führt. Eine kardiovaskuläre Phänotypisierung (24-Stunden-EKG, Strain-Echokardiographie, Biomarker-Analyse) von 1000 Krebspatienten wird durchgeführt, um i) ventrikuläre Arrhythmien, ii) Herzfunktionsstörungen, iii) klinische Korrelate, iv) Lebensqualität und v) prognostische Relevanz zu bewerten. Ein Biobanking ermöglicht die Interaktion mit translationalen Forschungsgruppen. Die ausführliche Vorhabenbeschreibung entnehmen Sie bitte in der beigefügten Anlage.

Neuplanung Standortprojekt (2021-2025): Clinical fingerprints of shared risk factors in myocardial infarction, heart failure and atrial fibrillation - an epidemiological research pipeline
ID 81Z0710114
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Renate Schnabel
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 572185.19€ 572.185,19
Begin 2020-08-0101.08.2020
End 2025-12-3131.12.2025
Projektdetails

Neuantrag Standortprojekt (2021-2025): Nutzung genomischer Daten zur Identifizierung neuer Behand-lungsziele für Herz-Kreislauf-Erkrankungen
ID 81Z0700107
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 2181816.42€ 2.181.816,42
Begin 2020-08-0101.08.2020
End 2025-12-3131.12.2025
Projektdetails

Neuantrag Standortprojekt (2020-2025): Modelling pathomechanisms of cardiomyopathy in human induced pluripotent stem cells
ID 81Z0710115
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 2718529.00€ 2.718.529,00
Begin 2020-08-0101.08.2020
End 2025-12-3131.12.2025
Projektdetails
Co-Projektleitung: Prof. Friederike Cuello und Prof. Lucie Carrier

Neuantrag Standortprojekt (2021-2025): Auswertung von Omics-Daten für die Klinische Translation
ID 81Z0700108
Institution Universität zu Lübeck
Project leader Inke König
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 434947.00€ 434.947,00
Begin 2020-08-1111.08.2020
End 2025-12-3131.12.2025
Projektdetails

Entwicklung epigenetischer Biomarker zur Therapie der Herzfibrose
ID 81Z0300113
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Elisabeth Zeisberg
Site Göttingen
Project type Partner Site Projects
Funding 345013.00€ 345.013,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Elektro-mechanische Bildgebung und Arrhythmie-Kontrolle
ID 81Z0300403
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Stefan Luther
Site Göttingen
Project type Partner Site Projects
Funding 729318.90€ 729.318,90
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Elektro-mechanische Bildgebung und Arrhythmie-Kontrolle
ID 81Z0300114
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stefan Luther
Site Göttingen
Project type Partner Site Projects
Funding 1030214.00€ 1.030.214,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Rechnergestützte Methoden in der Magnetresonanztomographie
ID 81Z0300115
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Martin Uecker
Site Göttingen
Project type Partner Site Projects
Funding 1735182.93€ 1.735.182,93
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Odoribacter splanchnicus in the regulation of blood pressure and CVD
ID 81Z0100110
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Dominik Müller
Site Berlin
Project type Partner Site Projects
Funding 345301.92€ 345.301,92
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Neuantrag Standortprojekt (2021-2025): Improving microvascular damage in diabetes melli-tus
ID 81Z0700109
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site München
Project type Partner Site Projects
Funding 710894.00€ 710.894,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails
Co-Projektleitung: Prof. Cor de Wit

Poly-targeting Strategie und Nanopathologie-Therapie
ID 81Z0300302
Institution Georg-August-Universität Göttingen
Project leader Lutz Ackermann
Site Göttingen
Project type Partner Site Projects
Funding 275454.75€ 275.454,75
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Elucidating the mechanism of cadiomyocyte metabolic reprogramming and its role in cardiac regeneration
ID 81Z0100111
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Suphansa Sawamiphak
Site Berlin
Project type Partner Site Projects
Funding 339587.17€ 339.587,17
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Cellular drivers of cardiac fibrosis – origin and function
ID 81Z0100112
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Jan Philipp Junker
Site Berlin
Project type Partner Site Projects
Funding 345303.00€ 345.303,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Neuantrag des Standortprojekts (2021-2025): Novel tools for high-throughput validation of thera-peutic targets for heart failure
ID 81Z0700206
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 973651.00€ 973.651,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

MD22 -Leistungsfähigkeit bei Herzinsuffizienz in der Kardio-Onkologie
ID 81Z0300118
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan von Haehling
Site Göttingen
Project type Partner Site Projects
Funding 2057224.00€ 2.057.224,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Establishing cell type-specific nanoparticle-based anti-miR delivery for vascular-repair in a large animal model of metabolic syndrome
ID 81Z0100213
Institution Charité - Universitätsmedizin Berlin
Project leader Nicolle Kränkel
Site Berlin
Project type Partner Site Projects
Funding 273420.04€ 273.420,04
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Poly-targeting Strategie und Nanopathologie-Therapie
ID 81Z0300117
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stephan Lehnart
Site Göttingen
Project type Partner Site Projects
Funding 1136924.00€ 1.136.924,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Poly-targeting Strategie und Nanopathologie-Therapie
ID 81Z0300502
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Stefan Hell
Site Göttingen
Project type Partner Site Projects
Funding 687296.94€ 687.296,94
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails
In Herzmuskelzellen löst die ankommende elektrische Erregungswelle bei spannungsabhängigen Kalziumkanälen einen Influx von extrazellularen Kalzium in das Zytosol aus. Dieser wird von dem Ryanodin-Rezeptor (RyR2) detektiert und setzt durch positive Rückkopplung weiteres zytosolisches Kalzium aus dem sarkoplasmischen Retikulum (SER) frei. Dies führt zur Kontraktion der Herzmuskelzelle. Eine RyR2-Kanal-Dysfunktion löst eine Zunahme der diastolischen SER Ca2+-Freisetzung (Ca2+-Leak) in Herzmuskelzellen aus, was direkt zur Entstehung von Arrhythmien und kontraktiler Dysfunktion beiträgt. Da bei chronischer Herzinsuffizienz zusätzlich die Protein-Expression der SER Ca2+-ATPase (SERCA2a) vermindert ist, entsteht eine kritische Synergie mit dem RyR2-abhängigen Ca2+-Leak. Ausgehend von diesem multifaktoriellen Krankheitsmechanismus entwickeln wir erstmals eine neue poly-targeting Strategie, die auf von uns entwickelten und hergestellten Pharmakaphoren basiert. Ziel ist es, durch einen Wirkstoff simultan die SERCA2a-Funktion zu steigern und gleichzeitig allosterisch das RyR2-vermittelten SER Ca2+-Leak zu hemmen. Dies stellt einen neuen kausalen Ansatz zur Behandlung von Arrhythmien und Herzinsuffizienzen dar.

The role of endothelial heterogeneity in small vessel muscularization and rarefaction in pulmonary hypertension
ID 81Z0100214
Institution Charité - Universitätsmedizin Berlin
Project leader Wolfgang Kübler
Site Berlin
Project type Partner Site Projects
Funding 487087.00€ 487.087,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Modulation of myeloid immune responses for the prevention of ischemic cardiomyopathy
ID 81Z0500107
Institution Universität Heidelberg
Project leader Florian Leuschner
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 568105.39€ 568.105,39
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Novel mTORC1 based therapeutic concepts
ID 81Z0500106
Institution Universität Heidelberg
Project leader Mirko Völkers
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 757144.19€ 757.144,19
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Proteomische Untersuchung von Herz-Kreislauf-Erkrankungen
ID 81Z0600302
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Matthias Mann
Site München
Project type Partner Site Projects
Funding 557461.00€ 557.461,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Allianz für die Regeneration bei Herzinsuffizienz
ID 81Z0300404
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Eberhard Bodenschatz
Site Göttingen
Project type Partner Site Projects
Funding 260126.96€ 260.126,96
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Behaviorale Prävention kardiovaskulärer Erkrankungen
ID 81Z0400105
Institution Universitätsmedizin Greifswald
Project leader Sabina Ulbricht
Site Greifswald
Project type Partner Site Projects
Funding 739559.53€ 739.559,53
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails
Im ersten Abschnitt werden Assoziationen zwischen unterschiedlichen Intensitäten körperlicher Aktivität sowie des Sitzverhaltens und Risikofaktoren der HFpEF (z. B. arterielle Hypertonie, Diabetes, Adipositas) sowie HFpEF-Parametern der Echokardiographie (z. B. Ratio aus maximaler frühdiastolischer Flussgeschwindigkeit der Mitralklappen und maximaler frühdiastolische Gewebegeschwindigkeit des Mitralklappenanulus (E/E´), Ratio aus maximaler früh- und spätdiastolischer Flussgeschwindigkeit d. Mitralklappe (E/A), Linksventrikuläre Muskelmasse (LVM)) und NT-pro BNP) analysiert. Ziel ist die Generierung von Erkenntnissen, insbesondere zur Bedeutung der verschiedenen Intensitäten körperlicher Aktivität für HFpEF Risikofaktoren Im zweiten Abschnitt des Arbeitspaktes werden Analyseprojekte aus Daten einer abgeschlossenen Pilotstudie generiert und durchgeführt. In dieser Studie wurde die Adhärenz von Patienten (Alter = 60 Jahre) mit Risikofaktoren einer HFpEF an einem strukturierteren Trainings- und Ernährungsprogramm erprobt. Gegenstand der Untersuchung ist der Wachstumsfaktor BDNF (eng. Brain-derived neurotrophic factor). BDNF gilt, in der individuellen Pathogenese, u. a. als Biomarker für neuronale Plastizität. .

Rechnergestützte Methoden in der Magnetresonanztomographie (MD-25)
ID 81Z0300202
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Susann Boretius
Site Göttingen
Project type Partner Site Projects
Funding 200408.91€ 200.408,91
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails
Die Arbeiten in dem Projekt sollen die Entwicklung von neuen Ansätzen, um effiziente MRT-Methoden für die Herzbildgebung in die klinische und prä-klinische Anwendung voranbringen. Die Arbeitspakete konzentrieren sich dabei auf die Frage nach der automatischen Bestimmung von Herz- und Atemphasen aus MRT-Daten, und die Nutzung dieser Information in Bildrekonstruktion und Nachverarbeitung. Dabei ist das Arbeitsprogramm als ein struktureller Rahmen zu sehen, der gleichzeitig die Entwicklung neuer Konzepte und Ideen zulassen soll. Das am DPZ angesiedelte Teilprojekt unterstützt den Ausbau der MR-Herzbildgebung an nicht-humanen Primaten sowie vergleichende Studien an Na-gern. Die hier entwickelten Methoden und Protokolle sollen insbesondere für laufende und zukünftige tanslationale Projekte in Kooperation mit unseren DZHK-Partnern ge-nutzt werden. Hier geht es darum sowohl stammzellbasierte als auch andere innovative Therapien zunächst am Modell der Maus zu erproben, dann die Übertragbarkeit auf den Menschen am Modell der nichthumanen Primaten zu prüfen und zu ersten Hu-manstudien zu kommen. Auf der Bildgebungsseite müssen bei diesen translationalen Modellen die räumliche und zeitliche Auflösung weiter verbessert werden, aber auch die Möglichkeiten der Bildgebung im Bereich der Perfusionsmessung, diffusionsbasierter Techniken und in-vivo-Spektroskopie weiter ausgebaut werden.

Allianz für die Identifizierung und Validierung von Targets bei Herzinsuffizienz
ID 81Z0300303
Institution Georg-August-Universität Göttingen
Project leader Lutz Ackermann
Site Göttingen
Project type Partner Site Projects
Funding 439201.12€ 439.201,12
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

PERSONIFY (deeP charactERiSatiON of InFlammatory cardi-omYopathy)-program
ID 81Z0100215
Institution Charité - Universitätsmedizin Berlin
Project leader Carsten Tschöpe
Site Berlin
Project type Partner Site Projects
Funding 487086.00€ 487.086,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Imaging
ID 81Z0200109
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eike Nagel
Site RheinMain
Project type Partner Site Projects
Funding 3035661.00€ 3.035.661,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Charakterisierung der zellulären Heterogenität und Immunzell-Clearance im kardiovaskulären System durch Massenspektrometrie- und NGS-gestützte biomolekulare Analytik
ID 81Z0200302
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Thomas Braun
Site RheinMain
Project type Partner Site Projects
Funding 2301072.53€ 2.301.072,53
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

MD26-UMG Allianz für die Regeneration bei Herzinsuffizienz
ID 81Z0300119
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Partner Site Projects
Funding 995735.00€ 995.735,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Allianz zur Regeneration des Herzens - TP-DPZ
ID 81Z0300203
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rüdiger Behr
Site Göttingen
Project type Partner Site Projects
Funding 1551773.44€ 1.551.773,44
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails
In der Förderphase 2021-2025 sollen numerische Modelle des menschlichen Herzens sowie von Herzen relevanter Großtiermodelle (Marmoset und Rhesusaffe) entwickelt werden. Diese Modelle bilden die Grundlage, um den therapeutischen Effekt Zell- oder Gen-basierter Verfahren vorhersagen zu können. Als nächste Generation der therapeutischen Herzpflaster werden durch genetische Manipulation von induzierten pluripotenten Stammzellen sogenannte hypo-immunogene EHM (hiEHM) weiterentwickelt und charakterisiert. Als Alternative werden mamuhaploidentische parthenogenetische Stammzellen aus unbefruchteten Eizellen von Rhesusmakaken entwickelt und in vivo getestet. Im Marmoset (Weißbüschelaffe) Modell wird der kardiale Gentransfer mittels AAV erprobt. Durch AAV-basiertes in-vivo gemone editing wird im Weißbüschelaffen Herzinsuffizienz induziert und diese Erkrankung im humannahen Modell charakterisiert.

Neuantrag Standortprojekt (2021-2025): Transcatheter tissue-engineered tricuspid valved stent implantation
ID 81Z0700207
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Georg Lutter
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 472752.00€ 472.752,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Novel molecular mechanisms and treatment of pediatric heart failure
ID 81Z0100216
Institution Charité - Universitätsmedizin Berlin
Project leader Sabine Klaassen
Site Berlin
Project type Partner Site Projects
Funding 576365.42€ 576.365,42
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

W2 Professur Klinische Epidemiologie der Herzinsuffizienz
ID 81Z0210103
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site RheinMain
Project type Partner Site Projects
Funding 1242646.93€ 1.242.646,93
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails
Zur strukturellen Stärkung der vorhandenen Exzellenz am DZHK-Standort soll eine neue W2-Professur (DZHK-Professur "Klinische Epidemiologie der Herzinsuffizienz") für systemorientierte kardiovaskuläre Forschung geschaffen werden. Den Fokus des Forschungsvorhabens soll hierbei ein systemorientierter Ansatz unter Nutzung der etablierten Ressourcen darstellen. Ein besonderer Schwerpunkt soll auf die interdisziplinäre Nutzung von "Big Data" für die Herz-Kreislauf-Forschung gelegt werden. Die interdisziplinäre und systemmedizinisch orientierte Ausrichtung soll fachspezifische und methodische Interaktionen und Synergien mit anderen Forschungsschwerpunkten schaffen. Dies gilt ebenso für die Zusammenarbeit mit anderen Fachbereichen (z.B. Bioinformatik, Informatik).

Analysis of the biomechanical properties of induced pluripotent stem cells from patients with congenital heart disease induced by titin mutations
ID 81X4300100
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
Funding 26560.00€ 26.560,00
Begin 2020-04-0101.04.2020
End 2021-06-3030.06.2021
Projektdetails

Deciphering the transcriptional profile of the dilated left ventricle from remodeled hearts by single nucleus RNA sequencing
ID 81X4300101
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Belal Mohamed
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE197)
Funding 26760.00€ 26.760,00
Begin 2020-04-0101.04.2020
End 2021-03-3131.03.2021
Projektdetails

FAIR-HF2-DZHK5: Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity and mortality
ID 81X1100214
Institution Charité - Universitätsmedizin Berlin
Project leader Stefan Anker
Site Berlin
Project type Clinical Studies
Funding 661538.00€ 661.538,00
Begin 2018-01-0101.01.2018
End 2024-09-3030.09.2024
Projektdetails

Long-term course and genetic impact in subjects with non-obstructive coronary artery disease (NobCAD): Results of the Leipzig LIFE Heart Study
ID 81X2100208
Institution Charité - Universitätsmedizin Berlin
Project leader Vera Regitz-Zagrosek
Site Berlin
Project type Cooperation with External Partners
Funding 45449.00€ 45.449,00
Begin 2014-07-2424.07.2014
End 2015-06-3030.06.2015
Projektdetails

Long-term course and genetic impact in subjects with non-obstructive coronary artery disease (NobCAD): Results of the Leipzig LIFE Heart Study
ID 81X2800101
Institution Universität Leipzig
Project leader Joachim Thiery
Site Extern
Project type Cooperation with External Partners
Funding 53099.09€ 53.099,09
Begin 2014-08-3131.08.2014
End 2015-06-3030.06.2015
Projektdetails

CRISPR/Cas9-mediated deletion of SerpinH1 in embryonic stem cells
ID 81X2800116
Institution Max-Planck-Institut für molekulare Biomedizin
Project leader Boris Greber
Site Extern
Project type Cooperation with External Partners
Funding 10562.10€ 10.562,10
Begin 2015-04-0101.04.2015
End 2015-12-3131.12.2015
Projektdetails

CRISPR/Cas9-mediated deletion of SerpinH1 in embryonic stem cells
ID 81X2300127
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Cooperation with External Partners
Funding 9570.81€ 9.570,81
Begin 2015-03-0101.03.2015
End 2015-12-3131.12.2015
Projektdetails

Klinische Anwendungen der humanen Thromboyztenproteomik und -phosphoproteomik.
ID 81X2800102
Institution Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V.
Project leader René Zahedi
Site Extern
Project type Cooperation with External Partners
Funding 28500.00€ 28.500,00
Begin 2014-08-2020.08.2014
End 2015-12-3131.12.2015
Projektdetails

Klinische Studien des Kompetenznetzes Vorhofflimmern e.V.: EAST - AFNET 4 und NOAH - AFNET 6
ID 81X2800182
Institution Kompetenznetz Vorhofflimmern e. V.
Project leader Paulus Kirchhof
Site Extern
Project type Competence Networks
Funding 471544.29€ 471.544,29
Begin 2019-01-0101.01.2019
End 2022-12-3131.12.2022
Projektdetails

Mechanisms for sex-specific differences in migration patterns of human endothelial cells.
ID 81X2100211
Institution Charité - Universitätsmedizin Berlin
Project leader Mario Lorenz
Site Berlin
Project type Cooperation with External Partners
Funding 10000.00€ 10.000,00
Begin 2014-08-2727.08.2014
End 2015-06-3030.06.2015
Projektdetails

Mechanisms for sex-specific differences in migration patterns of human endothelial cells.
ID 81X2800103
Institution Freie Universität Berlin
Project leader Petra Knaus
Site Extern
Project type Cooperation with External Partners
Funding 9951.79€ 9.951,79
Begin 2014-08-2626.08.2014
End 2015-06-3030.06.2015
Projektdetails

Nationales Register für angeborene Herzfehler mit Biomaterialbank
ID 81X2800189
Institution Nationales Register für angeborene Herzfehler e.V.
Project leader Ulrike Bauer
Site Extern
Project type Competence Networks
Funding 1844881.01€ 1.844.881,01
Begin 2019-01-0101.01.2019
End 2021-12-3131.12.2021
Projektdetails

Role of mitochondrial cAMP signaling in protective effects of estradiol in cardiomyocytes under oxidative stress
ID 81X2100210
Institution Charité - Universitätsmedizin Berlin
Project leader Yury Ladilov
Site Berlin
Project type Cooperation with External Partners
Funding 25305.62€ 25.305,62
Begin 2014-08-2626.08.2014
End 2015-12-3131.12.2015
Projektdetails

Role of mitochondrial cAMP signaling in protective effects of estradiol in cardiomyocytes under oxidative stress
ID 81X2800104
Institution Justus-Liebig-Universität Gießen
Project leader Yaser Abdallah
Site Extern
Project type Cooperation with External Partners
Funding 37000.00€ 37.000,00
Begin 2014-08-1414.08.2014
End 2015-12-3131.12.2015
Projektdetails

Systematic screening for evolutionary-conserved, disease-relevant long noncoding RNAs
ID 81X2200118
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Andreas Zeiher
Site RheinMain
Project type Cooperation with External Partners
Funding 15000.02€ 15.000,02
Begin 2014-11-1111.11.2014
End 2015-12-3131.12.2015
Projektdetails

Systematic screening for evolutionary-conserved, disease-relevant long noncoding RNAs - Teilprojekt Universität Potsdam
ID 81X2800107
Institution Universität Potsdam
Project leader Salim Seyfried
Site Extern
Project type Cooperation with External Partners
Funding 26670.00€ 26.670,00
Begin 2014-11-1212.11.2014
End 2015-12-3131.12.2015
Projektdetails

Clinical applications of human platelet proteomics and phosphoproteomics
ID 81X2210104
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Ulrich Walter
Site RheinMain
Project type Cooperation with External Partners
Funding 28830.00€ 28.830,00
Begin 2014-09-1919.09.2014
End 2015-12-3131.12.2015
Projektdetails

rAAV.MRTF-A-based vascular gene therapy in chronic hindlimb ischemia (GeneVaPad)
ID 81X2600628
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Translational Research Project
Funding 1243600.00€ 1.243.600,00
Begin 2021-01-1515.01.2021
End 2026-06-3030.06.2026
Projektdetails

Nucleic acid therapies: Towards cardiac-specific recombinant adeno-associated viruses (rAAVs) of human origin: Directed evolution and characterization of novel AAV variants isolated from human failing hearts in models with human relevance and relevance fo
ID 81X2710183
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 206542.00€ 206.542,00
Begin 2021-01-0101.01.2021
End 2024-12-3131.12.2024
Projektdetails

CRISPR-based repair of RBM20 disease variants to treat and prevent dilated cardiomyopathy
ID 81Z0500401
Institution Europäisches Laboratorium für Molekularbiologie (EMBL)
Project leader Lars Steinmetz
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 206203.53€ 206.203,53
Begin 2021-01-0101.01.2021
End 2022-12-3131.12.2022
Projektdetails

Postdoc start-up grant: Endothelial cell-derived extracelluar vesicles for therapeutic application in cardiovascular disease
ID 81X3200204
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Christoph Lipps
Site RheinMain
Project type Excellence Programme
Funding 76800.00€ 76.800,00
Begin 2021-01-0101.01.2021
End 2021-12-3131.12.2021
Projektdetails

Genomische Analyseplattform
ID 81Z0600105
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Matthias Heinig
Site München
Project type Partner Site Projects
Funding 609283.04€ 609.283,04
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Nucleic acid therapies: Towards cardiac-specific recombinant adeno-associated viruses (rAAVs) of human origin: Directed evolution and characterization of novel AAV variants isolated from human failing hearts in models with human relevance and relevance fo
ID 81X2300206
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rabea Hinkel
Site Göttingen
Project type Innovation Cluster
Funding 182510.00€ 182.510,00
Begin 2021-01-0101.01.2021
End 2024-12-3131.12.2024
Projektdetails
Das DPZ ist an WP4 ud WP 5 beteiligt: WP4: Beurteilung der Anreicherung von aus dem menschlichen Herzen stammenden rAAV-Kapsidvarianten im Herzen und davon abgeleiteten Kapsidbibliotheken in nicht-menschlichen Primaten nach Post-Myokardinfarkt (Post-MI-NHPs). WP5: Beurteilung der Herztransduktion und Bioverteilung von herzspezifischen rAAV-Kapsidvarianten in NHPs und Tiermodellen mit Relevanz für die präklinische GTMP-Entwicklung.

Postdoc start-up grant: Investigating SERCA2a regulators functional and molecular overlap - do DWORF and S100A1 synergistically regulate cardiac performance?
ID 81X3500127
Institution Universität Heidelberg
Project leader Zegeye Jebessa
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-01-0101.01.2021
End 2022-06-3030.06.2022
Projektdetails

Machine learning on cardiovascular data
ID 81Z0600106
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Matthias Heinig
Site München
Project type Partner Site Projects
Funding 492107.83€ 492.107,83
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Mechanismen und translationale Aspekte der Kollateralenbildung im ischämischen Gewebe
ID 81Z0700110
Institution Universität zu Lübeck
Project leader Harald Langer
Site München
Project type Partner Site Projects
Funding 422397.00€ 422.397,00
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Novel molecular mechanisms and Treatment of pediatric heart failure
ID 81Z0100304
Institution Deutsches Herzzentrum Berlin
Project leader Felix Berger
Site Berlin
Project type Partner Site Projects
Funding 436502.33€ 436.502,33
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Promotion of women scientists: The role of Janus kinase 1 in cardiac proteotoxicity
ID 81X3710111
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Sonia Singh
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 76473.99€ 76.473,99
Begin 2021-01-0101.01.2021
End 2022-11-3030.11.2022
Projektdetails

Sex-differential host-microbiome CVD risk – a longitudinal cohort approach// Geschlechstspezifische kardiovaskuläre Risiken in der Darmmikrobiom-Wirt-Achse - eine Longitudinalstudie
ID 81Z0100113
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sofia Forslund
Site Berlin
Project type Partner Site Projects
Funding 340835.03€ 340.835,03
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails
Dieses Projekt befasst sich mit Wechselwirkungen zwischen Wirt und Mikrobiom und Geschlechtsunterschieden bei CVD. Durch die Erstellung eines hochauflösenden longitudinalen Multi-Omics-Datensatzes, mit dem wesentliche Veränderungen der vaskulären und metabolischen Homöostasebeobachtet werden können, wird eine wichtige Grundlage zur Methodenentwicklung und -verbesserung in der Hochdurchsatz-Systemmedizin bei CVD geschaffen.

Nucleic acid therapies: Towards cardiac-specific recombinant adeno-associated viruses (rAAVs) of human origin: Directed evolution and characterization of novel AAV variants isolated from human failing hearts in models with human relevance and relevance fo
ID 81X2500195
Institution Universität Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 607835.00€ 607.835,00
Begin 2021-01-0101.01.2021
End 2024-12-3131.12.2024
Projektdetails

Virtual Heart Team - a Machine Intelligence augmented environment for evidence-based and data-driven therapeutic decision making
ID 81Z0100305
Institution Deutsches Herzzentrum Berlin
Project leader Alexander Meyer
Site Berlin
Project type Partner Site Projects
Funding 855822.77€ 855.822,77
Begin 2021-01-0101.01.2021
End 2025-12-3131.12.2025
Projektdetails

Postdoc start-up grant: Molecular mechanisms of immune checkpoint-inhibitor induced myocarditis
ID 81X3500128
Institution Universität Heidelberg
Project leader Markus Benjamin Heckmann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-02-0101.02.2021
End 2022-07-3131.07.2022
Projektdetails

Promotion of women scientists: Structural and genetic biomarkers in dilated cardiomyopathy: From molecular variants to clinical phenotypes
ID 81X3710112
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Christina Magnussen
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 71799.82€ 71.799,82
Begin 2021-02-0101.02.2021
End 2023-09-3030.09.2023
Projektdetails

New biomarkers for atrial fibrillation: Mechanisms of atrial fibrillation
ID 81Z0710116
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Paulus Kirchhof
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 414297.00€ 414.297,00
Begin 2021-03-0101.03.2021
End 2025-12-3131.12.2025
Projektdetails
Co-Projektleitung: Prof. Dr. Larissa Fabritz

Re-screening for novel CD40-TRAF6 interaction inhibitors (TRAF-STOPs 2.0)
ID 81X2600260
Institution Klinikum der Universität München
Project leader Dorothee Atzler
Site München
Project type Translational Research Project
Funding 405710.00€ 405.710,00
Begin 2021-03-0101.03.2021
End 2022-06-3030.06.2022
Projektdetails

A novel approach to target RNA levels and splice junctions in hiPS-CMs with CRISPR-Cas13d
ID 81X4300107
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 38000.00€ 38.000,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

AAV-mediated gene transfer into the vascular system in a large animal model
ID 81X2700234
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE048)
Funding 21482.29€ 21.482,29
Begin 2021-04-0101.04.2021
End 2023-06-3030.06.2023
Projektdetails

AAV-mediated gene transfer into the vascular system in a large animal model
ID 81X2600629
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE048)
Funding 21500.00€ 21.500,00
Begin 2021-04-0101.04.2021
End 2023-06-3030.06.2023
Projektdetails

Characterisation of the cardiac function of synaptopodin 2-like protein (CHAP)
ID 81X2700231
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Derk Frank
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE022)
Funding 49700.00€ 49.700,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

Characterisation of the cardiac function of synaptopodin 2-like protein (CHAP)
ID 81X2400147
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE022)
Funding 47849.34€ 47.849,34
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails
Cardiovascular disease development and heart failure are associated with various molecular alterations in the heart. One of the numerous altered but yet not fully characterized proteins is synaptopodin 2-like protein (Cytoskeletal Heart-enriched Actin-associated Protein CHAP). The protein belongs to the Z-disc proteins. It has been shown to be involved in the cardiac and skeletal muscle development and being associated with atrial fibrillation. Mice models of experimental heart failure showed higher CHAP expression. CHAP overexpressing transgenic mice displayed cardiac hypertrophy and fibrosis and it was concluded that the fetal form of the protein initiated progression to diastolic dysfunction. In line with these findings we observed increased protein level in cardiac tissue of patients with dilated cardiomyopathy (DCM) in comparison to controls. However, we estimated high abundance of CHAP protein already in heart biopsies of subjects with normal heart function. This suggests that the protein increase upon cardiac stress can also be involved in rather protective adaptations and that the protein as a potential therapeutic target should be investigated in more detail. We thus propose here to characterize the protein level and phosphorylation pattern upon physiological and pathophysiological conditions in patient samples and murine heart failure models. In collaboration with Prof. Frank (Kiel) we would like to investigate the impact of modulated CHAP protein levels on the cardiomyocyte’s response to biomechanical stress and identify the molecular alterations in NRVCM (neonatal rat ventricular cardiomyocytes) upon cyclic stretch. Characterization of CHAP in more detail will decipher the underlying mechanisms how the protein effect cardiac pathophysiology, possibly leading to various therapeutic approaches to prevent, halt or reverse pathologic disease progression.

Deciphering the dynamic molecular fingerprinting in inflammatory cardiomyopathy
ID 81X2710186
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE133)
Funding 17547.00€ 17.547,00
Begin 2021-04-0101.04.2021
End 2023-03-3030.03.2023
Projektdetails

Deciphering the dynamic molecular fingerprinting in inflammatory cardiomyopathy
ID 81X2200155
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Valentina Puntmann
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE133)
Funding 35452.80€ 35.452,80
Begin 2021-04-0101.04.2021
End 2023-03-3030.03.2023
Projektdetails

Decoding endothelial transcriptomic and regulatory responses to homeostatic and dysfunctional fluid flow profiles
ID 81X2100162
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Holger Gerhardt
Site Berlin
Project type Cooperation with External Partners
Funding 25500.00€ 25.500,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Gene therapy targeting cytokine secretion in autoimmune myocarditis: the regnase-1 approach
ID 81X2700235
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Anca Remes
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE068)
Funding 27500.00€ 27.500,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Identification of the role of the Rac1 activator Tiam1 in human cardiac fibroblasts with the help of engineered connective tissues
ID 81X4300103
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Susanne Lutz
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 45230.00€ 45.230,00
Begin 2021-04-0101.04.2021
End 2023-06-3030.06.2023
Projektdetails

Identification of the role of the Rac1 activator Tiam1 in human cardiac fibroblasts with the help of engineered connective tissues
ID 81X2500213
Institution Universität Heidelberg
Project leader Christiane Vettel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 30797.07€ 30.797,07
Begin 2021-04-0101.04.2021
End 2023-06-3030.06.2023
Projektdetails
Cardiac Rac1 signaling has been recognized as a potential therapeutic target in heart diseases due to its role in cardiomyocyte hypertrophy and fibrosis. The omnipresence of Rac1 signaling throughout the body, however, does not allow for direct Rac1 targeting. We therefore believe that regulators of Rac1 are the better choice for future therapeutic strategies. In this context, we have identified by in vitro and in vivo experiments the Rac1 activator Tiam1 as an interesting option1,2, including preliminary data presented at the DGK spring meeting 20193. To further validate Tiam1 as a regulator of cardiac fibrosis, we want to investigate its role in engineered connective tissues (ECT) composed of human cardiac fibroblasts and collagen 1. We aim to investigate the impact of Tiam1 on the biomechanical properties of ECT under high and low mechanical stress as well as in the additional presence of a general activation of adrenoceptors (aim 1). We further want to understand how Tiam1 is involved in pro-fibrotic signaling and the regulation of remodeling (aim 2 and 3). Moreover, Tiam1 as a Rac1 activator is predestinated to play a role in the production of reactive oxygen species, which could contribute to paracrine signaling in the myocardium. There is however so far, no data available on the influence of Tiam1 on the production of ROS in human cardiac fibroblasts.

Investigation of KCNH2-mutation-induced cardiac arrhythmias in a human 3D innervated heart muscle model
ID 81X2100165
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sebastian Diecke
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE168)
Funding 40000.00€ 40.000,00
Begin 2021-04-0101.04.2021
End 2022-11-0101.11.2022
Projektdetails

Peroxisomal calcium handling in cardiomyocytes
ID 81X4300105
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Sven Thoms
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 38980.00€ 38.980,00
Begin 2021-04-0101.04.2021
End 2022-09-3030.09.2022
Projektdetails

Peroxisomal calcium handling in cardiomyocytes
ID 81X2700233
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38969.62€ 38.969,62
Begin 2021-04-0101.04.2021
End 2022-09-3030.09.2022
Projektdetails

Platelet signatures in hypertension: from mouse to man
ID 81X2100166
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Hübner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 55000.00€ 55.000,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

Production and analysis of GWAS-based cardiovascular risk-modifying gene KO-iPSC lines
ID 81X2100266
Institution Charité - Universitätsmedizin Berlin
Project leader Elisabeth Tamara Strässler
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE200)
Funding 14500.00€ 14.500,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Proof of concept: Treating acute myocardial infarction with faecal transplantation in a transgenic animal model
ID 81X4300104
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Thomas Meyer
Site Göttingen
Project type Cooperation with External Partners
Funding 37625.00€ 37.625,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

Rewiring of endogenous signaling pathways to restore homeostasis in the injured mammalian heart
ID 81X4300106
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laua Zelarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 37656.00€ 37.656,00
Begin 2021-04-0101.04.2021
End 2023-04-3030.04.2023
Projektdetails

Role of PNUTS in myocarditis
ID 81X2500196
Institution Universität Heidelberg
Project leader Ziya Kaya
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 38200.00€ 38.200,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Role of PNUTS in myocarditis
ID 81X2700232
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38200.00€ 38.200,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Single nuclear transcription profile analysis of isogenic human induced pluripotent stem cell-derived disease models
ID 81X2100164
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Hübner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 57000.00€ 57.000,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

The effects of ACE2 expression on vascular function in obesity and atherosclerosis
ID 81X2200154
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ralf Brandes
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE097)
Funding 30000.00€ 30.000,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

The role of neutrophils in ST-elevation myocardial infarction and subsequent healing
ID 81X2600261
Institution Klinikum der Universität München
Project leader Kami Pekayvaz
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 23982.82€ 23.982,82
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

The role of neutrophils in ST-elevation myocardial infarction and subsequent healing
ID 81X2100163
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Hübner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 24000.00€ 24.000,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

The role of T cell H3K27 trimethylation on T cell polarization and its effects on atherosclerosis
ID 81X2600262
Institution Klinikum der Universität München
Project leader Dorothee Atzler
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE057)
Funding 20000.00€ 20.000,00
Begin 2021-04-0101.04.2021
End 2022-09-3030.09.2022
Projektdetails

Transcriptional control of cardiomyocyte stress response
ID 81X2400146
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 100000.00€ 100.000,00
Begin 2021-04-0101.04.2021
End 2023-12-3131.12.2023
Projektdetails
Pathological cardiac remodeling is a major risk factor for heart failure. It occurs in response to pathological stimuli such as chronic pressure overload (i.e. arterial hypertension). Cardiac remodeling is characterized by cardiomyocyte hypertrophy and interstitial fibrosis. Previously, we identified transcription factor EB (TFEB) and TFE3 as potent regulators of protein and energy homeostasis in cardiomyocytes and the heart contributing to cardiac stress response. Both transcription factors bind to highly conserved 10bp palindromic E-box elements in the promoter of their target genes, regulate similar gene sets and display partially redundant functions. Although the function of TFEB and TFE3 in non-muscle cells is well described, their individual and coordinate functions in cardiomyocytes are not well described. Here, we aim to investigate the function of TFEB and TFE3 in vitro in ardiomyocytes and in vivo in the heart. We will use adeno-associated viral vector of serotype 9 (AAV9)-mediated delivery of an RNA hairpin TFEB/TFE3-decoy oligonucleotide to attenuate their effects in mouse hearts. Cardiac hypertrophy will be induced by chronic pressure overload due to transverse aortic constriction (TAC) surgery. We will focus on cardiac stress response by performing phenotypical, functional, and molecular analyses. This will be complemented by in-vitro "proof-of-concept" approaches in cardiomyocytes. For that, we will generate AAV6 to overexpress and diminish TFEB and/or TFE3 in stressed and unstressed neonatal rat cardiomyocytes.

Transcriptional control of cardiomyocyte stress response
ID 81X2700230
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 99992.21€ 99.992,21
Begin 2021-04-0101.04.2021
End 2023-12-3131.12.2023
Projektdetails

A novel approach to target RNA levels and splice junctions in hiPS-CMs with CRISPR-Cas13d
ID 81X2500198
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 38000.00€ 38.000,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

Cardiomyocyte metabolic remodeling through the TBL1/TBLR1 co-factor complex
ID 81X4500101
Institution Universität Heidelberg
Project leader Mathias Konstandin
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE201)
Funding 38190.67€ 38.190,67
Begin 2021-04-0101.04.2021
End 2022-03-3131.03.2022
Projektdetails

Decoding endothelial transcriptomic and regulatory responses to homeostatic and dysfunctional fluid flow profiles
ID 81X2800200
Institution Westfälische Wilhelms-Universität Münster
Project leader Maria Odenthal-Schnittler
Site Extern
Project type Cooperation with External Partners
Funding 54744.00€ 54.744,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails
Entwicklung, Differenzierung und Kontrolle des vaskulären Systems, einschließlich der Endothelzellen (EC), werden durch die Flüssigkeitsscherspannung des Blutflusses entscheidend beeinflusst. Die Scherbeanspruchung kann unidirektional (stationär oder instationär) sein, was einen EC-protektiven Effekt hat, während eine gestörte und oszillierende Scherbeanspruchung zu einem entzündlichen endothelialen Phänotyp beiträgt. Obwohl ECs mechano-sensitiv sind, hängt ihre besondere Reaktion von der Natur und der Größe der angewandten Scherspannung ab. Die grundsätzliche Bedeutung der Scherbeanspruchung auf die Biologie der ECs ist bekannt, während nur wenige Informationen über die Regulation der Genexpression bei verschiedenen Formen der Scherbeanspruchung vorliegen. Wir beabsichtigen eine Plattform für eine zugängliche und erweiterbare Multiomik-Datenbank der endothelialen Flussreaktionen zu etablieren. Dazu werden HUVECs verschiedenen Scher-beanspruchungen und -Profilen (unidirektional, pulsierend und oszillierend) in einem gut etablierten Multi-Unit-Flow-System (das BTF-System) im Schnittler Labor ausgesetzt und Videoaufzeichnungen zur automatisierten Auswertung morphodynamischer Zellparameter erstellt. Aus den selben Proben werden RNA-Seq (Gerhardt Lab) und Multiplex-Chip-Seq durchgeführt und in Zusammenarbeit mit Dieter Beule (BIH Core Unit for Bioinformatics) prozessiert. Die einzigartige Reproduzierbarkeit des BTF-Systems und die umfassende Expertise der Partnerlabore werden eine zusätzliche Multiomik-Datenerfassung, einschließlich Proteomik und Metabolomik ermöglichen, um ein integriertes Bild der kreuzkorrelierten Endothelreaktionen zu erhalten. Die Daten werden auf dem SODAR Omics Datenmanagementsystem frei verfügbar gemacht. Wir sind überzeugt, dass diese Datenbank für weitere Untersuchungen zur Scherstress-induzierten EC-Biologie und zum Verständnis der klinischen Phänotypen der endothelialen Dysfunktion wichtig sein wird.

Postdoc start-up grant: Endothelial function and T cell-endothelium crosstalk in coronary macro- and microvascular disease
ID 81X3100212
Institution Charité - Universitätsmedizin Berlin
Project leader Teresa Gerhardt
Site Berlin
Project type Excellence Programme
Funding 80010.10€ 80.010,10
Begin 2021-04-0101.04.2021
End 2022-09-3030.09.2022
Projektdetails

Epigenetic maturation of induced pluripotent stem cell derived cardiomyocytes
ID 81X4300110
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Katrin Streckfuß-Bömeke
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 39200.00€ 39.200,00
Begin 2021-04-0101.04.2021
End 2022-09-3030.09.2022
Projektdetails

Epigenetic maturation of induced pluripotent stem cell derived cardiomyocytes
ID 81X2200157
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ralf Brandes
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 38800.00€ 38.800,00
Begin 2021-04-0101.04.2021
End 2022-09-3030.09.2022
Projektdetails

Etiology of heart field-specific population changes in Cadlr lncRNA mutant embryonic hearts
ID 81X2600417
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE199)
Funding 22500.00€ 22.500,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Etiology of heart field-specific population changes in Cadlr lncRNA mutant embryonic hearts
ID 81X2200156
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE199)
Funding 9000.00€ 9.000,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Gene therapy targeting cytokine secretion in autoimmune myocarditis: the regnase-1 approach
ID 81X2500199
Institution Universität Heidelberg
Project leader Ziya Kaya
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE068)
Funding 27500.00€ 27.500,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Identification of and targeting the interactome of the pro-fibrotic factor periostin in human cardiac fibroblasts
ID 81X2100168
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Shokoufeh Mahmoodzadeh
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 35500.00€ 35.500,00
Begin 2021-04-0101.04.2021
End 2023-09-3030.09.2023
Projektdetails

Identification of and targeting the interactome of the pro-fibrotic factor periostin in human cardiac fibroblasts
ID 81X4300109
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Susanne Lutz
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 39500.00€ 39.500,00
Begin 2021-04-0101.04.2021
End 2023-09-3030.09.2023
Projektdetails

Identifying a new gene therapy target for cardiac regeneration
ID 81X2300208
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rabea Hinkel
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE192)
Funding 29739.03€ 29.739,03
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails
Das Herz eines erwachsenen Säugetiers ist nicht in der Lage sich zu regenerieren, was für schwere Herzerkrankungen von großer Relevanz ist. Die Proliferation bereits vorhandener Kardiomyozyten (CM), die einer De-Differenzierung unterzogen werden, ist ein Schlüsselprozess für die kardiale Regeneration bei Zebrafischen und neugeborenen Mäusen. Diese Erkenntnisse motivieren Wissenschaftler, eine therapeutische Methode zur Förderung der CM-Proliferation durch Genübertragung zu entwickeln. Es gibt jedoch bis heute keinen gentherapeutischen Ansatz, der für die kardiale Regeneration bei Patienten funktionieren würde. Das zentrale Ziel dieses Vorhabens ist es, ein neues therapeutisches Ziel zu finden, das die CM-Proliferation nach einer Verletzung stimuliert, und den Mechanismus aufzuzeigen, der die CM-De-Differenzierung und -Proliferation reguliert. In früheren Studien konnten wir zeigen, dass TCF3, ein bHLH-Transkriptionsfaktor, eine CM-De-Differenzierung induziert und dass PDK3 (eine Pyruvatdehydrogenase-Kinase, die die Glykolyse fördert) die CM-Proliferation in gezüchteten CMs und in Zebrafischen stimuliert. In diesem Projekt werden wir prüfen, ob diese Faktoren die CM-Proliferation in einem Verletzungsmodell für erwachsene Säugetiere stimulieren, und die zugrundeliegenden Mechanismen untersuchen. Durch die Zusammenarbeit mit Prof. Dr. Hinkels Gruppe, welche über die Fachkompetenz und Technologie für Gentransportmethoden unter Verwendung von AAV-Vektoren verfügt, wollen wir mittels dieser Technologie die Rolle von TCF3 und PDK3 in einem Säugetier-Herzverletzungsmodell untersuchen. Wir hoffen, dass dieses Kooperationsprojekt unter Verwendung sowohl regenerativer als auch nicht-regenerativer Modelle einen signifikanten Einfluss auf die kardiale Regenerationstherapie hat und neue Erkenntnisse über die Mechanismen, die die CM-Dedifferenzierung und Proliferation regulieren, liefert.

Identifying new RNA targets in a nonhuman primate model for age-associated cardiovascular diseases
ID 81X2300207
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Matthias Mietsch
Site Göttingen
Project type Cooperation with External Partners
Funding 17149.41€ 17.149,41
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails
Hauptziel der Studie ist die Durchführung von Transkriptom- und Einzelzell-Genomanalysen von kardiovaskulären Geweben und deren Korrelation mit funktionellen Herzmessungen sowie histologischen Befunden zur Identifizierung potentieller nicht-kodierender RNA-Zielstrukturen mit Relevanz für Krankheitsentwicklungen während des Alterungsprozesses in einem humanrelevanten nicht-menschlichem Primatenmodell. Durch diesen Ansatz können zusätzlich potentielle neue Alters-Biomarker mit translationaler Bedeutung identifiziert werden. Die Kombination dieser molekularen Untersuchungen zusammen mit Magnetresonanztomografie des Herzens, hämodynamischen Druckmessungen und histologischen Gewebeanalysen erlaubt die umfangreiche Charakterisierung dieses für die Alterswissenschaft wichtigen Tiermodells.

Identifying a new gene therapy target for cardiac regeneration
ID 81X2200315
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Didier Stainier
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE192)
Funding 32743.50€ 32.743,50
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

Investigation of KCNH2-mutation-induced cardiac arrhythmias in a human 3D innervated heart muscle model
ID 81X4300108
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Maria Patapia Zafeiriou
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE168)
Funding 40000.00€ 40.000,00
Begin 2021-04-0101.04.2021
End 2022-11-0101.11.2022
Projektdetails

iPS derived cardiomyocytes as a tool to test the clinical significance and drug effectiveness in a novel mutation linked to CPVT
ID 81X2100268
Institution Charité - Universitätsmedizin Berlin
Project leader Felix Hohendanner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE029)
Funding 34000.00€ 34.000,00
Begin 2021-07-0101.07.2021
End 2023-07-3030.07.2023
Projektdetails

iPS derived cardiomyocytes as a tool to test the clinical significance and drug effectiveness in a novel mutation linked to CPVT
ID 81X2500214
Institution Universität Heidelberg
Project leader Ibrahim Akin
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE029)
Funding 34894.30€ 34.894,30
Begin 2021-07-0101.07.2021
End 2023-07-3030.07.2023
Projektdetails
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease that is associated with sudden cardiac death and often lethal in young adults. Several different mutations affecting cellular Ca2+ release upon stress have been associated with the disease. Treatment options include betablockers and class Ic antiarrhythmic substances (known to also decrease ryanodine receptor (RyR) mediated Ca2+ leak). We recently identified a female 43 years old patient with polymorph ventricular premature excitation and syncope upon stressful events. The family history unveiled several instances of sudden cardiac death in close relatives. Genetic testing showed a novel mutation in the TECRL gene (serin309), a gene that codes for trans-2,3-enoyl-CoA-reducase like protein which impacts ryanodine receptor mediated Ca2+ release. A different mutation in the same protein has only recently been linked to CPVT1. Within the scope of this project, human induced pluripotent stem cells (iPSc) are generated from this patient, human cardiomyocytes (iPSc-CMs) subsequently tested for pro-arrhythmic Ca2+ release, arrhythmic contractions (partner site Berlin) and altered action potential characteristics as well as ion channel current (partner site Mannheim). The applicants are also going to test different antiarrhythmic drugs in the iPSc-CMs to find the most effect drug in this setting. Additionally, we are going to use the CRISPR/Cas9 (CRISPR-associated protein 9) system to modify the suspected causative TECRL variant in CPVT-cells to a wild-type sequence (mutation correction) or knockout TECRL variant in a WT cell line. Ultimately the data gathered within the scope of this application might allow to effectively reduce the risk of arrhythmia in patients with this novel CPVT related mutation.

Promotion of women scientists: Manipulating the AP-1 Response to Promote Cardiac Regeneration in the Adult Mammalian Heart
ID 81X3200309
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Arica Beisaw
Site RheinMain
Project type Excellence Programme
Funding 47800.00€ 47.800,00
Begin 2021-04-0101.04.2021
End 2022-03-3131.03.2022
Projektdetails

Metabolic regulation of transcriptional decisions in the damaged cardiac vasculature
ID 81X2200158
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ingrid Fleming
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 12000.00€ 12.000,00
Begin 2021-06-0101.06.2021
End 2022-05-3131.05.2022
Projektdetails

Metabolite profiling in atrial fibrillation (AF)
ID 81X2400148
Institution Universitätsmedizin Greifswald
Project leader Matthias Nauck
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 30899.56€ 30.899,56
Begin 2021-04-0101.04.2021
End 2022-07-3131.07.2022
Projektdetails
Our objective in this study is to examine circulating metabolites related to the gut microbiome and possibly AF (gut-blood-atrial axis). We expect to be able to demonstrate a significant difference in circulating metabolites related to the gut microbiome in patients with AF compared to normal controls from the community, which will help us generate novel hypotheses on pathophysiological mechanisms of AF and identify targets for prevention. Our project combines the distinct research fields of AF epidemiology, metabolome phenotyping and gut microbiome assessment. We will use the synergies and share our expertise arising from our two groups with long-standing epidemiological expertise and existing AF cohorts (UKE), and the Functional Genomics Center of the University of Greifswald with ample experience in metabolome profiling of biofluids. In addition, we will tie in our currently ongoing project with partners from MDC Berlin on microbiome assessment.

Metabolite profiling in atrial fibrillation (AF)
ID 81X2710184
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Christin Börschel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 21360.50€ 21.360,50
Begin 2021-04-0101.04.2021
End 2022-07-3131.07.2022
Projektdetails

Patterns and predictors of left ventricular remodeling: A machine-learning based approach
ID 81X2600705
Institution Ludwig-Maximilians-Universität München
Project leader Susanne Rospleszcz
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE081)
Funding 24000.00€ 24.000,00
Begin 2021-04-0101.04.2021
End 2022-05-3131.05.2022
Projektdetails

Patterns and predictors of left ventricular remodeling: A machine-learning based approach
ID 81X2400149
Institution Universitätsmedizin Greifswald
Project leader Till Ittermann
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE081)
Funding 23593.54€ 23.593,54
Begin 2021-04-0101.04.2021
End 2022-05-3131.05.2022
Projektdetails
The project aims 1) to identify different patterns of left ventricular (LV) remodeling and 2) to identify relevant clinical predictors for these remodeling patterns on a population-based level. To achieve these aims, data from two cohort studies, SHIP (Greifswald) and KORA (Augsburg), will be combined and analyzed using state-of-the-art machine-learning methods. To assess LV remodeling, detailed magnetic resonance imaging (MRI) data are available in both studies, which include measurements of wall thickness in 16 segments, LV volumes and mass and diastolic filling rates. These data will be evaluated by unbiased, unsupervised clustering methods to derive different LV remodeling phenotypes, which are characterized by specific wall thickness and end-diastolic patterns. To assess potential clinical predictors for these LV remodeling phenotypes, extensive measurements of laboratory biomarkers and further covariables are available in both studies. In a hypothesis-free manner, automated variable selection methods will be applied to evaluate the association and relevance of clinical predictor variables with the LV remodeling phenotypes. The final result of this project consists in a manuscript draft where the novel LV remodeling phenotypes and associated clinical predictors are presented. This cooperation provides an opportunity for combining Greifswald’s substantial expertise in complex statistics with the ample database given by the MRI measurements from both SHIP and KORA.

Platelet signatures in hypertension: from mouse to man
ID 81X2210122
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Wolfram Ruf
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 51992.54€ 51.992,54
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails
In dieser SE wird der Effekt von Hypertonie auf das Plättchentranskriptom in Probanden bestimmt und zu den Transkriptomveränderungen in einem Mausmodell der plättchenabhängigen Hypertonie verglichen.

Postdoc start-up grant: Deciphering single platelet dynamics in thrombosis and chronic vascular inflammation
ID 81X3600222
Institution Klinikum der Universität München
Project leader Leo Nicolai
Site München
Project type Excellence Programme
Funding 79927.00€ 79.927,00
Begin 2021-05-0101.05.2021
End 2022-04-3030.04.2022
Projektdetails

Postdoc start-up grant: Elucidating the Role of Five Adipokines in the Presence, Prediction, and Treatment of HFpEF
ID 81X3400109
Institution Universitätsmedizin Greifswald
Project leader Stephanie Zylla
Site Greifswald
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-05-0101.05.2021
End 2023-10-3131.10.2023
Projektdetails
Heart failure with preserved ejection fraction (HFpEF) is a complex condition that is associated with high morbidity and mortality. However, understanding of its underlying pathophysiology and therapeutic options are still lacking. During recent years, the inflammatory connections between adipose tissue and cardiovascular function that may contribute to HFpEF received increasing attention. Adipokines as secretory products of adipose tissue are discussed to serve as potential therapeutics or biomarkers in HFpEF, but the existing evidence is still sparse. The following project aims to investigate comprehensively the role of a carefully selected panel of established and novel adipokines (adiponectin, chemerin, galectin-3, leptin, resistin) in the presence, prediction, and treatment of HFpEF. Therefore, data from a general population sample (SHIP-Trend, N = 4420) as well as from a large randomized controlled trial of HFpEF-patients (Ex-DHF, N = 322), who were randomized to a 12-month supervised exercise training intervention, will be examined. The overall project is divided into three well-structured working packages. They will serve to proof if the adipokines are associated with the presence and prediction of HFpEF and if differences in adipokine concentrations of HFpEF-patients depending on a received exercise intervention are detectable. The influence of parameters that may contribute to the clinical heterogeneity of HFpEF will be considered.

Production and analysis of GWAS-based cardiovascular risk-modifying gene KO-iPSC lines
ID 81X2700136
Institution Universitätsklinikum Schleswig-Holstein - Campus Lübeck
Project leader Zouhair Aherrharou
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE200)
Funding 60000.00€ 60.000,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Proof of concept: Treating acute myocardial infarction with faecal transplantation in a transgenic animal model
ID 81X2800199
Institution Philipps-Universität Marburg
Project leader Volker Ruppert
Site Extern
Project type Cooperation with External Partners
Funding 43700.00€ 43.700,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

Rewiring of endogenous signaling pathways to restore homeostasis in the injured mammalian heart
ID 81X2500197
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 38495.00€ 38.495,00
Begin 2021-04-0101.04.2021
End 2023-04-3030.04.2023
Projektdetails

Promotion of women scientists: Role of protein tyrosine phosphatase receptor sigma (PTPRs) during maladaptive myocardial remodelling
ID 81X3300111
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Arpita Chowdhury
Site Göttingen
Project type Excellence Programme
Funding 79656.00€ 79.656,00
Begin 2021-05-0101.05.2021
End 2021-12-3131.12.2021
Projektdetails

Single Cell Leukocyte Landscapes and Cardiovascular Risk in Children with Chronic Kidney Disease
ID 81X2600418
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE199)
Funding 42695.00€ 42.695,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Single Cell Leukocyte Landscapes and Cardiovascular Risk in Children with Chronic Kidney Disease
ID 81X2100269
Institution Charité - Universitätsmedizin Berlin
Project leader Nicola Wilck
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE199)
Funding 32304.88€ 32.304,88
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Single cell RNA sequencing in iPSC-derived nodal and atrial cells from patients with atrial fibrillation
ID 81X2800202
Institution Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein
Project leader Stefan Kirsch
Site Extern
Project type Cooperation with External Partners
Funding 30808.65€ 30.808,65
Begin 2021-05-0101.05.2021
End 2022-12-3131.12.2022
Projektdetails
In den letzten Jahren hat sich gezeigt, dass sowohl Transkriptionsfaktoren als auch ihre Modifikatoren und Zielmoleküle eine wichtige Rolle in der Pathophysiologie des Vorhofflimmerns (AF), der häufigsten Herzrhythmusstörung, spielen. Dies deutet daraufhin, dass eine deregulierte Genexpression einer der wesentlichen zugrundeliegenden Mechanismen darstellt. Gegenwärtig ist unser Wissen über die genregulatorischen Netzwerke im Zusammenhang mit dem Vorhofflimmern allerdings noch sehr begrenzt. Sinusknotendysfunktion (SND) und Vorhofflimmern koexistieren oft nebeneinander, doch der molekulare Mechanismus, der beide Erkrankungen verbindet, ist immer noch unzureichend verstanden. Der Transkriptionsfaktor Shox2 ist ein Schlüsselregulator der Sinusknotenentwicklung, und seine Fehlfunktion führt zu einer Bradykardie, wie bereits in Mäusen und Zebrafischen gezeigt wurde. Mutationen im SHOX2-Gen sind beim Menschen mit AF und SND assoziiert worden. Durch die Erzeugung patientenspezifisch induzierter pluripotenter Stammzellen (iPSCs) bietet sich somit die einzigartige Gelegenheit die molekularen Grundlagen in einem menschlichen Krankheitsmodell zu untersuchen. Die Verwendung von iPSC-abgeleiteten Kardiomyozyten von AF-Patienten, die Mutationen im SHOX2-Gen tragen, ermöglicht krankheitsrelevante genetische Pfade zu erforschen und zu verstehen. Insbesondere möchten wir Transkriptionsprofile von iPSC-abgeleiteten Kardiomyozyten spezifischer Subtypen (nodal- und atrial-ähnlich) unter Verwendung der Einzelzell-RNA-Sequenzierung (scRNA-seq) identifizieren, um die zugrundeliegenden Pathomechanismen zu verstehen, die durch die genetischen Varianten die Anfälligkeit für Vorhofflimmern erhöhen. Das etablierte iPSC-basierte Modellsystem kann anschließend für pharmakologische Zwecke eingesetzt werden und sich dadurch positiv auf die individuelle Medizin auswirken.

Single cell RNA sequencing in iPSC-derived nodal and atrial cells from patients with atrial fibrillation
ID 81X4500100
Institution Universität Heidelberg
Project leader Sandra Hoffmann
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 25800.00€ 25.800,00
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

Single nuclear transcription profile analysis of isogenic human induced pluripotent stem cell-derived disease models
ID 81X2710187
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 36755.03€ 36.755,03
Begin 2021-04-0101.04.2021
End 2022-12-3131.12.2022
Projektdetails

The effects of ACE2 expression on vascular function in obesity and atherosclerosis
ID 81X2700138
Institution Universität zu Lübeck
Project leader Kristina Kusche-Vihrog
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE097)
Funding 30000.00€ 30.000,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

The role of T cell H3K27 trimethylation on T cell polarization and its effects on atherosclerosis
ID 81X2710185
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE057)
Funding 19873.22€ 19.873,22
Begin 2021-04-0101.04.2021
End 2022-09-3030.09.2022
Projektdetails

Using massively parallel reporter assay to understand the regulatory landscape of coronary artery disease risk SNPs
ID 81X2100267
Institution Charité - Universitätsmedizin Berlin
Project leader Martin Kircher
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE202)
Funding 36400.00€ 36.400,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Using massively parallel reporter assay to understand the regulatory landscape of coronary artery disease risk SNPs
ID 81X2700137
Institution Universität zu Lübeck
Project leader Malte Spielmann
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE202)
Funding 25000.00€ 25.000,00
Begin 2021-04-0101.04.2021
End 2023-03-3131.03.2023
Projektdetails

Which is the optimal HFpEF animal model: Focus on comparison with HFpEF patients and skeletal muscle
ID 81X2600630
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Cooperation with External Partners
Funding 24000.02€ 24.000,02
Begin 2021-05-0101.05.2021
End 2022-04-3030.04.2022
Projektdetails

Cardiomyocyte metabolic remodeling through the TBL1/TBLR1 co-factor complex
ID 81X2600117
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Stephan Herzig
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE201)
Funding 38190.67€ 38.190,67
Begin 2021-05-0101.05.2021
End 2022-03-3131.03.2022
Projektdetails

Which is the optimal HFpEF animal model: Focus on comparison with HFpEF patients and skeletal muscle
ID 81X2800203
Institution Technische Universität Dresden
Project leader Volker Adams
Site Extern
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2021-05-0101.05.2021
End 2022-04-3030.04.2022
Projektdetails

Metabolic regulation of transcriptional decisions in the damaged cardiac vasculature
ID 81X2100167
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Tatiana Borodina
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 48000.00€ 48.000,00
Begin 2021-06-0101.06.2021
End 2022-05-3131.05.2022
Projektdetails

Automated detection of high-risk coronary lesions by deep-neural network optical coherence tomography (OCT) analysis
ID 81X2100270
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE194)
Funding 24007.00€ 24.007,00
Begin 2021-06-0101.06.2021
End 2022-11-3030.11.2022
Projektdetails

Automated detection of high-risk coronary lesions by deep-neural network optical coherence tomography (OCT) analysis
ID 81X2600528
Institution Deutsches Herzzentrum München
Project leader Philipp Nicol
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE194)
Funding 21925.34€ 21.925,34
Begin 2021-06-0101.06.2021
End 2022-11-3030.11.2022
Projektdetails

Postdoc start-up grant: Inhibiting PCSK6 to prevent fibrosis/adverse remodeling and preserve cardiac function
ID 81X3500130
Institution Universität Heidelberg
Project leader Tim Christian Kuhn
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 79990.96€ 79.990,96
Begin 2021-06-0101.06.2021
End 2022-11-3030.11.2022
Projektdetails

Postdoc start-up grant: Cpeb4 controls cardiac remodeling by its dynamic binding behavior to its mRNA target Zeb1
ID 81X3500131
Institution Universität Heidelberg
Project leader Vivien Kmietczyk
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-06-0101.06.2021
End 2022-05-3131.05.2022
Projektdetails

Cross-correlation between myocardial tissue immunohistochemistry and imaging fingerprinting of mycardial injury in postviral syndrome with CMR-evidence of mycarditis
ID 81X2100271
Institution Charité - Universitätsmedizin Berlin
Project leader Felicitas Escher
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE005)
Funding 20000.00€ 20.000,00
Begin 2021-07-0101.07.2021
End 2023-12-3131.12.2023
Projektdetails

Cross-correlation between myocardial tissue immunohistochemistry and imaging fingerprinting of myocardial injury in postviral syndrome with CMR-evidence of myocarditis
ID 81X2200159
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Valentina Puntmann
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE005)
Funding 19999.00€ 19.999,00
Begin 2021-07-0101.07.2021
End 2023-12-3131.12.2023
Projektdetails

Role of leukocyte derived Reactive Oxygen Species (ROS) and Nitric oxide (NO) on thrombopoiesis
ID 81X2600263
Institution Klinikum der Universität München
Project leader Tobias Petzold
Site München
Project type Cooperation with External Partners
Funding 40750.00€ 40.750,00
Begin 2021-07-0101.07.2021
End 2022-08-3131.08.2022
Projektdetails

Development and characterization of a pig model of TET2-mediated clonal hematopoiesis
ID 81X2600264
Institution Klinikum der Universität München
Project leader Christian Schulz
Site München
Project type Translational Research Project
Funding 313246.20€ 313.246,20
Begin 2021-07-0101.07.2021
End 2024-12-3131.12.2024
Projektdetails

Investigation of novel genes implicated in congenital heart disease (CHD)
ID 81X2600529
Institution Deutsches Herzzentrum München
Project leader Cordula Wolf
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE204)
Funding 15000.00€ 15.000,00
Begin 2021-07-0101.07.2021
End 2022-09-3030.09.2022
Projektdetails

Development and characterization of a pig model of TET2-mediated clonal hematopoiesis
ID 81X2600706
Institution Ludwig-Maximilians-Universität München
Project leader Eckhard Wolf
Site München
Project type Translational Research Project
Funding 203580.12€ 203.580,12
Begin 2021-07-0101.07.2021
End 2024-12-3131.12.2024
Projektdetails

Investigation of novel genes implicated in congenital heart disease (CHD)
ID 81X2700236
Institution Universitätsklinikum Schleswig-Holstein - Campus Kiel
Project leader Marc-Philip Hitz
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE204)
Funding 27999.45€ 27.999,45
Begin 2021-07-0101.07.2021
End 2022-09-3030.09.2022
Projektdetails

Identifizierung neuer RNA-Ziele in einem Primatenmodel für alters-assoziierte kardiovaskuläre Erkrankungen
ID 81X2800201
Institution Medizinische Hochschule Hannover
Project leader Thomas Thum
Site Extern
Project type Cooperation with External Partners
Funding 59754.44€ 59.754,44
Begin 2021-07-0101.07.2021
End 2022-12-3131.12.2022
Projektdetails
Aufgrund der weltweit zunehmenden Lebenserwartung älterer Menschen wird erwartet, dass das Auftreten von altersbedingten Herz-Kreislauf-Erkrankungen in den nächsten Jahrzehnten deutlich zunehmen wird. Neuere Studien deuten darauf hin, dass nicht-kodierende RNAs (ncRNAs), insbesondere mikroRNAs (miRNAs) und lange nicht-kodierende RNAs (lncRNAs) ein enormes Potenzial als Angriffspunkte für neue therapeutische Wirkstoffe gegen verschiedene Herz-Kreislauf-Erkrankungen darstellen könnten. Wir werden in diesem Vorhaben in kardiovaskulären Gewebeproben aus jungen und älteren Weißbüschelaffen vergleichende Untersuchungen zum Profil nicht-kodierender RNA-Moleküle vornehmen. Dabei werden modernste Techniken von globaler Transkriptomanalyse und Einzelzell-RNA-Sequenzierungsmethoden einschließlich bioinformatischer Aufarbeitung zum Einsatz kommen, um das RNA-Genomprofil auf Einzelzellbasis für verschiedene Zellpopulationen zu bewerten und zu analysieren.

Postdoc start-up grant: Microvascular imaging as early predictor for cardiac dysfunction after preeclampsia
ID 81X3100109
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Kristin Kräker
Site Berlin
Project type Excellence Programme
Funding 76049.25€ 76.049,25
Begin 2021-07-0101.07.2021
End 2023-06-3030.06.2023
Projektdetails

Promotion of women scientists: PCP-dependent control of muscle differentiation through modulation of nuclear mechanics
ID 81X3100110
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Daniela Panáková
Site Berlin
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-07-0101.07.2021
End 2022-12-3131.12.2022
Projektdetails

Postdoc start-up grant: Investigating cardiac troponin T-related cardiomyopathies using conditional degron strategies
ID 81X3200310
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Thomas Juan
Site RheinMain
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-07-0101.07.2021
End 2022-12-3131.12.2022
Projektdetails

Promotion of women scientists: Investigation of neuronal remodelling in a human iPSC derived-innervated cardiac muscle model
ID 81X3300112
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Maria Patapia Zafeiriou
Site Göttingen
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-07-0101.07.2021
End 2022-12-3131.12.2022
Projektdetails

Promotion of women scientists: A mutation-independent gene therapy to treat RyR2 gain-of function mutations causing CPVT
ID 81X3600702
Institution Ludwig-Maximilians-Universität München
Project leader Stefanie Fenske
Site München
Project type Excellence Programme
Funding 73624.19€ 73.624,19
Begin 2021-07-0101.07.2021
End 2022-06-3030.06.2022
Projektdetails

Comprehensive plattform for data collection via smartphone apps
ID 81Z0210104
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site RheinMain
Project type Digitale Technologien
Funding 49966.46€ 49.966,46
Begin 2021-07-0101.07.2021
End 2023-03-3131.03.2023
Projektdetails

Externe Validierung machine learning basierter Risikoscores für TAVI Eingriffe und Etablierung von data- und model-sharing für maschinelles Lernen im DZHK
ID 81Z0300120
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Seidler
Site Göttingen
Project type Digitale Technologien
Funding 99959.70€ 99.959,70
Begin 2021-07-0101.07.2021
End 2022-06-3030.06.2022
Projektdetails

Bereitstellung der DNA- und RNA-Daten der DZHKOmics Ressource
ID 81Z0700111
Institution Universität zu Lübeck
Project leader Silke Szymczak
Site Hamburg/Kiel/Lübeck
Project type Digitale Technologien
Funding 46113.00€ 46.113,00
Begin 2021-07-0101.07.2021
End 2022-06-3030.06.2022
Projektdetails

Bereitstellung der DNA- und RNA-Daten der DZHKOmics Ressource
ID 81Z0710117
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Digitale Technologien
Funding 19641.00€ 19.641,00
Begin 2021-07-0101.07.2021
End 2022-06-3030.06.2022
Projektdetails

Proof of concept of a 3d printed surface patterned PLLA stent in an in vivo model
ID 81X2600530
Institution Deutsches Herzzentrum München
Project leader Michael Joner
Site München
Project type Cooperation with External Partners
Funding 24764.00€ 24.764,00
Begin 2021-08-0101.08.2021
End 2023-07-3131.07.2023
Projektdetails

Proof of concept of a 3d printed surface patterned PLLA stent in an in vivo model
ID 81X2800205
Institution Universität des Saarlandes
Project leader Frank Mücklich
Site Extern
Project type Cooperation with External Partners
Funding 23236.00€ 23.236,00
Begin 2021-08-0101.08.2021
End 2023-07-3131.07.2023
Projektdetails

Postdoc start-up grant on advancing digital aspects: Assessment of heart failure mouse models by systematically comparing single cell transcriptomics data in mice and man
ID 81X3200119
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader David John
Site RheinMain
Project type Excellence Programme
Funding 71419.00€ 71.419,00
Begin 2021-08-0101.08.2021
End 2023-01-3131.01.2023
Projektdetails

Postdoc start-up grant: Impact of MRC2 on cardiac fibroblast plasticity during chronic cardiac injury in the human heart
ID 81X3200120
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Badder Kattih
Site RheinMain
Project type Excellence Programme
Funding 76829.00€ 76.829,00
Begin 2021-08-0101.08.2021
End 2022-07-3131.07.2022
Projektdetails

Postdoc start-up grant on advancing digital aspects: Envision! Virtual reality for a better understanding and treatment of congenital heart defects
ID 81X3600223
Institution Klinikum der Universität München
Project leader Nikolaus Thierfelder
Site München
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2021-08-0101.08.2021
End 2022-07-3131.07.2022
Projektdetails

TRICI-HF-DZHK24: TRICuspid Intervention in Heart Failure Trial
ID 81X1600213
Institution Klinikum der Universität München
Project leader Jörg Hausleiter
Site München
Project type Clinical Studies
Funding 762544.76€ 762.544,76
Begin 2021-09-0101.09.2021
End 2026-08-3131.08.2026
Projektdetails

TRICI-HF-DZHK24: DZHK-Biobanking
ID 81X1600214
Institution Klinikum der Universität München
Project leader Jörg Hausleiter
Site München
Project type Clinical Studies
Funding 75207.93€ 75.207,93
Begin 2021-09-0101.09.2021
End 2026-08-3131.08.2026
Projektdetails

TRICI-HF-DZHK24: TRICuspid Intervention in Heart Failure Trial
ID 81X1600608
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Silvia Egert-Schwender
Site München
Project type Clinical Studies
Funding 930021.24€ 930.021,24
Begin 2021-09-0101.09.2021
End 2026-08-3131.08.2026
Projektdetails

Gene therapy of cardiac hypertrophy
ID 81X2300209
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rabea Hinkel
Site Göttingen
Project type Translational Research Project
Funding 393880.00€ 393.880,00
Begin 2021-09-0101.09.2021
End 2025-12-3131.12.2025
Projektdetails

The molecular response to exercise training in patients with heart failure with preserved ejection fraction
ID 81X2400150
Institution Universitätsmedizin Greifswald
Project leader Martin Bahls
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE175)
Funding 19999.50€ 19.999,50
Begin 2021-09-0101.09.2021
End 2024-03-3131.03.2024
Projektdetails
The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously increasing and expected to rise further [1]. All randomized clinical trials exploring pharmacological treatment options have been unsuccessful [2, 3]. However, structured exercise training has not just shown to improve diastolic function but also cardiorespiratory exercise capacity [4]. However, the response to exercise training is not homogenous. Some individuals respond very fast and show beneficial effects as well as improve their prognosis. Unfortunately, other patients need a longer time to respond. This delayed response most likely has adverse effects on long term adaptation of an active lifestyle. Hence, a better understanding of the molecular response to exercise training is essential to allow for individualized exercise recommendations in the future. In this project we aim to characterize the molecular adaption to exercise training in the largest exercise trial in patients with HFpEF to date [5]. In the "exercise training in diastolic heart failure" (EX-DHF) a total of 322 patients were randomized either to structured exercise training or control group for twelve months. Here we plan to characterize the cardiovascular response response to exercise training by evaluating 92 protein biomarkers of the Target 96 panel CVDII (Olink Proteomics, Uppsala, Sweden). Blood samples are available for three time points (baseline, 3 months and 12 months). With the data obtained from this project we will be able to identify different subgroups of exercise responders.

Gene therapy of cardiac hypertrophy
ID 81X2700237
Institution Christian-Albrechts-Universität zu Kiel
Project leader Oliver J. Müller
Site Hamburg/Kiel/Lübeck
Project type Translational Research Project
Funding 377649.00€ 377.649,00
Begin 2021-09-0101.09.2021
End 2025-12-3131.12.2025
Projektdetails
Ziel der Studie ist es, einen gentherapeutischen Ansatz zur Hemmung einer erhöhten NFAT-Aktivität bei Herzhypertrophie in einem Großtiermodell im Hinblick auf die weitere Überführung in eine neue klinische Behandlungsoption für Patienten mit Aortenklappenstenose zu validieren. Die Antragsteller haben die Voraussetzungen für die Translation präklinischer Befunde, aus einem Mausmodell mit Herzinsuffizienz aufgrund erhöhter Nachlast (TAC-Modell), in ein Großtiermodell geschaffen, um in eben diesem die Toxizitätsprüfung vornehmen zu können. Wobei dieser Schritt, Proof of Concept, als Voraussetzung für die Translation der erhobenen Ergebnisse auf die Behandlung von Patienten mit Aortenstenose, sowohl bei persistierender Stenose als auch bei persistierender Herzinsuffizienz nach chirurgischer oder interventioneller Behandlung, dient.

Role of leukocyte derived Reactive Oxygen Species (ROS) and Nitric oxide (NO) on thrombopoiesis
ID 81X2800204
Institution Heinrich-Heine-Universität Düsseldorf
Project leader Amin Polzin
Site Extern
Project type Cooperation with External Partners
Funding 7250.00€ 7.250,00
Begin 2021-09-0101.09.2021
End 2022-08-3131.08.2022
Projektdetails

Gene therapy of cardiac hypertrophy
ID 81X4500102
Institution Universität Heidelberg
Project leader Markus Hecker
Site Heidelberg/Mannheim
Project type Translational Research Project
Funding 122471.00€ 122.471,00
Begin 2021-09-0101.09.2021
End 2025-12-3131.12.2025
Projektdetails

Etablierung eines Workflows zur klinischen Validierung von Wearablesignalen - Use case "Identifizierung von Dekompensationsmustern einer Herzinsuffizienz durch Wearables"
ID 81Z0100217
Institution Charité - Universitätsmedizin Berlin
Project leader Frank Edelmann
Site Berlin
Project type Digitale Technologien
Funding 12500.00€ 12.500,00
Begin 2021-09-0101.09.2021
End 2022-08-3131.08.2022
Projektdetails
Wearables ermöglichen kontinuierliche Signalaufzeichnungen, aus denen eine Vielzahl von Parametern generiert und medizinisch nutzbar gemacht werden können. In diesem Projekt soll für die weitere Nutzung im DZK ein Workflow etabliert werden, der es ermöglicht, Signale von tragbaren Sensoren standardisiert klinisch zu validieren. Als Use case dient eine Pilotstudie mit zwei Gruppen von Herzinsuffizienzpatienten, bei denen mit einem neuentwickelten Sensorarmband kontinuierlich Signale am Handgelenk aufgezeichnet werden. Mittels artificial intelligence (AI)/machine learning (ML)-Methoden sollen dann Muster einer Dekompensation der Herzinsuffizienz identifiziert werden. In Folgeprojekten sollen diese Muster genutzt werden, um Algorithmen zu entwickeln, die es ermöglichen mittels nichtinvasivem Monitoring Dekompensationsphasen bei Patienten mit Herzinsuffizienz frühzeitig zu erkennen.

Human iPSC-derived cardiomyocyte engraftment and cell distribution using different application techniques
ID 81Z0710118
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Simon Pecha
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 476476.00€ 476.476,00
Begin 2021-09-0101.09.2021
End 2025-12-3131.12.2025
Projektdetails

Rotation grant: The role of M4 macrophages in extracellular vesicle-mediated atherosclerotic plaque calcification
ID 81X3500133
Institution Universität Heidelberg
Project leader Jona Benjamin Krohn
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 102172.00€ 102.172,00
Begin 2021-09-1515.09.2021
End 2022-09-1414.09.2022
Projektdetails

Reduce MFA-DZHK25: Effect of anti-fibrotic therapy on regression of myocardial fibrosis after transcatheter aortic valve implantation (TAVI) in aortic stenosis patients with high fibrotic burden [Reduce MFA]
ID 81X1300121
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Miriam Puls
Site Göttingen
Project type Clinical Studies
Funding 1796851.85€ 1.796.851,85
Begin 2021-10-0101.10.2021
End 2025-05-3131.05.2025
Projektdetails

Reduce MFA-DZHK25: DZHK-Biobanking
ID 81X1300122
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Miriam Puls
Site Göttingen
Project type Clinical Studies
Funding 60446.76€ 60.446,76
Begin 2021-10-0101.10.2021
End 2025-05-3131.05.2025
Projektdetails

The molecular response to exercise training in patients with heart failure with preserved ejection fraction
ID 81X2210123
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE175)
Funding 79393.00€ 79.393,00
Begin 2021-10-0101.10.2021
End 2024-03-3131.03.2024
Projektdetails
The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously increasing and expected to rise further [1]. All randomized clinical trials exploring pharmacological treatment options have been unsuccessful [2, 3]. However, structured exercise training has not just shown to improve diastolic function but also cardiorespiratory exercise capacity [4]. However, the response to exercise training is not homogenous. Some individuals respond very fast and show beneficial effects as well as improve their prognosis. Unfortunately, other patients need a longer time to respond. This delayed response most likely has adverse effects on long term adaptation of an active lifestyle. Hence, a better understanding of the molecular response to exercise training is essential to allow for individualized exercise recommendations in the future. In this project we aim to characterize the molecular adaption to exercise training in the largest exercise trial in patients with HFpEF to date [5]. In the "exercise training in diastolic heart failure" (EX-DHF) a total of 322 patients were randomized either to structured exercise training or control group for twelve months. Here we plan to characterize the cardiovascular response response to exercise training by evaluating 92 protein biomarkers of the Target 96 panel CVDII (Olink Proteomics, Uppsala, Sweden). Blood samples are available for three time points (baseline, 3 months and 12 months). With the data obtained from this project we will be able to identify different subgroups of exercise responders.

The Genomic basis of Unexplained Cardiac Arrest: The GenUCA Investigators (BHF-DHF-DZHK-Kooperation)
ID 81X2500215
Institution Universität Heidelberg
Project leader Katherine Sattler
Site Heidelberg/Mannheim
Project type Internationale Kooperation
Funding 699122.92€ 699.122,92
Begin 2021-10-0101.10.2021
End 2025-09-3030.09.2025
Projektdetails
One in twenty people survive a life-threatening rhythm abnormality (cardiac arrest) without a clear explanation. Future treatment is limited and there may be undetected risk for their relatives. We will study the largest group of these survivors ever collected to better understand their genetics and underlying causes of their unexplained cardiac arrest. We will then test new genetic discoveries in genetically altered human cells and mice to find targets for new medicines. The electrical behaviour of these patients’ hearts will also be studied using 24-hour heart monitors. We aim to improve theirs and their relatives’ treatment and prevent sudden death.

Investigation of novel genes implicated in congenital heart disease (CHD)
ID 81X2600118
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Martin Hrabe de Angelis
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE204)
Funding 5000.00€ 5.000,00
Begin 2021-10-0101.10.2021
End 2022-09-3030.09.2022
Projektdetails

Postdoc start-up grant on advancing digital aspects: Standardized ECG processing pipeline for AI/ML-based classification of cardiovascular diseases
ID 81X3400110
Institution Universitätsmedizin Greifswald
Project leader Marcus Vollmer
Site Greifswald
Project type Excellence Programme
Funding 79521.56€ 79.521,56
Begin 2021-10-0101.10.2021
End 2023-09-3030.09.2023
Projektdetails
This project provides the basis for the automated and standardized processing and analysis of large quantities of digital ECGs using new and innovative methods from the field of artificial intelligence. This includes recognition of new ECG patterns and new prediction models for cardiovascular diseases including myocardial infarction, atrial fibrillation and heart failure. Standardized and expandable processing steps will be applied to data from large cohort studies such as the "Hamburg City Health Study", "Gutenberg Health Study", "Study of Health in Pomerania", "Cooperative Health Research in the Augsburg Region" and "Translational Registry for Cardiomyopathies". Our pipeline will assure that ECGs obtained in different studies within and outside the DZHK are comparable and cross-location AI/ML projects utilizing large ECG datasets can be carried out on uniformly processed ECGs.

Postdoc start-up grant on advancing digital aspects: Digital HeART (DHART) Research Portal
ID 81X3500132
Institution Universität Heidelberg
Project leader Etienne Boileau
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 43284.00€ 43.284,00
Begin 2021-10-0101.10.2021
End 2022-09-3030.09.2022
Projektdetails

Aufbereitung von Bildgebungs- und Befundungsdaten für Isoliertes und Verteiltes Lernen von KI-Ansätzen
ID 81Z0500108
Institution Universität Heidelberg
Project leader Sandy Engelhardt
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 68423.00€ 68.423,00
Begin 2021-10-0101.10.2021
End 2022-09-3030.09.2022
Projektdetails

Aufbereitung von Bildgebungs- und Befundungsdaten für Isoliertes und Verteiltes Lernen von KI-Ansätzen
ID 81Z0500205
Institution Universität Heidelberg
Project leader Boris Rudic
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 28661.80€ 28.661,80
Begin 2021-10-0101.10.2021
End 2022-09-3030.09.2022
Projektdetails
Die strukturierte Aufbereitung von Befundungsdaten in lesbare Formate und das Filtern von klinischen Daten unzureichender Qualität [1] ist essenziell für Verteilte Lernkonzepte, wo Algorithmen/Künstliche Neuronale Netze an verschiedenen Standorten iterativ trainiert und verbessert werden. In Anlehnung an "Federated Learning"-Konzepten [2] möchten wir Softwaremodule für die Datenverarbeitung schaffen, die es ermöglichen, nur Daten für das Lernverfahren zu nutzen, welche bestimmte Qualitätsvorgaben erfüllen. Diese Module werden den DZHK-Standorten zur Verfügung gestellt und sollen in Zukunft datenschutzkonforme großangelegte KI-Projekte ermöglichen, ohne dass Patientendaten die Kliniken verlassen müssen.

Methylation profile of circulating cell-free DNA as a diagnostic tool for heart disease stratification
ID 81X1100225
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Daten- und Probennutzung
Funding 35600.00€ 35.600,00
Begin 2021-11-0101.11.2021
End 2024-10-3131.10.2024
Projektdetails

Proteogenomic discovery of endothelium-derived microproteins in cardiovascular disease
ID 81X1200108
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Mauro Siragusa
Site RheinMain
Project type Daten- und Probennutzung
Funding 35000.00€ 35.000,00
Begin 2021-11-0101.11.2021
End 2024-03-3131.03.2024
Projektdetails

Cardiac disease causative mutations in the Eph/ephrin signalling pathway
ID 81X1200109
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Guillermo Luxán
Site RheinMain
Project type Daten- und Probennutzung
Funding 25000.00€ 25.000,00
Begin 2021-11-0101.11.2021
End 2023-10-3131.10.2023
Projektdetails

Proteogenomic discovery of endothelium-derived microproteins in cardiovascular disease
ID 81X1200301
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Mauro Siragusa
Site RheinMain
Project type Daten- und Probennutzung
Funding 5000.00€ 5.000,00
Begin 2021-11-0101.11.2021
End 2024-03-3131.03.2024
Projektdetails

The Genomic basis of Unexplained Cardiac Arrest: The GenUCA Investigators (BHF-DHF-DZHK-Kooperation)
ID 81X2600265
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site München
Project type Internationale Kooperation
Funding 97051.56€ 97.051,56
Begin 2021-10-0101.10.2021
End 2025-09-3030.09.2025
Projektdetails
One in twenty people survive a life-threatening rhythm abnormality (cardiac arrest) without a clear explanation. Future treatment is limited and there may be undetected risk for their relatives. We will study the largest group of these survivors ever collected to better understand their genetics and underlying causes of their unexplained cardiac arrest. We will then test new genetic discoveries in genetically altered human cells and mice to find targets for new medicines. The electrical behaviour of these patients’ hearts will also be studied using 24-hour heart monitors. We aim to improve theirs and their relatives’ treatment and prevent sudden death.

Rotation grant: Validation and evaluation of a non-invasive assessment of central venous oxygen saturation by CMR
ID 81X3100214
Institution Charité - Universitätsmedizin Berlin
Project leader Djawid Hashemi
Site Berlin
Project type Excellence Programme
Funding 95472.66€ 95.472,66
Begin 2021-11-0101.11.2021
End 2022-11-3030.11.2022
Projektdetails
The central blood oxygen level very close to or in the heart is a key parameter to differentiate between different diseases and it provides the chance of a better prognosis. Up to now the gold standard to measure requires an invasive procedure by a right catheterization, where cathether is pushed through veins into the right heart chamber. With this catheter blood samples can be taken, and their oxygen level can be measured. Since the number of patients requiring the measurement of the blood oxygen level increases due to an aging population and a higherincidence of cardiac diseases there is a need for a safe and non-invasive alternative approach to the right heart catheterization with fewer complications. This 2-step-study aims to (i) demonstrate that a method to measure the blood oxygen level non-invasively by cardiac MRI is as reliable as measuring it by right heart catheter and (ii) identify different levels of blood oxygen levels in different diseases by this method to better distinguish the reasons for patients presenting with shortness of breath which can be a symptom for cardiac diseases.

Postdoc start-up grant: Characterisation of VEGF-Beta regulation networks in monocytes – a transcriptomics approach
ID 81X3710113
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Christian Schulte
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 79308.00€ 79.308,00
Begin 2021-11-0101.11.2021
End 2023-03-3131.03.2023
Projektdetails

Entwicklung und Anwendung von Algorithmen zur Atemfrequenz-Messung basierend auf Holter-EKG-Daten in klinischen Datenbanken und populations-basierten Studien
ID 81Z0600107
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Annette Peters
Site München
Project type Digitale Technologien
Funding 9765.00€ 9.765,00
Begin 2021-11-0101.11.2021
End 2023-01-3131.01.2023
Projektdetails

Entwicklung eines AI-basierten, automatisierten Algorithmus zur Risikostratifizierung auf Intensivstation anhand von Biosignalanalysen: Eine multizentrische, prospektive Beobachtungsstudie
ID 81Z0600209
Institution Klinikum der Universität München
Project leader Konstantinos Rizas
Site München
Project type Digitale Technologien
Funding 50091.80€ 50.091,80
Begin 2021-11-0101.11.2021
End 2023-01-3131.01.2023
Projektdetails

Entwicklung und Anwendung von Algorithmen zur Atemfrequenz-Messung basierend auf Holter-EKG-Daten in klinischen Datenbanken und populations-basierten Studien
ID 81Z0600604
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Georg Schmidt
Site München
Project type Digitale Technologien
Funding 40032.98€ 40.032,98
Begin 2021-11-0101.11.2021
End 2023-01-3131.01.2023
Projektdetails

Rotation grant: Attenuating cardiovascular risk by targeting microbial metabolism and premature T cell aging
ID 81X3100213
Institution Charité - Universitätsmedizin Berlin
Project leader Johannes Benjamin Holle
Site Berlin
Project type Excellence Programme
Funding 107742.15€ 107.742,15
Begin 2021-12-0101.12.2021
End 2022-11-3030.11.2022
Projektdetails
The overall objective in this project is to prevent CVD in a high risk cohort of children and adolescents with advanced CKD on maintenance hemodialysis. This project will be embedded in a truly translational study concept, including mechanistic studies in mice.

Clinician scientist programme: FoxO1 and caloric restriction as regulators of lipotoxic left atrial dysfunction in metabolic HFpEF
ID 81X3100215
Institution Charité - Universitätsmedizin Berlin
Project leader David Bode
Site Berlin
Project type Excellence Programme
Funding 146950.28€ 146.950,28
Begin 2021-12-0101.12.2021
End 2025-08-3131.08.2025
Projektdetails

AI & model based decision support systems in cardiovascular disease
ID 81Z0100218
Institution Charité - Universitätsmedizin Berlin
Project leader Lukas Zanders
Site Berlin
Project type Digitale Technologien
Funding 88000.00€ 88.000,00
Begin 2021-12-0101.12.2021
End 2022-11-3030.11.2022
Projektdetails
AI and model based methods have huge potential to extend purely evidence-based methods for improving diagnosis and treatment planning. The DZHK site Berlin aims to implement computer assisted decision support systems (AI & model based DSS) in major cardiovascular diseases, including structural heart disease, cardiomyopathies and advanced coronary artery disease. Based on own previous work in this field on e.g. structural heart disease and intensive medical monitoring of patients, the initial focus will be coronary heart disease. However, the proposed methods create a basis that can also be transferred to other diseases and across DZHK sites. With these main goals in mind, the following methodological components shall be ad-vanced:

The role of urinary Dickkopf-3 in cardiorenal syndrome
ID 81X1300123
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Manuel Wallbach
Site Göttingen
Project type Daten- und Probennutzung
Funding 39930.00€ 39.930,00
Begin 2022-01-0101.01.2022
End 2023-12-3131.12.2023
Projektdetails

Characterisation and risk stratification of patient subgroups in dilated cardiomyopathy by utilisation of an inflammatory 47-plex-biomarker panel
ID 81X1400112
Institution Universitätsmedizin Greifswald
Project leader Kristin Lehnert
Site Greifswald
Project type Daten- und Probennutzung
Funding 40000.00€ 40.000,00
Begin 2022-01-0101.01.2022
End 2023-05-3131.05.2023
Projektdetails
Inflammation has been implicated in the pathogenesis of heart failure (HF) and dilated cardiomyopathy (DCM), and many reports have suggested that inflammatory cytokines may predict adverse outcome in these patients (1,2). There is a clinical need to identify specific biomarkers to guide diagnosis and treatment decisions as well as risk stratification in DCM patients (3). In a pilot study, we measured a 13-biomarker panel in our well characterized cohort of DCM patients with (DCMi) and without inflammation (DCM) in endomyocardial biopsies. We could show that these patients show significantly different inflammatory marker profiles, e.g. IL1ß was related to DCM while IL8 and IL10 were associated with DCMi. Using a random forest approach, we could identify further biomarkers (e.g. MCP-1, IL6) that were related with either DCM or DCMi (unpublished). Furthermore, IL8, IL10, IL18, MCP-1, and IL17A were differentially associated with 5- or 10-year survival. Due to these promising results we are currently analyzing a broader panel (47-plex) in our cohort. We aim to utilize DZHK biobank samples to further elucidate inflammatory patterns with the same broader panel of markers and a group of DCM patients comparable to our sample to gain further insight in inflammation pathways or to identify subgroups with distinct patterns to enhance mechanistic knowledge and validate our results.

Postdoc start-up grant: Interaction between sarcomere mechanics and chromatin remodelling in engineered heart tissue
ID 81X3100111
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Claudia Crocini
Site Berlin
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2022-01-0101.01.2022
End 2023-06-3030.06.2023
Projektdetails

Postdoc start-up grant: Role of Slit/Robo signaling in cardiomyocyte cytokinesis and regeneration
ID 81X3200311
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Chi-Chung Wu
Site RheinMain
Project type Excellence Programme
Funding 75304.00€ 75.304,00
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

Metabolic control of vascular diseases (Stammzellplatt-form)
ID 81Z0100101
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sebastian Diecke
Site Berlin
Project type Partner Site Projects
Funding 1506656.04€ 1.506.656,04
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Reprogramming
ID 81Z0600601
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Karl-Ludwig Laugwitz
Site München
Project type Partner Site Projects
Funding 988196.82€ 988.196,82
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Aufbau und Etablierung der W3 Professur "Myokardiale und Vaskuläre Interaktionen"
ID 81Z0210101
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Tommaso Gori
Site RheinMain
Project type Partner Site Projects
Funding 1820255.45€ 1.820.255,45
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

BIOMARKER RESEARCH
ID 81Z0200201
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Samuel Tobias Sossalla
Site RheinMain
Project type Partner Site Projects
Funding 1618295.72€ 1.618.295,72
Begin 2018-11-0101.11.2018
End 2025-12-3131.12.2025
Projektdetails

Systems-medicine approaches in cardiovascular disease
ID 81Z0710102
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 2534089.48€ 2.534.089,48
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Advanced Metabolic & Phenotyping Unit
ID 81Z0200102
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ingrid Fleming
Site RheinMain
Project type Partner Site Projects
Funding 1644069.34€ 1.644.069,34
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Bioinformatics
ID 81Z0200101
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Marcel Schulz
Site RheinMain
Project type Partner Site Projects
Funding 1978435.00€ 1.978.435,00
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Translation personalisierter Gen- und Chromatintherapien für die klinische Behandlung von Herzmuskelerkrankungen (HD-MO-5)
ID 81Z0500101
Institution Universität Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 3472994.90€ 3.472.994,90
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Biobanking, Nachwuchsförderung und Wissenschaftliche Kommunikation (HD-WE-1)
ID 81Z0500103
Institution Universität Heidelberg
Project leader Tanja Weis
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 3007247.78€ 3.007.247,78
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Translational Genomics and Epigenomics of Cardiomyopa-thies & Heart Failure (Genomische und Epigenomische Ursachen von Kardiomyopathien und ihre klinische Relevanz, HD-ME-2)
ID 81Z0500102
Institution Universität Heidelberg
Project leader Benjamin Meder
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 3422861.72€ 3.422.861,72
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Immunological mechanisms in Heart failure and DCM
ID 81Z0400102
Institution Universitätsmedizin Greifswald
Project leader Stephanie Könemann
Site Greifswald
Project type Partner Site Projects
Funding 2394228.24€ 2.394.228,24
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Translational Approach of Heart Failure Prevention and Therapy
ID 81Z0400101
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Partner Site Projects
Funding 7494063.67€ 7.494.063,67
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Platelet Therapy Research Group
ID 81Z0600201
Institution Klinikum der Universität München
Project leader Steffen Massberg
Site München
Project type Partner Site Projects
Funding 1917183.36€ 1.917.183,36
Begin 2018-08-0101.08.2018
End 2025-12-3131.12.2025
Projektdetails

Immune pathogenesis and therapy of vascular disease (Förderphase 2019-2020)
ID 81Z0600202
Institution Klinikum der Universität München
Project leader Christian Weber
Site München
Project type Partner Site Projects
Funding 867287.14€ 867.287,14
Begin 2018-08-0101.08.2018
End 2025-12-3131.12.2025
Projektdetails

Identifizierung und Validierung von Inotropie-verbessernden molekularen Targets
ID 81Z0500201
Institution Universität Heidelberg
Project leader Thomas Wieland
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 1253348.99€ 1.253.348,99
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails
Ziel des Projektes ist die Translation, der positiv-inotropen Antwort nach Carbachol-Stimulation, die an explantierten Rattenherzen, von RGS3L-überexprimierenden Tieren beobachte wurde, auf ein Herzinsuffizienzmodell der Ratte. Dazu muss 1.) der Nachweis der Kontraktilitätssteigerung durch Carbachol nach Überexpression von RGS3L in adulten Rattenkardiomyozyten (AP1) und 2.) Die schrittweise die Umsetzung und Validierung der AAV-RGS3L –Applikation und Wirk-samkeit am lebenden Tier erfolgen. Als erster Schritt erfolgt die Überprüfung der lang-fristigen Verträglichkeit und Wirksamkeit der Manipulation am gesunden Tier (AP2). In zweiten Schritt soll dann die RGS3L-Überexpression nach bewährtem Schema erfolgen und die Tiere im bereits beschriebenen Herzinfarktmodell auf die Entwicklung einer infarkt-bedingten Insuffizienz hin charakterisiert werden (AP3, Prophylaktischer Ansatz). Im abschließenden, dritten Projektteil ist die kurative Gabe des AAV-RGS3L geplant (AP4, kurativer Ansatz). Hier muss der richtige Zeitpunkt der AAV-Applikation nach dem Infarkt eruiert werden, der einerseits das Überleben des Tieres sichert und andererseits eine frühzeitige Überexpression von RGS3L erlaubt, dass sich ein protektiver Effekt gegenüber dem Auftreten der Insuffizienz entwickelt. Da über die kardiale Bedeutung von Tiam1, das nach unseren Erkenntnissen in der humanen Herzinsuffizienz hochreguliert ist und einen zentralen Bestandteil des Proteinkomplexes aus RGS3L und p190A-RhoGAP darstellt, wenig bekannt ist, werden zudem Tiam1-knockout-Mäuse eingehend kardial bzgl. Hypertrophie-Entwicklung, Kontraktilitätsveränderungen und Arrhythmie-Neigung charakterisiert werden (AP5).

RNA Therapy
ID 81Z0600401
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Partner Site Projects
Funding 2317189.75€ 2.317.189,75
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Experimental and clinical genomics of coronary artery disease (Förderphase 2019-2020)
ID 81Z0600501
Institution Deutsches Herzzentrum München
Project leader Heribert Schunkert
Site München
Project type Partner Site Projects
Funding 1829497.86€ 1.829.497,86
Begin 2018-07-0101.07.2018
End 2025-12-3131.12.2025
Projektdetails

Immune mechanisms in acute coronary syndrome
ID 81Z0100202
Institution Charité - Universitätsmedizin Berlin
Project leader Ulf Landmesser
Site Berlin
Project type Partner Site Projects
Funding 1166752.35€ 1.166.752,35
Begin 2018-10-0101.10.2018
End 2025-12-3131.12.2025
Projektdetails

Multiscale mechanistic phenotyping in Heart Failure with reduced Ejection Fraction (TYPE-HF)
ID 81Z0100204
Institution Charité - Universitätsmedizin Berlin
Project leader Frank Edelmann
Site Berlin
Project type Partner Site Projects
Funding 1631882.49€ 1.631.882,49
Begin 2018-11-0101.11.2018
End 2025-12-3131.12.2025
Projektdetails
Herzinsuffizienz mit reduzierter Ejektionsfraktion (HFrEF) - systolische Herzinsuffizienz- ist weiterhin die häufigste Form der Herzinsuffizienz mit fortbestehend schlechter Prognose. In der fortgeschrittener Form der Erkrankung findet sich unabhängig von der zu Grunde liegenden Ätiologie eine neuroendokrine Überaktivierung, die das Fortschreiten der Erkrankung begünstigt.

Die funktionelle Kopplung zwischen Endolysosomen und SR (Lyso-SR) für Remodelingprozesse in Kardiomyozyten und Entstehung kardialer Dysfunktion (HD-FR 1)
ID 81Z0500105
Institution Universität Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 976514.20€ 976.514,20
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Molekulare Mechanismen von Kardiomyopathien
ID 81Z0500104
Institution Universität Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 4196140.87€ 4.196.140,87
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Optoakustische Bildgebung der menschlichen Carotisatherosklerose
ID 81Z0600104
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Vasilis Ntziachristos
Site München
Project type Partner Site Projects
Funding 743386.68€ 743.386,68
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails

Metabolische Beeinflussung kardiovaskulärer Ereignisse - Einfluss von Ernährung auf den Verlauf der koronaren Herzkrankheit und therapeutische Behandlung kardiovaskulärer Schädigungen im Entwicklungsverlauf der Diabetesentstehung (CardioMet)
ID 81Z0100501
Institution Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Project leader Tilman Grune
Site Berlin
Project type Partner Site Projects
Funding 824268.00€ 824.268,00
Begin 2019-01-0101.01.2019
End 2025-12-3131.12.2025
Projektdetails
Im Projekt sollen Zusammenhänge zwischen Ernährung, körperlicher Aktivität sowie metabolischer Faktoren und dem Auftreten von Sekundärereignissen im Tierversuch und bei Patienten nach Herzinfarkt untersucht werden. Ziel des Tierversuches ist es die Möglichkeit zu testen, ob trotz einer andauernden metabolischen Belastung durch eine pharmakologische Behandlung die Dysfunktion der Herzmorphologie und –funktion in der NZO-Maus zu korrigieren ist. Es soll untersucht werden, ob es hierbei geschlechterspezifische Unterschiede gibt. Ziel der epidemiologischen Studie ist es, die Zusammenhänge zwischen Ernährung, körperlicher Aktivität sowie metabolischen Faktoren und dem Auftreten von Sekundärereignissen bei Patienten mit Zustand nach Herzinfarkt zu untersuchen. Dabei soll geprüft werden, ob folgende Faktoren mit einem verminderten Risiko für Sekundärereignisse assoziiert sind: 1) Ernährung mit einem Lebensmittelmuster, dessen Nährstoffprofil dem der mediterranen Ernährung ähnlich ist; 2) intermittierende körperliche Aktivität hoher Intensität.

Therapeutische Genomeditierung bei erblichen Herzerkrankungen
ID 81Z0300112
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Bernd Wollnik
Site Göttingen
Project type Partner Site Projects
Funding 865345.00€ 865.345,00
Begin 2019-06-0101.06.2019
End 2025-12-3131.12.2025
Projektdetails

DNA damage in cytoskeletal protein mutation-induced Atrial Fibrillation: a guide to novel treatment and screening targets (DZHK-BHF Cooperation)
ID 81X4300102
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Niels Voigt
Site Göttingen
Project type Internationale Kooperation
Funding 520000.00€ 520.000,00
Begin 2021-01-0101.01.2021
End 2024-12-3131.12.2024
Projektdetails

Computational assessment of genetic regulatory effects on RNA life using the DZHK OMICS resource
ID 81X1500110
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Daten- und Probennutzung
Funding 39518.00€ 39.518,00
Begin 2021-12-0101.12.2021
End 2022-11-3030.11.2022
Projektdetails

FEDEX - Erweiterung des Feasibility Explorers zur besseren Visualisierung der DZHK-Daten
ID 81X1300124
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Dagmar Krefting
Site Göttingen
Project type Digitale Technologien
Funding 50497.00€ 50.497,00
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

DZHK Preclinical RNA-seq data analysis portal (D-DAP)
ID 81X1600104
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Matthias Heinig
Site München
Project type Digitale Technologien
Funding 6361.00€ 6.361,00
Begin 2022-01-0101.01.2022
End 2023-09-3030.09.2023
Projektdetails

DZHK Preclinical RNA-seq data analysis portal (D-DAP)
ID 81X1500111
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 81136.00€ 81.136,00
Begin 2022-01-0101.01.2022
End 2023-09-3030.09.2023
Projektdetails

Epigenetic and RNA-based biomarker Validation in Cardiomyopathies
ID 81X1500109
Institution Universität Heidelberg
Project leader Jan Haas
Site Heidelberg/Mannheim
Project type Daten- und Probennutzung
Funding 40000.00€ 40.000,00
Begin 2021-12-0101.12.2021
End 2022-11-3030.11.2022
Projektdetails

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X1400114
Institution Universitätsmedizin Greifswald
Project leader Stefan Simm
Site Greifswald
Project type Digitale Technologien
Funding 4450.93€ 4.450,93
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails
Ziel des multizentrischen Projektes ist der Aufbau eines Federated Learning Konsortiums zur Bearbeitung einer klinischen Fragestellung hinsichtlich TAVI Prothesenselektionen unter Einbeziehung von 9 Kliniken aus 7 DZHK-Standorten und einem weiteren Klinikum. Neuartige Konzepte des Förderierten Lernens (FL) vollziehen ein dezentrales Trainieren von Neuronalen Netzen ohne dass die zugrundeliegenden Daten die einzelnen Standorte verlassen müssen (Datenhoheit verbleibt an den Standorten; Möglichkeit der Nutzung von Reproduzierbarkeitskohorten, die ein breites Spektrum an Patientencharakteristika und Aufnahmetechnik abbilden). Im Rahmen des Projektes soll ein erster Meilenstein hinsichtlich Datenaufbereitung von über 13.000 verfügbaren Patientendatensätzen und Implementierung einer Test-Architektur erreicht werden.

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X1100226
Institution Charité - Universitätsmedizin Berlin
Project leader Anja Hennemuth
Site Berlin
Project type Digitale Technologien
Funding 4038.18€ 4.038,18
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X1100307
Institution Deutsches Herzzentrum Berlin
Project leader Alexander Meyer
Site Berlin
Project type Digitale Technologien
Funding 4450.93€ 4.450,93
Begin 2022-03-0101.03.2022
End 2023-02-2828.02.2023
Projektdetails
Ziel des multizentrischen Projektes ist der Aufbau eines Federated Learning Konsortiums zur Bearbeitung einer klinischen Fragestellung hinsichtlich TAVI Prothesenselektionen unter Einbeziehung von 9 Kliniken aus 7 DZHK-Standorten und einem weiteren Klinikum. Neuartige Konzepte des Förderierten Lernens (FL) vollziehen ein dezentrales Trainieren von Neuronalen Netzen ohne dass die zugrundeliegenden Daten die einzelnen Standorte verlassen müssen (Datenhoheit verbleibt an den Standorten; Möglichkeit der Nutzung von Reproduzierbarkeitskohorten, die ein breites Spektrum an Patientencharakteristika und Aufnahmetechnik abbilden). Im Rahmen des Projektes soll ein erster Meilenstein hinsichtlich Datenaufbereitung von über 13.000 verfügbaren Patientendatensätzen und Implementierung einer Test-Architektur erreicht werden.

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X1600217
Institution Klinikum der Universität München
Project leader Clemens Scherer
Site München
Project type Digitale Technologien
Funding 4450.93€ 4.450,93
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X1710112
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Peter Bannas
Site Hamburg/Kiel/Lübeck
Project type Digitale Technologien
Funding 4450.93€ 4.450,93
Begin 2022-02-0101.02.2022
End 2023-01-3131.01.2023
Projektdetails

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X1500113
Institution Universität Heidelberg
Project leader Sandy Engelhardt
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 32026.20€ 32.026,20
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

Federated Deep-Learning to Support Protheses Selection from TAVI-CT
ID 81X1200110
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eike Nagel
Site RheinMain
Project type Digitale Technologien
Funding 4450.93€ 4.450,93
Begin 2022-02-0101.02.2022
End 2023-01-3131.01.2023
Projektdetails

FEDEX - Erweiterung des Feasibility Explorers zur besseren Visualisierung der DZHK-Daten
ID 81X1500112
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 47800.00€ 47.800,00
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

Identification of circulatory proteins reflecting myocardial processes relevant to disease progression in heart failure
ID 81X1100308
Institution Deutsches Herzzentrum Berlin
Project leader Christoph Knosalla
Site Berlin
Project type Digitale Technologien
Funding 3429.00€ 3.429,00
Begin 2022-06-0101.06.2022
End 2023-05-3131.05.2023
Projektdetails

Identifizierung von zirkulierenden Proteinen, die myokardiale Prozesse widerspiegeln, die für das Fortschreiten der Krankheit bei Herzinsuffizienz relevant sind
ID 81X1210104
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Jürgen Prochaska
Site RheinMain
Project type Daten- und Probennutzung
Funding 36980.72€ 36.980,72
Begin 2022-06-0101.06.2022
End 2023-05-3131.05.2023
Projektdetails
Die derzeitige Phänotypisierung des Syndroms der Herzinsuffizienz (HF) lässt noch immer eine angemessene molekulare Charakterisierung vermissen. Die Erforschung des molekularen Fingerabdrucks der HF bietet einen vielversprechenden Ansatz für phänotypisch unterschiedliche molekulare Signaturen, die die Herzfunktion und das Ergebnis vorhersagen, um neue mechanistische Erkenntnisse zu gewinnen. In der MyoVasc-Studie (NCT04064450) wurde ein gezielter Proteomik-Ansatz zur Analyse von EDTA-Plasmaproben unter Verwendung von vier Panels der Proximity-Extension-Assay-Technologie (Olink Target 96 Panels "Inflammation", "CVDII", "CVDIII" und "Cardiometabolic"; insgesamt: N=359 einzigartige proteomische Biomarker pro Probe) durchgeführt. Durch überwachte maschinelle Lernmethoden wurden spezifische proteomische Signaturen bei Personen mit HF identifiziert, die vielversprechende Ergebnisse liefern, um zu einem besseren Verständnis der molekularen Mechanismen verschiedener HF-Phänotypen (z. B. HF mit reduzierter bzw. erhaltener Ejektionsfraktion) beizutragen. Mit dem vorliegenden Projekt wollen wir periphere Blutproben und Gewebeproben von n=88 Personen mit denselben Proteinmarkern (N=359), die in der vorherigen Studie verwendet wurden, molekular charakterisieren. In Zusammenarbeit mit dem DZHB (Prof. Knosalla) wird die Gewebebank die Möglichkeit bieten, kardiale gewebespezifische Expressionsmuster und deren Zusammenhang mit dem zirkulären Proteinprofil bei Patienten mit HF zu untersuchen. Es soll analysiert werden, ob sich relevante lokale Gewebeproteinsignaturen in zirkulierenden Proteinen widerspiegeln. KI mit überwachtem maschinellem Lernen wird eingesetzt, um interessante Expressionsmuster zu entdecken. Mit Hilfe eines translationalen Ansatzes werden diese Informationen anschließend in die vorherigen Daten der MyoVasc-Daten integriert, um spezifische proteomische Signaturen zu entschlüsseln, die an der Entwicklung und dem Fortschreiten des HF-Syndroms beteiligt sind.

DZHK Preclinical RNA-seq data analysis portal (D-DAP)
ID 81X1700113
Institution Universität zu Lübeck
Project leader Silke Szymczak
Site Hamburg/Kiel/Lübeck
Project type Digitale Technologien
Funding 7506.00€ 7.506,00
Begin 2022-01-0101.01.2022
End 2023-09-3030.09.2023
Projektdetails

Proteomic exploration of pathophysiological pathways related to the novel biomarker CCN1 for prediction of all-cause mortality in patients with Dilated Cardiomyopathy
ID 81X1210103
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site RheinMain
Project type Daten- und Probennutzung
Funding 21115.54€ 21.115,54
Begin 2022-01-0101.01.2022
End 2023-08-3131.08.2023
Projektdetails
We have identified CCN1 as a novel circulating biomarker in cardiovascular patients with Acute Coronary Syndromes and now also in patients with Dilated Cardiomyopathy. In both clinical settings, CCN1 constitutes an independent prognostic biomarker to predict all-cause mortality. We now aim to replicate our findings measuring CCN1 by means of EIA assay technology in a validation cohort from the DZHK biobank. In order to gain novel insights into what disease process this biomarker reflects and how this impacts on mortality, we aim to perform a comprehensive analysis of proteins involved. To this end, we plan to perform proteomic analyses using the Olink Bioscience platform in 410 patients from the DZHK biobank and correlate CCN1 and pertinent proteins identified with this approach with all-cause mortality in these patients.

Proteomische Erforschung pathophysiologischer Signalwege verwandt mit dem neuartigen Biomarker CCN1 zur Vorhersage von Gesamtmortalität bei Patienten mit dilatativer Kardiomyopathie
ID 81X1200205
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Roland Klingenberg
Site RheinMain
Project type Daten- und Probennutzung
Funding 7493.00€ 7.493,00
Begin 2022-01-0101.01.2022
End 2023-08-3131.08.2023
Projektdetails

Replication of prognostic value of novel biomarker CCN1 in validation cohort from DZHK biobank; Exploration of underlying pathophysiology using a proteomics approach
ID 81X1400113
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Daten- und Probennutzung
Funding 3462.00€ 3.462,00
Begin 2022-01-0101.01.2022
End 2023-08-3131.08.2023
Projektdetails
We have identified CCN1 as a novel circulating biomarker in cardiovascular patients with Acute Coronary Syndromes and now also in patients with Dilated Cardiomyopathy. In both clinical settings, CCN1 constitutes an independent prognostic biomarker to predict all-cause mortality. We now aim to replicate our findings measuring CCN1 by means of EIA assay technology in a validation cohort from the DZHK biobank. In order to gain novel insights into what disease process this biomarker reflects and how this impacts on mortality, we aim to perform a comprehensive analysis of proteins involved. To this end, we plan to perform proteomic analyses using the Olink Bioscience platform in 410 patients from the DZHK biobank and correlate CCN1 and pertinent proteins identified with this approach with all-cause mortality in these patients.

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X1300125
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Seidler
Site Göttingen
Project type Digitale Technologien
Funding 15528.93€ 15.528,93
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails
Ziel des multizentrischen Projektes ist der Aufbau eines Federated Learning Konsortiums zur Bearbeitung einer klinischen Fragestellung hinsichtlich TAVI Prothesenselektionen unter Einbeziehung von 9 Kli-niken aus 7 DZHK-Standorten und einem weiteren Klinikum. Neuartige Konzepte des Förderierten Ler-nens (FL) vollziehen ein dezentrales Trainieren von Neuronalen Netzen ohne dass die zugrundeliegenden Daten die einzelnen Standorte verlassen müssen (Datenhoheit verbleibt an den Standorten; Möglichkeit der Nutzung von Reproduzierbarkeitskohorten, die ein breites Spektrum an Patientencharakteristika und Aufnahmetechnik abbilden). Im Rahmen des Projektes soll ein erster Meilenstein hinsichtlich Daten-aufbereitung von über 13.000 verfügbaren Patientendatensätzen und Implementierung einer Test-Architektur erreicht werden For the detailed desription please refer to the attached project funding application.

Clinician scientist programme: The complement system as an inflammatory link between obesity and atherosclerosis
ID 81X3700107
Institution Universität zu Lübeck
Project leader Elias Rawish
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 159690.00€ 159.690,00
Begin 2022-01-0101.01.2022
End 2025-11-1515.11.2025
Projektdetails

Postdoc start-up grant: CRISPR/Cas9 gene activity control with all-in-one mini-dCas9 transcription factors in cardiomyocytes
ID 81X3300113
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Eric Schoger
Site Göttingen
Project type Excellence Programme
Funding 79673.00€ 79.673,00
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

Postdoc start-up grant on advancing digital aspects: DZHK-Omics: Intuitive and standardized bulk RNA-sequencing analysis for the coding-naïve basic scientist
ID 81X3500135
Institution Universität Heidelberg
Project leader Mark Pepin
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 66872.16€ 66.872,16
Begin 2021-12-0101.12.2021
End 2023-12-3131.12.2023
Projektdetails

Rotation grant: Investigating the role of VARS2 in idiopathic dilated cardiomyopathy
ID 81X3500117
Institution Universität Heidelberg
Project leader Elham Kayvanpour
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 100844.00€ 100.844,00
Begin 2018-11-0101.11.2018
End 2019-10-3131.10.2019
Projektdetails

Junior research group: Elucidating the contribution of sex chromosomes to the CVD gender bias
ID 81X3600407
Institution Technische Universität München
Project leader Daniel Andergassen
Site München
Project type Excellence Programme
Funding 825000.00€ 825.000,00
Begin 2022-06-0101.06.2022
End 2025-05-3131.05.2025
Projektdetails

Rotation grant: Oxygenation-sensitive CMR: A medication-free protocol for cardiovascular imaging and stress tests
ID 81X3500134
Institution Universität Heidelberg
Project leader Lukas Damian Weberling
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 75242.00€ 75.242,00
Begin 2021-12-0101.12.2021
End 2022-11-3030.11.2022
Projektdetails

Postdoc start-up grant: Role of the CXCL12-CXCR4/ACKR3 axis in atherosclerotic plaque instability
ID 81X3600224
Institution Klinikum der Universität München
Project leader Laura Parma
Site München
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2022-07-0101.07.2022
End 2023-12-3131.12.2023
Projektdetails

Postdoc start-up grant: Discovery and exploration of novel drug targets for lowering cardiometabolic risk
ID 81X3600510
Institution Deutsches Herzzentrum München
Project leader Zhifen Chen
Site München
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

Postdoc start-up grant: Immune modulation of cardiac monocytes/macrophages due to metabolic acidic stress and the role of the transcription factor inducible cyclic AMP early repressor in ischemic heart disease
ID 81X3210105
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Michael Molitor
Site RheinMain
Project type Excellence Programme
Funding 79211.55€ 79.211,55
Begin 2022-06-0101.06.2022
End 2023-05-3131.05.2023
Projektdetails

Promotion of women scientists: The microbial effect on thrombus growth and platelet function in a deep vein thrombosis model
ID 81X3210104
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Klytaimnistra Kiouptsi
Site RheinMain
Project type Excellence Programme
Funding 79637.26€ 79.637,26
Begin 2022-03-0101.03.2022
End 2023-02-2828.02.2023
Projektdetails

Promotion of women scientists: Contribution of blood pressure related gene CRIP1 on pathology and progression of hypertension
ID 81X3710114
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Olga Schweigert
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 79962.95€ 79.962,95
Begin 2022-05-0101.05.2022
End 2023-12-3131.12.2023
Projektdetails

Rotation grant: Fetal hemoglobin induction as protein translation treatment option for inherent anaemia
ID 81X3200121
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Jeremy Epah
Site RheinMain
Project type Excellence Programme
Funding 107631.16€ 107.631,16
Begin 2022-02-0101.02.2022
End 2023-01-3131.01.2023
Projektdetails

Postdoc start-up grant: Sympathetic reinnervation during zebrafish heart regeneration
ID 81X3200312
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Mridula Balakrishnan
Site RheinMain
Project type Excellence Programme
Funding 63000.00€ 63.000,00
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

Postdoc start-up grant: The impact of tricuspid regurgitation on gut microbiome, immune homeostasis, and its consequences on the progression of atherosclerosis
ID 81X3500136
Institution Universität Heidelberg
Project leader Florian Sicklinger
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 79924.00€ 79.924,00
Begin 2022-07-0101.07.2022
End 2023-06-3030.06.2023
Projektdetails

Promotion of women scientists: The role of heteromeric TRPV1/4 channel complexes in endothelial mechanotransduction
ID 81X3100216
Institution Charité - Universitätsmedizin Berlin
Project leader Laura Michalick
Site Berlin
Project type Excellence Programme
Funding 77712.02€ 77.712,02
Begin 2022-03-0101.03.2022
End 2024-02-2929.02.2024
Projektdetails

Magnetic Resonance Guided Mesoscopic Insights into the Myocardium Using Parametric Mapping of the Effective Transverse Relaxation Time T2* at 7.0 Tesla in Healthy Controls and in Patients with Hypertrophic Cardiomyopathy
ID 81Z0100109
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Thoralf Niendorf
Site Berlin
Project type Partner Site Projects
Funding 110000.00€ 110.000,00
Begin 2019-01-0101.01.2019
End 2021-05-3030.05.2021
Projektdetails

Genome-wide characterization of the regulatory landscape of cardiovascular disease by CRISPR screening at single cell resolution.
ID 81Z0700112
Institution Universität zu Lübeck
Project leader Malte Spielmann
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 371972.00€ 371.972,00
Begin 2022-01-0101.01.2022
End 2025-12-3131.12.2025
Projektdetails

Translationale Immunzellphänotypisierung bei Atherosklerose und Thrombose
ID 81Z0600210
Institution Klinikum der Universität München
Project leader Konstantin Stark
Site München
Project type Partner Site Projects
Funding 473254.00€ 473.254,00
Begin 2022-03-0101.03.2022
End 2025-12-3131.12.2025
Projektdetails

AAVs for genetic manipulation of cardiovascular phenotypes
ID 81X2700241
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 44898.00€ 44.898,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

AAVs for genetic manipulation of cardiovascular phenotypes
ID 81X2200318
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Thomas Braun
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 11222.00€ 11.222,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

Analysis of the transcriptome in heart and skeletal muscle remodelling and the function of LMCD1
ID 81X2700239
Institution Universitätsklinikum Schleswig-Holstein
Project leader Lucia Kilian
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE031)
Funding 15000.00€ 15.000,00
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

Artificial Intelligence-enabled Electrocardiogram Analyses for the Development of Novel Clinical Screening Tools
ID 81X2710192
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Meraj Neyazi
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE167)
Funding 33166.00€ 33.166,00
Begin 2022-05-0101.05.2022
End 2023-05-3131.05.2023
Projektdetails

Artificial Intelligence-enabled Electrocardiogram Analyses for the Development of Novel Clinical Screening Tools
ID 81X2400154
Institution Universitätsmedizin Greifswald
Project leader Marcus Vollmer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE167)
Funding 33500.00€ 33.500,00
Begin 2022-05-0101.05.2022
End 2023-05-3131.05.2023
Projektdetails
The non-invasive biomarker electrocardiogram (ECG) is a direct representation of the electrophysiological activity of the heart, which can be affected by numerous cardiovascular diseases. While in many cases these changes can be interpreted by a medical professional, the early disease can lead to more subtle alterations of the physiological ECG, being little or not recognizable to physicians. Yet, especially the early identification of patients at risk permits an optimized personal health care and a better utilization of health care resources. Training Convolutional Neural Networks (CNN) enables the identification of subtle differences in ECGs by analyzing large amounts of data, potentiating the utility of this long-standing diagnostic modality. ECGs are standardized, cheap, easy to obtain from patients, and are already abundantly available in many databases, making them especially suitable for CNNs. Using cutting-edge CNN methods and combining data from the large population-based cohort studies Hamburg City Health Study (HCHS), Study of Health in Pomerania (SHIP), and Gutenberg Health Study (GHS), we aim to develop novel screening tools for several cardiovascular risk factors and diseases. Ultimately, this could lead to the development of instruments which can be used by a physician in medical practice. Only through a collaboration in expertise and data, a goal like this is achievable.

CMR based quantitative tissue characterisation using myocardial-mapping techniques
ID 81X2700238
Institution Universitätsklinikum Schleswig-Holstein
Project leader Inga Voges
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE133)
Funding 25000.00€ 25.000,00
Begin 2022-06-0101.06.2022
End 2025-01-3131.01.2025
Projektdetails

Deciphering the interplay of innate immune cells and platelets in cardiogenic shock by functional and proteomic analysis
ID 81X2400151
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 25870.00€ 25.870,00
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails
In this project, we aim to better understand the interplay of platelets, innate immunity and the coagulation cascade in cardiogenic and septic shock by prospectively and longitudinally profiling patients suffering from cardiogenic shock. To understand differences between sterile inflammation observed in CGS with immune responses to infection, we will include a septic shock and healthy control cohort. We combine multicolor flow cytometry panels and functional assays with unbiased large-scale methods, in particular proteomic analysis of peripheral neutrophils and platelets along with targeted multiplex analysis of blood plasma contents such as chemokines, granule proteins and coagulation factors. This approach allows for an in-depth understanding of the factors leading to immune dysregulation and organ dysfunction in the deadly setting of shock and may lead to identification of pathological pathways amenable for (immuno)therapeutic targeting.

A translational approach to catecholamine-driven acute heart failure
ID 81X2300211
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rabea Hinkel
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE192)
Funding 46000.00€ 46.000,00
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails
Die Takotsubo-Kardiomyopathie (TTC) ist ein Syndrom der akuten Herzinsuffizienz (AHF), das die Symptome eines akuten Myokardinfarkts aufgrund eines Katecholaminsturms nachahmt. Es gibt keine pathophysiologisch begründete Behandlungsmöglichkeit. Beim kardiogenen Schock sind die pharmakologischen Optionen aufgrund der Katecholamin-Kontraindikation zusätzlich eingeschränkt. Wir haben ein katecholamingetriebenes Mausmodell entwickelt, das die Merkmale der menschlichen TTC einschließlich AHF rekapituliert (mTTC). Überraschenderweise beobachteten wir eine signifikante Verbesserung der linksventrikulären Auswurffraktion durch eine einmalige Gabe des Vasopressors Endothelin-1 (ET), wodurch die Herzfunktion fast vollständig wiederhergestellt wurde, während die Myokardschädigung und das Überleben nicht beeinträchtigt wurden, aber die späte Myokardschädigung und Fibrose verbessert wurden. Darüber hinaus ergaben unsere Untersuchungen mit mTTC mehrere potenzielle Repurposing-Kandidaten mit positiven Wirkungen bei Mäusen. Da jedoch zu den pathophysiologischen Ereignissen bei der TTC möglicherweise auch ein Koronarspasmus mit mehreren Gefäßen und eine mikrovaskuläre Dysfunktion gehören, die insbesondere im Hinblick auf die ET eine Rolle spielen könnten, müssen unsere Ergebnisse in einem hämodynamisch besser übertragbaren Modell der TTC untersucht werden. Daher wollen wir unser Mausmodell der TTC in ein Schweinemodell (pTTC) übertragen, um künftig vielversprechende therapeutische Ansätze für die Takotsubo-Kardiomyopathie testen zu können.

Endomyocardial biopsy-derived living myocardial slices as a model system for inflammatory cardiomyopathy
ID 81X2800211
Institution Medizinische Hochschule Hannover
Project leader Thomas Thum
Site Extern
Project type Cooperation with External Partners
Funding 46890.24€ 46.890,24
Begin 2022-04-0101.04.2022
End 2025-12-3131.12.2025
Projektdetails

Endomyocardial biopsy-derived living myocardial slices as a model system for inflammatory cardiomyopathy
ID 81X2100273
Institution Charité - Universitätsmedizin Berlin
Project leader Carsten Tschöpe
Site Berlin
Project type Cooperation with External Partners
Funding 32682.00€ 32.682,00
Begin 2022-04-0101.04.2022
End 2025-12-3131.12.2025
Projektdetails

Epigenetic age acceleration and cardiometabolic health: a longitudinal investigation
ID 81X2400152
Institution Universitätsmedizin Greifswald
Project leader Alexander Teumer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE081)
Funding 25105.68€ 25.105,68
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails
Studies on epigenetic clocks and MetS are sparse and have been limited to cross-sectional analysis, a limited number of clocks, and small samples sizes [16, 17]. Recently, a longitudinal association between accelerated epigenetic age and MetS was reported in the Coronary Artery Risk Development in Young Adults (CARDIA) study, which involved two time points (5 years difference) in middle-age individuals [15]. To counter this research gap, we will systematically investigate epigenetic age acceleration over >14 years using three time points of the KORA study, focusing on MetS and its complications in cardiometabolic health. As most existing studies have relied on cross-sectional rather that "change"-focused longitudinal data, we will assess whether individual associations between epigenetic age acceleration and MetS change more notably during specific periods of life, e.g. in older ages. We will also analyze the "second generation" epigenetic clocks – gaining insight into specific biological mechanisms underlying metabolic dysfunction; compare our findings with the published CARDIA results; and discuss implications with regard to the German population.

Epigenomic dynamics of synthetic heart regeneration
ID 81X2200316
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Johnny Kim
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE106)
Funding 20900.00€ 20.900,00
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

The Na+/Ca2+ exchanger, not the Ca2+ uniporter, governs Ca2+ uptake in cardiac mitochondria across species from mice to men
ID 81X2800210
Institution Universitätsklinikum Würzburg
Project leader Christoph Maack
Site Extern
Project type Cooperation with External Partners
Funding 53759.00€ 53.759,00
Begin 2022-07-0101.07.2022
End 2023-09-3030.09.2023
Projektdetails
Die mitochondriale Ca2+ Aufnahme ist essenziell für die Regulation des Citratzykus während Veränderungen der kardialen Arbeitslast, z. B. während ß-adrenerger Stimulation. Beim Menschen kann das Herzzeitvolumen um das 4- bis 5-fache gesteigert werden, während in Mäusen dies nur um ca. 50% zunimmt, da diese bereits eine sehr hohe Herzfrequenz in Ruhe haben (um 600/min). Ca2+ wird rapide in Mitochondrien über den Ca2+ Uniporter (MCU) aufgenommen, aber langsam über einen Na+/Ca2+ Austauscher wieder heraustransportiert. Daher werden die steady-state Ca2+ Konzentrationen in Mitochondrien insbesondere über die Herz- (bzw. Stimulatons-) Frequenz reguliert. Da exzessive mitochondriale Ca2+ Aufnahme die sog. Permeability transtion Pore (PTP) öffnen kann, was zum Zelltod führt, ist die Regulation der steady-state mitochondrialen Ca2+Konzentration von großer Bedeutung. Im vorliegenden Projekt werden die Aktivitäten des MCU sowie des NCLX in humanen kardialen Mitochondrien mit denen in Nagetieren verglichen, in denen die Herzfrequenz höher als im Menschen ist. Basierend auf präliminären Daten spekulieren wir, dass die mitochondriale Ca2+ Aufnahme vor allem durch eine differentielle Aktivität und Expression des NCLX und weniger durch die des MCU reguliert wird. Die Ergebnisse der Studie sind von Bedeutung für die Interpretation von Daten aus Knock-out Mäusen, in denen MCU oder NCLX deletiert wurden, aber auch für therapeutische Strategien, die mitochondriale Ca2+ Homöostase zu beeinflussen.

Federated Deep Learning to Support Protheses Selection from TAVI-CT
ID 81X2800206
Institution Westfälische Wilhelms-Universität Münster
Project leader Stefan Orwat
Site Extern
Project type Digitale Technologien
Funding 4450.93€ 4.450,93
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails
Ziel des multizentrischen Projektes ist der Aufbau eines Federated Learning Konsortiums zur Bearbeitung einer klinischen Fragestellung hinsichtlich TAVI Prothesenselektionen unter Einbeziehung von 9 Kliniken aus 7 DZHK-Standorten und einem weiteren Klinikum. Neuartige Konzepte des Förderierten Lernens (FL) vollziehen ein dezentrales Trainieren von Neuronalen Netzen ohne dass die zugrundeliegenden Daten die einzelnen Standorte verlassen müssen (Datenhoheit verbleibt an den Standorten; Möglichkeit der Nutzung von Reproduzierbarkeitskohorten, die ein breites Spektrum an Patientencharakteristika und Aufnahmetechnik abbilden). Im Rahmen des Projektes soll ein erster Meilenstein hinsichtlich Datenaufbereitung von über 13.000 verfügbaren Patientendatensätzen und Implementierung einer Test-Architektur erreicht werden.

Functional assessment of atrial cardiomyocytes of Takotsubo Syndrome patients
ID 81X2710189
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Viacheslav Nikolaev
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE157)
Funding 49645.00€ 49.645,00
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

Functional characterization of two Kelch proteins in cardiomyocytes.
ID 81X2700240
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38200.00€ 38.200,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

Impact of extracorporeal circulation on the heart-brain axis: Quantification of perfusion by 4D MRI
ID 81X2300210
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Amir Moussavi
Site Göttingen
Project type Cooperation with External Partners
Funding 68599.74€ 68.599,74
Begin 2022-04-0101.04.2022
End 2024-07-3131.07.2024
Projektdetails
Die extrakorporale Zirkulation (ECC) wird routinemäßig bei herzchirurgischen Eingriffen und bei Patienten mit Herz- oder Lungenversagen zur Unterstützung der eingeschränkten kardiopulmonalen Funktion eingesetzt. In den letzten Jahren mehren sich jedoch die Hinweise auf eine veränderte zerebrale Perfusion, eine Störung der Blut-Hirn-Schranke und kognitive Beeinträchtigungen bei Patienten nach ECC-Eingriffen, die höchstwahrscheinlich auf Veränderungen der hämodynamischen Funktionen in Kombination mit Mikroembolien, vorübergehender Hypoxigenierung und Entzündungen zurückzuführen sind. In dieser Pilotstudie werden wir die Veränderungen der Herz-Hirn-Achse in einem etablierten Kleintiermodell des ECC mit Hilfe der 4D-Magnetresonanztomographie (MRT) untersuchen. Ziel dieses Projekts ist die Implementierung und Optimierung der Erfassung und Quantifizierung der zerebralen Perfusion während eines ECC bei gesunden Kaninchen. Die Methode wird zur Untersuchung der hämodynamischen Konsequenzen von ECC im Vergleich zum physiologischen Blutfluss eingesetzt. Unser externer Kooperationspartner verfügt über langjährige Erfahrungen mit kardiovaskulären Krankheitsmodellen und ECC-Szenarien in einer Vielzahl von Kleintiermodellen. Durch die Kombination ihres gut geeigneten ECC-Kaninchenmodells und unserer Expertise in der kardiovaskulären und neurologischen MRT von Kleintieren wird das Ergebnis dieses Projekts den Weg für zukünftige Studien an speziellen kardiovaskulären Krankheitsmodellen ebnen. Auf diese Weise werden wir zu einem besseren Verständnis der Mechanismen der Herz-Hirn-Achse beitragen und können individualisierte, sicherere ECC-Ansätze fördern.

Investigating the effects of metabolic rewiring on chromatin accessibility during cardiovascular progenitor specification and differentiation
ID 81X2500216
Institution Universität Heidelberg
Project leader Gergana Dobreva
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE178)
Funding 23000.00€ 23.000,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Investigating the role of central serotonin in atherosclerosis
ID 81X2100169
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Bader
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE001)
Funding 24100.00€ 24.100,00
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails

Flow-dependent regulation of autophagy and miR-126-5p trafficking in endothelial cells
ID 81X2600269
Institution Klinikum der Universität München
Project leader Donato Santovito
Site München
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

Flow-dependent regulation of autophagy and miR-126-5p trafficking in endothelial cells
ID 81X2800207
Institution Technische Universität Dresden
Project leader Henning Morawietz
Site Extern
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

Lipid nanoparticles containing microRNA-26b as therapeutic approach against atherosclerosis
ID 81X2600268
Institution Klinikum der Universität München
Project leader Kiril Bidzhekov
Site München
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2022-05-0101.05.2022
End 2023-04-3030.04.2023
Projektdetails

Lipid nanoparticles containing microRNA-26b as therapeutic approach against atherosclerosis
ID 81X2800208
Institution Universitätsklinikum Aachen
Project leader Emiel van der Vorst
Site Extern
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Deciphering the interplay of innate immune cells and platelets in cardiogenic shock by functional and proteomic analysis
ID 81X2600267
Institution Klinikum der Universität München
Project leader Rainer Kaiser
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 22130.00€ 22.130,00
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails

Epigenetic age acceleration and cardiometabolic health: a longitudinal investigation
ID 81X2600119
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Melanie Waldenberger
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE081)
Funding 22887.72€ 22.887,72
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails

Functional consequences of autonomic nervous system imbalance in the aging heart
ID 81X2600270
Institution Klinikum der Universität München
Project leader Sebastian Clauss
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE163)
Funding 29500.00€ 29.500,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Investigating diabetes-induced electrical remodeling leading to arrhythmias
ID 81X2600266
Institution Klinikum der Universität München
Project leader Sebastian Clauss
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE181)
Funding 24000.00€ 24.000,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Investigating the role of central serotonin in atherosclerosis
ID 81X2600271
Institution Klinikum der Universität München
Project leader Johan Duchene
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE001)
Funding 23900.00€ 23.900,00
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails

Prothrombotic mechanisms of autoimmune antibodies in COVID-19
ID 81X2600272
Institution Klinikum der Universität München
Project leader Konstantin Stark
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE208)
Funding 55391.00€ 55.391,00
Begin 2022-05-0101.05.2022
End 2023-09-3030.09.2023
Projektdetails

The role of thrombogenic autoantibodies in cardiovascular sequelae of post-acute COVID-19 syndrome
ID 81X2600273
Institution Klinikum der Universität München
Project leader Konstantin Stark
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE076)
Funding 24000.00€ 24.000,00
Begin 2022-05-0101.05.2022
End 2023-12-3131.12.2023
Projektdetails

Leveraging mechanisms from zebrafish to promote engraftment of transplanted human cardiomyocytes
ID 81X2200317
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Arica Beisaw
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE209)
Funding 24266.50€ 24.266,50
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Leveraging mechanisms from zebrafish to promote engraftment of transplanted human cardiomyocytes
ID 81X2710191
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Florian Weinberger
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE209)
Funding 24266.50€ 24.266,50
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Multimodal data analysis for disease course prediction in pediatric suspected myocarditis
ID 81X2100274
Institution Charité - Universitätsmedizin Berlin
Project leader Anja Hennemuth
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE206)
Funding 37291.00€ 37.291,00
Begin 2022-04-0101.04.2022
End 2024-03-0101.03.2024
Projektdetails

Proteomic profiling of human induced pluripotent stem cell-derived cardiomyocyte models of modified microtubules
ID 81X2400153
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 37686.00€ 37.686,00
Begin 2022-04-0101.04.2022
End 2024-06-3030.06.2024
Projektdetails
One of the most important microtubule (MT) modification is ¿-tubulin detyrosination (= removal of the C-terminal tyrosine), which is catalysed by vasohibin (VASH1/2) and its chaperone, small vasohibin-binding protein (SVBP). The reverse reaction (= ligation of the C-terminal tyrosine) is catalysed by the tubulin tyrosine ligase (TTL). The role of MT network during progression of cardiac diseases has gained interest in recent years with the findings that MT detyrosination and associated cardiomyocyte stiffness is markedly elevated in hypertrophic cardiomyopathy (HCM) and heart failure. To better understand the role of modified MT in the autophagy-lysososomal process, which is impaired in HCM, we recently generated human induced-pluripotent stem cell (iPSC) lines, deficient in either SVBP or TTL gene with CRISPR/Cas9 genetic tools. The goal of this collaborative project is to define the interactome of the MT-modified iPSC-derived cardiomyocyte lines. The proteomic profiling mass spectrometry programme will be divided in two steps: 1) global proteomic analysis, and 2) targeted interactome after enrichment of proteins, i.e. by co-immunoprecipitation of specific proteins which connect MTs to molecular motors, autophagosome and/or lysosome. In the past years the group of Lucie Carrier successfully implemented disease modeling in iPSC-derived cardiomyocytes in their experimental repertoire and the group of Elke Hammer is well known for long-standing experience in mass spectrometry-based proteomics and data analysis.

Proteomic profiling of human induced pluripotent stem cell-derived cardiomyocyte models of modified microtubules
ID 81X2710188
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Niels Pietsch
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 28980.00€ 28.980,00
Begin 2022-04-0101.04.2022
End 2024-06-3030.06.2024
Projektdetails

Exploiting endothelial long non-coding RNAs to promote regenerative angiogenesis in the damaged myocardium
ID 81X2200165
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ralf Brandes
Site RheinMain
Project type Internationale Kooperation
Funding 395900.00€ 395.900,00
Begin 2022-05-0101.05.2022
End 2026-04-3030.04.2026
Projektdetails

Role of CRIP1 in monocytes and macrophages in myocardial infarction
ID 81X2710190
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Olga Schweigert
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE205)
Funding 20400.00€ 20.400,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

Telomere shortening in heart failure: The role of myocardial inflammation and reactive oxygen species and the impact on myocardial regeneration
ID 81X2210124
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Wenzel Philip
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE076)
Funding 44721.12€ 44.721,12
Begin 2022-04-0101.04.2022
End 2024-06-3030.06.2024
Projektdetails

Prothrombotic mechanisms of autoimmune antibodies in COVID-19
ID 81X2210125
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Wolfram Ruf
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE208)
Funding 55320.00€ 55.320,00
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

The role of thrombogenic autoantibodies in cardiovascular sequelae of post-acute COVID-19 syndrome
ID 81X2210126
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Wolfram Ruf
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE076)
Funding 24000.00€ 24.000,00
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails

Investigating the effects of metabolic rewiring on chromatin accessibility during cardiovascular progenitor specification and differentiation
ID 81X2200163
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ingrid Fleming
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE178)
Funding 53400.00€ 53.400,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Gene editing of human iPSCs to investigate the effects of cysteinolysis in stemness
ID 81X2200162
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Sofia Iris Bibli
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 12000.00€ 12.000,00
Begin 2022-04-0101.04.2022
End 2023-06-3030.06.2023
Projektdetails

AAVs for genetic manipulation of cardiovascular phenotypes
ID 81X2200164
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ralf Brandes
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 33676.00€ 33.676,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

CMR based quantitative tissue characterisation using myocardial-mapping techniques
ID 81X2200160
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Valentina Puntmann
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE133)
Funding 24997.00€ 24.997,00
Begin 2022-06-0101.06.2022
End 2025-01-3131.01.2025
Projektdetails

Functional consequences of autonomic nervous system imbalance in the aging heart
ID 81X2200161
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Julian Uwe Gabriel Wagner
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE163)
Funding 10500.00€ 10.500,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Spatial transcriptomics of human dilated cardiomyopathy
ID 81X2100171
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 24000.00€ 24.000,00
Begin 2022-07-0101.07.2022
End 2023-12-3131.12.2023
Projektdetails

Telomere shortening in heart failure: The role of myocardial inflammation and reactive oxygen species and the impact on myocardial regeneration
ID 81X2100272
Institution Charité - Universitätsmedizin Berlin
Project leader Felicitas Escher
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE076)
Funding 29760.00€ 29.760,00
Begin 2022-04-0101.04.2022
End 2024-06-3030.06.2024
Projektdetails

Testing MuRF1 directed small molecules as a novel treatment option for HFpEF using ZSF1 obese rats
ID 81X2500217
Institution Universität Heidelberg
Project leader Siegfried Labeit
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 38200.00€ 38.200,00
Begin 2022-05-0101.05.2022
End 2023-05-3131.05.2023
Projektdetails

Uncovering cardioprotective strategies by. transcriptional profiling of immune checkpoint inhibitor-associated myocarditis (ICIM)
ID 81X2100170
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Huebner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 38200.00€ 38.200,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

TRINITY-DZHK26: A multicenter, randomized, double-blind, placebo-controlled TRial evaluating Immunosuppressive treatment in patients with chronic virus-Negative Inflammatory cardiomyopaThY
ID 81X1600215
Institution Klinikum der Universität München
Project leader Ulrich Grabmaier
Site München
Project type Clinical Studies
Funding 1041223.99€ 1.041.223,99
Begin 2022-01-0101.01.2022
End 2027-03-3131.03.2027
Projektdetails

TRINITY-DZHK26: DZHK-Biobanking
ID 81X1600216
Institution Klinikum der Universität München
Project leader Ulrich Grabmaier
Site München
Project type Clinical Studies
Funding 35639.95€ 35.639,95
Begin 2022-01-0101.01.2022
End 2027-03-3131.03.2027
Projektdetails

TRINITY-DZHK26: A multicenter, randomized, double-blind, placebo-controlled TRial evaluating Immunosuppressive treatment in patients with chronic virus-Negative Inflammatory cardiomyopaThY
ID 81X1600609
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Silvia Egert-Schwender
Site München
Project type Clinical Studies
Funding 515107.28€ 515.107,28
Begin 2022-01-0101.01.2022
End 2027-03-3131.03.2027
Projektdetails

TRINITY-DZHK26: A multicenter, randomized, double-blind, placebo-controlled TRial evaluating Immunosuppressive treatment in patients with chronic virus-Negative Inflammatory cardiomyopaThY - Biometrie
ID 81X1600704
Institution Ludwig-Maximilians-Universität München
Project leader Ulrich Mansmann
Site München
Project type Clinical Studies
Funding 41040.99€ 41.040,99
Begin 2022-01-0101.01.2022
End 2027-03-3131.03.2027
Projektdetails

Quantitative-imaging in cardiac transthyretin amyloidosis (I-CARE)
ID 81X4500103
Institution Universität Heidelberg
Project leader Fabian aus dem Siepen
Site Heidelberg/Mannheim
Project type Internationale Kooperation
Funding 279667.00€ 279.667,00
Begin 2021-12-0101.12.2021
End 2026-11-3030.11.2026
Projektdetails

Epigenomic dynamics of synthetic heart regeneration
ID 81X4300111
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE106)
Funding 24460.00€ 24.460,00
Begin 2022-01-0101.01.2022
End 2022-12-3131.12.2022
Projektdetails

The Na+/Ca2+ exchanger, not the Ca2+ uniporter, governs Ca2+ uptake in cardiac mitochondria across species from mice to men
ID 81X4300112
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Niels Voigt
Site Göttingen
Project type Cooperation with External Partners
Funding 48388.00€ 48.388,00
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

Cellular interactome changes by DLK1 activation to enhance regenerative capacity in a human heart failure model
ID 81X4300113
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Malte Tiburcy
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 19986.92€ 19.986,92
Begin 2022-04-0101.04.2022
End 2023-10-3030.10.2023
Projektdetails

Functional assessment of atrial cardiomyocytes of Takotsubo Syndrome patients
ID 81X4300114
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Daniela Hübscher
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE157)
Funding 47916.40€ 47.916,40
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

Investigating diabetes-induced electrical remodeling leading to arrhythmias
ID 81X4300115
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Niels Voigt
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE181)
Funding 24000.00€ 24.000,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Molecular characterization of uORF-mediated translation regulation in cardiomyocytes.
ID 81X4300116
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 25000.00€ 25.000,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Gene editing of human iPSCs to investigate the effects of cysteinolysis in stemness
ID 81X4300117
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 35600.00€ 35.600,00
Begin 2022-04-0101.04.2022
End 2023-06-3030.06.2023
Projektdetails

Cellular interactome changes by DLK1 activation to enhance regenerative capacity in a human heart failure model
ID 81X4500104
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 76100.00€ 76.100,00
Begin 2022-04-0101.04.2022
End 2023-10-3030.10.2023
Projektdetails

Role of CRIP1 in monocytes and macrophages in myocardial infarction
ID 81X4500105
Institution Universität Heidelberg
Project leader Josephine Bock
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE205)
Funding 46266.00€ 46.266,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

Analysis of the transcriptome in heart and skeletal muscle remodelling and the function of LMCD1
ID 81X4500106
Institution Universität Heidelberg
Project leader Jan Haas
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 15000.00€ 15.000,00
Begin 2022-04-0101.04.2022
End 2023-09-3030.09.2023
Projektdetails

Functional characterization of two Kelch proteins in cardiomyocytes
ID 81X4500107
Institution Universität Heidelberg
Project leader Ashraf Yusuf Rangrez
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 38200.00€ 38.200,00
Begin 2022-04-0101.04.2022
End 2024-03-3131.03.2024
Projektdetails

Molecular characterization of uORF-mediated translation regulation in cardiomyocytes.
ID 81X4500108
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 25000.00€ 25.000,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

Multimodal data analysis for disease course prediction in pediatric suspected myocarditis
ID 81X4300118
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE206)
Funding 37709.00€ 37.709,00
Begin 2022-04-0101.04.2022
End 2024-03-0101.03.2024
Projektdetails

Real-time MRI-guided targeted endomyocardial biopsy of radiofrequency ablation lesions in a porcine model
ID 81X4300119
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Christina Unterberg-Buchwald
Site Göttingen
Project type Translational Research Project
Funding 739401.49€ 739.401,49
Begin 2022-04-0101.04.2022
End 2025-03-3131.03.2025
Projektdetails

Uncovering cardioprotective strategies by. transcriptional profiling of immune checkpoint inhibitor-associated myocarditis (ICIM)
ID 81X4500109
Institution Universität Heidelberg
Project leader Lorenz Lehmann
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 38200.00€ 38.200,00
Begin 2022-04-0101.04.2022
End 2023-03-3131.03.2023
Projektdetails

A translational approach to catecholamine-driven acute heart failure
ID 81X4500110
Institution Universität Heidelberg
Project leader Bastian Bruns
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE192)
Funding 30400.00€ 30.400,00
Begin 2022-04-0101.04.2022
End 2023-12-3131.12.2023
Projektdetails

Identification of biomarkers for non-stenosing allograft vasculopathy after heart transplantation
ID 81X2710193
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
Funding 42220.40€ 42.220,40
Begin 2022-07-0101.07.2022
End 2023-07-3131.07.2023
Projektdetails

Identification of biomarkers for non-stenosing allograft vasculopathy after heart transplantation
ID 81X2100307
Institution Deutsches Herzzentrum Berlin
Project leader Isabell Just-Lauer
Site Berlin
Project type Shared Expertise (SE)
Funding 31457.00€ 31.457,00
Begin 2022-08-0101.08.2022
End 2023-07-3131.07.2023
Projektdetails

Testing MuRF1 directed small moleculaes as a novel Treatment Option for HFpEF using ZSF1 obese rats
ID 81X2800212
Institution Technische Universität Dresden
Project leader Volker Adams
Site München
Project type Cooperation with External Partners
Funding 38200.00€ 38.200,00
Begin 2022-06-0101.06.2022
End 2023-05-3131.05.2023
Projektdetails

CABA-HFPEF-DZHK27: CAtheter-Based Ablation of atrial fibrillation vs. conventional treatment in patients with Heart Failure with Preserved Ejection Fraction
ID 81X1100227
Institution Charité - Universitätsmedizin Berlin
Project leader Abdul Parwani
Site Berlin
Project type Clinical Studies
Funding 2881589.00€ 2.881.589,00
Begin 2022-07-0101.07.2022
End 2027-07-3131.07.2027
Projektdetails

CABA-HFPEF-DZHK27: DZHK-Biobanking
ID 81X1100228
Institution Charité - Universitätsmedizin Berlin
Project leader Abdul Parwani
Site Berlin
Project type Clinical Studies
Funding 238723.00€ 238.723,00
Begin 2022-07-0101.07.2022
End 2027-07-3131.07.2027
Projektdetails

Promotion of women scientists: Endosomal transport regulators in metabolic cardiovascular diseases
ID 81X3600104
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Anja Zeigerer
Site München
Project type Excellence Programme
Funding 72900.00€ 72.900,00
Begin 2022-07-0101.07.2022
End 2023-12-3131.12.2023
Projektdetails

CABA-HFPEF-DZHK27: Statistik
ID 81X1300126
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Clinical Studies
Funding 146736.00€ 146.736,00
Begin 2022-08-0101.08.2022
End 2027-07-3131.07.2027
Projektdetails

Spatial transcriptomics of human dilated cardiomyopathy
ID 81X2600120
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Matthias Heinig
Site München
Project type Shared Expertise (SE)
Funding 24000.00€ 24.000,00
Begin 2022-09-0101.09.2022
End 2023-12-3131.12.2023
Projektdetails

Determination of sphingosine-1-phosphate, ceramides, sphingomyelins and phosphatidylcholines in the population-based cohorts SHIP-START-1 and SHIP-TREND-0 and their association with cardiovascular diseases and mortality.
ID 81X2400155
Institution Universitätsmedizin Greifswald
Project leader Stefan Gross
Site Greifswald
Project type Cooperation with External Partners
Funding 14647.37€ 14.647,37
Begin 2022-09-0101.09.2022
End 2024-05-3131.05.2024
Projektdetails
According to the World Health Organization 17.9 million people die due to cardiovascular diseases (CVD) each year, this being the leading cause of death (31%) worldwide. The aim of the current project is to determine plasma levels of shingosine-1-phosphate, ceramides, sphingomyelins and phosphatidylcholines in two independent population-based cohorts of the Study of Health in Pomerania (SHIP). We will use the first follow-up examination of the initial SHIP-START cohort, SHIP-START-1, and the baseline examination of the independent SHIP-TREND cohort, SHIP-TREND-0. This will enable us to calculate e.g. the two risk scores CERT1 and CERT2 in our cohort and we will investigate how these biomarkers levels and scores are associated with cardiovascular diseases like prevalent CVD, CHD, atherosclerosis or myocardial infarction as well as all-cause and cardiovascular mortality in our two independent cohorts.

Postdoc start-up grant on advancing digital aspects: HoloHeart – Development of a toolkit for a virtual interactive experience of the human heart
ID 81X3500137
Institution Universität Heidelberg
Project leader Ann-Kathrin Rahm
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2022-10-0101.10.2022
End 2023-09-3030.09.2023
Projektdetails

Targeting maladaptive cardiac hypertrophy in cardiomyopathy and heart failure
ID 81Z0500109
Institution Universität Heidelberg
Project leader Norbert Frey
Site Heidelberg/Mannheim
Project type Partner Site Projects
Funding 1435608.66€ 1.435.608,66
Begin 2022-10-0101.10.2022
End 2025-12-3131.12.2025
Projektdetails

Promotion of women scientists: Interleukin-17A mediated inflammation in myocardial infarction in a mouse model of psoriasis-like skin disease
ID 81X3210106
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Susanne Karbach
Site RheinMain
Project type Excellence Programme
Funding 78013.92€ 78.013,92
Begin 2022-09-0101.09.2022
End 2024-08-3131.08.2024
Projektdetails

Rotation grant: Advanced echocardiography in patients undergoing transcatheter aortic valve implantation (TAVI)
ID 81X3710115
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Lisa Voigtländer
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 90396.00€ 90.396,00
Begin 2022-11-0101.11.2022
End 2023-10-3131.10.2023
Projektdetails

Postdoc start-up grant on advancing digital aspects: Automatic species-independent myocardial segmentation of real-time cardiovascular MRI
ID 81X3300203
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Amir Moussavi
Site Berlin
Project type Excellence Programme
Funding 78244.66€ 78.244,66
Begin 2022-10-0101.10.2022
End 2024-03-3131.03.2024
Projektdetails
Die Echtzeit-MRT (RT-MRT) ist eine vielversprechende neue Bildgebungstechnik, die eine frei atmende kardiovaskuläre MRT ohne Synchronisierung mit einem EKG ermöglicht, wie sowohl in vorläufigen translationalen als auch klinischen Studien gezeigt wurde. Der ergänzende Schritt zur Anwendbarkeit der Echtzeit-MRT in der klinischen und translationalen Routine ist jedoch eine schnelle und robuste Pipeline zur Bewertung der Herzfunktion anhand der aufgenommenen Bilder, was aufgrund der großen Datenmenge, der geringeren räumlichen Auflösung und des geringeren Gewebekontrasts zwischen Myokard und Blut in den Herzkammern eine Herausforderung darstellt. Soweit wir wissen, gibt es nur ein kommerziell erhältliches Softwarepaket für die Quantifizierung von Echtzeit-MRT, das leider auf menschliche Datensätze beschränkt ist. Ziel dieses Projekts ist die Entwicklung und Etablierung eines (halb-)automatischen, speziesunabhängigen Algorithmus zur Bewertung der Herzmorphologie und -funktion mittels Echtzeit-MRT in einer Vielzahl von Tiermodellen und Menschen. Wir werden einen neuartigen frequenzbasierten Ansatz verfolgen, um automatisch kardiorespiratorische Phasen und Myokardkonturen (Endokard und Epikard) zu erkennen. Der entwickelte Algorithmus zur Myokardsegmentierung wird an Datensätzen gesunder menschlicher Probanden und Rhesusaffen (nicht-menschlicher Primaten=NHP) mit induziertem Myokardinfarkt entwickelt und optimiert, die zuvor im Rahmen eines gemeinsamen DZHK-Forschungsprojekts erhoben wurden. Das Projekt verspricht, einen geeigneten Quantifizierungsansatz für die Beurteilung der Herzfunktion mittels Echtzeit-MRT zu liefern.

GECT-DZHK28: DZHK-Biobanking
ID 81X1100230
Institution Charité - Universitätsmedizin Berlin
Project leader Boris Schmitt
Site Berlin
Project type Clinical Studies
Funding 978.42€ 978,42
Begin 2022-09-0101.09.2022
End 2024-12-3131.12.2024
Projektdetails

GECT-DZHK28: A First-in-Human Feasibility Study to Evaluate the Safety (and Short term Effectiveness) of the Autologous GrOwnValve Transcatheter Pulmonary Heart Valve
ID 81X1100229
Institution Charité - Universitätsmedizin Berlin
Project leader Boris Schmitt
Site Berlin
Project type Clinical Studies
Funding 417987.72€ 417.987,72
Begin 2022-09-0101.09.2022
End 2030-02-2828.02.2030
Projektdetails

Postdoc start-up grant on advancing digital aspects: Digital twins for diagnosis and treatment-planning of patients with complex univentricular physiology
ID 81X3100217
Institution Charité - Universitätsmedizin Berlin
Project leader Jan Brüning
Site Berlin
Project type Excellence Programme
Funding 69173.93€ 69.173,93
Begin 2022-10-0101.10.2022
End 2023-12-3131.12.2023
Projektdetails

Determination of sphingosine-1-phosphate, ceramides, sphingomyelins and phosphatidylcholines in the population-based cohorts SHIP-START-1 and SHIP-TREND-0 and their association with cardiovascular diseases and mortality
ID 81X2800213
Institution Universitätsklinikum Jena
Project leader Gräler Markus
Site Extern
Project type Cooperation with External Partners
Funding 65484.00€ 65.484,00
Begin 2022-09-0101.09.2022
End 2024-05-3131.05.2024
Projektdetails
According to the World Health Organization 17.9 million people die due to cardiovascular diseases (CVD) each year, this being the leading cause of death (31%) worldwide. The aim of the current project is to determine plasma levels of shingosine-1-phosphate, ceramides, sphingomyelins and phosphatidylcholines in two independent population-based cohorts of the Study of Health in Pomerania (SHIP). We will use the first follow-up examination of the initial SHIP-START cohort, SHIP-START-1, and the baseline examination of the independent SHIP-TREND cohort, SHIP-TREND-0. This will enable us to calculate e.g. the two risk scores CERT1 and CERT2 in our cohort and we will investigate how these biomarkers levels and scores are associated with cardiovascular diseases like prevalent CVD, CHD, atherosclerosis or myocardial infarction as well as all-cause and cardiovascular mortality in our two independent cohorts.

Clinician scientist programme: Assessment of cardiac wasting-induced cardiomyopathy with cardiac MRI in advanced cancer patients
ID 81X3100218
Institution Charité - Universitätsmedizin Berlin
Project leader Sara Hadzibegovic
Site Berlin
Project type Excellence Programme
Funding 149995.02€ 149.995,02
Begin 2022-10-0101.10.2022
End 2025-09-3030.09.2025
Projektdetails
The aim of this translational study is to research the underlying pathophysiology of cardiac wasting-induced cardiomyopathy in advanced stage cancer patients. A comprehensive assessment including cardiac MRI, biobanking and cardiorespiratory reflex physiology will be performed in 96 advanced stage cancer patients (without severe CV disease or active infection) and compared to 24 healthy controls and 48 patients with heart failure (HF) (all similar age and a 50:50 male/female ratio). The status of all patients and controls will be reassessed after 4 and 8 months. This project will provide new insights for further translational research projects and clinical therapeutic developments in cardio-oncology.

Postdoc start-up grant: mTOR in diabetic cardiomyopathy
ID 81X3100219
Institution Charité - Universitätsmedizin Berlin
Project leader Christian Oeing
Site Berlin
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2022-10-0101.10.2022
End 2023-09-3030.09.2023
Projektdetails
The protein complex mechanistic target of rapamycin (mTOR) is involved in the development of many different diseases. In the failing heart mTOR is known to be hyperactivated, but its role in the diabetic heart remains controversial mostly due to lack of adequate models. Complete knockout models or transgenic overexpression models remain rather artificial. In data generated in the U.S. and Berlin, we developed a novel genetic mouse model, in which a more physiological fine-tuning of the mTOR complex can be achieved to regulate mTOR in both directions – to inhibit or hyperactivate. But, this mechanism is only active when the cell is exposed to a pathological stimulus. The healthy heart remains intact. In this project we study the influence of mTOR signaling in the diabetic heart. We already found exciting insights showing that mTOR (hyper-)activation contributes to a worsening of diabetic cardiomyopathy while mTOR suppression in the diabetic heart minimized disease progression. Altered autophagy and a shift in cell metabolism might be responsible for this mechanism. This we would like to investigate further, test new drugs to exploit this cellular mechanism to ultimately contribute to find a novel therapy for all the patients suffering from diabetes.

Rotation grant: Biomarker- and cardiac-MRI-based identification of risk factors for functional impairment and structural remodeling in patients with ventricular arrhythmias
ID 81X3500138
Institution Universität Heidelberg
Project leader Janek Salatzki
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 86859.87€ 86.859,87
Begin 2022-11-0101.11.2022
End 2023-10-3131.10.2023
Projektdetails

Junior research group: Circadian rhythms and metabolism in heart failure: from molecular insights to therapeutic targets
ID 81X3200313
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Pieterjan Dierickx
Site RheinMain
Project type Excellence Programme
Funding 825000.00€ 825.000,00
Begin 2023-01-0101.01.2023
End 2025-12-3131.12.2025
Projektdetails

Junior research group: Immune modulatory effects of aldosterone in pulmonary hypertension-associated lung vascular maladaptation’s
ID 81X3100305
Institution Deutsches Herzzentrum Berlin
Project leader Jana Grune
Site Berlin
Project type Excellence Programme
Funding 786246.71€ 786.246,71
Begin 2022-12-0101.12.2022
End 2025-11-3030.11.2025
Projektdetails

Rotation grant: A randomized, controlled trial to study the effect of colchicine in patients with CHIP mutations and heart failure with reduced ejection fraction (HFrEF) - CHIP-HF
ID 81X3200122
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Klara Kirschbaum
Site RheinMain
Project type Excellence Programme
Funding 89400.00€ 89.400,00
Begin 2022-11-0101.11.2022
End 2023-10-3131.10.2023
Projektdetails

Clinician Scientist Programm: Modulation of coronary sinus pressure to develop a new treatment for microvascular disease.
ID 81X3210107
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Helen Ullrich
Site RheinMain
Project type Excellence Programme
Funding 151832.23€ 151.832,23
Begin 2022-11-0101.11.2022
End 2025-08-1515.08.2025
Projektdetails

Postdoc start-up grant: The role of lymphatic cyclooxygenases in cardiovascular disease
ID 81X3710116
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Sandra Hemkemeyer
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2022-12-0101.12.2022
End 2024-02-2929.02.2024
Projektdetails

Postdoc start-up grant on advancing digital aspects: Machine learning-based prognosis: assessment of novel CMR features in a prospective patient cohort
ID 81X3100220
Institution Charité - Universitätsmedizin Berlin
Project leader Djawid Hashemi
Site Berlin
Project type Excellence Programme
Funding 75482.43€ 75.482,43
Begin 2022-12-0101.12.2022
End 2024-05-3131.05.2024
Projektdetails
Kernelemente der ärztlichen Versorgung von Patient*innen sind eine Diagnose und die darauf aufbauende Therapie. Kränkere Patient*innen von weniger Kranken oder Patient*innen mit schlechterer von denen mit besserer Prognose unterscheiden zu können, gehört zu den grundständigen ärztlichen Fertigkeiten, die von zentraler Bedeutung sind, wenn es beispielsweise darum geht, Therapiestrategien zu intensivieren oder zu verändern. Bilddaten gehören in der Kardiologie zu den zentralen Instrumenten der Diagnostik der Patient*innen, um genau diese Unterschiede besser herauszuarbeiten. Traditionell werden aus den erhobenen Bilddaten einfache, häufig messbare Werte herausgelesen, die dann in der Folge in die klinischen Entscheidungen und Therapiestrategien eingehen. Gerade Bilder mittels MRT des Herzens bieten eine hohe Dichte and zeitlicher und räumlicher Information, sodass gerade diese Bilder das Potenzial bieten, aus ihnen mehr abzuleiten als traditionelle Messwerte. Mittels künstlicher Intelligenz (KI) kann aus erhobenen Bildern mehr erkannt werden. Ebenso können Algorithmen lernen Bilddaten von Patienten mit anderen Daten dieser Patienten, wie Erkrankungen, Krankenhausaufenthalte oder Todeszeitpunkte mit genau diesen Bilddaten assoziiert sind. Je besser man den Algorithmus der Daten trainiert, desto besser ist er auch darin, korrekt klinische Ereignisse wie Tod oder Krankenhausaufenthalte zu prognostizieren. Die Observationsstudie BeLOVE, welche Patient*innen mit einem deutlich erhöhten kardiovaskulären Risikoprofil einschließt, bietet die Möglichkeit in einem bedeutenden Maß Herz-MRT-Daten auszuwerten und damit ein Prognosemodell zur Risikostratifizierung von Kardiologie-Patient*innen zu entwickeln sowie zu validieren. Die Entwicklung und Überprüfung auf die Verlässlichkeit eines solchen KI-Ansatzes zur Prognosebeurteilung von Patient*innen ist das Hauptziel dieses Forschungsvorhabens.

Intercepting post-BURN INjury cardiac muscle wastinG and HEART failure: deciphering the molecular pathomechanisms for diagnostic and therapeutic intervention development
ID 81X2400156
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Internationale Kooperation
Funding 244051.00€ 244.051,00
Begin 2023-01-0101.01.2023
End 2026-08-3131.08.2026
Projektdetails

Rotation grant: The role of the nuclear receptor ROR? in the metabolic stress response of the heart
ID 81X3500139
Institution Universität Heidelberg
Project leader Daniel Finke
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 112192.63€ 112.192,63
Begin 2023-01-0101.01.2023
End 2024-03-3131.03.2024
Projektdetails

Postdoc start-up grant on advancing digital aspects: Towards a non-invasive diagnostic classifier in transthyretin amyloidosis
ID 81X3500140
Institution Universität Heidelberg
Project leader Jennifer Furkel
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-01-0101.01.2023
End 2024-03-3131.03.2024
Projektdetails

Postdoc start-up grant: Characterizing the role of the RNA-binding protein Mbnl2 during cardiac remodeling
ID 81X3500141
Institution Universität Heidelberg
Project leader Maja Bencun
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 79999.17€ 79.999,17
Begin 2023-01-0101.01.2023
End 2024-04-3030.04.2024
Projektdetails

PRIMARY - Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for >65 Year-olds
ID 81X1100231
Institution Charité - Universitätsmedizin Berlin
Project leader Volkmar Falk
Site Berlin
Project type Clinical Studies
Funding 1364596.00€ 1.364.596,00
Begin 2023-01-0101.01.2023
End 2027-06-3030.06.2027
Projektdetails

DZG Innovation Fund: Cell type specific targeting for future in vivo delivery in cell and gene therapy
ID 81X2700242
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type DZG Innovation Cluster
Funding 70333.32€ 70.333,32
Begin 2023-01-0101.01.2023
End 2025-01-3131.01.2025
Projektdetails

Rotation grant: Cardiometabolic hemostasis during aerobic fitness training early after acute ischemic stroke
ID 81X3100221
Institution Charité - Universitätsmedizin Berlin
Project leader Alexander Heinrich Nave
Site Berlin
Project type Excellence Programme
Funding 95938.01€ 95.938,01
Begin 2023-01-0101.01.2023
End 2024-12-3131.12.2024
Projektdetails

DZG Innovation Fund: Cell type specific targeting for future in vivo delivery in cell and gene therapy
ID 81X4500111
Institution Universität Heidelberg
Project leader Johannes Backs
Site Heidelberg/Mannheim
Project type DZG Innovation Cluster
Funding 70333.32€ 70.333,32
Begin 2023-01-0101.01.2023
End 2025-01-3131.01.2025
Projektdetails

Postdoc start-up grant: Exploiting long non-coding RNAs as targets and templates in RNA therapy for vascular disease
ID 81X3600609
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Francesca Fasolo
Site München
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-02-0101.02.2023
End 2024-01-3131.01.2024
Projektdetails

DZG Innovation Fund: Cell type specific targeting for future in vivo delivery in cell and gene therapy
ID 81X2600631
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Alessandra Moretti
Site München
Project type DZG Innovation Cluster
Funding 70333.33€ 70.333,33
Begin 2023-02-0101.02.2023
End 2025-01-3131.01.2025
Projektdetails

Intercepting post-BURN INjury cardiac muscle wastinG and HEART failure: deciphering the molecular pathomechanisms for diagnostic and therapeutic intervention development
ID 81X4500112
Institution Universität Heidelberg
Project leader Patrick Most
Site Heidelberg/Mannheim
Project type Internationale Kooperation
Funding 588657.04€ 588.657,04
Begin 2023-02-0101.02.2023
End 2026-08-3131.08.2026
Projektdetails

Promotion of women scientists: Glutamine rewiring to proline biosynthesis is indispensable for endothelial cell growth
ID 81X3200123
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Anastasia Kyselova
Site RheinMain
Project type Excellence Programme
Funding 79775.00€ 79.775,00
Begin 2023-02-0101.02.2023
End 2024-01-3131.01.2024
Projektdetails

Characterization of cerebrovascular pathologies due to Phactr1 or NEMO deletion using light-sheet microscopy of the murine vasculature
ID 81X2700139
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE211)
Funding 55000.00€ 55.000,00
Begin 2023-03-0101.03.2023
End 2025-02-2828.02.2025
Projektdetails

Ceramide dependent lipotoxicity in calcific aortic valve disease
ID 81X1700114
Institution Universität zu Lübeck
Project leader Elias Rawish
Site Hamburg/Kiel/Lübeck
Project type Daten- und Probennutzung
Funding 25000.00€ 25.000,00
Begin 2023-03-0101.03.2023
End 2024-08-3131.08.2024
Projektdetails

Characterization of cerebrovascular pathologies due to Phactr1 or NEMO deletion using light-sheet microscopy of the murine vasculature
ID 81X2300301
Institution Georg-August-Universität Göttingen
Project leader Jan Huisken
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE211)
Funding 55000.00€ 55.000,00
Begin 2023-03-0101.03.2023
End 2025-02-2828.02.2025
Projektdetails

Clinician scientist programme: Re-EvALuating the diagnosis and prognosis of Myocardial Infarction type 1 (REAL-MI)
ID 81X3600225
Institution Klinikum der Universität München
Project leader Lauren Sams
Site München
Project type Excellence Programme
Funding 124414.50€ 124.414,50
Begin 2023-03-0101.03.2023
End 2025-02-2828.02.2025
Projektdetails

TRP starter grant: Inhibition of ADAMTS7 by siRNA to prevent restenosis: first steps towards the preclinical study
ID 81X2700140
Institution Universität zu Lübeck
Project leader Zouhair Aherrahrou
Site Hamburg/Kiel/Lübeck
Project type Translational Research Project
Funding 147747.00€ 147.747,00
Begin 2023-03-0101.03.2023
End 2024-08-3131.08.2024
Projektdetails

Junior research group: Sex dimorphism in human cardiac health and disease
ID 81X3100222
Institution Charité - Universitätsmedizin Berlin
Project leader Claudia Crocini
Site Berlin
Project type Excellence Programme
Funding 824630.36€ 824.630,36
Begin 2023-03-0101.03.2023
End 2026-02-2828.02.2026
Projektdetails

TRP starter grant: Cardiomyocyte-specific endogenous transcriptional restoration of KLF15 by nuclease-dead Cas9 as a novel therapeutic concept in heart failure
ID 81X4300129
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Translational Research Project
Funding 75077.00€ 75.077,00
Begin 2023-03-0101.03.2023
End 2024-11-3030.11.2024
Projektdetails

Arrhythmogenic effects of neutrophil-expressed target proteins on cardiomyocyte electrophysiology
ID 81X2100275
Institution Charité - Universitätsmedizin Berlin
Project leader Jana Grune
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE181)
Funding 35000.00€ 35.000,00
Begin 2023-04-0101.04.2023
End 2024-03-3131.03.2024
Projektdetails

A20 isoforms as potential novel biomarkers and therapeutic targets for acute myocardial infarction
ID 81X2100276
Institution Charité - Universitätsmedizin Berlin
Project leader Adelheid Kratzer
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 37500.00€ 37.500,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Investigating Huntington’s disease (HD) related cardiomyopathy in a human iPSC-based 3D neurocardiac interface model
ID 81X2100174
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sebastian Diecke
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 37500.00€ 37.500,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Targeting the microbiota-immune interface with propionate to alleviate cardiovascular risk in CKD
ID 81X2100172
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Nicola Wilck
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE199)
Funding 29500.00€ 29.500,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Cardiac inflammation after ischemic stroke – understanding stroke as a systemic disease
ID 81X2100277
Institution Charité - Universitätsmedizin Berlin
Project leader Karen Gertz
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE205)
Funding 36500.02€ 36.500,02
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Cardiac inflammation after ischemic stroke – understanding stroke as a systemic disease
ID 81X4500113
Institution Universität Heidelberg
Project leader Florian Leuschner
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE205)
Funding 36500.00€ 36.500,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Analysis of hemodynamics using cardiovascular magnetic resonance at ultrahigh field strengths
ID 81X2100280
Institution Charité - Universitätsmedizin Berlin
Project leader Jeanette Schulz-Menger
Site Berlin
Project type Cooperation with External Partners
Funding 35075.91€ 35.075,91
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

CRIP1: A potential marker to predict COVID-19 severity and its association to hypertension and CVDs
ID 81X2710194
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Jorge Enrique Duque-Escobar
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 20112.00€ 20.112,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Extending the DNA-Methylation sample of the SHIP-Trend cohort to foster cardiovascular research
ID 81X2400157
Institution Universitätsmedizin Greifswald
Project leader Alexander Teumer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE041)
Funding 22948.98€ 22.948,98
Begin 2023-04-0101.04.2023
End 2024-07-3131.07.2024
Projektdetails

To unravel the mechanism of action of JAK1 inhibition in a desmin-related cardiomyopathy model
ID 81X2710195
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Sonia Singh
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE099)
Funding 23500.00€ 23.500,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

CRIP1: A potential marker to predict COVID-19 severity and its association to hypertension and CVDs
ID 81X2400158
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 29888.00€ 29.888,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

To unravel the mechanism of action of JAK1 inhibition in a desmin-related cardiomyopathy model
ID 81X2400159
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE099)
Funding 26212.00€ 26.212,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Targeting the microbiota-immune interface with propionate to alleviate cardiovascular risk in CKD
ID 81X2600419
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE199)
Funding 45500.00€ 45.500,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Regulation of integrated disc assembly and contribution to mechano-transduction in cardiac health and disease
ID 81X2710196
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Janice Raabe
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE213)
Funding 25000.00€ 25.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Intercellular communication in Noonan syndrome-associated cardiac hypertrophy
ID 81X4500114
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 40200.00€ 40.200,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Regulation of intercalated disc assembly and contribution to mechano-transduction in cardiac health and disease
ID 81X2400161
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE213)
Funding 25000.00€ 25.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Investigation of vesicular transport of damaged proteins in cardiomyocytes during pathological remodeling
ID 81X2400160
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE213)
Funding 39120.00€ 39.120,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Characterisation of the genetic background of patients of the Greifswald DCM cohort by gene panel sequencing – A prerequisite for integrated analysis of multi-omics data with clinical phentoypes
ID 81X2400162
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE031)
Funding 14350.00€ 14.350,00
Begin 2023-04-0101.04.2023
End 2024-03-3131.03.2024
Projektdetails

Regulators of postischemic neovascularization and their role in ischemic stroke
ID 81X2200319
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Stefan Offermanns
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE075)
Funding 21480.00€ 21.480,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Arrhythmogenic effects of neutrophil-expressed target proteins on cardiomyocyte electrophysiology.
ID 81X4300120
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Niels Voigt
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE181)
Funding 40000.00€ 40.000,00
Begin 2023-04-0101.04.2023
End 2024-03-3131.03.2024
Projektdetails

Intercellular communication in Noonan syndrome-associated cardiac hypertrophy
ID 81X4300121
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 39800.00€ 39.800,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Contribution of protein kinase D1 to the functional crosstalk between cardiomyocytes and fibroblasts
ID 81X2400163
Institution Universitätsmedizin Greifswald
Project leader Jens Fielitz
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE080)
Funding 50000.00€ 50.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Cluster-based phenotypes of left ventricular wall thickness: can they predict incident CVD?
ID 81X2400164
Institution Universitätsmedizin Greifswald
Project leader Till Ittermann
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE081)
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Investigation of vascular network development in innervated cardiac muscle tissue
ID 81X2100173
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Sebastian Diecke
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE168)
Funding 40000.00€ 40.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Inflammation – thrombosis crosstalk in patients with high cardiovascular risk
ID 81X2800217
Institution Universitätsklinikum Aachen
Project leader Heidi Noels
Site Extern
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Macrophage Metabolism in Cardiac Remodelling after Ischemic Tissue Damage
ID 81X2600274
Institution Klinikum der Universität München
Project leader Christian Schulz
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE130)
Funding 24175.00€ 24.175,00
Begin 2023-04-0101.04.2023
End 2024-08-3131.08.2024
Projektdetails

Effects of the erythroid-ACKR1 polymorphism in ANCA-associated vasculitis
ID 81X2600275
Institution Klinikum der Universität München
Project leader Sabine Steffens
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE219)
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-07-3131.07.2024
Projektdetails

Light sheet imaging of nonclassical monocytes in the healthy young, aged or stressed mouse heart
ID 81X2600276
Institution Klinikum der Universität München
Project leader Sabine Steffens
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE211)
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-07-3131.07.2024
Projektdetails

The influence of cardiac-specific overexpression of immune checkpoints on the pathogenesis of myocarditis.
ID 81X4500115
Institution Universität Heidelberg
Project leader Ziya Kaya
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 38200.00€ 38.200,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Molecular characterization of mTORC1-mediated metabolic remodeling in cardiomyocytes
ID 81X4500116
Institution Universität Heidelberg
Project leader Mirko Völkers
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE210)
Funding 38200.00€ 38.200,00
Begin 2023-04-0101.04.2023
End 2024-07-3131.07.2024
Projektdetails

Functional characterization of atrial cardiomyopathy in a porcine AF model via automated patch-clamp
ID 81X4500117
Institution Universität Heidelberg
Project leader Constanze Schmidt
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE181)
Funding 37136.00€ 37.136,00
Begin 2023-04-0101.04.2023
End 2024-03-3131.03.2024
Projektdetails

Characterisation of the genetic background of patients of the Greifswald DCM cohort by gene panel sequencing – A prerequisite for integrated analysis of multi-omics data with clinical phentoypes
ID 81X4500118
Institution Universität Heidelberg
Project leader Jan Haas
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 57400.00€ 57.400,00
Begin 2023-04-0101.04.2023
End 2024-03-3131.03.2024
Projektdetails

MMLV- and AAV-mediated CRISPR perturbation in cardiac cells
ID 81X4500119
Institution Universität Heidelberg
Project leader Ralf Gilsbach
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE047)
Funding 38200.00€ 38.200,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Identification and characterization of enhancers in cardiac remodeling
ID 81X4500120
Institution Universität Heidelberg
Project leader Lorenz Lehmann
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE182)
Funding 20500.00€ 20.500,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Molecular characterization of mTORC1-mediated metabolic remodeling in cardiomyocytes
ID 81X2100278
Institution Charité - Universitätsmedizin Berlin
Project leader Gabriele Schiattarella
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE210)
Funding 38200.15€ 38.200,15
Begin 2023-04-0101.04.2023
End 2024-07-3131.07.2024
Projektdetails

Effects of the erythroid-ACKR1 polymorphism in ANCA-associated vasculitis
ID 81X2100279
Institution Charité - Universitätsmedizin Berlin
Project leader Adrian Schreiber
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE219)
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-07-3131.07.2024
Projektdetails

Investigation of vesicular transport of damaged proteins in cardiomyocytes during pathological remodeling
ID 81X4300122
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE213)
Funding 39120.00€ 39.120,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

AAV-mediated SOX9 deletion as a therapeutic approach after MI
ID 81X2700243
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38200.00€ 38.200,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Regulators of postischemic neovascularization and their role in ischemic stroke
ID 81X2700141
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE075)
Funding 25614.00€ 25.614,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

The influence of cardiac-specific overexpression of immune checkpoints on the pathogenesis of myocarditis.
ID 81X2700244
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38200.00€ 38.200,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

T P V R (Transcatheter Pulmonary valve replacement) with biodegradable stent
ID 81X2700245
Institution Universitätsklinikum Schleswig-Holstein
Project leader Georg Lutter
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE048)
Funding 20750.00€ 20.750,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Cluster-based phenotypes of left ventricular wall thickness: can they predict incident CVD?
ID 81X2600707
Institution Ludwig-Maximilians-Universität München
Project leader Susanne Rospleszcz
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE081)
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

MMLV- and AAV-mediated CRISPR perturbation in cardiac cells
ID 81X2600420
Institution Technische Universität München
Project leader Stefan Engelhardt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE047)
Funding 38200.00€ 38.200,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

AAVs for enhanced y-globin translation through synthetic lncRNA
ID 81X2700246
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 28350.00€ 28.350,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Identification and characterization of enhancers in cardiac remodeling
ID 81X2700247
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE182)
Funding 20000.00€ 20.000,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

TRP starter grant: Cardiomyocyte-specific endogenous transcriptional restoration of KLF15 by nuclease-dead Cas9 as a novel therapeutic concept in heart failure
ID 81X4500121
Institution Universität Heidelberg
Project leader Lorenz Lehmann
Site Heidelberg/Mannheim
Project type Translational Research Project
Funding 23766.80€ 23.766,80
Begin 2023-04-0101.04.2023
End 2024-11-3030.11.2024
Projektdetails

A20 isoforms as potential novel biomarkers and therapeutic targets for acute myocardial infarction
ID 81X4300123
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Antje Ebert
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 37500.00€ 37.500,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Identifying molecular mechanisms counteracting catecholamine-induced cardiotoxicity
ID 81X4300124
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Thomas Meyer
Site Göttingen
Project type Cooperation with External Partners
Funding 37200.00€ 37.200,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Investigation of vascular network development in innervated cardiac muscle tissue
ID 81X4300126
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Maria Patapia Zafeiriou
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE168)
Funding 40000.00€ 40.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Functional characterization of atrial cardiomyopathy in a porcine AF model via automated patch-clamp
ID 81X4300127
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Niels Voigt
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE181)
Funding 38263.96€ 38.263,96
Begin 2023-04-0101.04.2023
End 2024-03-3131.03.2024
Projektdetails

Short-term volume overload, a potential antifibrotic target in cardiac fibrosis
ID 81X4300128
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Belal Mohamed
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE user  (SE216)
Funding 36440.00€ 36.440,00
Begin 2023-04-0101.04.2023
End 2024-10-3131.10.2024
Projektdetails

Investigating Huntington’s disease (HD) related cardiomyopathy in a human iPSC-based 3D neurocardiac interface model
ID 81X4300125
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Maria Patapia Zafeiriou
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 37500.00€ 37.500,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Deep learning-based discovery of immune changes induced by alleviation of high-grade aortic stenosis - pilot study
ID 81X2700142
Institution Universität zu Lübeck
Project leader Ingp Eitel
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE218)
Funding 50000.00€ 50.000,00
Begin 2023-04-0101.04.2023
End 2025-04-3030.04.2025
Projektdetails

Spatial Transcriptomic Atlas of the aged Heart
ID 81X2200166
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Cooperation with External Partners
Funding 10680.00€ 10.680,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

AAVs for enhanced y-globin translation through synthetic lncRNA
ID 81X2200167
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ralf Brandes
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 20000.00€ 20.000,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Characterization of long-term cardiac sequelae of post-acute COVID-19 in home-recovered patients
ID 81X2200168
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Valentina Puntmann
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE125)
Funding 25000.00€ 25.000,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Contribution of protein kinase D1 to the functional crosstalk between cardiomyocytes and fibroblasts
ID 81X2710197
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Friederike Cuello
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE080)
Funding 50000.00€ 50.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Identifying molecular mechanisms counteracting catecholamine-induced cardiotoxicity
ID 81X2800216
Institution Julius-Maximilians-Universität Würzburg
Project leader Katrin Streckfuß-Bömeke
Site Extern
Project type Cooperation with External Partners
Funding 42625.00€ 42.625,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Temporally controlled mapping of newly synthesized myeloid proteomes in myocardial infarction
ID 81X2800220
Institution Universitätsklinikum Bonn
Project leader Felix Meissner
Site Extern
Project type Cooperation with External Partners
Funding 29800.00€ 29.800,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Characterization of long-term cardiac sequelae of post-acute COVID-19 in home-recovered patients
ID 81X2600632
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE125)
Funding 25011.94€ 25.011,94
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Resistance training in elderly heart failure patients with and without sarcopenia - the role of growth and sex hormones
ID 81X2600633
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Martin Halle
Site München
Project type Cooperation with External Partners
Funding 23139.08€ 23.139,08
Begin 2023-04-0101.04.2023
End 2024-04-3030.04.2024
Projektdetails

T P V R (Transcatheter Pulmonary valve replacement) with biodegradable stent
ID 81X2600634
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE048)
Funding 20750.00€ 20.750,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Translational proteomics for cardiovascular diseases: from population prediction to clinical and therapeutic applications_Prot4CVD
ID 81X2100281
Institution Charité - Universitätsmedizin Berlin
Project leader Claudia Langenberg
Site Berlin
Project type Internationale Kooperation
Funding 499833.99€ 499.833,99
Begin 2023-04-0101.04.2023
End 2027-03-3131.03.2027
Projektdetails

AAV-mediated SOX9 deletion as a therapeutic approach after MI
ID 81X2500218
Institution Universität Heidelberg
Project leader Jörg Heineke
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 37800.00€ 37.800,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

TRP starter grant: Cardiomyocyte-specific endogenous transcriptional restoration of KLF15 by nuclease-dead Cas9 as a novel therapeutic concept in heart failure
ID 81X2300212
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rabea Hinkel
Site Göttingen
Project type Translational Research Project
Funding 51115.02€ 51.115,02
Begin 2023-04-0101.04.2023
End 2024-11-3030.11.2024
Projektdetails

MIF in heart failure: role of the MIF superfamily and mechanisms of mitochondrial dysfunction
ID 81X2800221
Institution Universität Duisburg-Essen - Universitätsklinikum Essen
Project leader Ulrike Hendgen-Cotta
Site Extern
Project type Cooperation with External Partners
Funding 23804.32€ 23.804,32
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

Spatial Transcriptomic Atlas of the aged Heart
ID 81X2800215
Institution Universitätsklinikum Aachen
Project leader Christoph Kuppe
Site Extern
Project type Cooperation with External Partners
Funding 42611.00€ 42.611,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Inflammation - thrombosis crosstalk in patients with high cardiovascular risk
ID 81X2600277
Institution Klinikum der Universität München
Project leader Yvonne Döring
Site München
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

MIF in heart failure: role of the MIF superfamily and mechanisms of mitochondrial dysfunction
ID 81X2600278
Institution Klinikum der Universität München
Project leader Jürgen Bernhagen
Site München
Project type Cooperation with External Partners
Funding 24164.50€ 24.164,50
Begin 2023-04-0101.04.2023
End 2024-12-3131.12.2024
Projektdetails

The Immune Checkpoint Landscape of the atherosclerotic plaque: Setting up the Cellular Indexing of Transcriptomes and Epitopes by sequencing (Cite-seq)
ID 81X2600279
Institution Klinikum der Universität München
Project leader Dorothee Atzler
Site München
Project type Cooperation with External Partners
Funding 24000.00€ 24.000,00
Begin 2023-04-0101.04.2023
End 2024-04-3030.04.2024
Projektdetails

Temporally controlled mapping of newly synthesized myeloid proteomes in myocardial infarction
ID 81X2600280
Institution Klinikum der Universität München
Project leader Tonina Theres Müller
Site München
Project type Cooperation with External Partners
Funding 18200.00€ 18.200,00
Begin 2023-04-0101.04.2023
End 2024-09-3030.09.2024
Projektdetails

Epigenetic modification of endothelial cells by red blood cell metabolites
ID 81X2600123
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Henriette Uhlenhaut
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE101)
Funding 35840.00€ 35.840,00
Begin 2023-04-0101.04.2023
End 2025-03-3131.03.2025
Projektdetails

Extending the DNA-Methylation sample of the SHIP-Trend cohort to foster cardiovascular research
ID 81X2600121
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Melanie Waldenberger
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE041)
Funding 87844.85€ 87.844,85
Begin 2023-05-0101.05.2023
End 2024-07-3131.07.2024
Projektdetails

Faircode4DZHK - Zentrale Code Repositories für das DZHK
ID 81X1500114
Institution Universität Heidelberg
Project leader Sandy Engelhardt
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 49852.56€ 49.852,56
Begin 2023-05-0101.05.2023
End 2024-11-3030.11.2024
Projektdetails

Postdoc start-up grant: Targeting mtDNA heteroplasmy by modulating mitochondrial turnover in human iPSC-derived cardiomyocytes
ID 81X3300114
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Mario Pavez-Giani
Site Göttingen
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-05-0101.05.2023
End 2024-07-3131.07.2024
Projektdetails

Promotion of women scientists: AAV microRNA Tough Decoy for treating pulmonary hypertension: a new translational approach in pig
ID 81X3600226
Institution Klinikum der Universität München
Project leader Olympia Bikou
Site München
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-05-0101.05.2023
End 2024-05-3131.05.2024
Projektdetails

Somatostatin receptors as a target to improve endothelial function in heart failure patients
ID 81X2200205
Institution Kerckhoff-Klinik, Gesellschaft mit beschränkter Haftung
Project leader Muhammad Aslam
Site RheinMain
Project type Cooperation with External Partners
Funding 23900.00€ 23.900,00
Begin 2023-05-0101.05.2023
End 2025-12-3131.12.2025
Projektdetails

Deep learning-based discovery of immune changes induced by alleviation of high-grade aortic stenosis - pilot study
ID 81X2500301
Institution Deutsches Krebsforschungszentrum (DKFZ)
Project leader Felix Hartmann
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE218)
Funding 50000.00€ 50.000,00
Begin 2023-05-0101.05.2023
End 2025-04-3030.04.2025
Projektdetails

Macrophage Metabolism in Cardiac Remodelling after Ischemic Tissue Damage
ID 81X2210127
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philip Wenzel
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE130)
Funding 23458.74€ 23.458,74
Begin 2023-05-0101.05.2023
End 2024-08-3131.08.2024
Projektdetails

Epigenetic modification of endothelial cells by red blood cell metabolites
ID 81X2210128
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Katrin Schäfer
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE101)
Funding 8970.00€ 8.970,00
Begin 2023-05-0101.05.2023
End 2025-04-3030.04.2025
Projektdetails

Pulmonary hypertension induced Right heart failure: Occurrence of genetic variations and disturbed BMP & TGFb signalling explaining impaired mechanotransduction and heterogenous adaptation to pressure overload (PROMETHEUS)
ID 81X2100282
Institution Charité - Universitätsmedizin Berlin
Project leader Gabriele Schiattarella
Site Berlin
Project type Internationale Kooperation
Funding 232344.56€ 232.344,56
Begin 2023-05-0101.05.2023
End 2027-04-3030.04.2027
Projektdetails

Somatostatin receptors as a target to improve endothelial function in heart failure patients
ID 81X2800222
Institution Medizinische Hochschule Brandenburg CAMPUS GmbH
Project leader Yury Ladilov
Site Extern
Project type Cooperation with External Partners
Funding 24199.92€ 24.199,92
Begin 2023-05-0101.05.2023
End 2025-12-3131.12.2025
Projektdetails

Risk stratification in patients with ischaemic and non-ischaemic cardiomyopathy by means of Periodic Repolarization Dynamics derived from 10-second, 12-lead ECG recordings
ID 81X1600218
Institution Klinikum der Universität München
Project leader Konstantinos Rizas
Site München
Project type Daten- und Probennutzung
Funding 40000.00€ 40.000,00
Begin 2023-05-0101.05.2023
End 2024-08-3131.08.2024
Projektdetails

Pulmonary hypertension induced Right heart failure: Occurrence of genetic variations and disturbed BMP & TGFb signalling explaining impaired mechanotransduction and heterogenous adaptation to pressure overload (PROMETHEUS)
ID 81X2200320
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Pullamsetti Soni
Site RheinMain
Project type Internationale Kooperation
Funding 267600.00€ 267.600,00
Begin 2023-05-0101.05.2023
End 2027-04-3030.04.2027
Projektdetails

Light sheet imaging of nonclassical monocytes in the healthy young, aged or stressed mouse heart
ID 81X2300302
Institution Georg-August-Universität Göttingen
Project leader Jan Huisken
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE211)
Funding 24000.00€ 24.000,00
Begin 2023-05-0101.05.2023
End 2024-07-3131.07.2024
Projektdetails

The Immune Checkpoint Landscape of the atherosclerotic plaque: Setting up the Cellular Indexing of Transcriptomes and Epitopes by sequencing (Cite-seq)
ID 81X2800219
Institution Universität zu Köln
Project leader Holger Winkels
Site Extern
Project type Cooperation with External Partners
Funding 24804.92€ 24.804,92
Begin 2023-05-0101.05.2023
End 2024-04-3030.04.2024
Projektdetails

Intercepting post-BURN INjury cardiac muscle wastinG and HEART failure: deciphering the molecular pathomechanisms for diagnostic and therapeutic intervention development
ID 81X2800214
Institution BG Kliniken Ludwigshafen und Tübingen gGmbH
Project leader Gabriel Hundeshagen
Site Extern
Project type Internationale Kooperation
Funding 256416.83€ 256.416,83
Begin 2023-05-0101.05.2023
End 2026-08-3030.08.2026
Projektdetails

Resistance training in elderly heart failure patients with and without sarcopenia - the role of growth and sex hormones
ID 81X2800218
Institution Technische Universität Dresden
Project leader Volker Adams
Site Extern
Project type Cooperation with External Partners
Funding 24780.00€ 24.780,00
Begin 2023-05-0101.05.2023
End 2024-04-3030.04.2024
Projektdetails

ECG Federated Learning of TAVI Outcomes (ECG-FLO)
ID 81X1400115
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Digitale Technologien
Funding 32397.59€ 32.397,59
Begin 2023-05-0101.05.2023
End 2025-06-3030.06.2025
Projektdetails

Short-term volume overload, a potential antifibrotic target in cardiac fibrosis
ID 81X2600122
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Juliane Merl-Pham
Site München
Project type Shared Expertise (SE)
SE Trait SE provider  (SE216)
Funding 36500.00€ 36.500,00
Begin 2023-05-0101.05.2023
End 2024-10-3131.10.2024
Projektdetails

ECG Federated Learning of TAVI Outcomes (ECG-FLO)
ID 81X1500115
Institution Universität Heidelberg
Project leader Sandy Engelhardt
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 43575.80€ 43.575,80
Begin 2023-06-0101.06.2023
End 2025-06-3030.06.2025
Projektdetails

ECG Federated Learning of TAVI Outcomes (ECG-FLO)
ID 81X1600219
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site München
Project type Digitale Technologien
Funding 9386.26€ 9.386,26
Begin 2023-06-0101.06.2023
End 2025-06-3030.06.2025
Projektdetails

German Cardiovascular Collaborative Cohorts within the DZHK (G-CCC@DZHK)
ID 81X1100232
Institution Charité - Universitätsmedizin Berlin
Project leader Joachim Weber
Site Berlin
Project type Clinical Studies
Funding 106947.12€ 106.947,12
Begin 2023-06-0101.06.2023
End 2025-06-3030.06.2025
Projektdetails

German Cardiovascular Collaborative Cohorts within the DZHK (G-CCC@DZHK)
ID 81X1400116
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Clinical Studies
Funding 31121.00€ 31.121,00
Begin 2023-06-0101.06.2023
End 2025-06-3030.06.2025
Projektdetails

ECG Federated Learning of TAVI Outcomes (ECG-FLO)
ID 81X1300128
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Seidler
Site Göttingen
Project type Digitale Technologien
Funding 4500.00€ 4.500,00
Begin 2023-06-0101.06.2023
End 2025-06-3030.06.2025
Projektdetails

Chronic adaptive immune activation in chronic ischemic heart failure
ID 81X1200111
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Wesley Abplanalp
Site RheinMain
Project type Daten- und Probennutzung
Funding 40000.00€ 40.000,00
Begin 2023-06-0101.06.2023
End 2024-05-3131.05.2024
Projektdetails

German Cardiovascular Collaborative Cohorts within the DZHK (G-CCC@DZHK)
ID 81X1500116
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 37852.50€ 37.852,50
Begin 2023-06-0101.06.2023
End 2025-06-3030.06.2025
Projektdetails

Clinician scientist programme: Targeting the cation channel TRPC6 to reduce restenosis after stent implantation
ID 81X3600511
Institution Deutsches Herzzentrum München
Project leader Christian Gräßer
Site München
Project type Excellence Programme
Funding 188300.91€ 188.300,91
Begin 2023-07-0101.07.2023
End 2026-03-3131.03.2026
Projektdetails

Postdoc start-up grant: Impact of aging on the cardiac lymphatic system
ID 81X3200124
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Julian Wagner
Site RheinMain
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-08-0101.08.2023
End 2024-07-3131.07.2024
Projektdetails

Promotion of women scientists: Discovering the functionality of splicing-driven subcellular RNA localization across cardiac cell types
ID 81X3200125
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Gabrijela Dumbovic
Site RheinMain
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-08-0101.08.2023
End 2024-07-3131.07.2024
Projektdetails

Postdoc start-up grant: Temporal and functional resolution of neutrophil phenotypes at different stages of venous thrombosis
ID 81X3600227
Institution Klinikum der Universität München
Project leader Kami Pekayvaz
Site München
Project type Excellence Programme
Funding 79999.86€ 79.999,86
Begin 2023-08-0101.08.2023
End 2024-07-3131.07.2024
Projektdetails

Postdoc start-up grant: Non-coding RNA control of the maternal heart remodeling in pregnancy and lactation
ID 81X3600408
Institution Technische Universität München
Project leader Dena Esfandyari
Site München
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-08-0101.08.2023
End 2024-07-3131.07.2024
Projektdetails

Impact of extracorporeal circulation on the heart-brain axis: Quantification of perfusion by 4D MRI
ID 81X2800209
Institution Heinrich-Heine-Universität Düsseldorf
Project leader Alexander Assmann
Site Extern
Project type Cooperation with External Partners
Funding 28360.78€ 28.360,78
Begin 2022-12-0101.12.2022
End 2024-07-3131.07.2024
Projektdetails

Postdoc start-up grant: The role of Pank4 as novel key player in cardiac remodeling and energy metabolism
ID 81X3100502
Institution Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Project leader Christiane Ott
Site Berlin
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2022-12-0101.12.2022
End 2024-05-3131.05.2024
Projektdetails

Postdoc start-up grant: Identification of the endothelial function and the molecular mode of action of the IncRNA HIF1a-AS1
ID 81X3200107
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Matthias Leisegang
Site RheinMain
Project type Excellence Programme
Funding 59955.32€ 59.955,32
Begin 2017-12-0101.12.2017
End 2018-12-3131.12.2018
Projektdetails

Ernährung, körperliche Aktivität und koronare Herzkrankheit
ID 81Z0100107
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Tobias Pischon
Site Berlin
Project type Partner Site Projects
Funding 107998.50€ 107.998,50
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Zelluläre Mechanismen des pulmonalen Gefäßumbaus bei pulmonaler Hypertonie infolge von Linksherzerkrankung
ID 81Z0100201
Institution Charité - Universitätsmedizin Berlin
Project leader Wolfgang M. Kübler
Site Berlin
Project type Partner Site Projects
Funding 37050.20€ 37.050,20
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails
Die überwiegende Zahl von Patienten mit Linksherzinsuffizienz NYHA III und NYHA IV weisen erhöhte pulmonal-arterielle Drücke von =19 mmHg im Sinne einer Borderline-pulmonalen Hypertonie (PH) bzw. =25 mmHg im Sinne einer manifesten PH auf (Ghio, Gavazzi et al., 2001). Damit stellt die pulmonale Hypertonie bei Linksherzinsuffizienz die bei weitem häufigste Form der pulmonalen Hypertonie dar (Simonneau, Robbins et al., 2009). Bedeutsamerweise ist die PH dabei nicht alleinig eine passive Folge des ver-mehrten Rückstaus des Blutes in die Lungenstrombahn, sondern weist in der Regel eine relevante reaktive Komponente auf. So weisen Patienten mit Herzinsuffizienz und erhaltener Ejektionsfraktion (HfpEF) typischerweise bei gleichem pulmonalkapillären Wedgedruck höhere pulmonal-arterielle Spitzendrücke als Ausdruck eines erhöhten pulmonal-vaskulären Widerstandes auf (Lam, Roger et al., 2009). In der klinischen Diagnostik unterscheidet man entsprechend anhand des transpulmonalen Druckgradien-ten (TPG) zwischen "passiver" (TPG < 12 mmHg) versus "reaktiver" oder "out-of-proportion" (TPG > 12 mmHg) PH; in den letzten Jahren zunehmend auch anhand des diastolischen pulmonal-vaskulären Druckgradienten (DPG) zwischen "isolierter postka-pillärer" (DPG < 7 mmHg) und "kombinierter prä- und postkapillärer" (DPG < 7 mmHg) PH (Naeije, Vachiery et al., 2013). Das Vorliegen einer "reaktiven" bzw. "kombinierten prä- und postkapillären" PH geht dabei mit einer erheblichen Zunahme der Morbidität in Form einer häufigeren Entwicklung eines Rechtsherzversagens (Ghio et al., 2001) so-wie in der Folge mit einer erhöhten Mortalität einher (Cappola, Felker et al., 2002).

Clinical imaging 2.0
ID 81Z0200108
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eike Nagel
Site RheinMain
Project type Partner Site Projects
Funding 1136500.00€ 1.136.500,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Advanced proteomics and informatics unit
ID 81Z0200301
Institution Max-Planck-Institut für Herz- und Lungenforschung
Project leader Thomas Braun
Site RheinMain
Project type Partner Site Projects
Funding 867943.96€ 867.943,96
Begin 2018-07-0101.07.2018
End 2020-12-3131.12.2020
Projektdetails

Allianz zur Identifikation und Validierung von Targets bei Herzinsuffizienz
ID 81Z0300101
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Wolfram-Hubertus Zimmermann
Site Göttingen
Project type Partner Site Projects
Funding 1034538.00€ 1.034.538,00
Begin 2018-08-0101.08.2018
End 2020-12-3131.12.2020
Projektdetails

Echtzeit-Magnetresonanztomographie
ID 81Z0300102
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Martin Uecker
Site Göttingen
Project type Partner Site Projects
Funding 734907.00€ 734.907,00
Begin 2018-08-0101.08.2018
End 2020-12-3131.12.2020
Projektdetails

Arrhythmie-Imaging und -Kontrolle
ID 81Z0300105
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stefan Lehnart
Site Göttingen
Project type Partner Site Projects
Funding 301866.12€ 301.866,12
Begin 2018-09-0101.09.2018
End 2020-12-3131.12.2020
Projektdetails

Arrhythmie-Imaging und -Kontrolle
ID 81Z0300111
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Stefan Luther
Site Göttingen
Project type Partner Site Projects
Funding 356696.24€ 356.696,24
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Allianz zur Regeneration des Herzens
ID 81Z0300201
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rüdiger Behr
Site Göttingen
Project type Partner Site Projects
Funding 746809.12€ 746.809,12
Begin 2018-10-0101.10.2018
End 2020-12-3131.12.2020
Projektdetails
Nicht-humane Primatenmodelle, v.a. Weißbüschelaffen und Rhesusaffen, setzen sich zunehmend in der spät-translationalen Entwicklung von Strategien für die Regeneration bei Herzmuskelschwäche durch. Seit 2011 wurden im Deutschen Primatenzentrum (DPZ) die Grundvoraussetzungen für die Durchführung kardiovaskulärer Studien im Weißbüschelaffen und Rhesusaffen geschaffen. Im Förderzeitraum 2019-2020 sollen Modelle für Gentherapie mittels CRISPR/Cas-Genomeditierung sowie allogene Zellthe-rapeutika für die individualisierte Therapie bei Herzmuskelschwäche (Links- und Rechtsherzversagen) entwickelt werden. Nicht-lineare Simulationsmodelle sollen ent-wickelt werden, um mechanisch und parakrin aktive Ersatzgewebe strukturell und funk-tionell für die in vivo Anwendung zu optimieren. Dieses Projekt wird in einer Instituts-übergreifenden Allianz zur Regeneration des Herzens bestehend aus den Arbeitsgrup-pen Behr (DPZ), Bodenschatz (MPI-DS) und Zimmermann (UMG) am Göttingen Cam-pus bearbeitet.

MD18 Arrhythmie-Imaging und Kontrolle (Teilprojekt 1)
ID 81Z0300402
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Stefan Luther
Site Göttingen
Project type Partner Site Projects
Funding 279799.44€ 279.799,44
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails
Die wissenschaftlichen Ziele des beantragten Projektes sind: · Proof-of-Concept eines neuen elektro-mechanischen Bildgebungsverfahrens zur hoch-aufgelösten raum-zeitlichen Charakterisierung kardialer Arrhythmien im Langendorff-pefundierten Ganzherz (Schwein) · Translation der Ergebnisse im Rahmen der Translational-Pipeline des DZHK (Late preclinical Translational Research Project (TRP), Early Clinical Study). Details s. Vorhabenbeschreibung.

Sequenzierplattform
ID 81Z0600101
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Thomas Meitinger
Site München
Project type Partner Site Projects
Funding 230606.56€ 230.606,56
Begin 2018-07-0101.07.2018
End 2020-12-3131.12.2020
Projektdetails

Leveraging genomic data to identify novel treatment targets
ID 81Z0700101
Institution Universität zu Lübeck
Project leader Jeanette Erdmann
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 941294.63€ 941.294,63
Begin 2018-08-0101.08.2018
End 2020-12-3131.12.2020
Projektdetails

Nutzung genomweiter Genotyp- und Sequenzdaten für genetische Risikoprofile in der Präzisionsmedizin
ID 81Z0700102
Institution Universität zu Lübeck
Project leader Inke R. König
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 136800.00€ 136.800,00
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Gentherapie von vaskulären Endorganschäden
ID 81Z0700104
Institution Universität zu Lübeck
Project leader Markus Schwaninger
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 216288.36€ 216.288,36
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Intrazelluläre Signale in der Mikrozirkulation in vivo
ID 81Z0700106
Institution Universität zu Lübeck
Project leader Cor de Wit
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 124284.40€ 124.284,40
Begin 2019-01-0101.01.2019
End 2020-12-3131.12.2020
Projektdetails

Epigenetics in cardiac hypertrophy
ID 81Z0700201
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 422175.77€ 422.175,77
Begin 2018-07-0101.07.2018
End 2020-12-3131.12.2020
Projektdetails

Cardiac repair and mechanisms of cardiac biology and disease in hiPSC
ID 81Z0710101
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Arne Hansen
Site Hamburg/Kiel/Lübeck
Project type Partner Site Projects
Funding 641513.32€ 641.513,32
Begin 2018-07-0101.07.2018
End 2021-06-3030.06.2021
Projektdetails

Entwicklung von TPH-Inhibitoren für pulmonale Hypertonie und Atherosklerose
ID 81Z1100105
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Michael Bader
Site Berlin
Project type Partner Site Projects
Funding 166000.00€ 166.000,00
Begin 2016-04-0101.04.2016
End 2017-09-3030.09.2017
Projektdetails

Proteoglycans and glycosaminoglycans as targets for magnetic particle imaging of unstable atherosclerotic plaques
ID 81Z1100202
Institution Charité - Universitätsmedizin Berlin
Project leader Verena Stangl
Site Berlin
Project type Partner Site Projects
Funding 34700.00€ 34.700,00
Begin 2016-10-0101.10.2016
End 2017-12-3131.12.2017
Projektdetails

Aufbau und Etablierung der W3 Professur "Myokardiale und Vaskuläre Interaktionen"
ID 81Z1210101
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Tommaso Gori
Site RheinMain
Project type Partner Site Projects
Funding 949800.00€ 949.800,00
Begin 2016-08-0101.08.2016
End 2018-12-3131.12.2018
Projektdetails

Phenomics in HFpEF
ID 81Z2100203
Institution Charité - Universitätsmedizin Berlin
Project leader Burkert Pieske
Site Berlin
Project type Partner Site Projects
Funding 314186.80€ 314.186,80
Begin 2016-10-0101.10.2016
End 2018-12-3131.12.2018
Projektdetails

Untersuchung kardiovaskulärer Schädigungen im Zuge der Entwicklung und Manifestierung des Diabetes in der New Zealand Obese-Maus, einem Mausmodell für das Metabolische Syndrom
ID 81Z2100502
Institution Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Project leader Tilman Grune
Site Berlin
Project type Partner Site Projects
Funding 81240.00€ 81.240,00
Begin 2016-08-0101.08.2016
End 2018-01-3131.01.2018
Projektdetails
In einer Pilotstudie untersuchen wir das Auftreten kardiovaskulärer Schädigungen im Zeitverlauf der Diabetesentstehung in männlichen NZO- und C57B6/J-Mäusen, wobei letztere als Kontrollen dienen. • Erfassung von Blutdruck und Herzrate mittels implantierbarer Transmitter und durch Anwendung der Tail-Cuff-Methode während der Diabetesentstehung in männlichen NZO-Mäusen • Untersuchung der Herz- und Gefäßmorphologie, von molekularen Veränderungen in für die kardiovaskuläre Funktion relevanten Geweben und des Blutdrucks mit Hilfe finaler Arteria Carotis-Messung während der Diabetesentstehung in männlichen NZO-Mäusen • Untersuchung der Herz- und Gefäßfunktion während der Diabetesentstehung in männlichen NZO-Mäusen mittels Echokardiographie und finaler Magnetresonanztomographie.

Faircode4DZHK - Zentrale Code Repositories für das DZHK
ID 81X1300127
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Dagmar Krefting
Site Göttingen
Project type Digitale Technologien
Funding 50146.76€ 50.146,76
Begin 2023-06-0101.06.2023
End 2024-11-3030.11.2024
Projektdetails
Faircode4DZHK stellt eine zentrale Infrastruktur zur Unterstützung bei der Entwicklung und Nachnutzung von digitalen Lösungen des DZHK bereit. Insbesondere wird die Dokumentation und Bereitstellung von Code sowie virtuellen Laufzeitumgebungen (Container) von DZHK-Projektergebnissen nach den Kriterien der guten wissenschaftlichen Praxis für Forschungssoftware gewährleistet. Im Rahmen des Projektes soll sowohl die Konzeptionierung als auch Umsetzung erfolgen in enger Abstimmung mit einer neu zu gründenden DZHK Projektgruppe "FAIR Science".

German Cardiovascular Collaborative Cohorts within the DZHK (G-CCC@DZHK)
ID 81X1600105
Institution Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Project leader Birgit Linkohr
Site München
Project type Clinical Studies
Funding 33595.00€ 33.595,00
Begin 2023-07-0101.07.2023
End 2025-06-3030.06.2025
Projektdetails

ECG Federated Learning of TAVI Outcomes (ECG-FLO)
ID 81X1710113
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Renate Schnabel-Bonin
Site Hamburg/Kiel/Lübeck
Project type Digitale Technologien
Funding 9386.26€ 9.386,26
Begin 2023-07-0101.07.2023
End 2025-06-3030.06.2025
Projektdetails

Concept for a common research platform: German Cardiovascular Collaborative Cohorts within the DZHK (G-CCC@DZHK)
ID 81X1710114
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Stefan Blankenberg
Site Hamburg/Kiel/Lübeck
Project type Clinical Studies
Funding 224864.62€ 224.864,62
Begin 2023-07-0101.07.2023
End 2025-06-3030.06.2025
Projektdetails

German Cardiovascular Collaborative Cohorts within the DZHK (G-CCC@DZHK)
ID 81X1210105
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Daniela Zahn
Site RheinMain
Project type Clinical Studies
Funding 31619.00€ 31.619,00
Begin 2023-07-0101.07.2023
End 2025-06-3030.06.2025
Projektdetails
Harmonisation and linking data (sources) between different studies, and IT systems are becoming increasingly important within clinical research projects. Gathering information on suitable data e.g. for meta-analysis, validation cohorts, or case-control studies is time-consuming. However, up to now, only project-specific solutions exist. These solutions are often accompanied by large efforts regarding administration, data quality assurance and data preparation for collaborative analyses. This was the motivation for a joint initiative by several German cohort studies (HCHS, SHIP, GHS, KORA, BeLOVE) within the DZHK to evaluate concepts for the creation of a common research platform with clear harmonisation standards and definitions, and to develop a use-case scenario for applications within the DZHK. The outcome of the present initiative shall be a common research platform available to all members of the DZHK: German Collaborative Cardiovascular Cohorts at DZHK (G-CCC@DZHK).

TRP starter grant: Development of a novel platelet inhibitor that blocks the CXCL12-CXCR4 axis to prevent and treat atherothrombosis
ID 81X2600281
Institution Klinikum der Universität München
Project leader Philipp von Hundelshausen
Site München
Project type Translational Research Project
Funding 150000.00€ 150.000,00
Begin 2023-07-0101.07.2023
End 2024-12-3131.12.2024
Projektdetails

Promotion of women scientists: Reverse cardiac remodelling in murine models of low-flow low-gradient aortic stenosis
ID 81X3300115
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Manar El Kenani
Site Göttingen
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-08-0101.08.2023
End 2024-07-3131.07.2024
Projektdetails

Postdoc start-up grant: The impact of COVID-19 on long-term vascular and cardiac inflammation.
ID 81X3200126
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Julian Leberzammer
Site RheinMain
Project type Excellence Programme
Funding 80000.00€ 80.000,00
Begin 2023-08-0101.08.2023
End 2024-12-3131.12.2024
Projektdetails

Postdoc start-up grant: Delineating Molecular Patterns of MINOCA for Diagnostic and Therapeutic Purposes
ID 81X3100223
Institution Charité - Universitätsmedizin Berlin
Project leader Jasper Iske
Site Berlin
Project type Excellence Programme
Funding 75839.67€ 75.839,67
Begin 2023-08-0101.08.2023
End 2024-12-3131.12.2024
Projektdetails
Despite major advances in the treatment of acute myocardial infarction (MI), myocardial infarction without obstructive coronary arteries (MINOCA) represents a poorly defined clinical picture, accounting for up to 15% of all MI cases. In contrast to classic MI, in which there is a large occlusion in one of the coronary vessels, patients with MINOCA suffer from many, small micro-vessel occlusions that are undetectable on cardiac catheterization examination due to their size. Until today there is a lack of early diagnostic methods as well as adapted therapies for MINOCA, which leads to a high mortality rate of these patients. Therefore, in this project we would like to characterize molecular alterations underlying the development of MINOCA and distinguish it from a classical MI by means of a newly developed animal model close to the clinic. Thus, we can identify molecules that could allow early diagnosis of MINOCA in patients with acute myocardial infarction and simultaneously serve as therapeutic targets, paving the way for early and adapted therapy.

Clinician scientist fellowship: Mechanisms of CXCL4-dependent Extracellular Vesicle-Mediated Vascular Remodeling in Atherosclerosis
ID 81X3500142
Institution Universität Heidelberg
Project leader Jona Krohn
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 170390.10€ 170.390,10
Begin 2023-09-0101.09.2023
End 2026-08-3131.08.2026
Projektdetails

Understanding the role of the gut microbiome as a mediator of organ protection by SGLT-2 inhibitors
ID 81X2100175
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Dominik Müller
Site Berlin
Project type DZG Innovation Cluster
Funding 161600.00€ 161.600,00
Begin 2023-10-0101.10.2023
End 2025-09-3030.09.2025
Projektdetails

Understanding the role of the gut microbiome as a mediator of organ protection by SGLT-2 inhibitors
ID 81X4500122
Institution Universität Heidelberg
Project leader Norbert Frey
Site Heidelberg/Mannheim
Project type DZG Innovation Cluster
Funding 74000.00€ 74.000,00
Begin 2023-10-0101.10.2023
End 2025-09-3030.09.2025
Projektdetails

The gut microbiome as a functional modifier of myelopoiesis and inflammatory vascular endothelial phenotypes in cardiometabolic disease
ID 81X2100283
Institution Charité - Universitätsmedizin Berlin
Project leader Arash Haghikia
Site Berlin
Project type DZG Innovation Cluster
Funding 68000.00€ 68.000,00
Begin 2023-10-0101.10.2023
End 2025-11-3030.11.2025
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X1500117
Institution Universität Heidelberg
Project leader Sandy Engelhardt
Site Heidelberg/Mannheim
Project type Digitale Technologien
Funding 59390.85€ 59.390,85
Begin 2023-10-0101.10.2023
End 2025-10-3131.10.2025
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X1100233
Institution Charité - Universitätsmedizin Berlin
Project leader Anja Hennemuth
Site Berlin
Project type Digitale Technologien
Funding 70386.60€ 70.386,60
Begin 2023-10-0101.10.2023
End 2025-10-3131.10.2025
Projektdetails
Ein zentrales "Pooling" multizentrischer Daten an einem zentralen Datenspeicherstandort ist datenschutz- und sicherheitsrechtlich meist unzulässig. Die Plattform und Infrastruktur für föderiertes Lernen, die in dem Projekt "Federated Learning of TAVI Outcomes (FLOTO)" entwickelt wurde, ermöglicht, dass die Daten in den einzelnen Kliniken bleiben, und die Algorithmen dezentral trainiert werden. Der Use-case hat gezeigt, dass die entwickelte Plattform grundlegende Funktionen abdeckt, aber noch erweitert werden muss. Im Laufe dieses Projektes soll die entwickelte Plattform erweitert werden. Neben Performance-Optimierungen soll die Integration in die klinische IT-Landschaft verbessert und Algorithmen den Entwicklern Visualisierungen zum Überprüfen des Trainingsvorgangs bereitgestellt werden. Mit Hilfe des existierenden Anwendungsfalls FLOTO und der dort bereits vorliegenden Daten können diese neuen Konzepte direkt ab Start des Projektes getestet werden und die bestehende Plattform in Bezug auf Performance und Stabilität optimiert werden. Das zweite Teilprojekt adressiert die Entwicklung individualisierter Scores zur Klassifizierung von Patienten mit Verdickung des Herzmuskels anhand einer Kombination von Daten aus der Herz-Magnetresonanztomographie und persönlichen Daten unter Nutzung künstlicher Intelligenz für Bildauswertung und -interpretation. Hier soll zum einen die bestehende Infrastruktur genutzt werden, um die Adaption von Bildverarbeitungslösungen an die Daten verschiedener Zentren zu ermöglichen. Zum anderen werden die gut strukturierten Daten der UK-Biobank und vorhandener DZHK-Studien genutzt, um die Scoring-Modelle zu trainieren.

Brain heart interfaces: Connectivity and functional mapping of cardiovascular brain circuits
ID 81X2600282
Institution Klinikum der Universität München
Project leader Sarajo Mohanta
Site München
Project type Innovation Cluster
Funding 450000.00€ 450.000,00
Begin 2023-10-0101.10.2023
End 2026-09-3030.09.2026
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X1600220
Institution Klinikum der Universität München
Project leader Stefan Kääb
Site München
Project type Digitale Technologien
Funding 10830.00€ 10.830,00
Begin 2023-10-0101.10.2023
End 2025-10-3131.10.2025
Projektdetails

Intercellular communication pathways in atherosclerosis and plaque destabilisation (PLAK-TALK)
ID 81X2600635
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Lars Maegdefessel
Site München
Project type Internationale Kooperation
Funding 499800.00€ 499.800,00
Begin 2023-10-0101.10.2023
End 2027-09-3030.09.2027
Projektdetails

TRP starter grant: New generation of nanodomain specific beta-blockers for better heart failure therapy
ID 81X2710198
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Viacheslav Nikolaev
Site Hamburg/Kiel/Lübeck
Project type Translational Research Project
Funding 149673.00€ 149.673,00
Begin 2023-10-0101.10.2023
End 2025-03-3131.03.2025
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X1400117
Institution Universitätsmedizin Greifswald
Project leader Marcus Dörr
Site Greifswald
Project type Digitale Technologien
Funding 10100.01€ 10.100,01
Begin 2023-10-0101.10.2023
End 2025-10-3131.10.2025
Projektdetails
Ein zentrales "Pooling" multizentrischer Daten an einem zentralen Datenspeicherstandort ist datenschutz- und sicherheitsrechtlich meist unzulässig. Die Plattform und Infrastruktur für föderiertes Lernen, die in dem Projekt "Federated Learning of TAVI Outcomes (FLOTO)" entwickelt wurde, ermöglicht, dass die Daten in den einzelnen Kliniken bleiben, und die Algorithmen dezentral trainiert werden. Der Use-case hat gezeigt, dass die entwickelte Plattform grundlegende Funktionen abdeckt, aber noch erweitert werden muss. Im Laufe dieses Projektes soll die entwickelte Plattform erweitert werden. Neben Performance-Optimierungen soll die Integration in die klinische IT-Landschaft verbessert und Algorithmen den Entwicklern Visualisierungen zum Überprüfen des Trainingsvorgangs bereitgestellt werden. Mit Hilfe des existierenden Anwendungsfalls FLOTO und der dort bereits vorliegenden Daten können diese neuen Konzepte direkt ab Start des Projektes getestet werden und die bestehende Plattform in Bezug auf Performance und Stabilität optimiert werden. Das zweite Teilprojekt adressiert die Entwicklung individualisierter Scores zur Klassifizierung von Patienten mit Verdickung des Herzmuskels anhand einer Kombination von Daten aus der Herz-Magnetresonanztomographie und persönlichen Daten unter Nutzung künstlicher Intelligenz für Bildauswertung und -interpretation. Hier soll zum einen die bestehende Infrastruktur genutzt werden, um die Adaption von Bildverarbeitungslösungen an die Daten verschiedener Zentren zu ermöglichen. Zum anderen werden die gut strukturierten Daten der UK-Biobank und vorhandener DZHK-Studien genutzt, um die Scoring-Modelle zu trainieren.

CIT-DZHK29: Cyclosporine In Takotsubo syndrome
ID 81X1500118
Institution Universität Heidelberg
Project leader Norbert Frey
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 2228540.47€ 2.228.540,47
Begin 2023-10-0101.10.2023
End 2028-02-2929.02.2028
Projektdetails

CIT-DZHK29: Cyclosporine In Takotsubo syndrome - DZHK-Biobanking
ID 81X1500119
Institution Universität Heidelberg
Project leader Norbert Frey
Site Heidelberg/Mannheim
Project type Clinical Studies
Funding 31506.72€ 31.506,72
Begin 2023-10-0101.10.2023
End 2028-02-2929.02.2028
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X1200112
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Eike Nagel
Site RheinMain
Project type Digitale Technologien
Funding 107000.60€ 107.000,60
Begin 2023-11-0101.11.2023
End 2025-10-3131.10.2025
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X1300129
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Tim Friede
Site Göttingen
Project type Digitale Technologien
Funding 10704.00€ 10.704,00
Begin 2023-11-0101.11.2023
End 2025-10-3131.10.2025
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X1710115
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Renate Schnabel-Bonin
Site Hamburg/Kiel/Lübeck
Project type Digitale Technologien
Funding 10362.00€ 10.362,00
Begin 2023-11-0101.11.2023
End 2025-10-3131.10.2025
Projektdetails

Brain heart interfaces: Takotsubo- and Stroke-heart syndrome: two sides of the same coin?
ID 81X2100284
Institution Charité - Universitätsmedizin Berlin
Project leader Karen Gertz
Site Berlin
Project type Innovation Cluster
Funding 165000.00€ 165.000,00
Begin 2023-11-0101.11.2023
End 2026-11-3030.11.2026
Projektdetails

Brain heart interfaces: Takotsubo- and Stroke-heart syndrome: two sides of the same coin?
ID 81X2100176
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Henrike Maatz
Site Berlin
Project type Innovation Cluster
Funding 165000.00€ 165.000,00
Begin 2023-11-0101.11.2023
End 2026-11-3030.11.2026
Projektdetails

Nucleic acid therapies: AAV-based epigenetic perturbation - from translational disease models to anti-arrhythmic strategies
ID 81X4500124
Institution Universität Heidelberg
Project leader Ralf Gilsbach
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 775185.00€ 775.185,00
Begin 2023-11-0101.11.2023
End 2026-10-3131.10.2026
Projektdetails

Nucleic acid therapies: AAV-based epigenetic perturbation - from translational disease models to anti-arrhythmic strategies
ID 81X4300131
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Laura Zelarayan
Site Göttingen
Project type Innovation Cluster
Funding 122100.00€ 122.100,00
Begin 2023-11-0101.11.2023
End 2026-10-3131.10.2026
Projektdetails

Brain heart interfaces: Importance of brain regions on heart failure progression
ID 81X4300130
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Karl Toischer
Site Göttingen
Project type Innovation Cluster
Funding 508005.37€ 508.005,37
Begin 2023-11-0101.11.2023
End 2027-01-3131.01.2027
Projektdetails

Brain heart interfaces: Takotsubo- and Stroke-heart syndrome: two sides of the same coin?
ID 81X4500123
Institution Universität Heidelberg
Project leader Bastian Bruns
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 165000.00€ 165.000,00
Begin 2023-11-0101.11.2023
End 2026-11-3030.11.2026
Projektdetails

Brain heart interfaces: Takotsubo- and Stroke-heart syndrome: two sides of the same coin?
ID 81X2500219
Institution Universität Heidelberg
Project leader Daniel Dürschmied
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 165000.00€ 165.000,00
Begin 2023-11-0101.11.2023
End 2026-11-3030.11.2026
Projektdetails
Takotsubo- or the Broken-Heart syndrome is often triggered by an episode of severe stress followed by acute heart failure in the absence of coronary obstruction, which may also occur in the so- called Stroke-heart syndrome early after stroke. Both cause significant mortality and lack a specific therapy. They also share other aspects, including brain regions typically affected, high levels of stress hormones, and myocardial inflammation. We propose that both syndromes are driven by overlapping as well as distinct pathophysiology. We will compare the functional and molecular features of animal models of both syndromes and dissect the role of inflammatory and other cell types in the heart by single-cell sequencing and cell culture studies. The results will be confirmed by clinical data and heart biopsies of Takotsubo patients, acquired in this study. A treatment approach will then be tested in both animal and cellular models with the potential for human therapy.. Takotsubo syndrome (TTS) is often triggered by an episode of stress followed by acute heart failure in the absence of coronary obstruction, which may also occur in Stroke-heart syndrome (SHS) early after stroke. Both cause significant mortality and lack a specific therapy. They also share other aspects, including brain regions typically affected, high levels of catecholamines, and myocardial inflammation. We propose that both syndromes are driven by overlapping and distinct pathophysiology. We will compare the functional and molecular features of murine models of TTS and of SHS and dissect the role of inflammatory, myocardial and endothelial cells in the heart by single nucleus RNA-sequencing and human-induced pluripotent stem cell modelling in co-culture studies. The results will be confirmed clinically and with myocardial biopsies of TTS patients. Pharmacological treatment will then be tested in both animal and cellular models with translational potential for an early clinical trial.

Brain heart interfaces: Takotsubo- and Stroke-heart syndrome: two sides of the same coin?
ID 81X2700143
Institution Universität zu Lübeck
Project leader Thomas Stiermaier
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 240000.00€ 240.000,00
Begin 2023-12-0101.12.2023
End 2026-11-3030.11.2026
Projektdetails

The gut microbiome as a functional modifier of myelopoiesis and inflammatory vascular endothelial phenotypes in cardiometabolic disease
ID 81X2210129
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Christoph Reinhardt
Site RheinMain
Project type DZG Innovation Cluster
Funding 307000.37€ 307.000,37
Begin 2023-12-0101.12.2023
End 2025-11-3030.11.2025
Projektdetails
Unter Nutzung der Schlüsselkompetenzen des DZHK, des DKTK und des DZD wird das Projekt gnotobiotische Ldlr-defiziente Hyperlipidämie-Mausmodelle untersuchen, um die Rolle des Darmmikrobioms und seiner Metaboliten kausal zu erforschen. Es wird untersucht, wie das Darmmikrobiom auf die sinusoidalen Endothelien in der Leber und im Knochenmark einwirkt. Dies sind relevante Signalknotenpunkte, die die Entwicklung metabolischer und vaskulärer Entzündungen, die Atherogenese und letztlich das Wachstum arterieller Thromben bestimmen. Unser Projekt wird etablierte keimfreie Mausmodelle nutzen, um die aus der Mikrobiota stammende kurzkettige Fettsäure Propionat und ihre Auswirkungen auf das Sinusoidalendothel, die Myelopoese, die Magakaryopoese und die Thrombozytenreaktivität kausal und mechanistisch zu untersuchen. Die Ergebnisse aus verschiedenen präklinischen Modellen werden anhand von Plasmaproben aus einer Interventionsstudie an Menschen mit Hypercholesterinämie, die mit Propionat supplementiert wurden, auf ihre translationalen Auswirkungen hin geprüft.

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X2800224
Institution Universitätsklinikum Würzburg
Project leader Bettina Baeßler
Site Extern
Project type Digitale Technologien
Funding 10355.64€ 10.355,64
Begin 2024-02-0101.02.2024
End 2025-10-3131.10.2025
Projektdetails

TRP starter grant: Anti-androgenic strategies in porcine heart failure
ID 81X4500125
Institution Universität Heidelberg
Project leader Constanze Schmidt
Site Heidelberg/Mannheim
Project type Translational Research Project
Funding 133773.00€ 133.773,00
Begin 2023-12-0101.12.2023
End 2025-05-3131.05.2025
Projektdetails

Brain heart interfaces: Extracellular RNA and microvascular dysfunction drive sex-differences in stroke-heart syndrome
ID 81X2100285
Institution Charité - Universitätsmedizin Berlin
Project leader Ran Xu
Site Berlin
Project type Innovation Cluster
Funding 890000.00€ 890.000,00
Begin 2023-12-0101.12.2023
End 2026-11-3030.11.2026
Projektdetails

Brain heart interfaces: Extracellular RNA and microvascular dysfunction drive sex-differences in stroke-heart syndrome
ID 81X2700248
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 10000.00€ 10.000,00
Begin 2023-12-0101.12.2023
End 2026-11-3030.11.2026
Projektdetails
Wir sehen, dass im Rahmen der Subarachnoidalblutung / hämorrhagischer Schlaganfall, extrazelluäre RNA (exRNA) freigesetzt wird, die sich dann im Gehirn von extraparenchymal bis nach parenchymal ausbreitet und mit einer sekundären Hirnschädigung assoziiert ist. Ferner lässt sich exRNA zeitversetzt auch im Blut von Mäusen und Patienten und bei der Maus auch im kardialen Gewebe nach hämorrhagischem Schlaganfall nachweisen. Die endogene RNAse Aktivität ist dabei nachweislich bei den Patienten vermindert. Wenn wir die Mäuse mit RNAse behandeln, können wir einerseits den sekundären Hirnschaden nach Schlaganfall mindern und andererseits auch die kardialen Veränderungen nach Schlaganfall (diastolische Dysfunktion und Fibrose) erfolgreich therapieren. Wir sehen also, dass RNAse1 (endogen im Endothel vorhanden) protektiv wirkt. Eine AAV-basierte Überexpression im Endothel könnte somit eine neue translationale Therapieform darstellen, die wir hier im Mausmodell testen möchten. Die Expertise für die AAV-Generierung liegt am DZHK Standort Kiel / AG Müller vor, wo der AAV und ein entsprechender Kontroll-AAV im Kalendarjahr 2024 generiert werden soll.

TRP starter grant: Anti-androgenic strategies in porcine heart failure
ID 81X2500220
Institution Universität Heidelberg
Project leader Jörg Heineke
Site Heidelberg/Mannheim
Project type Translational Research Project
Funding 16214.99€ 16.214,99
Begin 2023-12-0101.12.2023
End 2025-05-3131.05.2025
Projektdetails

Multicentric AI development for cardiovascular disease classification and therapy support based on imaging data
ID 81X2800223
Institution Universität Münster
Project leader Stefan Orwat
Site Extern
Project type Digitale Technologien
Funding 10176.00€ 10.176,00
Begin 2024-02-0101.02.2024
End 2025-10-3131.10.2025
Projektdetails

Nucleic acid therapies: Targeted AAV vectors for efficient cardiovascular gene transfer
ID 81X2700144
Institution Universität zu Lübeck
Project leader Malte Spielmann
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 85900.00€ 85.900,00
Begin 2024-01-0101.01.2024
End 2026-12-3131.12.2026
Projektdetails

Nucleic acid therapies: Targeted AAV vectors for efficient cardiovascular gene transfer
ID 81X2700249
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver Müller
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 295199.84€ 295.199,84
Begin 2024-01-0101.01.2024
End 2026-12-3131.12.2026
Projektdetails
Der Einsatz von Adeno-assoziierten Virus-Vektoren (AAV) für die Gentherapie bei Patienten mit Herz-Kreislauf-Erkrankungen wird durch eine eingeschränkte Transduktionseffizienz, mangelnde Spezifität und daraus resultierende mögliche Lebertoxizität, potenzielle Immunogenität und Unterschiede zwischen unterschiedlichen Spezies eingeschränkt. Dieses Projekt zielt darauf ab, neuartige AAV-Vektoren zu etablieren, die einen gezielten Gentransfer in Herzmuskelzellen, Bindegewebezellen im Herzen sowie in Gefäßendothelzellen und vaskuläre glatte Muskelzellen erlauben. Hierzu sollen bereits in den Arbeitsgruppen etablierte neuartige Methoden und Werkzeuge eingesetzt werden, um auf bestimmte Zelltypen optimierte AAV-Vektoren aus AAV-Bibliotheken mit randomisierten Oberflächenproteinen zu identifizieren und zusätzlich die Spezifität durch Hochdurchsatzanalyse vielversprechender Enhancer-Elemente zu verbessern. Mittels Hochdurchsatzanalysen auf der Grundlage von Barcodes und Einzelzellsequenzierung sollen multiple vielversprechende AAV-Vektoren und Enhancerelemente parallel in Zellkultur- und Tiermodellen hinsichtlich Effizienz und Spezifität charakterisiert werden. Am Ende sollen die neuen AAV-Vektoren innerhalb und außerhalb des DZHKs zum Einsatz in präklinischen Modellen wie auch perspektivisch in zukünftigen klinischen Studien eingesetzt werden.

Nucleic acid therapies: Targeted AAV vectors for efficient cardiovascular gene transfer
ID 81X2300213
Institution Deutsches Primatenzentrum Gesellschaft mit beschränkter Haftung - Leibniz-Institut für Primatenforschung
Project leader Rabea Hinkel
Site Göttingen
Project type Innovation Cluster
Funding 162225.10€ 162.225,10
Begin 2024-01-0101.01.2024
End 2026-12-3131.12.2026
Projektdetails
Die Verwendung von AAV-Vektoren für die Gentherapie bei Patienten mit Herz-Kreislauf-Erkrankungen ist durch die mangelnde in vivo Transduktionseffizienz bei kardiovaskulären Zelltypen, die fehlende Spezifität und die daraus resultierende hepatische Toxizität, sowie die potenzielle Immunogenität und die Unterschiede zwischen den einzelnen Spezies limitiert. Dieses Projekt zielt daher darauf ab neuartige AAV-Vektoren zu etablieren, die spezifisch Kardiomyozyten, kardiale Fibroblasten, vaskuläre Endothelzellen und vaskuläre glatte Muskelzellen adressieren. Wir werden neuartige, von den Antragstellern entwickelte Methoden und Instrumente anwenden, um optimierte AAV-Vektoren für verschiedene Zelltypen mit randomisierten Oberflächenproteinen aus AAV-Bibliotheken auszuwählen und zusätzlich die Spezifität durch Hochdurchsatzanalyse von vielversprechenden Enhancer-Elementen zu verbessern. Die Auswahl und Validierung von AAV-Bibliotheken in Primatenmodellen und bearbeitetem menschlichem Herzgewebe, in Kombination mit fortgeschrittenen Hochdurchsatzanalysen , letzteres auf Basis von Barcode- und Einzelzellsequenzierung, ermöglicht es neue zielgerichtete AAV-Vektoren zu identifizieren, welche für zukünftige klinische Studien geeignet sind.

Postdoc start-up grant: Inhibition of mRNA translation by S100A1: Characterization of a novel anti-hypertrophy mechanism
ID 81X3500143
Institution Universität Heidelberg
Project leader Julia Ritterhoff
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 85000.00€ 85.000,00
Begin 2024-01-0101.01.2024
End 2024-12-3131.12.2024
Projektdetails

Postdoc start-up grant: Targeting macrophage metabolism to prevent adverse cardiac remodelling and preserve cardiac function
ID 81X3600228
Institution Klinikum der Universität München
Project leader Lukas Tomas
Site München
Project type Excellence Programme
Funding 85000.00€ 85.000,00
Begin 2024-01-0101.01.2024
End 2025-12-3131.12.2025
Projektdetails

Postdoc start-up grant on advancing digital aspects: Predicting heart failure recovery by wearables and machine learning
ID 81X3300116
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Nicolai Spicher
Site Göttingen
Project type Excellence Programme
Funding 85000.00€ 85.000,00
Begin 2024-01-0101.01.2024
End 2024-12-3131.12.2024
Projektdetails

Postdoc start-up grant: Role of STAT1 signaling in development of HFpEF post Chronic Kidney Injury
ID 81X3600229
Institution Klinikum der Universität München
Project leader Payel Sen
Site München
Project type Excellence Programme
Funding 85000.00€ 85.000,00
Begin 2024-01-0101.01.2024
End 2025-12-3131.12.2025
Projektdetails

Right ventricle and atrial dysfunction in diabetics and DCM patients assessed by advanced CMR
ID 81X1600221
Institution Klinikum der Universität München
Project leader Roberto Lorbeer
Site München
Project type Daten- und Probennutzung
Funding 40000.00€ 40.000,00
Begin 2024-01-0101.01.2024
End 2026-06-3030.06.2026
Projektdetails

TRP starter grant: New treatment option for hypertrophic cardiomyopathy
ID 81X2600531
Institution Deutsches Herzzentrum München
Project leader Cordula Wolf
Site München
Project type Translational Research Project
Funding 149650.12€ 149.650,12
Begin 2024-01-0101.01.2024
End 2025-06-3030.06.2025
Projektdetails

Brain heart interfaces: Central serotonin in atherosclerosis
ID 81X2100177
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Natalia Alenina
Site Berlin
Project type Innovation Cluster
Funding 259601.98€ 259.601,98
Begin 2024-01-0101.01.2024
End 2026-06-3030.06.2026
Projektdetails

Postdoc start-up grant on advancing digital aspects: Man-machine interaction-based phenotyping in patients with severe aortic stenosis
ID 81X3600610
Institution Klinikum rechts der Isar der Technischen Universität München
Project leader Markus Lacher
Site München
Project type Excellence Programme
Funding 85000.00€ 85.000,00
Begin 2024-01-0101.01.2024
End 2025-12-3131.12.2025
Projektdetails

Prospektives, multizentrisches Langzeitregister für Patienten mit Vorhofflimmern in Deutschland
ID 81X1600209
Institution Klinikum der Universität München
Project leader Michael Näbauer
Site Extern
Project type Competence Networks
Funding 108786.24€ 108786,24
Begin 2019-01-0101.01.2019
End 2019-12-3131.12.2019
Projektdetails
Das AFNET 2- EORP Register ist ein prospektives, multizentrisches Langzeitregister für Patienten mit Vorhofflimmern, das das Kompetenznetz Vorhofflimmern (AFNET e.V.) in Kooperation mit der Deutschen Gesellschaft für Kardiologie (DGK) und der Europäischen Gesellschaft für Kardiologie (ESC, EURObservational Research Programme EORP) durchgeführt. Ziel ist, den aktuellen Stand der Versorgung von Patienten mit Vorhofflimmern in Deutschland zu erheben und Einblick in Komplikationen und Mortalität in Bezug auf Komorbiditäten und Behandlung zu erhalten. Das Register umfasst 3485 konsekutive Patienten mit EKG-dokumentiertem Vorhofflimmern, die von Mai 2014 bis März 2016 von insgesamt 132 Studienzentren aus allen Bereichen der medizinischen Versorgung (Praxen und Kliniken, mit und ohne kardiologische Fachspezialisierung) eingeschlossen wurden, um ein repräsentatives Bild der Versorgung im klinischen Alltag zu erhalten. Dokumentiert werden klinische Charakteristika der Patienten einschließlich Begleiterkrankungen unter besonderer Berücksichtigung von Risikofaktoren für Schlaganfall und Blutungen, diagnostische und therapeutische Prozeduren, antithrombotische Therapie, Antiarrhythmika, Kardioversion und Katheterablation. Die Nachbeobachtung der Patienten über 3 Jahre ermöglicht den längerfristigen Verlauf und die Prognose von Vorhofflimmern im klinischen Versorgungsalltag zu erfassen und zu evaluieren.

Nucleic acid therapies: Targeted AAV vectors for efficient cardiovascular gene transfer
ID 81X2710199
Institution Universitätsklinikum Hamburg-Eppendorf (UKE)
Project leader Thomas Eschenhagen
Site Hamburg/Kiel/Lübeck
Project type Innovation Cluster
Funding 86700.00 €€ 86.700,00 €
Begin 2024-01-0101.01.2024
End 2026-12-3131.12.2026
Projektdetails

Postdoc start-up grant: Appraisal of novel human T cell subtype modulating adaption to atherosclerotic vascular occlusion
ID 81X3700108
Institution Universität zu Lübeck
Project leader Henry Nording
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 84550.00 €€ 84.550,00 €
Begin 2024-03-0101.03.2024
End 2026-02-2828.02.2026
Projektdetails

Nucleic acid therapies: Targeted AAV vectors for efficient cardiovascular gene transfer
ID 81X4500126
Institution Universitätsklinikum Heidelberg
Project leader Dirk Grimm
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 269700.00 €€ 269.700,00 €
Begin 2024-01-0101.01.2024
End 2026-12-3131.12.2026
Projektdetails
Obwohl AAV-Vektoren zunehmend in klinischen Studien eingesetzt werden, stoßen sie bei der Gentherapie von Herz-Kreislauf-Erkrankungen immer noch an Grenzen. Dieses Konsortium will die Hürden überwinden, die sich aus der mangelnden Effizienz und Spezifität von AAV-Vektoren für viele kardiovaskuläre Zelltypen, den hepatischen Nebenwirkungen und den Unterschieden zwischen den Arten ergeben. Wir wollen neuartige AAV-Vektoren entwickeln, die auf Kardiomyozyten, kardiale Fibroblasten, vaskuläre Endothelzellen und vaskuläre glatte Muskelzellen abzielen. Das Targeting wird auf der Transduktionsebene durch die Auswahl von randomisierten Peptid-Display- und Shuffle-AAV-Kapsid-Bibliotheken erreicht. Parallel dazu werden wir neue AAV-Enhancer-Bibliotheken auf der Grundlage bioinformatischer Algorithmen für das Hochdurchsatz-Screening erstellen. Auswahl und Validierung dieser Bibliotheken in NHP-Modellen und künstlich hergestelltem menschlichen Herzgewebe mit Hilfe fortschrittlicher Sequenzierungs- und Bioinformatik-Techniken werden neuartige zielgerichtete AAV Vektoren identifizieren, die die Genexpression in kardiovaskulären Zelltypen von Patienten erleichtern.

Brain heart interfaces: The neurovascular unit in the aging heart
ID 81X2200169
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Stefanie Dimmeler
Site RheinMain
Project type Innovation Cluster
Funding 52177.00 €€ 52.177,00 €
Begin 2024-02-0101.02.2024
End 2027-02-2828.02.2027
Projektdetails

Postdoc start-up grant on advancing digital aspects: Predictive modeling of inflammation-driven cardiovascular disease outcomes with artificial intelligence
ID 81X3100224
Institution Charité - Universitätsmedizin Berlin
Project leader Hendrik Bartolomaeus
Site Berlin
Project type Excellence Programme
Funding 79100.00 €€ 79.100,00 €
Begin 2024-02-0101.02.2024
End 2025-01-3131.01.2025
Projektdetails

Brain heart interfaces: Central serotonin in atherosclerosis
ID 81X2600283
Institution Klinikum der Universität München
Project leader Johan Duchene
Site München
Project type Innovation Cluster
Funding 266602.00 €€ 266.602,00 €
Begin 2024-01-0101.01.2024
End 2026-06-3030.06.2026
Projektdetails

Nucleic acid therapies: Cross-species optimization of viral vector-based gene editing in the heart
ID 81X4500127
Institution Universität Heidelberg
Project leader Dirk Grimm
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 307517.00 €€ 307.517,00 €
Begin 2024-01-0101.01.2024
End 2026-12-3131.12.2026
Projektdetails
CRISPR-basierte Tools bieten die Möglichkeit, krankheitsverursachende Mutationen zu korrigieren. Zu diesem Zweck müssen die Gen-Editing-Enzyme an das Zielgewebe abgegeben werden, was meist durch Adeno-assoziierte Viren (AAVs) erreicht wird. Wir und andere haben AAVs mit hoher Affinität zu Muskelzellen und geringer Ausrichtung auf andere Gewebe entwickelt und ihre Fähigkeit, die Genbearbeitung bei Mäusen zu vermitteln, erfolgreich demonstriert. Um eine klinische Umsetzung zu ermöglichen, müssen Sicherheit und Wirksamkeit bei Schweinen mit einer ähnlichen Herzphysiologie wie beim Menschen nachgewiesen werden. Die größte Hürde besteht darin, dass die AAVs häufig Leistungsunterschiede zwischen den Arten aufweisen und die meisten Kapsidvarianten weder an Schweinen noch an Menschen getestet wurden. Deshalb möchten wir in diesem Projekt 50 der "besten" AAV-Varianten in Mäusen, Schweinen und menschlichem vaskularisiertem Herzgewebe zu testen um die beste(n) AAV-Variante(n) für die Durchführung einer präzisen Genombearbeitung im Herzen zu ermitteln. Als Proof-of-Concept werden wir eine krankheitsverursachende Variante des kardialen Spleißfaktors RBM20 einführen, die zu einer dilatativen Kardiomyopathie führt.

Nucleic acid therapies: Cross-species optimization of viral vector-based gene editing in the heart
ID 81X2500403
Institution Europäisches Laboratorium für Molekularbiologie (EMBL)
Project leader Lars Steinmetz
Site Heidelberg/Mannheim
Project type Innovation Cluster
Funding 223357.68 €€ 223.357,68 €
Begin 2024-01-0101.01.2024
End 2026-12-3131.12.2026
Projektdetails

Postdoc start-up grant on advancing digital aspects: Prioritizing splicing regulation in heart failure through genome and transcriptome sequencing data integration
ID 81X3500144
Institution Universität Heidelberg
Project leader Thiago Britto Borges
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 84725.84 €€ 84.725,84 €
Begin 2024-02-0101.02.2024
End 2025-07-3131.07.2025
Projektdetails

Brain heart interfaces: The neurovascular unit in the aging heart
ID 81X2600708
Institution Ludwig-Maximilians-Universität München
Project leader Eckhard Wolf
Site München
Project type Innovation Cluster
Funding 90000.00 €€ 90.000,00 €
Begin 2024-02-0101.02.2024
End 2027-02-2828.02.2027
Projektdetails

Brain heart interfaces: The neurovascular unit in the aging heart
ID 81X2210130
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site RheinMain
Project type Innovation Cluster
Funding 116404.46 €€ 116.404,46 €
Begin 2024-03-0101.03.2024
End 2027-02-2828.02.2027
Projektdetails
In the modern society, increased life expectancy has led to a shift in the distribution of relevant diseases. Hence, age-related pathologies, particularly cardiovascular diseases, rank as leading causes of death globally1. During aging, the heart undergoes various structural and cellular changes that underlie cellular alterations and result in reduced cardiac function2,3. The cardiac autonomic nervous system has caught special attention in this context as a decline of sympathetic fibers in the aging left ventricle was associated with decreased heart rate variability (HRV) and increased arrhythmic risk. As putative mechanism nervous regression was suggested as a consequence of a disturbed neurovascular interaction possibly driven by vascular senescence. Since heart failure with preserved ejection fraction (HFpEF) is a prominent age-related cardiovascular disease, the present proposal is meant to understand the involvement of the neurovascular unit in the pathophysiology of HFpEF.

Discovering the microvascular landscape from a platelet perspective – mapping a blood-bone marrow-heart axis to identify therapeutic targets for heart failure
ID 81X2100286
Institution Charité - Universitätsmedizin Berlin
Project leader Tobias Petzold
Site Berlin
Project type Internationale Kooperation
Funding 497454.00 €€ 497.454,00 €
Begin 2024-04-0101.04.2024
End 2028-03-3131.03.2028
Projektdetails

TRP starter grant: Development of a novel NIRF-IVUS intravascular imaging system for in-vivo intracoronary imaging
ID 81X2600532
Institution Deutsches Herzzentrum München
Project leader Michael Joner
Site München
Project type Translational Research Project
Funding 51509.25 €€ 51.509,25 €
Begin 2024-03-0101.03.2024
End 2025-09-3030.09.2025
Projektdetails

Brain heart interfaces: The neurovascular unit in the aging heart
ID 81X2600284
Institution Klinikum der Universität München
Project leader Sebastian Clauss
Site München
Project type Innovation Cluster
Funding 149999.80 €€ 149.999,80 €
Begin 2024-03-0101.03.2024
End 2027-02-2828.02.2027
Projektdetails

Orthogonal testing of CD40-TRAF6 interaction inhibitors
ID 81X2600285
Institution Klinikum der Universität München
Project leader Dorothee Atzler
Site München
Project type Translational Research Project
Funding 166170.00 €€ 166.170,00 €
Begin 2024-05-0101.05.2024
End 2024-12-3131.12.2024
Projektdetails

TRP starter grant: Development of a novel NIRF-IVUS intravascular imaging system for in-vivo intracoronary imaging
ID 81X2600421
Institution Technische Universität München
Project leader Vasilis Ntziachristos
Site München
Project type Translational Research Project
Funding 98071.63 €€ 98.071,63 €
Begin 2024-04-0101.04.2024
End 2025-09-3030.09.2025
Projektdetails

Postdoc start-up grant on advancing digital aspects: 3D reconstruction and rapid prototyping for treatment planning in congenital heart disease
ID 81X3100225
Institution Charité - Universitätsmedizin Berlin
Project leader Jan Brüning
Site Berlin
Project type Excellence Programme
Funding 84843.26 €€ 84.843,26 €
Begin 2024-09-0101.09.2024
End 2025-08-3131.08.2025
Projektdetails

A new hypothesis for some dominant diseases affecting the heart
ID 81X4300134
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Lukas Cyganek
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE171)
Funding 31600.00 €€ 31.600,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

A new hypothesis for some dominant diseases affecting the heart
ID 81X2200322
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Didier Stainier
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE171)
Funding 31240.00 €€ 31.240,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Understanding the mechano-signalling role of the Z-disc in the pathogenesis of hypertrophic cardiomyopathy
ID 81X2100287
Institution Charité - Universitätsmedizin Berlin
Project leader Claudia Crocini
Site Berlin
Project type Internationale Kooperation
Funding 500000.00 €€ 500.000,00 €
Begin 2024-09-0101.09.2024
End 2028-08-3131.08.2028
Projektdetails

Common biomarkers in the secretome of patient-derived iPSC-CMs and cardiomyopathy patients
ID 81X1300131
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Antje Ebert
Site Göttingen
Project type Daten- und Probennutzung
Funding 40000.00 €€ 40.000,00 €
Begin 2024-08-1515.08.2024
End 2026-07-1414.07.2026
Projektdetails

Promotion of women scientists: Deciphering the function of DNA demethylation for heart regeneration and remodeling
ID 81X3200315
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Fan Wu
Site RheinMain
Project type Excellence Programme
Funding 90000.00 €€ 90.000,00 €
Begin 2024-09-0101.09.2024
End 2025-08-3131.08.2025
Projektdetails

Elucidating the function of cardiomyocyte hypertrophic-related genes in single cells with Cas13 RNA Perturb-seq
ID 81X2700253
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver J. Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 50000.00 €€ 50.000,00 €
Begin 2024-11-0101.11.2024
End 2026-04-3030.04.2026
Projektdetails

Exploring the role of ?-aminobutyric acid in cardiac electrophysiology in health and disease
ID 81X4300133
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Niels Voigt
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE181)
Funding 29679.00 €€ 29.679,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Applying large language models to enhance data extraction for clinical research
ID 81X4710101
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Benedikt Beer
Site Hamburg/Kiel/Lübeck
Project type Cooperation with External Partners
Funding 25000.00 €€ 25.000,00 €
Begin 2024-09-0101.09.2024
End 2026-02-2828.02.2026
Projektdetails

TRP starter grant: Targeting PCSK6 to reduce cardiac fibrosis and prevent heart failure
ID 81X4500128
Institution Universität Heidelberg
Project leader Tim Christian Kuhn
Site Heidelberg/Mannheim
Project type Translational Research Project
Funding 149939.92 €€ 149.939,92 €
Begin 2024-08-0101.08.2024
End 2026-01-3131.01.2026
Projektdetails

Investigating cilia function during cardiac valve formation using Brillouin microscopy
ID 81X2200323
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Didier Stainier
Site RheinMain
Project type Cooperation with External Partners
Funding 19150.00 €€ 19.150,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Postdoc start-up grant: KDM5 reshapes the cardiac epigenome by sensing metabolic alterations and enables heart regeneration
ID 81X3200316
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Xiang Li
Site RheinMain
Project type Excellence Programme
Funding 85000.00 €€ 85.000,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Mitochondrial dysfunction as a key factor in CKD-induced HFpEF
ID 81X2600286
Institution Klinikum der Universität München
Project leader Daphne Merkus
Site München
Project type Cooperation with External Partners
Funding 24000.00 €€ 24.000,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3030.08.2026
Projektdetails

Cell-specific role of the clonal hematopoiesis driver gene EZH2 in the context of ischemic heart failure
ID 81X2600289
Institution Klinikum der Universität München
Project leader Dorothee Atzler
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE057, SE228)
Funding 13000.00 €€ 13.000,00 €
Begin 2024-10-0101.10.2024
End 2026-03-3131.03.2026
Projektdetails

Endothelial cells after heart failure using AAV vectors
ID 81X2600636
Institution Klinikum der Technischen Universität München (TUM Klinikum)
Project leader Christian Kupatt
Site München
Project type Shared Expertise (SE)
SE Trait SE provider
Funding 30000.00 €€ 30.000,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Large language models for German clinical routine text annotation in the cardiovascular domain
ID 81X2600533
Institution Deutsches Herzzentrum München im Klinikum der Technischen Universität München (TUM Klinikum)
Project leader Nils Krüger
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE222)
Funding 13258.00 €€ 13.258,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Studying Ca2+ handling and its role in arrhythmogenesis in a RYR2-deficient preclinical pig model
ID 81X2600288
Institution Klinikum der Universität München
Project leader Sebastian Clauß
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE181)
Funding 24000.00 €€ 24.000,00 €
Begin 2024-10-0101.10.2024
End 2025-09-3030.09.2025
Projektdetails

The functional role of miR-144 in atrial arrhythmogenesis in a murine knockout model
ID 81X2600290
Institution Klinikum der Universität München
Project leader Philipp Tomsits
Site München
Project type Shared Expertise (SE)
SE Trait SE user  (SE181)
Funding 24000.00 €€ 24.000,00 €
Begin 2024-10-0101.10.2024
End 2025-09-3030.09.2025
Projektdetails

Mechanical Challenge of Titin Elastic Domain Deficient Human Engineered Heart Tissue
ID 81X2100182
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Pragati Parakkat
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE024)
Funding 37499.99 €€ 37.499,99 €
Begin 2024-09-0101.09.2024
End 2026-02-2828.02.2026
Projektdetails

Metabolic syndrome as risk factor for CVD: Differential DLK- and CRIP1-dependent gene expression
ID 81X2100178
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Janine Altmüller
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE215)
Funding 46500.00 €€ 46.500,00 €
Begin 2024-08-0101.08.2024
End 2026-01-3131.01.2026
Projektdetails

Postdoc start-up grant: Control of inflammation by a translational burst in the infarcted myocardium
ID 81X3500146
Institution Universität Heidelberg
Project leader Christoph Hofmann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 83530.00 €€ 83.530,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Promotion of women scientists: Dissecting the genetic basis of the heart-brain connection in atrial arrhythmias and epilepsy
ID 81X3500147
Institution Universität Heidelberg
Project leader Sandra Hoffmann
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 90000.00 €€ 90.000,00 €
Begin 2024-09-0101.09.2024
End 2025-08-3131.08.2025
Projektdetails

Importance of erythrocyte-derived nitric oxide for blood pressure regulation
ID 81X4500129
Institution Universität Heidelberg
Project leader Marc Freichel
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE119)
Funding 25972.00 €€ 25.972,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Microbiota-derived metabolites in the intestinal mucosa microenvironment as risk factor for CVD
ID 81X2100180
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Dominik Müller
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE178)
Funding 31199.94 €€ 31.199,94 €
Begin 2024-09-0101.09.2024
End 2025-08-3131.08.2025
Projektdetails

Postdoc start-up grant: Temporal and functional characterization of human immune phenotypes in cardiogenic shock
ID 81X3600231
Institution Klinikum der Universität München
Project leader Rainer Kaiser
Site München
Project type Excellence Programme
Funding 85000.00 €€ 85.000,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Postdoc start-up grant: Molecular interaction of a novel blood biomarker and atrial high rate episode burden
ID 81X3710118
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Laura Sommerfeld
Site Hamburg/Kiel/Lübeck
Project type Excellence Programme
Funding 84998.00 €€ 84.998,00 €
Begin 2024-10-0101.10.2024
End 2025-11-3030.11.2025
Projektdetails

Consensus transcriptional landscape of cardiac cells during heart failure
ID 81X2100181
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Hübner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 50000.00 €€ 50.000,00 €
Begin 2024-09-0101.09.2024
End 2026-02-2828.02.2026
Projektdetails

Promotion of women scientists: Illuminating aberrant cell-cell communication patterns of senescent regions in aging hearts
ID 81X3200128
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Nina Baumgarten
Site RheinMain
Project type Excellence Programme
Funding 54524.65 €€ 54.524,65 €
Begin 2024-08-0101.08.2024
End 2025-07-3030.07.2025
Projektdetails

Atrial cardiomyopathy subtype discrimination at a single cell resolution
ID 81X2100183
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Norbert Hübner
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE006)
Funding 61000.00 €€ 61.000,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Studies on the relationship between gut microbiome dysbiosis and adverse hemodynamic outcome after acute myocardial infarction
ID 81X2800225
Institution Philipps-Universität Marburg
Project leader Volker Ruppert
Site Extern
Project type Cooperation with External Partners
Funding 53627.00 €€ 53.627,00 €
Begin 2024-08-0101.08.2024
End 2026-01-3131.01.2026
Projektdetails

Endothelial cells after heart failure using AAV vectors
ID 81X2700250
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver J. Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 32000.00 €€ 32.000,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Exploring the role of ?-aminobutyric acid in cardiac electrophysiology in health and disease
ID 81X4710102
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Manu Beerens
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE181)
Funding 20321.00 €€ 20.321,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Innate immunotherapy in atherosclerosis
ID 81X2700252
Institution Universitätsklinikum Schleswig-Holstein
Project leader Oliver J. Müller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE161)
Funding 38200.00 €€ 38.200,00 €
Begin 2024-10-0101.10.2024
End 2026-03-3131.03.2026
Projektdetails

Mechanical Challenge of Titin Elastic Domain Deficient Human Engineered Heart Tissue
ID 81X4710103
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Marc Hirt
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE024)
Funding 37500.00 €€ 37.500,00 €
Begin 2024-09-0101.09.2024
End 2026-02-2828.02.2026
Projektdetails

Type 1 collagen is a novel RNA binding protein: uncovering the function of its interactions with RNA
ID 81X2500221
Institution Universität Heidelberg
Project leader Rhys Wardman
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE213)
Funding 38043.60 €€ 38.043,60 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Clinician scientist fellowship: Targeted cardiac inactivation of guanylate binding protein 5 protects from radiation-induced myocardial fibrosis
ID 81X3500148
Institution Universität Heidelberg
Project leader Jannek Brauer
Site Heidelberg/Mannheim
Project type Excellence Programme
Funding 125127.00 €€ 125.127,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Metabolic syndrome as risk factor for CVD: Differential DLK- and CRIP1-dependent gene expression
ID 81X4710100
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Elke Oetjen
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE215)
Funding 3500.00 €€ 3.500,00 €
Begin 2024-08-0101.08.2024
End 2026-01-0101.01.2026
Projektdetails

Applying large language models to enhance data extraction for clinical research
ID 81X2800226
Institution Leuphana Universität Lüneburg
Project leader Ricardo Usbeck
Site Extern
Project type Cooperation with External Partners
Funding 25000.00 €€ 25.000,00 €
Begin 2024-09-0101.09.2024
End 2026-02-2828.02.2026
Projektdetails

Proteomic signatures of structural heart disease in relation to interventional valve treatment.
ID 81X2700251
Institution Universitätsklinikum Schleswig-Holstein
Project leader Derk Frank
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE175)
Funding 41385.00 €€ 41.385,00 €
Begin 2024-09-0101.09.2024
End 2026-03-3131.03.2026
Projektdetails

Single cell analysis of blood mononuclear cells of patients with atrial fibrillation
ID 81X4710105
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Tanja Zeller
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE062)
Funding 27000.00 €€ 27.000,00 €
Begin 2024-10-0101.10.2024
End 2025-10-3131.10.2025
Projektdetails

Studies on cognitive function, cerebral blood flow and the microstructure of cerebral vessels
ID 81X2700145
Institution Universität zu Lübeck
Project leader Walter Raasch
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE user  (SE226)
Funding 27500.00 €€ 27.500,00 €
Begin 2024-08-0101.08.2024
End 2025-12-3131.12.2025
Projektdetails

Metabolomic and proteomic changes in endothelial cells as a possible cause of thrombus non-resolution in patients with chronic thromboembolic pulmonary hypertension
ID 81X2210133
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Magdalena Bochenek
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE216)
Funding 15920.00 €€ 15.920,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Impact of proteostasis and macrophage polarization on iron and ferritin status in heart failure
ID 81X2100502
Institution Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Project leader Christiane Ott
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE user  (SE183)
Funding 37500.00 €€ 37.500,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Proteomic signatures of structural heart disease in relation to interventional valve treatment.
ID 81X2210132
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Philipp Wild
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE175)
Funding 41385.00 €€ 41.385,00 €
Begin 2024-09-0101.09.2024
End 2026-03-3131.03.2026
Projektdetails

Importance of erythrocyte-derived nitric oxide for blood pressure regulation
ID 81X2210131
Institution Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Project leader Rajinikanth Gogiraju
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE119)
Funding 12300.00 €€ 12.300,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Innate immunotherapy in atherosclerosis
ID 81X4500133
Institution Universität Heidelberg
Project leader Kai-Uwe Jarr
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 38200.00 €€ 38.200,00 €
Begin 2024-10-0101.10.2024
End 2026-03-3131.03.2026
Projektdetails

Endothelial cells after heart failure using AAV vectors
ID 81X2200171
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Simone-Franziska Glaser
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE161)
Funding 48000.00 €€ 48.000,00 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Impact of proteostasis and macrophage polarization on iron and ferritin status in heart failure
ID 81X4500134
Institution Universität Heidelberg
Project leader Martina Muckenthaler
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE183)
Funding 37500.00 €€ 37.500,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

The complex world of the RNA binding proteins RBPMS and RBPMS2 in cell type specific isoform heterogeneity
ID 81X4500135
Institution Universität Heidelberg
Project leader Christoph Dieterich
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE152)
Funding 26740.00 €€ 26.740,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Large language models for German clinical routine text annotation in the cardiovascular domain
ID 81X4500136
Institution Universität Heidelberg
Project leader Phillip Richter-Pechanski
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE222)
Funding 34742.00 €€ 34.742,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Cell-specific role of the clonal hematopoiesis driver gene EZH2 in the context of ischemic heart failure
ID 81X4710104
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Edzard Schwedhelm
Site Hamburg/Kiel/Lübeck
Project type Shared Expertise (SE)
SE Trait SE provider  (SE057)
Funding 15000.00 €€ 15.000,00 €
Begin 2024-10-0101.10.2024
End 2026-03-3131.03.2026
Projektdetails

Microbiota-derived metabolites in the intestinal mucosa microenvironment as risk factor for CVD
ID 81X2200170
Institution Johann Wolfgang Goethe-Universität Frankfurt am Main
Project leader Ingrid Fleming
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE provider  (SE178)
Funding 43800.00 €€ 43.800,00 €
Begin 2024-09-0101.09.2024
End 2025-08-3131.08.2025
Projektdetails

Consensus transcriptional landscape of cardiac cells during heart failure
ID 81X4500130
Institution Universität Heidelberg
Project leader Julio Saez-Rodriguez
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 26400.00 €€ 26.400,00 €
Begin 2024-09-0101.09.2024
End 2026-02-2828.02.2026
Projektdetails

Functional characterization of upstream open reading frame (uORF)-encoded microproteins in
ID 81X4500131
Institution Universität Heidelberg
Project leader Maja Bencun
Site Heidelberg/Mannheim
Project type Cooperation with External Partners
Funding 38200.00 €€ 38.200,00 €
Begin 2024-09-0101.09.2024
End 2026-03-3131.03.2026
Projektdetails

Atrial cardiomyopathy subtype discrimination at a single cell resolution
ID 81X4500132
Institution Universität Heidelberg
Project leader Constanze Schmidt
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE user  (SE006)
Funding 13980.19 €€ 13.980,19 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Studies on cognitive function, cerebral blood flow and the microstructure of cerebral vessels
ID 81X2100179
Institution Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
Project leader Ralf Dechend
Site Berlin
Project type Shared Expertise (SE)
SE Trait SE provider  (SE226)
Funding 27500.00 €€ 27.500,00 €
Begin 2024-08-0101.08.2024
End 2025-12-3131.12.2025
Projektdetails

Studies on the relationship between gut microbiome dysbiosis and adverse hemodynamic outcome after acute myocardial infarction
ID 81X4300132
Institution Georg-August-Universität Göttingen - Universitätsmedizin
Project leader Thomas Meyer
Site Göttingen
Project type Cooperation with External Partners
Funding 47700.00 €€ 47.700,00 €
Begin 2024-08-0101.08.2024
End 2026-01-3131.01.2026
Projektdetails

Studying Ca2+ handling and its role in arrhythmogenesis in a RYR2-deficient preclinical pig model
ID 81X4300135
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Niels Voigt
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE181)
Funding 24000.00 €€ 24.000,00 €
Begin 2024-10-0101.10.2024
End 2025-09-3030.09.2025
Projektdetails

The complex world of the RNA binding proteins RBPMS and RBPMS2 in cell type specific isoform heterogeneity
ID 81X2200321
Institution Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Project leader Thomas Braun
Site RheinMain
Project type Shared Expertise (SE)
SE Trait SE user  (SE152)
Funding 24000.00 €€ 24.000,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

The functional role of miR-144 in atrial arrhythmogenesis in a murine knockout model
ID 81X4300136
Institution Georg-August-Universität Göttingen - Universitätsmedizin Göttingen
Project leader Niels Voigt
Site Göttingen
Project type Shared Expertise (SE)
SE Trait SE provider  (SE181)
Funding 24000.00 €€ 24.000,00 €
Begin 2024-10-0101.10.2024
End 2025-09-3030.09.2025
Projektdetails

TRP starter grant: Induction of tolerance to pig cardiac allo- and xenografts by thymic co-transplantation
ID 81X2600287
Institution Klinikum der Universität München
Project leader Sebastian Michel
Site München
Project type Translational Research Project
Funding 140000.00 €€ 140.000,00 €
Begin 2024-09-0101.09.2024
End 2026-02-2828.02.2026
Projektdetails

Whole genome sequencing of DCM patients of the multi center, double blind study for mmunoadsorption with subsequent IgG substitution therapy (IA/IgG)
ID 81X4500137
Institution Universität Heidelberg
Project leader Jan Haas
Site Heidelberg/Mannheim
Project type Shared Expertise (SE)
SE Trait SE provider  (SE031)
Funding 28000.00 €€ 28.000,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

Functional characterization of upstream open reading frame (uORF)-encoded microproteins in cardiomyocytes
ID 81X2800228
Institution Universität Bayreuth
Project leader Janosch Hennig
Site Extern
Project type Cooperation with External Partners
Funding 38200.00 €€ 38.200,00 €
Begin 2024-09-0101.09.2024
End 2026-03-3131.03.2026
Projektdetails

Type 1 collagen is a novel RNA binding protein: uncovering the function of its interactions with RNA
ID 81X2400165
Institution Universitätsmedizin Greifswald
Project leader Mohamed Ghait
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE213)
Funding 38356.40 €€ 38.356,40 €
Begin 2024-09-0101.09.2024
End 2026-08-3131.08.2026
Projektdetails

Causal impact of lipid-associated DNA methylation changes on cardiometabolic health
ID 81X2400167
Institution Universitätsmedizin Greifswald
Project leader Alexander Teumer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE provider  (SE081)
Funding 24000.00 €€ 24.000,00 €
Begin 2024-10-0101.10.2024
End 2025-12-3131.12.2025
Projektdetails

CRIP1 association to vasoactive and atherogenic factors in CAD patients: A study from the DZHK Heart Bank
ID 81X1710116
Institution Universitätsklinikum Hamburg-Eppendorf
Project leader Olga Schweigert
Site Hamburg/Kiel/Lübeck
Project type Daten- und Probennutzung
Funding 40002.57 €€ 40.002,57 €
Begin 2024-09-0101.09.2024
End 2025-08-3131.08.2025
Projektdetails

Whole genome sequencing of DCM patients of the multi center, double blind study for immunoadsorption with subsequent IgG substitution therapy (IA/IgG)
ID 81X2400166
Institution Universitätsmedizin Greifswald
Project leader Elke Hammer
Site Greifswald
Project type Shared Expertise (SE)
SE Trait SE user  (SE031)
Funding 13600.00 €€ 13.600,00 €
Begin 2024-10-0101.10.2024
End 2026-09-3030.09.2026
Projektdetails

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1701 total entries
Last update 10.12.2024