Detection of plaque vulnerability with a novel hybrid intravascular NIRF-IVUS imaging system

the Despite advances in cardiovascular imaging techniques, no imaging method can distinguish stable from unstable plaques. This project aims to develop a hybrid system for medical routine use that couples vascular ultrasound with near-infrared fluorescence. With the hybrid system, molecular parameters of the inflammation can be recorded, and at the same time, the degree of permeability of unstable plaques can be determined. This technology should enable identification of patients at risk for further cardiovascular events and early intervention with appropriate therapy. The tasks of this translational project include reducing the catheter size for hybrid imaging, conducting a preclinical proof-of-concept, investigating the safety of the technology, and, finally, developing a prototype for clinical studies.