Preserve-Synch-DZHK30

Left bundle branch area pacing versus right ventricular pacing to maintain physiological ventricular activation in patients with normal or mildly reduced left ventricular ejection fraction (Preserve-Synch-DZHK30)

In the nationwide clinical study PRESERVE-SYNCH DZHK30, researchers at LMU University Hospital Munich and the German Heart Center of the Charité (DHZC) are investigating a novel pacemaker therapy that could help prevent heart failure caused by conventional pacemakers.

The new method, known as physiological left bundle branch area pacing (LBBAP), more closely mimics the heart’s natural signal conduction. Instead of artificially initiating the electrical signal “from the outside,” the heart’s intrinsic conduction system – the His-Purkinje system – is specifically activated. In a healthy heart, this system ensures that all heart muscle cells contract at the right time, enabling the heart to efficiently pump blood throughout the body. The researchers aim to determine whether this new technique could provide a gentler and more effective alternative to traditional pacemakers.

More than 20 hospitals across Germany are participating in the study. Around 200 patients with advanced AV block – individuals who are permanently dependent on a pacemaker – are expected to take part.

The scientific leadership is shared by PD Dr. Florian Blaschke (DHZC) and PD Dr. Moritz Sinner (LMU University Hospital Munich). The Charité is also assuming legal responsibility for the project. The study is funded by the German Centre for Cardiovascular Research (DZHK).

Publications

There are no publications yet.

Principal Investigators

Principal investigator: Florian Blaschke (Berlin), Co-PI: Moritz Sinner (München)

Study recruitment is available in these cities

The map only displays recruitment locations within Germany.