DZHK Paper of the month

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair. Circulation. 2017;135:1832–1847. DOI: 10.1161/CIRCULATIONAHA.116.024145, DZHK authors: Tiburcy, Balfanz, Schlick, Meyer, Chang Liao, Levent, Raad, Zeidler,...

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus, Circulation, doi: 10.1161/CIRCULATIONAHA.116.024152, DZHK authors: Kessler, Wobst, Wolf, Vilne, Dang, Sager, Kastrati, Erdmann, Kaiser, Schunkert

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function, J Clin Invest. 2017. doi:10.1172/JCI84840, DZHK authors: Wild, Schillert, Teumer, Völker, Edelmann, Friedrich, Peters, Wachter, Völzke, Ziegler, Münzel, Pieske, Schunkert,...

Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias, Nature Communications 8 (2017), Article number: 14155 (2017) doi:10.1038/ncomms14155, DZHK authors: Jungen, Scherschel, Eickholt, Klatt, Bork, Willems, Nikolaev, Meyer

Catheter ablation...

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension, Science Translational Medicine, Vol. 9, Issue 375, DOI: 10.1126/scitranslmed.aah4923, DZHK authors: Kossmann, Lagrange, Jäckel, Jurk, Ehlken, Brandt, Li, Daiber, Reinhardt,...

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure, Circulation, 2016; CIRCULATIONAHA.116.022852, DZHK authors: Nikolaev, Würtz, Voigt, Müller, Meder, Katus, Vettel, Lehmann, Backs, Lutz, Wieland

Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis, Sci. Transl. Med. 8, 367ra168 (2016), DZHK authors: Petzold, Siess, Schulz, Massberg

Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells, Science Translational Medicine (2016), doi:10.1126/scitranslmed.aaf8781, DZHK authors: Weinberger, Breckwoldt, Reichenspurner, Hansen, Eschenhagen

Axial tubule junctions control rapid calcium signaling in atria, Clin Invest. (2016) doi:10.1172/JCI88241, DZHK authors: Brandenburg, Wagner, Hebisch, Didié, Gotthardt, Nikolaev, Hasenfuss, Lehnart.

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation, Nature Medicine (2016) doi:10.1038/nm.4172, DZHK-Autoren: Stellos, Gatsiou, John, Lunella, Jaé, Boon, Manavski, Uchida, Boeckel,...