DZHK Paper of the month

ApoE attenuates unresolvable inflammation by complex formation with activated C1q, Nature Medicine. DZHK authors: Yin, Mohanta, Steffens, Eckstein, Weber

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis, Journal of Experimental Medicine, DZHK authors: Weckbach, Grabmaier, Massberg

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage. Circulation. DZHK authors: Bartolomaeus, Balogh, Marko, Tsvetkov, Wundersitz, Avery, Haase, Kräker, Kusche-Vihrog, Fielitz, Gollasch, Dechend, Müller, Wilck

Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Science Translational Medicine. DZHK authors: Mohamed, Hartmann, Tirilomis, Richter, Zeisberg, Didié, Lehnart, Luther, Voigt, Seidler, Sossalla, Hasenfuss, Toischer

Machine learning for real-time prediction of complications in critical care: a retrospective study. Lancet Resp Med. DZHK authors: Meyer, Kühne, Sündermann, Stamm, Falk

Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial. The Lancet, Volume 392 (2018). DZHK authors: Wegscheider, Edelmann, Schöbel, Dreger, Anker, Stangl

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation. European Heart Journal, ehy333. DZHK authors: Kröller-Schön, Daiber, Pinto, Wild, Rapp, Münzel

Chrono-pharmacological targeting of the CCL2-CCR2 axis ameliorates atherosclerosis. Cell Metabolism (2018), DZHK authors: Winter, Silvestre-Roig, Ortega-Gomez, Schumski, Drechsler, Immler, Sperandio, Zeller, Weber, Viola, Soehnlein

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes. EMBO Molecular Medicine (2018), DZHK authors: Tóth, Schell, Lévay, Vettel, Theis, Haslinger, Alban, Werhahn, Frischbier, Krebs‐Haupenthal, Katus, Wieland, Backs

H19 Induces Abdominal Aortic Aneurysm Development and Progression. Circulation, 2018. DZHK authors: Li, Busch, Hofmann, Ramanujam, Dueck, Engelhardt, Boon, Eckstein, Maegdefessel