DZHK Paper of the month

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing, Nature Genetics, 2016, DZHK authors: Hitz, Abdul-Khaliq, Bauer, Berger, Kramer, Pickardt, Klaassen

Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease—results from the large AtheroGene study. European Heart Journal, doi:10.1093/eurheartj/ehw250, DZHK authors: Karakas, Lackner, Münzel, Schnabel, Blankenberg, Zeller

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression, Nature Communications 7, Article number: 11317, 2016, DZHK authors: Eden, Meder, Völkers, Busch, Hrabě de Angelis, Most, Frey

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis, JACC. 67, NO. 17, 2016, DZHK authors: Meyer, Ramanujam, Engelhardt, Sarikas

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, N Engl J Med. 2016 March 2, DZHK authors: Erdmann, König, Franke, Kessler, Laugwitz, Meitinger, Peters, Strauch, Kastrati,...

Intestinal Congestion and Right Ventricular Dysfunction: A Link with Appetite Loss, Inflammation, and Cachexia in Chronic Heart Failure, Eur Heart J. 2016, DZHK authors: Valentova, von Haehling, Döhner, Ebner, Scherbakov, Anker, Sandek

FoxO1 Couples Metabolic Activity and Growth State in the Vascular Endothelium. Nature (2016), DZHK authors: Braun, Rajewski, Gerhardt, Potente

Critical Role of RAGE and HMGB1 in Inflammatory Heart Disease. Proceedings of the National Academy of Sciences of the United States of America, 2015 Dec 29. pii: 201522288. DZHK authors: Mueller, Katus, Kaya

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5, Science Translational Medicine 09 Dec 2015: DOI: 10.1126/scitranslmed.aad5330, DZHK authors: Bongiovanni, Horckmans, Paulin, Ng, Hinkel, von Hundelshausen,...

Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA, Nucleic Acids Research, doi:10.1093/nar/gkv1244, DZHK authors: Cui, Rickert-Sperling