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March 2014

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Overview
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MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1, Nature Medicine 2014, doi:10.1038/nm.3487, (DZHK-authors: Schober, Weber)

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Atherosclerotic lesions develop preferentially at sites of disturbed blood flow. As shown by Christian Weber in Nature Medicine, doi:10.1038/nm.3487, and his coworkers, this predilection stems from effects of disturbed blood flow on endothelial expression of the microRNA miR-126-5p, which maintains the proliferative reserve of endothelial cells through repression of the Notch pathway inhibitor Dlk1.

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