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May 2023

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Overview
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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation. DZHK authors: Giorgia Ciliberti, Jedrzej Hoffmann, Andre Schneider, Stefan Guenther, Johannes Backs, Thomas Braun, Stefanie Dimmeler, Markus Sperandio, Konstantinos Stellos. Immunity. 2023 May 9, DOI: doi.org/10.1016/j.immuni.2023.03.021

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A team of international scientists led by the Heidelberg University, Medical Faculty Mannheim, and the Newcastle University (Great Britain) has succeeded in decoding a new mechanism of the so-called immune cell trafficking by examining vascular diseases. Surprisingly, the fine-tuning of this fundamental immune defense process is carried out by an RNA editing system (ADAR2) in the endothelial cells that line the blood vessels. This knowledge could open up new therapeutic approaches for a large number of inflammatory diseases.

Original publication

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